| Gene Name | ORF Name | Function GO Term | Process GO Term | Component GO Term | Interacting Genes | Description | Gene Product | Phenotype |
| CDC39 | YCR093W | 3'-5' exoribonuclease activity | regulation of transcription from Pol II promoter* | nucleus* | YIL038C YPR072W YPL235W YGR134W YNL288W YNR052C YDL145C YGL137W YOR110W YER068W YOL133W YJL141C YAL021C YDR376W | Required for Start B in mitosis and spindle pole body separation at meiosis I | basal transcription inhibitor|transcriptional regulator | Null mutant is inviable; arrests in G(sub)1 at pachytene at the mononucleate stage with duplicated, |
| CDC4 | YFL009W | protein binding* | ubiquitin-dependent protein catabolism* | nucleus* | YDL132W YDR328C YLR079W YJL194W YDR054C | Init. of DNA synthesis & spindle pole body separation; dispensable for both mitotic and meiotic spin | ubiquitin ligase subunit | Null mutant is inviable. cdc4 mutants arrest in meiosis at the mononucleate stage with duplicated sp |
| CDC40 | YDR364C | pre-mRNA splicing factor activity* | nuclear mRNA splicing, via spliceosome* | nuclear pore* | YMR213W YAL032C YKL095W | Required for proper timing of DNA synthesis at all temperatures and completion of DNA synthesis at a | beta transducin family | Null mutant is viable, temperature sensitive at 36 degrees celsius, arrests at the mononucleate stag |
| CDC42 | YLR229C | signal transducer activity* | establishment of cell polarity (sensu Saccharomyces)* | plasma membrane* | YDL135C YBR077C YGL211W YGR151C YNL298W YNL271C YLR319C YPL242C YCR077C YMR303C YAL041W YBR200W YER149C YBR171W YDR310C YKL007W YIL034C YPL161C YGR200C YPL086C YOR188W YJL157C YGR152C YBL085W YHL007C YHR111W YMR312W YPL101W YER111C YLL021W YDR126W YH | Budding blocked at 36 degree C in ts mutant | Rho subfamily of Ras-like proteins | Null mutant is inviable; temperature sensitive mutations unable to form buds and display delocalized |
| CDC43 | YGL155W | signal transducer activity* | establishment of cell polarity (sensu Saccharomyces)* | intracellular | YKL019W | may participate in a ras-like C-terminus modification of proteins involved in nuclear division and b | protein geranylgeranyltransferase type 1 polypeptide subunit | temperature sensitive mutants unable to form buds and display delocalized cell-surface deposition |
| CDC45 | YLR103C | DNA binding | DNA replication initiation* | replication fork* | YLR274W YBR202W YBR277C YJR070C YLR235C YMR166C YOR024W YGL127C YJL030W YCR077C YEL003W YLR268W YML094W YPR141C YBR036C YCL061C YGL086W YGL244W YLR055C YOL064C YOR043W YOR123C YPL055C YCR086W YJR140C YMR048W YMR039C YPR135W YDR289C YFR019W YGL173C YM | Cdc45p assembles into a complex with Cdc46p/Mcm5p | chromosomal DNA replication initiation protein | required for minichromosome maintenance and chromosomal DNA replication |
| CDC46 | YLR274W | chromatin binding* | DNA replication initiation* | cytoplasm* | YEL032W YBR202W YLR103C YGL201C YOR080W | Member of complex that acts at ARS's to initiate replication | | Null mutant is inviable; at nonpermissive temperature cdc46(ts) mutants arrest with a large bud and |
| CDC47 | YBR202W | chromatin binding* | DNA replication initiation* | nucleus* | YBR202W YIL150C YLR274W YEL032W YGL001C YLR103C YDL029W | Essential for initiation of DNA replication | | Null mutant is inviable, at nonpermissive temperature cdc47(ts) mutants arrest with a large bud and |
| CDC48 | YDL126C | ATPase activity | ubiquitin-dependent protein catabolism* | nucleus* | YDR049W YNL271C YDR028C YDR337W YBR170C YGL246C YBL058W YGR048W YDL190C YKL213C YBL103C YDR037W YGR078C | Microsomal protein of CDC48/PAS1/SEC18 family of ATPases; full length homology to mammalian protein | | Null mutant is inviable |
| CDC5 | YMR001C | protein serine/threonine kinase activity | protein amino acid phosphorylation* | nucleus* | YNL175C YLR347C YJL019W YAL047C YFL008W YDL003W YIL026C YJL074C YDR229W YNL092W YDR386W YBR060C YIL106W YAR019C | CDC5 is dispensable for premeiotic DNA synthesis and recombination, but required for tripartite syna | protein kinase | Null mutant is inviable. cdc5(ts) mutants form synaptonemal complexes lacking central elements and a |
