ALG1 YBR110W beta-1,4-mannosyltransferase activity N-linked glycosylation integral to membrane YDL055C beta-1,4-mannosyltransferase beta-1,4-mannosyltransferase Null mutant is inviable
ASI2 YNL159C molecular_function unknown ubiquitin-dependent protein catabolism integral to membrane YOR128C YNL159C YER022W Amino acid Sensor-Independent (ASI) genes encode membrane proteins Asi1p, Asi2p and Asi3p.
ASM4 YDL088C structural molecule activity mRNA-nucleus export* nuclear pore YMR153W YML031W Suppressor of thermosensitive mutations in the DNA polymerase delta gene nuclear pore complex subunit Null mutant is viable in some strain backgrounds (including CEN.PK2); however, in the FY1679 genetic
ATG15 YCR068W lipase activity autophagy* integral to membrane* YER019W Cytoplasm to vacuole targeting mutant. essential for intravacuolar lysis of autophagic bodies. amino lipase (putative) cvt17 is defective in lysis of autophagic vesicles after delivery to the vacuole. Null mutant is sta
AXL1 YPR122W metalloendopeptidase activity bud site selection* integral to membrane* YKL011C YPR111W determinant in axial budding pattern of haploid cells, involved in processing of a-factor human insulin-degrading endoprotease homolog (putative) Null mutant is viable; exhibits reduced a-factor expresion; haploid mutants show bipolar budding pat
BRE4 YDL231C molecular_function unknown endocytosis integral to membrane YCR016W contains several putative trans-membrane domains null mutant is sensitive to brefeldin A
CAX4 YGR036C pyrophosphatase activity N-linked glycosylation* integral to endoplasmic reticulum membrane YDR318W YKL190W CAX4p contains 3 short stretches of amino acids that are characteristic for a wide variety of phosph contains 3 short stretches of amino acids that are characteristic for a wide variety of phosphatases Null mutant is viable with severely affected growth rate, hypo-N-glycosylation of secretory proteins
CDC1 YDR182W molecular_function unknown DNA repair* integral to membrane YDL192W YCR044C Protein that affects bud emergence, intrachromosomal recombination, and nuclear division Null mutant is inviable
CDC31 YOR257W structural constituent of cytoskeleton microtubule nucleation* nuclear pore* YNL188W YHR102W Required for spindle pole body duplication and mitosis in meiosis II; calcium-binding protein compon nuclear pore complex subunit|spindle pole body calcium-binding protein component Null mutant is inviable. cdc31 mutants form reductional dyads with unduplicated spindle pole bodies
CDC40 YDR364C pre-mRNA splicing factor activity* nuclear mRNA splicing, via spliceosome* nuclear pore* YMR213W YAL032C YKL095W Required for proper timing of DNA synthesis at all temperatures and completion of DNA synthesis at a beta transducin family Null mutant is viable, temperature sensitive at 36 degrees celsius, arrests at the mononucleate stag
CNE1 YAL058W molecular_function unknown ER-associated protein catabolism integral to endoplasmic reticulum membrane YNL171C YNR036C YGL084C YNL064C YKL194C YKL197C YOR236W YNL322C Functions in endoplasmic reticulum protein quality control calnexin and calreticulin homolog Null mutant is viable, increase of cell-surface expression of ste2-3p, increase in secretion of hete
COX14 YML129C molecular_function unknown aerobic respiration* integral to membrane* YOR110W Mitochondrial membrane protein, required for assembly of cytochrome c oxidase mitochondrial membrane protein Nuclear respiration deficient, lack cytochromes a and a3 and detectable cytochrome oxidase activity
CSG2 YBR036C molecular_function unknown calcium ion homeostasis integral to endoplasmic reticulum membrane YBR265W YDL015C YMR272C YDR270W YDR062W YDR208W YDR297W YKL203C YER093C YPL231W YMR296C YNL330C YOL004W YPL057C YOR070C YLR085C YLR103C Required for growth in high (>25mM) calcium, contains 9 or 10 putative membrane spanning regions required for mannosylation of inositolphosphorylceramide (IPC) Null mutant is viable but Ca2+-sensitive; a presumed point mutant is sensitive to Ca2+ levels greate
CUE1 YMR264W protein binding ER-associated protein catabolism* integral to endoplasmic reticulum membrane YGL083W YHR007C Cue1p assembles with Ubc7p. Cue1p recruits Ubc7p to the cytosolic surface of the endoplasmic reticul Ubc7p binding and recruitment protein Null mutant is viable and shows stabilization of ER degradation substrates
ECM7 YLR443W molecular_function unknown cell wall organization and biogenesis integral to membrane YDL013W YMR307W Involved in cell wall maintenance A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent
