| Gene Name | ORF Name | Function GO Term | Process GO Term | Component GO Term | Interacting Genes | Description | Gene Product | Phenotype |
| SGV1 | YPR161C | cyclin-dependent protein kinase activity | protein amino acid phosphorylation* | nucleus | YMR125W YLR226W | CDC28/cdc2 related protein kinase | CDC28/cdc2 related protein kinase | Null mutant is inviable. |
| SHE2 | YKL130C | mRNA binding | mRNA localization, intracellular | cytoplasm | YBR027C YCL033C YCR087W YGR066C YKR022C YOL073C YAL041W YNL189W YKL130C YDR174W YBR169C YLR037C YML088W YML106W YAL029C YBR130C YPR020W YNL023C YDR503C YMR314W YIL105C YJL048C | Required for mother cell-specific HO expression | Null mutant is viable | |
| SHE3 | YBR130C | mRNA binding | mRNA localization, intracellular | cytoplasm* | YBR130C YKL130C YAL029C YGL106W YLR092W YBR143C YJL071W YMR047C YBR109C YHR107C | cytoplasmic protein involved in mother-specific HO expression | Null mutant is viable. | |
| SHE4 | YOR035C | protein binding | actin cytoskeleton organization and biogenesis* | cytoplasm | YER156C YGR119C YPL200W YOR326W YBR109C YBR234C YDL029W YBR023C YHR142W YLR342W YJR075W YBL061C YNL322C YOR067C | Required for mother cell-specific HO expression | Null mutant is viable | |
| SHE9 | YDR393W | molecular_function unknown | mitochondrion organization and biogenesis* | mitochondrial inner membrane | YLR330W | Mrna (identified by a library screen) that causes growth arrest when overexpressed. Mitochondria | ||
| SHM1 | YBR263W | glycine hydroxymethyltransferase activity | one-carbon compound metabolism | mitochondrion | YML018C YFR031C-A | Serine hydroxymethyltransferase, mitochondrial | Null mutant is viable. | |
| SHM2 | YLR058C | glycine hydroxymethyltransferase activity | one-carbon compound metabolism | cytoplasm | YKL104C YFR009W YKR099W YNL189W YDL043C YNL290W | serine hydroxymethyltransferase | Null mutant is viable | |
| SHO1 | YER118C | osmosensor activity | pseudohyphal growth* | plasma membrane* | YDL155W YER118C YDL204W YDL226C YMR153W YJL128C | Transmembrane osmosensor (structurally unrelated to SLN1) with four transmembrane segments & a cytop | transmembrane osmosensor | Null mutant is viable; mutants are high-osmolarity sensitive when combined with both ssk2 and ssk22 |
| SHQ1 | YIL104C | molecular_function unknown | snoRNA metabolism | nucleoplasm | YNL326C YNL124W YMR296C YCL014W YLR175W | required for SnoRNAs of the box H/ACA Quantitative accumulation | Null: inviable. | |
| SHR3 | YDL212W | chaperone activity | ER to Golgi transport* | integral to endoplasmic reticulum membrane | YDR508C | Protein required for appearance of amino acid permeases on the cell surface | ER integral membrane component | Null mutants are viable, specifically accumulate amino acid permeases in the endoplasmic reticulum |
| SHR5 | YOL110W | palmitoyltransferase activity | RAS protein signal transduction* | extrinsic to endoplasmic reticulum membrane | Involved in RAS localization and palmitoylation | Null mutant is viable; exhibits normal palmityltransferase activity in vitro and attenuates Ras func | ||
| SHS1 | YDL225W | structural constituent of cytoskeleton | establishment of cell polarity (sensu Saccharomyces)* | septin ring | YHR033W YJR070C YNL298W YNL271C YDR148C YNR035C YDL029W YNL233W YER155C YPL235W YOR259C YDL117W YER111C YNR016C YGR282C YDR097C YHR107C YLR314C YCL039W YCR002C YER066C-A YER016W YKL079W YOR326W YPR135W | Interacts with Spa2p and plays a role in cytokinesis | deficient for cytokinesis | |
| SHY1 | YGR112W | molecular_function unknown | respiratory gaseous exchange | mitochondrial inner membrane | YJL168C YLR200W YGR078C | involved in respiration | similar to the mammalian SURF-1 gene | Deletion of part of SHY1 produces a phenotype similar to that of G91 mutants. Disruption of SHY1 at |
| SIC1 | YLR079W | protein binding* | G1/S transition of mitotic cell cycle* | nucleus* | YLR127C YAR019C YBR135W YGL003C YGR092W YBR160W YPR120C YDR054C YFL009W YDL132W YDR328C | P40 inhibitor of Cdc28p-Clb5 protein kinase complex | Null mutant is viable, shows increased frequency of broken and lost chromosomes; sic1 deletion mutan | |
| SIF2 | YBR103W | NAD-dependent histone deacetylase activity* | chromatin silencing at telomere* | nucleus* | YJR141W YMR155W YCR077C YDL185W YML109W YGL236C YLR347C YGL178W YMR061W YIL112W YCR033W YGL194C YKR029C YLR409C YEL064C YDL112W YDR227W YGR296W YDR155C YOL068C YMR273C YGR239C YHL004W YGL023C YOR319W YJL168C YLR418C YPR141C YLR200W YGR078C YNL153C YE | Sir4p-Interacting Factor | Null mutant is viable, exhibits increased telomeric silencing | |
