Component GO Term endoplasmic reticulum and related genes


Total 164
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Gene NameORF NameFunction GO TermProcess GO TermComponent GO TermInteracting GenesDescriptionGene ProductPhenotype
SPC2YML055Wprotein bindingsignal peptide processingsignal peptidase complexYBR217W YOL016C YER022W YLR078C subunit of signal peptidase complex, homologous to mammalian protein SPC25signal peptidase complex subunit|similar to mammalian protein SPC25Null mutant is viable. spc1 spc2 double deletion mutants grow relatively well as compared to wild-ty
SPC3YLR066Wsignal peptidase activitysignal peptide processingsignal peptidase complexYJR091C signal peptidase subunitNull mutant is inviable.
SPT14YPL175Wtransferase activity, transferring hexosyl groupsGPI anchor biosynthesisendoplasmic reticulumYDR215C N-acetylglucosaminyl-phosphatidylinositol biosynthetic proteinN-acetylglucosaminyl-phosphatidylinositol biosynthetic proteinsuppression of Ty transcription
SRP14YDL092Wsignal sequence bindingprotein-ER targetingsignal recognition particleYPR088C YKL122C Signal recognition particle subunitNull mutant is viable
SRP54YPR088Csignal sequence bindingprotein-ER targetingsignal recognition particleYCL037C YOR128C YER155C YDL051W YDL092W YML105C YKL122C YPL243W YPL210C YOR272W YKR036C YMR106C Signal recognition particle subunit (homolog of mammalian SRP54)Amaya et al. (J. Biochem. (Tokyo) 107:457-463) report that a SRP54 deletion is inviable, whereas Han
SRP68YPL243Wsignal sequence bindingprotein-ER targetingsignal recognition particleYPR088C part of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protsignal recognition particle componentNull mutant is viable, associated with slow cell growth and inefficient protein translocation across
SRP72YPL210Csignal sequence bindingprotein-ER targetingsignal recognition particleYPR088C part of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protsignal recognition particle componentNull mutant is viable, associated with slow cell growth and inefficient protein translocation across
SSS1YDR086Cprotein transporter activitycotranslational membrane targetingtransloconYLR378C YBL022C Subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p), involved in transfer of secretoER protein|Sec61 trimeric complex component|Ssh1 trimeric complex componentNull mutant is inviable. Depletion of the Sss1 protein rapidly results in accumulation of multiple s
SUR2YDR297Wsphingosine hydroxylase activitysphingolipid biosynthesis*endoplasmic reticulumYCR009C YBR036C Possibly hydroxylates ceramide-1 at C-4 to give ceramide-2. Or, hydroxylates DHS at C-4 to give PHS,sphingosine hydroxylaseNull mutant has altered phospholipid levels; suppressor of rvs161 and rvs167 mutations.
SUR4YLR372Wfatty acid elongase activitysphingolipid biosynthesis*endoplasmic reticulum*YPL076W YCR034W YCR009C YPL031C Elongase III synthesizes 20-26-carbon fatty acids from C18-CoA primerselongaseNull mutants is viable, not sensitive to UV or gamma radiation. sur4 mutants suppress rad3, rvs161 d
TIP20YGL145Wmolecular_function unknownretrograde (Golgi to ER) transportendoplasmic reticulumYDR498C YOR075W YNL258C YLR373C YPR086W YLR268W YPR105C transport protein that interacts with Sec20p; required for protein transport from the endoplasmic retransport protein that interacts with Sec20p; required for protein transport from the endoplasmic re
UFD1YGR048Wprotein bindingubiquitin-dependent protein catabolism*endoplasmic reticulumYHR039C-A YBR170C YDL126C YKR002W YDR390C YPL222W Ubiquitin fusion degradation proteinHomozygous ufd1-1 mutant diploids exhibit sporulation defects. loss of Ufd1 blocks ER-associated pro
USE1YGL098WSNAP receptor activityretrograde (Golgi to ER) transportendoplasmic reticulumYEL017W YDR373W Use1p is a SNARE and forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p. The protein is locali
VMA21YGR105Wmolecular_function unknownprotein complex assemblyendoplasmic reticulum*YFR018C YKL190W YLR039C YLR262C YPR159W YBR164C YAL013W YDR126W Protein involved in vacuolar H-ATPase assembly or function. Required for the biogenesis of a functioNull mutant is viable but grows slowly and exhibits increased calcium sensitivity. Null mutants also
WBP1YEL002Cdolichyl-diphosphooligosaccharide-protein glycosyltransferase activityN-linked glycosylation*endoplasmic reticulum*YPL227C YGL022W YMR149W YJL002C YML115C YBL082C wheat germ agglutinin-binding proteinoligosaccharyl transferase glycoprotein complex, beta subunitlethal
YDC1YPL087Wceramidase activityresponse to heat*endoplasmic reticulumYeast dihydro-ceramidasealkaline dihydroceramidase with minor reverse activityNull mutant is viable.
YEA4YEL004WUDP-N-acetylglucosamine transporter activitycell wall chitin biosynthesis*endoplasmic reticulumShows sequence similarity to GOG5, a gene involved in vanadate resistance
YOS9YDR057Wprotein transporter activityER to Golgi transportendoplasmic reticulumAppears to play a direct role in the transport of GPI-anchored proteins to the Golgi apparatus.membrane-associated glycoproteinAccelerates Gas1 transport and processing in cells overexpressing YOS9. Gas1 processing is slowed in
YPC1YBR183Wceramidase activityceramide metabolismendoplasmic reticulumYeast Phyto-ceramidasealkaline ceramidase with reverse activityNull mutant is viable and two times more heat resistant than the wild-type parental strain.
YSR3YKR053Csphingosine-1-phosphate phosphatase activitysphingolipid biosynthesisendoplasmic reticulumYDR403W Yeast Sphingolipid Resistance GeneDHS-1-P phosphataseNull mutant is viable and accumulates of dihydrosphingosine-1-P
YBR096Wmolecular_function unknownbiological_process unknownendoplasmic reticulumHypothetical ORF
YBR159Wketoreductase activityfatty acid elongationendoplasmic reticulum*microsomal beta-keto-reductase
YBR273Cmolecular_function unknownbiological_process unknownendoplasmic reticulumHypothetical ORF
YBR287Wmolecular_function unknownbiological_process unknownendoplasmic reticulum
YCL045Cmolecular_function unknownbiological_process unknownendoplasmic reticulumHypothetical ORF
YDL072Cmolecular_function unknownbiological_process unknownendoplasmic reticulumHypothetical ORF
YDL121Cmolecular_function unknownbiological_process unknownendoplasmic reticulumHypothetical ORF
YDL193Wprenyltransferase activitybiological_process unknownendoplasmic reticulum*Protein required for cell viability
YDR056Cmolecular_function unknownbiological_process unknownendoplasmic reticulum*Hypothetical ORF
YDR196Cdephospho-CoA kinase activitycoenzyme A biosynthesisendoplasmic reticulum*predicted to catalyze the final step in synthesis of Coenzyme A