ENB1 YOL158C ferric-enterobactin transporter activity ferric-enterobactin transport integral to membrane* Siderophore transporter for enterobactin; AFT1 regulon enterobactin transporter Null mutants are viable but are unable to take up and utilize iron from enterobactin
ERD2 YBL040C HDEL sequence binding protein-ER retention integral to endoplasmic reticulum membrane ER protein retention HDEL receptor Null mutant is inviable
ERF2 YLR246W palmitoyltransferase activity protein-membrane targeting* integral to endoplasmic reticulum membrane YJR146W Mutation has an Effect on Ras Function. Implicated in signaling pathway. Null mutant is viable, but has a synthetic growth defect in the absence of RAS2; Deletion of ERF2 re
ERP3 YDL018C molecular_function unknown secretory pathway integral to membrane Emp24p/Erv25p related protein 2 p24 protein involved in membrane trafficking
ERP4 YOR016C molecular_function unknown secretory pathway integral to membrane Emp24p/Erv25p related protein 4 p24 protein involved in membrane trafficking
ERP5 YHR110W molecular_function unknown secretory pathway integral to membrane Emp24p/Erv25p related protein 5 p24 protein involved in membrane trafficking
ERP6 YGL002W molecular_function unknown secretory pathway integral to membrane Emp24p/Erv25p related protein 6 p24 protein involved in membrane trafficking
ERS1 YCR075C L-cystine transporter activity L-cystine transport integral to membrane Suppressor of ERD1 mutation; seven transmembrane domain protein
ERV15 YBR210W molecular_function unknown axial budding integral to membrane Putative ER vesicle protein with similarity to Erv14p
ERV41 YML067C molecular_function unknown ER to Golgi transport integral to endoplasmic reticulum membrane* YML130C YAL042W ER vesicle protein Null mutant is viable.
ERV46 YAL042W molecular_function unknown ER to Golgi transport integral to endoplasmic reticulum membrane* YDL239C YML067C YML130C ER vesicle protein of 46 kDa ER-Golgi transport vesicle protein Null mutant is viable but cold sensitive.
FCY21 YER060W cytosine-purine permease activity biological_process unknown integral to membrane identical to FCY2 purine-cytosine permease
FCY22 YER060W-A cytosine-purine permease activity biological_process unknown integral to membrane identical to FCY2 purine-cytosine permease
GAA1 YLR088W GPI-anchor transamidase activity attachment of GPI anchor to protein integral to endoplasmic reticulum membrane YIR038C YHR215W ER protein essential for attaching GPI (glycosylphosphatidylinositol) to protein GPI:protein transamidase component (putative) Null mutant is inviable; temperature-sensitive mutant, after shifting to restrictive temperature, do
GLE1 YDL207W molecular_function unknown poly(A)+ mRNA-nucleus export nuclear pore YDL207W YDR192C YKL068W YER107C YMR047C YEL024W YMR255W YIL115C Polyadenylated-RNA-export factor; the HIV Rev protein may mimic function of Gle1 nuclear pore complex subunit|nuclear-export-signal (NES)-containing protein Null mutant is inviable
GLE2 YER107C structural molecule activity mRNA-nucleus export* nuclear pore YHL008C YNL189W YKL068W YDR192C YMR047C YEL024W YGL143C YDR300C YDL207W YGL092W Nuclear pore protein required for poly(A)+ RNA export, has beta-transducin (WD-40) repeats nuclear pore complex subunit|rae1 S. pombe homolog gle2 mutations exhibit double mutant inviability in combination with nup100 mutants
GON1 YAL048C molecular_function unknown vesicle-mediated transport integral to membrane Null mutant is viable but exhibits slightly reduced secretion of over-produced PrA. Null mutants als
GOS1 YHL031C v-SNARE activity intra-Golgi transport* integral to membrane YLR026C YKL196C YKL006C-A YBL050W YPL051W YOR070C YLR039C YLR262C YLR418C YBR164C YDR126W SNARE protein with a C-terminal membrane anchor
GOlgi Snare
GPI10 YGL142C molecular_function unknown GPI anchor biosynthesis integral to membrane YML012W Involved in glycosyl phosphatidyl inositol synthesis; could be the target of the GPI synthesis inhib alpha 1,2 mannosyltransferase (putative) Null mutant is inviable but can be complemented by the homologous cDNA from humans that encodes the
GPI16 YHR188C GPI-anchor transamidase activity attachment of GPI anchor to protein integral to endoplasmic reticulum membrane YJR015W YDL137W YDL192W YBR296C YNL092W Glycosyl Phosphatidyl Inositol 16 GPI transamidase component, human PIG-T homologue Null: inviable.
