| Gene Name | ORF Name | Function GO Term | Process GO Term | Component GO Term | Interacting Genes | Description | Gene Product | Phenotype |
| APC1 | YNL172W | protein binding* | ubiquitin-dependent protein catabolism* | anaphase-promoting complex | YLR102C YDL008W YLR127C YDR118W YOR249C YKL022C YHR166C YFR036W YBL084C YGL240W YHR135C | anaphase-promoting complex component | ubiquitin ligase subunit | |
| APC11 | YDL008W | protein binding* | ubiquitin-dependent protein catabolism* | anaphase-promoting complex | YLR102C YLR127C YDR118W YOR249C YKL022C YHR166C YFR036W YBL084C YGL240W YNL172W | subunit of the Anaphase Promoting Complex; all known APC subunits co-immunoprecipitate with epitope- | anaphase promoting complex (APC) subunit | Null mutant is inviable at 25 C |
| APC2 | YLR127C | protein binding* | ubiquitin-dependent protein catabolism* | anaphase-promoting complex | YER179W YLR102C YDR118W YOR249C YKL022C YHR166C YFR036W YBL084C YGL240W YNL172W YER095W YGR052W YLR079W YDL008W | subunit of the Anaphase Promoting Complex; all known APC subunit co-immunoprecipitate with epitope-t | anaphase promoting complex (APC) subunit | Null mutant is inviable at 25 deg. C; ts mutants arrest in metaphase due to defect in the degradatio |
| APC4 | YDR118W | protein binding* | ubiquitin-dependent protein catabolism* | anaphase-promoting complex | YLR102C YOR249C YKL022C YHR166C YFR036W YBL084C YGL240W YNL172W YDL008W YLR127C | subunit of the Anaphase Promoting Complex; all known APC subunits co-immunoprecipitate with epitope- | anaphase promoting complex (APC) subunit | Null mutant is inviable at 25 C |
| APC5 | YOR249C | protein binding* | ubiquitin-dependent protein catabolism* | anaphase-promoting complex | YLR102C YKL022C YHR166C YFR036W YBL084C YGL240W YNL172W YDL008W YLR127C YDR118W | subunit of the Anaphase Promoting Complex; all known APC subunits co-immunoprecipitate with epitope- | anaphase promoting complex (APC) subunit | Null mutant is inviable at 25 C |
| APC9 | YLR102C | protein binding* | ubiquitin-dependent protein catabolism* | anaphase-promoting complex | YKL022C YHR166C YFR036W YBL084C YGL240W YML092C YNL176C YNL172W YDL008W YLR127C YDR118W YOR249C YMR092C YNL298W | required for structural stability and the incorporation of Cdc27p into the APC. | anaphase promoting complex (APC) subunit | Null mutant is viable at 37 C but show delay in entry into anaphase at 37 C |
| APE2 | YKL157W | leucyl aminopeptidase activity | peptide metabolism | cytoplasm* | YPR168W YHR114W YJL078C YMR307W YBR055C | Removal of intron fused YKL158W and YKL157W (Davis et al.(2000) NAR 28:1700-6) | aminopeptidase yscII | Null mutant is viable |
| APE3 | YBR286W | aminopeptidase activity | vacuolar protein catabolism | vacuole (sensu Fungi) | YDR311W YPL200W YGL100W | Aminopeptidase yscIII | aminopeptidase yscIII | Null mutant is viable but exhibited reduced vacuolar aminopeptidase activities and could not hydroly |
| APL5 | YPL195W | molecular_function unknown | Golgi to vacuole transport | AP-3 adaptor complex | YJL024C YGR261C YBR288C YGL019W YLR039C YLR262C | Delta-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to | clathrin assembly complex AP-3 adaptin component delta-like subunit | Null mutant is viable, rescues yck1,yck2 double mutant |
| APL6 | YGR261C | molecular_function unknown | Golgi to vacuole transport | AP-3 adaptor complex | YBR288C YHR174W YPL195W YPL115C YLR039C YLR262C | beta3-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to | clathrin assembly complex beta adaptin component (putative) | Null mutant is viable, null rescues yck1 yck2 double mutant |
| APM1 | YPL259C | clathrin binding | vesicle-mediated transport | AP-1 adaptor complex | YBL104C YPR029C YKL135C YKL010C YPR159W YNL132W YHR027C YPR016C YLR328W YER165W YPL043W YOL010W YLR196W YPL093W YCL059C YNL308C YOL077C YHR052W YBR221C YLR329W | medium subunit of the clathrin-associated protein complex | clathrin associated protein complex medium subunit | Null mutant is viable, enhances the slow growth and late Golgi sorting defects of a chc1-ts mutant |
| APM2 | YHL019C | clathrin binding | vesicle-mediated transport | AP-1 adaptor complex | YFR045W YPR029C YKL135C YBR019C | homologous to the medium chain of mammalian clathrin-associated protein complex | | Null mutant is viable |
| APM3 | YBR288C | molecular_function unknown | Golgi to vacuole transport | AP-3 adaptor complex | YBR014C YOR089C YGR261C YPL195W YPL016W YHR135C YNL154C YBR097W YDR323C YDR495C YGL095C YML097C YOR036W YLR262C | Mu3-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to t | clathrin associated protein complex medium subunit | Null mutant is viable, even combined with apm1 and apm2 |
| APM4 | YOL062C | molecular_function unknown | intracellular protein transport | AP-2 adaptor complex | YFL045C YBL037W YFR049W | Clathrin associated protein, medium subunit | clathrin associated protein complex medium subunit | |
