AAC1 YMR056C ATP:ADP antiporter activity ATP/ADP exchange mitochondrial inner membrane YLL013C YHR005C-A YBR217W YER171W minor species of mitochondrial ADP/ATP translocator, highly homologous to PET9 (AAC2) and AAC3 ADP/ATP translocator Null mutant is viable, shows altered colony morphology
AAC3 YBR085W ATP:ADP antiporter activity ATP/ADP exchange mitochondrial inner membrane YHR135C YBR217W YML058W YJL173C YGR262C YDL059C YER171W YER161C YOR181W highly homologous to PET9 (AAC2) and AAC1; expression occurs only under anaerobic conditions ADP/ATP translocator Null mutant is viable; pet9,aac3 double null mutant is inviable under anaerobic conditions
AAR2 YBL074C molecular_function unknown assembly of spliceosomal tri-snRNP snRNP U5 YDR283C YDL208W YHR165C component of free U5 snRNP and recycling factor for U4/U6.U5 tri-snRNP complex; (originally describe growth defect and defect in splicing the pre-mRNA of the MATa1 cistron
AAT1 YKL106W aspartate transaminase activity aspartate biosynthesis* mitochondrion YLR447C YCL018W aspartate aminotransferase, mitochondrial aspartate aminotransferase Null mutant is viable; aat1 leu2 double mutant is inviable.
AAT2 YLR027C aspartate transaminase activity nitrogen metabolism* cytoplasm* YLR314C YNL244C YMR059W aspartate aminotransferase, cytosolic aspartate aminotransferase
ABC1 YGL119W chaperone activity mitochondrial electron transport, ubiquinol to cytochrome c mitochondrion YJR091C multicopy suppressor of a cytochrome b mRNA translation defect, essential for the electron transfer null mutant is viable, no oxygen uptake and no growth on non-fermentable media
ABD1 YBR236C mRNA (guanine-N7-)-methyltransferase activity mRNA capping nucleus* YOR151C YML010W RNA (guanine-7-)methyltransferase (cap methyltransferase) RNA (guanine-7-)methyltransferase (cap methyltransferase) null mutant is inviable
ABF1 YKL112W transcription factor activity* chromatin silencing at HML and HMR (sensu Saccharomyces)* nuclear chromatin transcriptional activator and ARS1 binding protein ARS1 binding protein|transcriptional activator Null mutant is inviable
ABF2 YMR072W DNA binding mitochondrial genome maintenance* mitochondrial chromosome YOL004W YGL127C YDL198C YKL037W HMG-1 homolog, mitochondrial HMG-1 homolog
ABP1 YCR088W protein binding establishment of cell polarity (sensu Saccharomyces)* cytoplasm* YOR284W YJR065C YDR342C YOR367W YCR084C YHR016C YDR523C YDR129C YBL007C YNL243W YDR388W YFL039C YNL138W YNL298W YPL204W YNL094W YIL095W YHR199C Actin binding protein actin binding protein Null mutant is viable
ABP140 YOR239W actin cross-linking activity actin cytoskeleton organization and biogenesis actin filament YKL093W YOR172W YOR232W YLR447C actin filament binding protein actin filament binding protein Null mutant is viable.
ACA1 YER045C specific RNA polymerase II transcription factor activity transcription initiation from Pol II promoter nucleus YGR247W YOR059C YMR308C YGL181W YGR123C contains an ATF/CREB-like bZIP domain; transcriptional activator basic leucine zipper (bZIP) transcription factor
ACC1 YNR016C acetyl-CoA carboxylase activity* protein-nucleus import* cytosol* YJR064W YDL047W YLR386W YER179W YIL061C YPR110C YDR398W YDL225W YMR106C acetyl-CoA carboxylase acetyl CoA carboxylase acc1 spores fail to enter vegetative growth
ACE2 YLR131C transcriptional activator activity G1-specific transcription in mitotic cell cycle nucleus* YMR304W YNL157W YPR159W involved in transcriptional regulation of CUP1. enters nucleus only at the end of mitosis. zinc finger transcription factor Null mutant is viable, exhibits decreased CUP1 mRNA expression
ACF2 YLR144C glucan 1,3-beta-glucosidase activity actin cytoskeleton organization and biogenesis intracellular YDR388W glucan-hydrolyzing protein that specifically acts on 1,3-beta linkages, with an endolytic mode of ac Null mutant shows defect in in vitro actin assembly in the permeabilized cell assay
ACH1 YBL015W acetyl-CoA hydrolase activity acetate metabolism* mitochondrion* YPR110C YJR068W YMR059W YJR035W Mannose-containing glycoprotein which binds concanavalin A acetyl CoA hydrolase
ACN9 YDR511W molecular_function unknown gluconeogenesis* mitochondrial intermembrane space YGL181W
ACO1 YLR304C aconitate hydratase activity tricarboxylic acid cycle* cytosol* YNL192W YPL204W YDR480W YIL007C YMR059W YOR005C YGR040W YER171W YBR136W YAR007C YOL094C YLR262C YJR035W YMR049C YOL006C Aconitase, mitochondrial aconitase glutamate auxotrophy
ACP1 YKL192C acyl carrier activity fatty acid biosynthesis mitochondrion YDL239C YDR084C YPL163C mitochondrial acyl carrier protein acyl carrier protein The null mutant is viable but respiratory-deficient and contains only 5-10% of the wild-type amount