GPI17 YDR434W GPI-anchor transamidase activity attachment of GPI anchor to protein integral to endoplasmic reticulum membrane Glycosyl Phosphatidyl Inositol 17 GPI transamidase component, human PIG-S homologue Null Mutant:inviable
GPI8 YDR331W GPI-anchor transamidase activity attachment of GPI anchor to protein integral to endoplasmic reticulum membrane YER081W Protein involved in the attachment of glycosylphosphatidylinositol (GPI) anchors to proteins Null mutant is inviable
HSD1 YOR311C molecular_function unknown biological_process unknown integral to membrane* YDL049C ER membrane protein ER membrane protein Null mutant is viable, no other notable phenotype.
KRE6 YPR159W glucosidase activity cell wall organization and biogenesis* integral to membrane* YBL053W YBR042C YDL206W YDR248C YEL047C YGL081W YGL196W YFL036W YOR080W YDR137W YGR105W YOR068C YGL244W YML115C YAL055W YGL200C YLL043W YPL192C YKL041W YJL176C YDR385W YIL052C YDR233C YGL135W YKL120W YDR358W YGL215W YLR018C YLR131C YLR165C YKL190W YD cell wall beta-glucan assembly beta-glucan synthase (putative) Null mutant is viable, slow growing, killer toxin-resistant, possesses half the normal level of wild
MAD2 YJL030W molecular_function unknown mitotic spindle checkpoint nuclear pore* YJL064W YML094C-A YPL017C YLR200W YNL153C YEL003W YCR065W YER016W YGR078C YML094W YOR349W YPR141C YNL098C YOL012C YDR254W YOR195W YPL018W YDR318W YJR135C YBR107C YLR381W YDR359C YPR046W YBR194W YGL060W YGL116W YDR206W YGR014W YER105C YGL229C YNL236W spindle checkpoint complex subunit spindle checkpoint complex subunit
MIP6 YHR015W RNA binding mRNA-nucleus export nuclear pore YDR172W YPL169C RNA-binding protein, interacts with MEX67
MPS3 YJL019W molecular_function unknown spindle pole body duplication (sensu Saccharomyces)* integral to membrane* YMR001C YOL104C YLR233C YOL012C MonoPolar Spindle
98 kDa Nuclear Envelope Protein. essential integral membrane protein that local Spindle pole body duplication|nuclear envelope protein Null: null mutant is inviable. Other phenotypes: ts mutants fail in SPB duplication; The temperature
MTR2 YKL186C protein binding poly(A)+ mRNA-nucleus export nuclear pore YPL138C mRNA transport regulator mRNA transport regulator Null mutant is inviable; mtr2 mutants exhibit nuclear mRNA accumulation and nucleolar fragmentation
NDC1 YML031W structural constituent of cytoskeleton protein-nucleus import* nuclear pore* YOR284W YMR153W YGR010W YDL088C dispensable for mitotic spindle pole body duplication, but required for insertion of nascent spindle multiple transmembrane domains (putative)|nuclear envelope protein|nuclear pore complex subunit Null mutant is inviable. Conditional lethal mutants are available that show asymmetric chromosomal s
NEM1 YHR004C molecular_function unknown sporulation (sensu Saccharomyces)* integral to membrane* YKL057C YJR042W YBR195C YDL116W YAL009W YLR039C YLR262C YMR307W Nuclear Envelope Morphology Null mutant is viable but exhibits slow growth at 37 deg. and 16 deg and has an abnormal nuclear env
NIC96 YFR002W structural molecule activity mRNA-nucleus export* nuclear pore YGR120C YMR153W YGL172W YGR119C YML103C YMR129W YJL039C YJL041W Part of complex at nuclear pore containing in addition NSP1p, NUP49p, and p54 96 kDa nucleoporin-interacting component|nuclear pore complex subunit Null mutant is inviable
NSP1 YJL041W structural molecule activity mRNA-nucleus export* nuclear pore YLR423C YDR116C YGL172W YDR395W YJL061W YIL115C YMR193W YMR024W YDR322W YJL063C YML025C YLR312W-A YFR002W YMR047C YDL116W YLR293C YGR119C Nucleoskeletal protein found in nuclear pores and spindle pole body nuclear pore complex subunit Null mutant is inviable.
