Component GO Term conoid and related genes


Total 123
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Gene NameORF NameFunction GO TermProcess GO TermComponent GO TermInteracting GenesDescriptionGene ProductPhenotype
NUP49YGL172Wstructural molecule activitymRNA-nucleus export*nuclear pore*YHR216W YMR294W YNL041C YNL086W YFR002W YJL041W YBR017C YAL034W-A YGR119C localizes to discrete spots in the nuclear envelopenuclear pore complex subunitNull mutant is inviable; some nsp1 nsp49 alleles exhibit synthetic lethality
NUP53YMR153Wstructural molecule activitymRNA-nucleus export*nuclear poreYLR324W YMR153W YGL170C YGL092W YOL129W YER118C YDL088C YDR307W YER026C YGL044C YGL104C YGL237C YHL004W YHR190W YJL039C YJL057C YJL117W YLR295C YML125C YMR298W YNL234W YOL018C YML064C YML031W YFR002W YER105C YMR129W YOL065C Component of karyopherin docking complex of the nuclear pore complexkaryopherin docking complex component of the nuclear pore complex|nuclear pore complex subunitNull mutant is viable but disrupts Kap121 localization to the nuclear envelope.
NUP57YGR119Cstructural molecule activitymRNA-nucleus export*nuclear poreYEL043W YKL061W YKL103C YLR423C YMR294W YGR120C YPR046W YDL065C YDR416W YGL172W YGL170C YJL041W YBR017C YMR139W YPR083W YMR236W YGL005C YGR218W YOL069W YOR035C YFR002W YMR308C Forms complex with Nsp1p, Nup49p, and Nic96p at nuclear pore; this complex participates in nucleocytnuclear pore protein (nucleoporin)Null mutant is inviable
NUP60YAR002Wstructural constituent of nuclear porenucleocytoplasmic transport*nuclear poreYLR347C YLR418C YPR141C YPR135W YMR078C YCL016C YCL061C YNL273W YNL250W YDR363W nuclear pore proteinnuclear pore complex subunit
NUP82YJL061Wstructural molecule activitymRNA-nucleus export*nuclear poreYKL061W YLR423C YER105C YJL041W YIL115C YMR047C YEL005C YFR008W YBL079W Interacts with nuclear pore complex and participates in nucleocytoplasmic transport; required for po82 kDa protein, with putative coiled-coil domain, has carboxy-terminal domain, containing heptad repNull mutant is inviable; cells depleted of Nup82p, or cells with temperature-sensitive Nup82p at non
NUP84YDL116Wstructural molecule activitymRNA-nucleus export*nuclear poreYCL044C YCL069W YHR033W YOL014W YPL124W YJL117W YGL179C YKL057C YGL092W YDR113C YHR004C YMR047C YJL041W YOR180C YHL004W YCL051W YCR039C YDL044C YGL263W YJL090C YOR294W YPL091W YLR208W YKR082W YOL131W YJR042W YGL100W YAL009W component of nuclear pores; Part of complex with Nup120p, Nup85p, Sec13p, and a Sec13p homolognuclear pore complex subunit|similar to mammalian Nup107pNull mutant is viable but has defects in nuclear membrane and nuclear pore complex organization and
NUP85YJR042Wstructural molecule activitymRNA-nucleus export*nuclear poreYMR209C YOR176W YGL100W YPL215W YOR160W YDL116W YPL169C YLR208W YHR004C Protein in nuclear pore complex; may function in nuclear envelope integrity; may also be involved innuclear pore complex subunitNull mutant is viable but is temperature-sensitive; at nonpermissive temperature, null mutant accumu
OST3YOR085Wdolichyl-diphosphooligosaccharide-protein glycosyltransferase activityprotein complex assembly*integral to membrane*YDL232W YOR002W YGR227W YOR067C YDR126W Catalyzes the transfer of oligosaccharide from dolichol-oligosaccharide donor to consensus glycosylaoligosaccharyl transferase glycoprotein complex 34 kDa gamma subunitNull mutant is viable but shows underglycosylation of soluble and membrane-bound glycoproteins and c
PDR15YDR406WATP-binding cassette (ABC) transporter activitytransportintegral to membranesimilar to Pdr5p and Pdr10pmultidrug resistance transporter (putative)
PHO36YOL002Cmolecular_function unknownbiological_process unknownintegral to membraneYHR114W Involved in PHO signaling pathwayNull: viable
POM152YMR129Wstructural molecule activitymRNA-nucleus export*nuclear poreYJL057C YMR153W YML103C YFR002W May be involved in duplication of nuclear pores and nuclear pore complexes during S-phasemembrane glycoprotein|nuclear pore complex subunitNull mutant is viable; overproduction inhibits cell growth; synthetically lethal with NUP170 and NUP
POM34YLR018Cmolecular_function unknownnucleocytoplasmic transportnuclear poreYPR159W nuclear pore integral membrane proteinintegral membrane protein|nuclear pore complex subunit
PRM1YNL279Wmolecular_function unknownplasma membrane fusionintegral to membrane*YOL108C pheromone-regulated membrane proteinNull mutant is viable but exhibits a mating defect.
