| Gene Name | ORF Name | Function GO Term | Process GO Term | Component GO Term | Interacting Genes | Description | Gene Product | Phenotype |
| TOM71 | YHR117W | protein transporter activity | biological_process unknown | mitochondrial outer membrane | YOR110W | Translocase of the Outer Mitochondrial membrane, 71.9 kDa | protein translocase 71 kDa component of the outer membrane of mitochondria | Null mutant is viable, shows slight decrease in growth on non-fermentable carbon sources at 37C and |
| TOP1 | YOL006C | DNA topoisomerase type I activity | regulation of transcription from Pol II promoter* | nucleus | YFR011C YMR233W YDR249C YLR235C YOR044W YCR077C YNR051C YNL250W YML032C YMR224C YPR046W YMR012W YOR032C YBR098W YJL115W YLR234W YPL024W YMR190C YGL207W YLR304C YML062C YPR190C YOR033C YKL003C YOL115W YNL099C YOR045W YBL002W YBR049C YNL330C YCL067C YL | topoisomerase I | topoisomerase I | Null mutant is viable |
| TOP2 | YNL088W | DNA topoisomerase type II activity | meiotic recombination* | nucleus* | YBR025C YGL019W YLR197W YDR510W YMR246W YDR381W YOR061W YBR087W YLR154C YDR138W YDL101C YOR010C YGL130W YPL074W YJR076C YIL035C YOR039W | An essential type II topoisomerase that catalyzes topology changes in DNA via transient breakage and | topoisomerase II | Null mutant is inviable; top2 mutants arrest at the mononucleate stage, Rec- mutants suppress the me |
| TOP3 | YLR234W | DNA topoisomerase type I activity | meiotic recombination* | nucleus | YDL101C YDR097C YGR239C YDR138W YOR144C YPR135W YHR191C YMR078C YLR200W YGR078C YMR048W YNL273W YJR043C YOL006C YLR103C YDL017W YDR052C YJR057W YBR098W YDR386W YBR094W YHR154W YJL092W YHR031C | DNA Topoisomerase III | DNA topoisomerase III | Null mutant exhibits a genomic instability phenotype that includes slow growth, hyper-sensitivity to |
| TOR1 | YJR066W | protein binding* | meiosis* | plasma membrane* | YLR116W | Involved in cell cycle signaling and meiosis | phosphatidylinositol kinase homolog | Null mutant is viable, grows slowly; rapamycin resistance, tor1 tor2 double mutant is inviable |
| TOR2 | YKL203C | protein binding* | signal transduction* | plasma membrane* | YMR200W YBL105C YBR229C YBR036C | putative protein/phosphatidylinositol kinase involved in signaling activation of translation initiat | | Null mutant is inviable, exhibits disruption of the polarized distribution of the actin cytoskeleton |
| TOS2 | YGR221C | molecular_function unknown | biological_process unknown | bud neck* | YAL041W | Target of SBF | | |
| TPC1 | YGR096W | transporter activity | transport | mitochondrial inner membrane* | | Tpc1p is a transporter that catalyzes the uptake of the essential cofactor thiamine pyrophosphate (T | mitochondrial thiamine pyrophosphate transporter | |
| TPD3 | YAL016W | protein phosphatase type 2A activity | protein biosynthesis* | nucleus* | YML109W YDL134C YPL152W YAL024C YDL188C YMR273C YOR014W YGR281W YHR158C YGR161C YGL190C YDR482C YHR082C YHR135C YOL113W YNL127W | protein phosphatase 2A regulatory subunit A | protein phosphatase 2A regulatory subunit A | Null mutant is viable, defective in cytokinesis at reduced temperatures, defective in transcription |
| TPI1 | YDR050C | triose-phosphate isomerase activity | gluconeogenesis* | cytoplasm* | YNL127W | induced under stress conditions | triosephosphate isomerase | Null mutant is viable. |
| TPK1 | YJL164C | protein serine/threonine kinase activity* | protein amino acid phosphorylation* | cytoplasm* | YMR319C YDR212W YIL033C YLL040C YKL166C YFL033C YPL203W YNL093W | putative catalytic subunit of cAMP-dependent protein kinase | cAMP-dependent protein kinase catalytic subunit (putative) | multicopy suppression of ras mutant |
| TPK2 | YPL203W | protein serine/threonine kinase activity* | protein amino acid phosphorylation* | cytoplasm* | YIL033C YKL166C YLR177W YJL164C YHR135C | Involved in nutrient control of cell growth and division | cAMP-dependent protein kinase catalytic subunit | Null mutant haploids are defective for invasive growth; diploid homozygous null mutants are defectiv |
| TPK3 | YKL166C | protein serine/threonine kinase activity* | protein amino acid phosphorylation* | cytoplasm* | YNL227C YHR214W-A YHR033W YGR240C YGL234W YLR216C YGL137W YIL033C YPR160W YML001W YKL166C YJL164C YPL203W YHR135C YNL093W YDR490C | Involved in nutrient control of cell growth and division | cAMP-dependent protein kinase catalytic subunit | Null mutant is viable, tpk1 tpk2 tpk3 triple mutant is inviable |
| TPM1 | YNL079C | actin lateral binding | establishment of cell polarity (sensu Saccharomyces)* | contractile ring (sensu Saccharomyces)* | YOR326W YCL037C YER155C YJL187C YPL031C YHR030C YDR150W YBR023C YLR330W YHR142W YBL061C | Actin-binding protein that stabilizes actin filaments; Tpm1, the main tropomyosin, is required for t | tropomyosin I | Null mutant is viable, grows slowly, exhibits cell size heterogeneity, has delocalized deposition of |