NUP1 YOR098C protein binding* mRNA-nucleus export* nuclear pore YDR132C YKL061W YKR064W YOL070C YPR172W YNL189W YHR129C YCR086W YMR159C YOR326W YMR032W YOR370C YGL037C YBR126C YBL058W YAL055W YOR229W YDR395W YKL020C YLL001W YPR187W YMR271C YLR359W YHR068W YMR096W YJR159W YBL079W YDL029W YMR235C YGL016W YBR017C YL nuclear pore complex protein nuclear pore complex subunit Davis and Fink (Cell 61:965-978) report that a NUP1 deletion is inviable, whereas Schlaich and Hurt
NUP100 YKL068W structural molecule activity mRNA-nucleus export* nuclear pore YBR216C YDR034C YDR335W YGR218W YNL243W YDL207W YMR047C YER107C YLR347C YNL298W Participates in nucleocytoplasmic transport; member of GLFG-containing family of nucleoporins nuclear pore complex subunit Null mutant is viable with no obvious phenotypes; synthetically lethal with nup116 and gle2 mutants
NUP116 YMR047C structural molecule activity mRNA-nucleus export* nuclear pore YAR066W YBL094C YBR027C YBR137W YBR144C YBR273C YDR271C YGR139W YGR151C YHL049C YHR209W YIL055C YJL061W YJR079W YJR136C YJR141W YKL061W YKL088W YLR077W YLR294C YLR312C YLR434C YMR157C YMR206W YNL194C YNL300W YNL319W YNR040W YNR061C YNR074C YOL111C YO Involved in nucleocytoplasmic transport; may be required for biogenesis of tRNA nuclear pore complex subunit Null mutant grows slowly, accumulates unspliced pre-tRNAs, acumulates poly(A)+ RNA in the nucleus, a
NUP120 YKL057C structural molecule activity mRNA-nucleus export* nuclear pore YGR161C-C YOR142W-A YER086W YNR012W YGL092W YGR249W YLR208W YDL116W YAL009W YHR004C YLR216C Nucleoporin 100 kDa protein (predicted molecular weight is 120 kDa) with two leucine zipper motifs, coiled-coil Null mutant is viable but grows slower, is temperature-sensitive, and shows nucleolar fragmentation
NUP133 YKR082W structural molecule activity mRNA-nucleus export* nuclear pore YDL116W YLR208W YLR330W YJL099W YHR142W YJR075W Nuclear pore complex protein involved in poly(A)+ RNA transport, nuclear pore distribution, and poss nuclear pore complex subunit Null mutant is viable but grows slowly and is temperature-sensitive; at nonpermissive temperature, p
NUP145 YGL092W structural molecule activity mRNA-nucleus export* nuclear pore YER107C YGL060W YLR208W YGR178C YHR036W YKL057C YMR153W YPR111W YGL100W YDL116W YLR347C Nuclear pore complex protein with GLFG motif nuclear pore complex subunit Null mutant is inviable, depletion of Nup145p in vivo leads rapidly to nuclear retention of polyaden
NUP157 YER105C structural molecule activity mRNA-nucleus export* nuclear pore YIL061C YJL030W YMR153W YEL015W YBL079W YJL061W YPR120C yeast nuclear pore complex component nuclear pore complex subunit Null mutant is viable; synthetically lethal with nup170 and nup188