PRM10YJL108Cmolecular_function unknownconjugation with cellular fusionintegral to membranepheromone-regulated membrane protein
PRM2YIL037Cmolecular_function unknownconjugation with cellular fusionintegral to membraneYMR059W pheromone-regulated membrane protein
PRM4YPL156Cmolecular_function unknownconjugation with cellular fusionintegral to membraneYGL181W pheromone-regulated membrane protein
PRM5YIL117Cmolecular_function unknownconjugation with cellular fusionintegral to membraneYOL116W YLR295C YKL092C pheromone-regulated membrane protein
PRM6YML047Cmolecular_function unknownconjugation with cellular fusionintegral to membraneYAL013W YPL181W YMR263W pheromone-regulated membrane protein
PRM7YDL039Cmolecular_function unknownconjugation with cellular fusionintegral to membranepheromone-regulated membrane protein
RCE1YMR274Cprenyl-dependent CAAX protease activityprotein processing*integral to endoplasmic reticulum membraneYLR039C YLR262C YLR418C Protease involved in ras and a-factor terminal proteolysisproteaseNull mutant is viable, has defects in Ras localization and signaling, and suppresses the activated p
RTA1YGR213Cmolecular_function unknownbiological_process unknownintegral to membraneYHR134W YOR059C involved in 7-aminocholesterol resistanceNull mutant is viable; overexpression confers resistance to 7-aminocholesterol
SAC1YKL212Winositol/phosphatidylinositol phosphatase activitydephosphorylation*integral to endoplasmic reticulum membrane*YBR017C YKL093W YFL039C YIL007C YKL190W Inactivation of Sac1p leads to specific increase in cellular levels of phosphatidylinositol 4-phosphphosphoinositide phosphatasesuppressor of actin mutations, suppressor of sec14 alleles, inositol auxotrophy
SAC3YDR159Wprotein bindingmRNA-nucleus export*RNA nuclear export complexYNL271C YER016W A component of the nuclear pore that is involved in the nuclear export of both mRNA and proteinNull mutant is viable, grows more slowly and is larger than wild-type cells; exhibits increased beno
SEC12YNR026Cguanyl-nucleotide exchange factor activityER to Golgi transport*integral to endoplasmic reticulum membrane*Required for recruitment of Sar1p and vesicle formation at the endoplasmic reticulum.guanine nucleotide exchange factor for Sar1pNull mutant is inviable. Defective in endoplasmic reticulum to Golgi transport.
SEH1YGL100Wstructural molecule activitymRNA-nucleus export*nuclear poreYLR208W YBR286W YGL092W YLR359W YDL116W YJL002C YGL137W YOR014W YJR042W YOR080W YDR128W YAL009W Nuclear pore protein, homologous to sec13nuclear pore complex subunit
SHR3YDL212Wchaperone activityER to Golgi transport*integral to endoplasmic reticulum membraneYDR508C Protein required for appearance of amino acid permeases on the cell surfaceER integral membrane componentNull mutants are viable, specifically accumulate amino acid permeases in the endoplasmic reticulum
SKN1YGR143Wglucosidase activitycell wall organization and biogenesis*integral to membraneYKL176C YGR135W YGR133W YOL023W YDR244W YBL025W YBR254C Involved in (1->6)-beta-glucan biosynthesishighly homologous to Kre6p|type II membrane protein (putative)Null mutant is viable; exhibits no alterations in killer sensitivity, growth, or (1->6)-beta-glucan
SNA2YDR525W-Amolecular_function unknownbiological_process unknownintegral to membraneHomology to PMP3/SNA1 (Sensitivity to Na+)Null mutant is viable.
SPO7YAL009Wmolecular_function unknownmeiosis*integral to membrane*YDL040C YLR342W YJL176C YKL057C YGL100W YHR004C YDR211W YML103C YDL116W dispensable for mitosis, but required for a normal mutation rate, required for premeiotic DNA syntheNull mutant is viable, sporulation defective
SRP102YKL154Wsignal recognition particle bindingprotein-ER targetingintegral to endoplasmic reticulum membraneYLR288C YDR292C Signal recognition particle receptor beta subunitNull mutant is viable but exhibits slow growth and cannot grow on nonfermentable carbon sources. Tem