| APN1 | YKL114C | DNA-(apurinic or apyrimidinic site) lyase activity | DNA repair* | nucleus* | YOR264W YJR057W | major apurinic/apyrimidinic endonuclease/3'-repair diesterase | major apurinic/apyrimidinic endonuclease/3'-repair diesterase | hypersensitive to both oxidative and alkylating agents that damage DNA; higher rate of spontaneous m |
| APN2 | YBL019W | phosphodiesterase I activity* | DNA repair | nucleus | YEL009C | AP endonuclease 2, homolog of human HAP1 and E. coli exoIII | AP endonuclease | The apn2 null mutant is viable and is not MMS sensitive. The apn1 apn2 null mutant, however, is extr |
| APP1 | YNL094W | molecular_function unknown | actin cytoskeleton organization and biogenesis | actin cortical patch (sensu Saccharomyces)* | YAL049C YLL050C YHR179W YCR088W YPL004C YDR155C YKL085W YGR196C YMR105C YNL025C YJR082C YLR429W YBR133C YDR235W YOR368W YDR388W YNL243W YBL106C YJL187C | Actin Patch Protein | Unknown | Null: Viable. Other phenotypes: Unknown |
| APS3 | YJL024C | molecular_function unknown | Golgi to vacuole transport | AP-3 adaptor complex | YPL195W | sigma3-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase t | | Null mutant is viable, rescues yck1,yck2 double mutant |
| AQR1 | YNL065W | monocarboxylic acid transporter activity* | drug transport* | plasma membrane | | A(acids, azoles) Q(quinidine, quinine) Resistance | multidrug resistance transporter | Null mutant is viable, but exhibits increased susceptibility to low-chain organic acids (C2-C6), azo |
| AQY1 | YPR192W | water channel activity | water transport | plasma membrane | | Aquaporin | aquaporin | Null mutant is viable and exhibits improved viability when grown under hypo-osmolar or hyper-osmolar |
| AQY2 | YLL052C | water channel activity | water transport | plasma membrane* | YMR094W | aquaporin water channel in yeast | MIP family member|aquaporin (putative) | |
| ARA1 | YBR149W | aldo-keto reductase activity* | carbohydrate metabolism | cytosol | YDL211C YNL128W YBR055C | D-arabinose dehydrogenase | D-arabinose dehydrogenase | Null mutant is viable but cannot produce D-arabinono-1,4-lactone, a precursor of D-erythroascorbic a |
| ARC1 | YGL105W | tRNA binding | tRNA-nucleus export* | cytoplasm* | YGL245W YKL205W YGR264C YCR002C YBR217W YMR059W YBR017C YML095C | associated with tRNA and amino acyl-tRNA synthetases; has affinity for quadruplex nucleic acids | | Null mutant is viable, leads to slow growth and reduced MetRS activity; arc1- mutants are synthetic |
| ARC15 | YIL062C | structural molecule activity* | actin cortical patch assembly | mitochondrial membrane* | YJR065C YLR370C YKL013C YNR035C YBR234C YDL029W | Arp complex subunit | | Null mutant exhibits severe growth defects. Cells with mutations in Arp2 and Arc15 are defective in |
| ARC18 | YLR370C | structural constituent of cytoskeleton | actin filament organization | Arp2/3 protein complex | YJR065C YOR361C YKL013C YNR035C YDL029W YGR240C YIL062C YJR091C YBR234C YJR043C YNL192W YBR023C YLR330W YJL099W YBL061C | Arp2/3 complex subunit | | |
| ARC19 | YKL013C | structural molecule activity | actin cortical patch assembly | Arp2/3 protein complex | YIL062C YLR370C YNR035C YJR065C YDL029W YBR234C YDR063W | Arp complex subunit | | Null mutant is viable, but exhibits severe growth defects |
| ARC35 | YNR035C | structural molecule activity | cell growth and/or maintenance | Arp2/3 protein complex | YJR065C YKL013C YDL029W YBR234C YIL062C YLR370C YHR114W YGL208W YDL225W | Arp complex subunit | | Null mutant exhibits severe growth defects; synthetic lethal with vma2. |
| ARC40 | YBR234C | structural constituent of cytoskeleton | actin filament organization | Arp2/3 protein complex | YNL040W YLR241W YBL062W YLR111W YJR065C YDR129C YNL298W YHR030C YJL095W YOR035C YHR064C YJR075W YPL043W YLR370C YKL013C YNR035C YIL062C YML069W YMR309C YNL233W YBR023C YBL061C YLR330W YJL099W YHR142W YNL322C YEL031W YER083C YBR200W YER155C YMR109W YE | Arp2/3 complex subunit, 40 kilodalton | | Null mutant is inviable |
| ARD1 | YHR013C | peptide alpha-N-acetyltransferase activity | protein amino acid acetylation | cytoplasm | YBR084W YMR116C YGR254W YHR023W YDL040C YGR090W YPR141C YPR135W YJR075W YDL049C YGR166W YJL062W | subunit of the major N alpha-acetyltransferase; complexes with Nat1p | N alpha-acetyltransferase major subunit|complexes with Nat1p | inability to respond to alpha-factor, enter stationary phase or sporulate, required for full repress |
| ARE1 | YCR048W | sterol O-acyltransferase activity | sterol metabolism | endoplasmic reticulum | YCL026C-A YLR427W YLR242C | Acyl-CoA cholesterol acyltransferase (sterol-ester synthetase) | acyl-CoA cholesterol acyltransferase (sterol-ester synthetase) | Null mutant is viable, slightly reduces in vivo and in vitro ergosterol esterification. Deletion of |