NUP159 YIL115C structural molecule activity mRNA-nucleus export* nuclear pore YDR395W YDL207W YJL041W YJL061W YLR347C YOR160W YJR132W Located on cytoplasmic side of nuclear pore complex; may be involved in nuclear import or mRNA expor contains coiled-coil domain and repeated motifs typical of nucleoporins|nuclear pore complex subunit Null mutant is inviable; at nonpermissive temperature, a temperature-sensitive mutant shows cessatio
NUP170 YBL079W structural molecule activity mRNA-nucleus export* nuclear pore YOR098C YER105C YJL061W YLR335W Component of yeast nuclear pore complex; may play a role in localizing specific nucleoporins to nucl nuclear pore complex subunit Null mutant is viable; synthetically lethal with nup157, nup188, and pom152; changing NUP170 express
NUP188 YML103C structural molecule activity mRNA-nucleus export* nuclear pore YMR129W YAL009W YFR002W Localized at both the cytoplasmic and nucleoplasmic faces of the nuclear pore complex (NPC); may for nuclear pore complex subunit Null mutant is viable but exhibits abnormalities in nuclear envelope and nuclear pore morphology; do
NUP192 YJL039C structural constituent of nuclear pore nuclear pore organization and biogenesis nuclear pore YBR059C YMR153W YMR032W YBR270C YLR447C YFR002W large yeast nucleoporin nuclear pore complex subunit Null mutant is inviable.
NUP2 YLR335W structural molecule activity mRNA-nucleus export* nuclear pore YOR020C YGL044C YBL079W YGL016W YNL189W YLR347C YJR132W Localizes to discrete spots in the nuclear envelope; probably functions in transport through nuclear nucleoporin Null mutant is viable; some combinations of alleles of nup1, nsp1 and nup2 are synthetically lethal
NUP42 YDR192C structural molecule activity mRNA-nucleus export* nuclear pore YOR134W YDL207W YER081W YGR218W YJR069C YNL092W YMR255W YER107C YBR017C interacts specifically with the HIV-1 Rev protein effector domain;
Ulp1 Interacting Protein 1 42 kDa protein associated with nuclear pore complexes; structurally related to the FG-nucleoporin fa Null mutant is viable, NUP42 is essential for the export of heat shock mRNAs following stress
NUP49 YGL172W structural molecule activity mRNA-nucleus export* nuclear pore* YHR216W YMR294W YNL041C YNL086W YFR002W YJL041W YBR017C YAL034W-A YGR119C localizes to discrete spots in the nuclear envelope nuclear pore complex subunit Null mutant is inviable; some nsp1 nsp49 alleles exhibit synthetic lethality
NUP53 YMR153W structural molecule activity mRNA-nucleus export* nuclear pore YLR324W YMR153W YGL170C YGL092W YOL129W YER118C YDL088C YDR307W YER026C YGL044C YGL104C YGL237C YHL004W YHR190W YJL039C YJL057C YJL117W YLR295C YML125C YMR298W YNL234W YOL018C YML064C YML031W YFR002W YER105C YMR129W YOL065C Component of karyopherin docking complex of the nuclear pore complex karyopherin docking complex component of the nuclear pore complex|nuclear pore complex subunit Null mutant is viable but disrupts Kap121 localization to the nuclear envelope.