| CDC50 | YCR094W | transcription regulator activity | G1 phase of mitotic cell cycle* | late endosome* | YGL090W YJR091C | cell division cycle mutant | | Null mutant is cold-sensitive and sensitive to MMS and HU |
| CDC53 | YDL132W | structural molecule activity* | ubiquitin-dependent protein catabolism* | nuclear ubiquitin ligase complex* | YLR128W YDR274C YDL006W YNL055C YEL060C YPL258C YDR328C YAL040C YPL256C YLR134W YMR199W YDL017W YLR079W YIL046W YFL009W YJR090C YJL194W YDR054C YGR087C YLR100W YLR368W YGL249W YBR280C YLR097C YJL149W YOR080W YOL133W YLR352W YDR306C YML088W | acts together with Cdc4p and Cdc34p to control the G1-S phase transition, assists in mediating the p | | Cells arrest in G1 with active Cln kinases but no Clb-associated Cdc28p kinase activity |
| CDC54 | YPR019W | chromatin binding* | DNA replication initiation* | nucleus* | YDL029W YDR143C YBR060C YNL261W | essential for initiation of DNA replication; homolog of S. pombe CDC21 | | Null mutant is inviable; at nonpermissive temperature cdc54(ts) mutants arrest with a large bud and |
| CDC6 | YJL194W | protein binding* | pre-replicative complex formation and maintenance | pre-replicative complex | YBR160W YKL145W YDR196C YDL132W YDR054C YFL009W | Protein involved in initiation of DNA replication | pre-initiation complex component | arrest at initiation of S phase |
| CDC60 | YPL160W | leucine-tRNA ligase activity | leucyl-tRNA aminoacylation | cytoplasm | YPL111W YNL244C YPR110C YCR079W | cytosolic leucyl tRNA synthetase | leucine--tRNA ligase | arrest at START point of cell cycle upon shift to restrictive temperature |
| CDC7 | YDL017W | protein serine/threonine kinase activity | protein amino acid phosphorylation* | nucleoplasm | YBL023C YCR022C YCR050C YEL023C YFR057W YNR048W YOR006C YGL250W YJR070C YKL056C YLR235C YOR027W YLR386W YJL030W YGL019W YJR032W YDR032C YGL086W YLR055C YPR119W YJR140C YJL138C YMR055C YHR191C YCL016C YJR053W YML016C YML032C YMR078C YDR363W YDL160C YL | Required for mitotic DNA synthesis but dispensable for premeiotic DNA synthesis and spindle pole bod | Cdc7p-Dbf4p kinase complex catalytic subunit | Null mutant is inviable. cdc7 mutant arrests at G(sub)1/S phase with duplicated spindle pole bodies |
| CDC73 | YLR418C | Pol II transcription elongation factor activity | RNA elongation from Pol II promoter | transcription elongation factor complex | YDL033C YDR334W YEL033W YER084W YER139C YLR168C YLR269C YML012C-A YNL140C YNL198C YPL182C YPR084W YCL037C YOR089C YCR077C YOR080W YNL025C YEL031W YER122C YOR216C YLR268W YDR137W YHL031C YGL020C YLR039C YLR262C YEL061C YLR373C YIL128W YPL069C YAL013W | accessory factor associated with RNA polymerase II by affinity chromatography | | Mutations affect cell growth and the abundance of transcripts from a subset of genes |
| CDC8 | YJR057W | thymidylate kinase activity | DNA repair* | nucleus* | YDR438W YDR458C YKL098W YLR235C YMR198W YLR268W YGL020C YCL061C YCR086W YGL173C YKL032C YDR453C YER173W YBR098W YPL194W YHR178W YLR234W YNL299W YMR190C YDR446W YDR452W YDR490C YER167W YJR034W YKL113C YKL114C YNL218W YNL229C YNL241C YOR304W | Essential for mitotic DNA synthesis. Required for premeiotic DNA synthesis, synaptonemal complexes, | thymidylate kinase | Null mutant is inviable. cdc8 mutants are defective in continued replication during S phase of the c |
| CDC9 | YDL164C | DNA ligase (ATP) activity | DNA recombination* | replication fork | YOR378W YEL030W YLR276C YBR088C YGL207W YHR178W | Essential for mitosis and meiosis, dispensable for intragenic recombination, but required for haploi | DNA ligase | cell division cycle blocked at 36 degrees, increased sensitivity to ultraviolet radiation and bleomy |