| SIK1 | YLR197W | molecular_function unknown | rRNA modification* | nucleus* | YOR303W YJL033W YCL059C YPL043W YCR057C YIL008W YMR236W YJL069C YMR116C YLR175W YOL115W YNL061W YNL088W YIL035C YDL014W | part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); similar to microtubule bi | U3 snoRNP protein | wild-type gene suppresses toxicity of GAL4-I-Kappa-B alpha in yeast |
| SIL1 | YOL031C | molecular_function unknown | SRP-dependent cotranslational membrane targeting, translocation | endoplasmic reticulum | YLR412W | ER-localized protein required for protein translocation into the ER, interacts with the ATPase domai | Nucleotide exchange factor | |
| SIM1 | YIL123W | molecular_function unknown | microtubule cytoskeleton organization and biogenesis | cell wall (sensu Fungi) | YER165W | (putative) invovled in control of DNA replication | Null mutant is viable; mutant allows an extra round of DNA replication without mitosis | |
| SIN3 | YOL004W | histone deacetylase activity | regulation of transcription from Pol II promoter* | histone deacetylase complex | YCR084C YIL061C YGL019W YBR036C YNL097C YPL181W YIL084C YMR263W YBR095C YPL139C YNL330C YHR178W YIL035C YOR061W YDR207C YDR169C YPR023C YFR037C YFR013W YBL003C YMR075W YMR072W YDL076C YMR053C YMR019W YLR103C YBR245C YOR160W YAL034C YIL131C YNL068C YN | DNA binding protein involved in transcriptional regulation | DNA binding protein|involved in transcriptional regulation | inviable, reduced potassium dependency |
| SIN4 | YNL236W | RNA polymerase II transcription mediator activity | transcription from Pol II promoter | mediator complex | YGR046W YGR117C YOL148C YJL030W YPL016W YJL013C YDR054C YJR034W YOR290C YOR355W YKL012W YGL238W YOR153W YFR033C YDL005C YOL135C YGR220C YBL093C YBR253W YNL025C YGR274C YBR081C YOL051W YGR252W | involved in positive and negative regualtion of transcription, possibly via changes in chromatin str | RNA polymerase II holoenzyme/mediator subunit | Null mutant is viable, temperature sensitive, displays defects in both positive and negative regulat |
| SIP1 | YDR422C | SNF1A/AMP-activated protein kinase activity | protein amino acid phosphorylation* | vacuole | YER029C YDR477W YDL153C YHR114W YLR453C YPR078C YMR106C YGL115W YLR306W | SNF1 protein kinase substrate | protein kinase complex component | Null mutant is viable, exhibits a slight increase in GAL gene expression |
| SIP18 | YMR175W | phospholipid binding | response to osmotic stress* | soluble fraction | Salt-Induced Protein | Null mutant is viable. | ||
| SIP2 | YGL208W | SNF1A/AMP-activated protein kinase activity | protein amino acid phosphorylation* | cytoplasm* | YGL115W YFL045C YNR035C YOR136W YER027C YDR212W YDR477W | Member of a family of proteins, including Sip1p and Gal83p, that interact with Snf1p and Snf4p and a | Null mutant is viable | |
| SIP3 | YNL257C | transcription cofactor activity | transcription initiation from Pol II promoter | nucleus | YDR477W | Interacts with SNF1 protein kinase | transcriptional activator (putative) | Null mutant is viable; does not confer snf1 phenotypes |
| SIP4 | YJL089W | specific RNA polymerase II transcription factor activity | regulation of transcription from Pol II promoter* | nucleus | Possibly involved in Snf1p regulated transcriptional activation | |||
| SIP5 | YMR140W | molecular_function unknown | cellular response to glucose starvation | cytoplasm | YLR373C | Sip5 facilitates the interaction between the Reg1Glc7 phosphatase and the Snf1 kinase. | interaction between Reg1 and Snf1 is reduced threefold in a sip5Delta mutant. | |
| SIR1 | YKR101W | DNA binding* | chromatin silencing at HML and HMR (sensu Saccharomyces)* | chromatin silencing complex | YGL127C YLR442C | repressor of silent mating loci | silent mating loci repressor | |
| SIR2 | YDL042C | histone deacetylase activity* | chromatin silencing at telomere* | nucleolus* | YOL086C YLR249W YJL076W YGR282C YGR192C YDR227W YLR453C | regulator of silencing at HML, HMR, telomeres, and rDNA | nuclear NAD-dependent deacetylase | Null mutant is viable; sir2 mutations suppress mitotic and meiotic intra- and interchromosomal rDNA |
| SIR3 | YLR442C | histone binding* | double-strand break repair via nonhomologous end-joining* | nucleolus* | YMR226C YDR023W YJL026W YDL185W YKL081W YBL045C YGR155W YMR307W YMR223W YLR355C YER043C YMR318C YDR227W YKR101W YNL216W | regulator of silencing at HML, HMR, and telomeres | silencing regulator at HML, HMR, and telomeres | sterile |
| SIR4 | YDR227W | histone binding* | double-strand break repair via nonhomologous end-joining* | nuclear telomere cap complex* | YFL006W YFL045C YER151C YMR284W YBR103W YNL216W YDL042C YFL007W YLR442C | Sir4 binding to Rap1 initiates the sequential association of Sir and other proteins, allowing the su | silencing regulator at HML, HMR, and telomeres | sterile |