NUP57 YGR119C structural molecule activity mRNA-nucleus export* nuclear pore YEL043W YKL061W YKL103C YLR423C YMR294W YGR120C YPR046W YDL065C YDR416W YGL172W YGL170C YJL041W YBR017C YMR139W YPR083W YMR236W YGL005C YGR218W YOL069W YOR035C YFR002W YMR308C Forms complex with Nsp1p, Nup49p, and Nic96p at nuclear pore; this complex participates in nucleocyt nuclear pore protein (nucleoporin) Null mutant is inviable
NUP60 YAR002W structural constituent of nuclear pore nucleocytoplasmic transport* nuclear pore YLR347C YLR418C YPR141C YPR135W YMR078C YCL016C YCL061C YNL273W YNL250W YDR363W nuclear pore protein nuclear pore complex subunit
NUP82 YJL061W structural molecule activity mRNA-nucleus export* nuclear pore YKL061W YLR423C YER105C YJL041W YIL115C YMR047C YEL005C YFR008W YBL079W Interacts with nuclear pore complex and participates in nucleocytoplasmic transport; required for po 82 kDa protein, with putative coiled-coil domain, has carboxy-terminal domain, containing heptad rep Null mutant is inviable; cells depleted of Nup82p, or cells with temperature-sensitive Nup82p at non
NUP84 YDL116W structural molecule activity mRNA-nucleus export* nuclear pore YCL044C YCL069W YHR033W YOL014W YPL124W YJL117W YGL179C YKL057C YGL092W YDR113C YHR004C YMR047C YJL041W YOR180C YHL004W YCL051W YCR039C YDL044C YGL263W YJL090C YOR294W YPL091W YLR208W YKR082W YOL131W YJR042W YGL100W YAL009W component of nuclear pores; Part of complex with Nup120p, Nup85p, Sec13p, and a Sec13p homolog nuclear pore complex subunit|similar to mammalian Nup107p Null mutant is viable but has defects in nuclear membrane and nuclear pore complex organization and
NUP85 YJR042W structural molecule activity mRNA-nucleus export* nuclear pore YMR209C YOR176W YGL100W YPL215W YOR160W YDL116W YPL169C YLR208W YHR004C Protein in nuclear pore complex; may function in nuclear envelope integrity; may also be involved in nuclear pore complex subunit Null mutant is viable but is temperature-sensitive; at nonpermissive temperature, null mutant accumu
OST3 YOR085W dolichyl-diphosphooligosaccharide-protein glycosyltransferase activity protein complex assembly* integral to membrane* YDL232W YOR002W YGR227W YOR067C YDR126W Catalyzes the transfer of oligosaccharide from dolichol-oligosaccharide donor to consensus glycosyla oligosaccharyl transferase glycoprotein complex 34 kDa gamma subunit Null mutant is viable but shows underglycosylation of soluble and membrane-bound glycoproteins and c
PDR15 YDR406W ATP-binding cassette (ABC) transporter activity transport integral to membrane similar to Pdr5p and Pdr10p multidrug resistance transporter (putative)
PHO36 YOL002C molecular_function unknown biological_process unknown integral to membrane YHR114W Involved in PHO signaling pathway Null: viable
POM152 YMR129W structural molecule activity mRNA-nucleus export* nuclear pore YJL057C YMR153W YML103C YFR002W May be involved in duplication of nuclear pores and nuclear pore complexes during S-phase membrane glycoprotein|nuclear pore complex subunit Null mutant is viable; overproduction inhibits cell growth; synthetically lethal with NUP170 and NUP
POM34 YLR018C molecular_function unknown nucleocytoplasmic transport nuclear pore YPR159W nuclear pore integral membrane protein integral membrane protein|nuclear pore complex subunit
PRM1 YNL279W molecular_function unknown plasma membrane fusion integral to membrane* YOL108C pheromone-regulated membrane protein Null mutant is viable but exhibits a mating defect.
PRM10 YJL108C molecular_function unknown conjugation with cellular fusion integral to membrane pheromone-regulated membrane protein
PRM2 YIL037C molecular_function unknown conjugation with cellular fusion integral to membrane YMR059W pheromone-regulated membrane protein
PRM4 YPL156C molecular_function unknown conjugation with cellular fusion integral to membrane YGL181W pheromone-regulated membrane protein
PRM5 YIL117C molecular_function unknown conjugation with cellular fusion integral to membrane YOL116W YLR295C YKL092C pheromone-regulated membrane protein
PRM6 YML047C molecular_function unknown conjugation with cellular fusion integral to membrane YAL013W YPL181W YMR263W pheromone-regulated membrane protein
PRM7 YDL039C molecular_function unknown conjugation with cellular fusion integral to membrane pheromone-regulated membrane protein
RCE1 YMR274C prenyl-dependent CAAX protease activity protein processing* integral to endoplasmic reticulum membrane YLR039C YLR262C YLR418C Protease involved in ras and a-factor terminal proteolysis protease Null mutant is viable, has defects in Ras localization and signaling, and suppresses the activated p
RTA1 YGR213C molecular_function unknown biological_process unknown integral to membrane YHR134W YOR059C involved in 7-aminocholesterol resistance Null mutant is viable; overexpression confers resistance to 7-aminocholesterol
SAC1 YKL212W inositol/phosphatidylinositol phosphatase activity dephosphorylation* integral to endoplasmic reticulum membrane* YBR017C YKL093W YFL039C YIL007C YKL190W Inactivation of Sac1p leads to specific increase in cellular levels of phosphatidylinositol 4-phosph phosphoinositide phosphatase suppressor of actin mutations, suppressor of sec14 alleles, inositol auxotrophy
SAC3 YDR159W protein binding mRNA-nucleus export* RNA nuclear export complex YNL271C YER016W A component of the nuclear pore that is involved in the nuclear export of both mRNA and protein Null mutant is viable, grows more slowly and is larger than wild-type cells; exhibits increased beno
SEC12 YNR026C guanyl-nucleotide exchange factor activity ER to Golgi transport* integral to endoplasmic reticulum membrane* Required for recruitment of Sar1p and vesicle formation at the endoplasmic reticulum. guanine nucleotide exchange factor for Sar1p Null mutant is inviable. Defective in endoplasmic reticulum to Golgi transport.