| TPM2 | YIL138C | actin lateral binding | establishment of cell polarity (sensu Saccharomyces)* | contractile ring (sensu Saccharomyces)* | | Actin-binding protein that stabilizes actin filaments; Tpm2 with Tpm1, the main tropomyosin, is requ | tropomyosin isoform II | Null mutant is viable, exhibits no detectable phenotype; tpm1 tpm2 double deletion mutants are invia |
| TPN1 | YGL186C | vitamin/cofactor transporter activity | vitamin/cofactor transport | plasma membrane | | transport of pyridoxine | plasma membrane pyridoxine transport protein | |
| TPO1 | YLL028W | spermine transporter activity* | polyamine transport | plasma membrane* | YGL166W | plasma membrane-bound exporter, involved in the detoxification of excess spermidine | | |
| TPO2 | YGR138C | spermine transporter activity | polyamine transport | plasma membrane* | | Polyamine transport protein | | |
| TPO3 | YPR156C | spermine transporter activity | polyamine transport | plasma membrane* | YBR285W YLR297W YPR037C | Polyamine transport protein | | |
| TPO4 | YOR273C | spermine transporter activity* | polyamine transport | plasma membrane* | YEL072W | Polyamine transport protein | | |
| TPS1 | YBR126C | alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity | response to stress* | cytoplasm* | YIL177C YMR251W YDR074W YMR261C YNL310C YBR265W YJL138C YDR028C YBR126C YJR138W YBL023C YKR059W YGL035C YIR032C YGL253W YLR411W YPR035W YNL076W YML100W YMR106C YNL244C YOL133W YLL019C YOR089C YCR079W YGR092W YDR247W YMR139W YDL017W YER112W YBR055C YF | Probable regulator of glucose influx into the cell & into glycolytic pathway, indirectly regulating | trehalose-6-phosphate synthase/phosphatase complex 56 kDa synthase subunit | null is viable, but does not grow on glucose and/or fructose,and shows lack of trehalose |
| TPS2 | YDR074W | trehalose phosphatase activity | response to stress* | alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) | YAR066W YDR074W YER019C-A YMR261C YML100W YBR126C YLR447C YHR196W YOR067C | Trehalose-6-phosphate phosphatase | trehalose-6-phosphate phosphatase | Null mutant is viable, exhibits complete loss of trehalose-6-phosphate phosphatase activity, measure |
| TPS3 | YMR261C | alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity | response to stress* | alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) | YMR261C YML100W YBR126C YDR074W | 115 kD regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex | trehalose-6-phosphate synthase/phosphatase complex 115 kDa regulatory subunit | Null mutant is viable |
| TPT1 | YOL102C | tRNA 2'-phosphotransferase activity | tRNA splicing | nucleus | YNL132W YKR081C YDL014W YBR248C | Gene encodes a protein implicated in the last step of tRNA splicing in yeast: transfer of the splice | tRNA 2'-phosphotransferase | Null mutant is inviable |
| TRA1 | YHR099W | histone acetyltransferase activity | regulation of transcription from Pol II promoter* | histone acetyltransferase complex | YBR081C YDR448W YFL024C YOR244W YJL098W YDR146C YGR252W YDL213C YDR176W YIR009W YHR090C | TRA1 is the homolog of the human protein TRRAP which we have isolated as an essential cofactor of c- | ATM/Mec1/TOR1/TOR2-related|NuA4 complex component | Null mutant is inviable. |
| TRF4 | YOL115W | DNA-directed DNA polymerase activity | mitotic chromosome condensation* | nucleus | YPL146C YML056C YNL039W YLR197W YKR048C YIL079C YMR308C YLR432W YDL175C YAR073W YGR174C YHR195W YJL050W YBR251W YNL299W YOL006C YFL008W YFR031C | TRF5 homolog; Involved in mitotic chromsome condensation; associates with Smc1p and Smc2p | DNA polymerase sigma | |
| TRF5 | YNL299W | DNA-directed DNA polymerase activity | sister chromatid cohesion | nucleus | YOL115W YLR039C YLR103C YJR057W | TRF4 homolog; TRF4/5 function is required for proper mitosis | DNA polymerase sigma | Null mutant is viable; trf4 trf5 mutants are inviable; trf4 (ts) trf5 double mutant is hypersensitiv |
| TRK1 | YJL129C | potassium ion transporter activity | potassium ion homeostasis | plasma membrane | YBR068C | 180 kDa high affinity potassium transporter | 180 kDa high affinity potassium transporter | Null mutant is viable, requires added potassium; trk1 trk2 double mutants are viable |
| TRK2 | YKR050W | potassium ion transporter activity | potassium ion homeostasis | plasma membrane | YDR311W YBR068C | membrane protein; low affinity potassium transport | low affinity potassium transport|membrane protein | Null mutant is viable, requires added potassium; trk1 trk2 double mutants are viable |
| TRL1 | YJL087C | RNA ligase (ATP) activity | tRNA splicing* | nucleoplasm* | YLR447C YKL108W YIL035C | tRNA ligase | tRNA ligase | Null mutant is inviable |