| CDH1 | YGL003C | enzyme activator activity | ubiquitin-dependent protein catabolism* | nucleus* | YHR152W YLR079W YMR048W | CDC20 homolog 1 | required for Clb2 and Ase1 degradation | Null mutant is viable but defective in Clb2p and Ase1p degradation; deletion of cdh1 causes pheromon |
| CDS1 | YBR029C | phosphatidate cytidylyltransferase activity | phosphatidylglycerol biosynthesis* | mitochondrion* | | CDP-diacylglycerol synthase, CTP-phosphatidic acid cytidylyltransferase, CDP-diglyceride synthetase | phosphatidate cytidylyltransferase | Null mutant is inviable |
| CEF1 | YMR213W | pre-mRNA splicing factor activity | nuclear mRNA splicing, via spliceosome | spliceosome complex | YDR416W YCR063W YLR423C YGL120C YML049C YLR275W YDR364C YLR117C YBR065C YMR288W YLL036C YNR011C YER013W YAL032C YPL151C YPR101W YKL173W YDL209C YGL128C YGR278W YHR165C | homolog of S. pombe cdc5+. c-Myb DNA binding motif at amino terminus is required for cellular growth | protein complex component associated with the splicing factor Prp19p | Null mutant is inviable, arrests in G2/M, exhibits abnormal nuclear morphologies. Essential for mRNA |
| CEG1 | YGL130W | mRNA guanylyltransferase activity | mRNA capping | nucleus | YHR121W YMR309C YER155C YKR001C YGL120C YMR012W YDL014W YAL035W YNL088W YBL075C YER103W YNL030W YBR221C YGL207W YPL228W YOL145C YBR079C YOL078W YIL131C YDL140C | mRNA guanylyltransferase (mRNA capping enzyme), alpha subunit | mRNA capping enzyme alpha subunit|mRNA guanylyltransferase | Null mutant is inviable |
| CEM1 | YER061C | 3-oxoacyl-acyl-carrier protein synthase activity | hexadecanal biosynthesis | mitochondrion | YPL073C | homology with beta-keto-acyl synthases | beta-keto-acyl synthase homolog | Null mutant is viable; exhibits respiratory-deficient growth |
| CEP3 | YMR168C | DNA bending activity* | mitotic spindle checkpoint | condensed nuclear chromosome kinetochore | YJR060W | Cbf3 kinetochore complex binds CDE III centromere element; Cep3p contains an N-terminal Zn2Cys6 type | Cbf3 kinetochore protein complex subunit b | Null mutant is inviable; mutations within the zinc finger domain result in cells that exhibit a G2-M |
| CET1 | YPL228W | polynucleotide 5'-phosphatase activity | mRNA capping | nucleus | YGL130W | Interacts with Ceg1p, the mRNA capping enzyme alpha subunit; removes gamma-phosphate from triphospha | RNA 5'-triphosphatase|mRNA capping enzyme beta subunit (80 kDa) | Null mutant is inviable |
| CFT1 | YDR301W | cleavage/polyadenylation specificity factor activity | mRNA polyadenylation* | mRNA cleavage factor complex* | YGR240C YER133W YLR115W YKR002W YNL317W YAL043C YDR195W YMR061W YGR156W YKL059C YLR277C YJR093C YPR107C | Functions in cleavage of 3'-ends of pre-mRNAs, prior to polyadenylation; 23.5% identical to the 160- | 150 kDa protein associated with polyadenylation factor 1 (PF I)|cleavage factor II (CF II) component | Null mutant is inviable |
| CFT2 | YLR115W | cleavage/polyadenylation specificity factor activity | mRNA polyadenylation* | mRNA cleavage factor complex* | YER133W YKR002W YNL317W YAL043C YGR156W YKL059C YLR277C YJR093C YHL035C YPR107C YJL033W YDR228C YDR195W YMR061W YDR301W | cleaves pre-mRNAs prior to polyadenylation; homologous to both the 73- and 100-kDa subunits of mamma | 105 kDa protein associated with polyadenylation factor 1 (PF I)|cleavage factor II (CF II) component | Null mutant is inviable |
| CGR1 | YGL029W | molecular_function unknown | rRNA processing* | nucleolus | YNL243W | Coiled-coil growth-regulated. May contribute to compartmentalization of nucleolar constituents. | coiled-coil protein | Null mutant is inviable; CGR1 expression is down-regulated in the postdiauxic growth phase |
| CHA4 | YLR098C | transcription factor activity | regulation of transcription, DNA-dependent* | nucleus | YDR034C YPL130W YDL076C YDL239C | Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain | DNA binding transcriptional activator of CHA1 | Unable to grow with serine or threonine as the sole nitrogen source, suppresses ilv1 mutant by causi |