SEH1 YGL100W structural molecule activity mRNA-nucleus export* nuclear pore YLR208W YBR286W YGL092W YLR359W YDL116W YJL002C YGL137W YOR014W YJR042W YOR080W YDR128W YAL009W Nuclear pore protein, homologous to sec13 nuclear pore complex subunit
SHR3 YDL212W chaperone activity ER to Golgi transport* integral to endoplasmic reticulum membrane YDR508C Protein required for appearance of amino acid permeases on the cell surface ER integral membrane component Null mutants are viable, specifically accumulate amino acid permeases in the endoplasmic reticulum
SKN1 YGR143W glucosidase activity cell wall organization and biogenesis* integral to membrane YKL176C YGR135W YGR133W YOL023W YDR244W YBL025W YBR254C Involved in (1->6)-beta-glucan biosynthesis highly homologous to Kre6p|type II membrane protein (putative) Null mutant is viable; exhibits no alterations in killer sensitivity, growth, or (1->6)-beta-glucan
SNA2 YDR525W-A molecular_function unknown biological_process unknown integral to membrane Homology to PMP3/SNA1 (Sensitivity to Na+) Null mutant is viable.
SPO7 YAL009W molecular_function unknown meiosis* integral to membrane* YDL040C YLR342W YJL176C YKL057C YGL100W YHR004C YDR211W YML103C YDL116W dispensable for mitosis, but required for a normal mutation rate, required for premeiotic DNA synthe Null mutant is viable, sporulation defective
SRP102 YKL154W signal recognition particle binding protein-ER targeting integral to endoplasmic reticulum membrane YLR288C YDR292C Signal recognition particle receptor beta subunit Null mutant is viable but exhibits slow growth and cannot grow on nonfermentable carbon sources. Tem
STE23 YLR389C metallopeptidase activity proteolysis and peptidolysis* integral to membrane YJR053W YER161C YKL116C involved in a-factor processing effects a-factor secretion and mating by a cells
STE24 YJR117W metalloendopeptidase activity* peptide pheromone maturation integral to endoplasmic reticulum membrane YBR234C YDL029W YDR315C YLR200W YGR078C YNL153C YEL003W YML094W YNL322C zinc metallo-protease that catalyzes the first step of N-terminal processing of the yeast a-factor p zinc metallo-protease Null mutant is viable, exhibits a mating efficiency of ~5% that of a wild-type strain and an a-facto
SUR7 YML052W molecular_function unknown sporulation (sensu Saccharomyces) integral to membrane* Multicopy suppressor of rvs167 mutation integral membrane protein (putative) Null mutant is viable, exhibits no growth defects on non-fermentable carbon sources or sensitivites
SWF1 YDR126W molecular_function unknown biological_process unknown integral to membrane YDL133W YGL007W YGR228W YHR151C YKL118W YKR033C YLR374C YPL102C YOR085W YCR044C YJL095W YEL031W YER083C YGL005C YGR105W YHL031C YKR001C YML071C YNL041C YNL051W YOL018C YLR039C YMR186W YGR229C YLR373C YPL069C YJL036W YPL161C YKL110C YLR384C YMR312W YP Spore Wall Formation Profilin synthetic lethal
SYS1 YJL004C molecular_function unknown vesicle organization and biogenesis* integral to Golgi membrane YOR070C YLR039C YLR262C YDR126W Multicopy suppressor of ypt6 null mutation Null mutant is viable. sys1 ypt6 double mutant displays enhanced defects in vacuolar sorting and cel
THP1 YOL072W protein binding bud site selection* nuclear pore* YJR091C YLR418C Null mutant is viable and shows transcription-associated hyper-recombination and transcription elong
ULP1 YPL020C cysteine-type peptidase activity* G2/M transition of mitotic cell cycle* nuclear pore* YCR007C YJL067W YIR038C YDR100W YML008C YDR480W YBR038W YMR308C YGR209C Ubl (ubiquitin-like protein)-specific protease 1; initially processes Smt3; also acts as a deconjuga Smt3-specific protease Null mutant is lethal. Temperature-sensitive mutants accumulate in G2/M at the restrictive temperatu
VMR1 YHL035C ATP-binding cassette (ABC) transporter activity transport integral to membrane YLR115W YIL035C ABC transporter ABC transporter Null: multidrug and cadmium sensitivity
VTI1 YMR197C v-SNARE activity intra-Golgi transport* integral to Golgi membrane YOL018C YLR026C YKL196C YGL095C YJR091C YOR036W YBL050W YDR468C YOR106W Involved in cis-Golgi membrane traffic interacts with two t-SNARES, Sed5p and Pep12p|v-SNARE Null mutant is inviable
YRB2 YIL063C structural molecule activity mRNA-nucleus export* nuclear pore YMR235C YGR218W YHR011W YOL061W YJR091C YDR131C YGL097W Ran-GTPase-binding protein involved in nuclear export nuclear protein that interacts with Gsp1p and Crm1p Null mutant is viable, cold sensitive, synthetically lethal with rna1-1 but not nup2 deletion mutant
YAL048C molecular_function unknown vesicle-mediated transport integral to membrane
YDL222C molecular_function unknown cell wall organization and biogenesis integral to membrane* The authentic, non-tagged protein was localized to the mitochondria; cell cortex protein
YDR090C molecular_function unknown biological_process unknown integral to membrane Hypothetical ORF
YDR438W molecular_function unknown biological_process unknown integral to membrane Hypothetical ORF
YER185W molecular_function unknown biological_process unknown integral to membrane Hypothetical ORF
YFL054C transporter activity* water transport integral to membrane Hypothetical ORF
YGL139W molecular_function unknown biological_process unknown integral to membrane Hypothetical ORF
YGR149W molecular_function unknown biological_process unknown integral to membrane Hypothetical ORF
YHL035C ATP-binding cassette (ABC) transporter activity transport integral to membrane ABC transporter
YHR048W drug transporter activity drug transport integral to membrane Hypothetical ORF
YHR140W molecular_function unknown biological_process unknown integral to membrane Hypothetical ORF
YKR065C molecular_function unknown biological_process unknown integral to membrane The authentic, non-tagged protein was localized to the mitochondria
YLR004C transporter activity transport integral to membrane Hypothetical ORF
YLR046C molecular_function unknown biological_process unknown integral to membrane Putative membrane protein, transcription is activated by paralogous transcription factors Yrm1p and
YLR404W molecular_function unknown biological_process unknown integral to membrane Hypothetical ORF
YMR040W molecular_function unknown biological_process unknown integral to membrane Hypothetical ORF
YMR148W molecular_function unknown biological_process unknown integral to membrane Hypothetical ORF
YNL095C molecular_function unknown biological_process unknown integral to membrane Hypothetical ORF
YNR062C molecular_function unknown biological_process unknown integral to membrane Hypothetical ORF
YOL002C molecular_function unknown biological_process unknown integral to membrane Involved in PHO signaling pathway
YOL101C molecular_function unknown biological_process unknown integral to membrane Hypothetical ORF
YPL264C molecular_function unknown biological_process unknown integral to membrane Hypothetical ORF
YPR071W molecular_function unknown biological_process unknown integral to membrane Hypothetical ORF