ACS1 YAL054C acetate-CoA ligase activity acetyl-CoA biosynthesis* cytosol YHR041C YLR049C YNL189W one of 2 acetyl-coA synthetases in yeast acetyl CoA synthetase Null mutant is viable and grows on ethanol or glucose (but not acetate) as sole carbon source (but w
ACS2 YLR153C acetate-CoA ligase activity acetyl-CoA biosynthesis cytosol YIL061C YJR091C YPR165W YNL244C YBR055C one of 2 acetyl-coA synthetases in yeast acetyl CoA synthetase Null mutant is viable, and grows on ethanol or acetate as sole carbon source, but is unable to grow
ACT1 YFL039C structural constituent of cytoskeleton cell wall organization and biogenesis* actin cortical patch (sensu Saccharomyces)* YGR080W YNL138W YDR388W YNL271C YLR319C YCL037C YKL212W YLL050C YOR122C YBR200W YJL005W YGL240W YFL024C YML126C YOR244W YHR023W YAL029C YDL002C YLR196W YMR061W YER155C YPL242C YDR129C YDL143W YCR088W YEL013W YOR181W Involved in cell polarization, endocytosis and other cytoskeletal functions actin Null mutant is inviable; ts mutants show osmosensitivity and defects in actin organization at non-pe
ADA2 YDR448W transcription co-activator activity histone acetylation* SAGA complex YER148W YHR099W YDL165W YPL254W YDR176W YOL148C YBR081C YBR198C YGR252W YOL135C YBR253W YGR274C YDR167W YGL112C YBR278W YHR166C YKL012W YLR291C YDR392W YDR228C transcription factor, member of ADA and SAGA, two transcriptional adaptor/HAT (histone acetyltransfe ADA and SAGA component, two transcriptional adaptor/HAT (histone acetyltransferase) complexes|transc Null mutant is viable, grows poorly on minimal media
ADE16 YLR028C IMP cyclohydrolase activity* aerobic respiration* cytosol YLR373C AICAR transformylase/IMP cyclohydrolase 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase/IMP cyclohydrolase Null mutant is viable; ade16 ade17 double mutant requires adenine
ADE17 YMR120C IMP cyclohydrolase activity* 'de novo' IMP biosynthesis cytosol YOR212W YBR055C AICAR transformylase/IMP cyclohydrolase 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase/IMP cyclohydrolase Null mutant is viable; ade16 ade17 double mutants require adenine
ADE3 YGR204W formate-tetrahydrofolate ligase activity purine base biosynthesis cytoplasm YFR031C-A YPR086W YNL135C YBR055C Required for the biosynthesis of purines, thymidylate, methionine, histidine, pantothenic acid and f C1-tetrahydrofolate synthase Null mutant is viable, adenine auxotroph, histidine auxotroph
ADE5,7 YGL234W phosphoribosylamine-glycine ligase activity* purine base metabolism cytoplasm YBR049C YOR298W YBR217W YJR068W YOL094C YBL026W YKL166C glycinamide ribotide synthetase and aminoimidazole ribotide synthetase aminoimidazole ribotide synthetase|glycinamide ribotide synthetase Adenine requiring
ADH1 YOL086C alcohol dehydrogenase activity fermentation cytosol YML085C YPR180W YAL059W YOR244W YBR207W YOR304W YGL009C YOL135C YPL082C YAL029C YFR021W YBR114W YDR164C YDR170C YDL042C YBR058C YAL027W YAL034C YNL127W YOR056C Adh protein catalyzes activities for the production of certain carboxylate esters. alcohol dehydrogenase Null mutant is viable and sensitive to formaldehyde.
ADH2 YMR303C alcohol dehydrogenase activity fermentation* cytoplasm YFL042C YPR110C YHR135C YLR097C YKL108W YKL189W YLR229C YOL094C YNL068C YDR386W YDL175C YLR216C YLR074C YDR499W Glucose-repressible alcohol dehydrogenase II catalyzes activities for the production of certain carb alcohol dehydrogenase II Null mutant is viable
ADH3 YMR083W alcohol dehydrogenase activity fermentation mitochondrial matrix* YLR080W YBR074W YML058W shows a high affinity for alcohols with a double bond conjugated to the alcohol function. alcohol dehydrogenase isoenzyme III Null mutant is viable
ADH6 YMR318C alcohol dehydrogenase (NADP) activity aldehyde metabolism* soluble fraction YJR035W YLR442C YMR307W NADPH-dependent alcohol dehydrogenase medium chain alcohol dehydrogenase
ADH7 YCR105W alcohol dehydrogenase (NADP) activity alcohol metabolism soluble fraction NADP(H)-dependent alcohol dehydrogenase medium chain alcohol dehydrogenase
ADK1 YDR226W adenylate kinase activity cell proliferation cytoplasm* YOR176W YJR091C YPL031C YBL036C YDR177W YDL043C YML064C YFR028C adenylate kinase adenylate kinase Null mutant is viable, has a petite phenotype
ADK2 YER170W adenylate kinase activity biological_process unknown mitochondrial inner membrane YKL002W Adenylate kinase (mitochondrial GTP:AMP phosphotransferase) adenylate kinase|mitochondrial GTP:AMP phosphotransferase null mutant is viable
ADP1 YCR011C ATP-binding cassette (ABC) transporter activity transport cytoplasm* YNL154C Shows homology to ATP-dependent permeases
ADR1 YDR216W transcription factor activity transcription* nucleus YDL029W YPR110C YDL145C YBR017C YOL133W YER177W YMR106C YGR123C Controls the expression of ADH2, peroxisomal protein genes, and genes required for ethanol, glycerol positive transcriptional regulator abolished derepression of ADH2
ADY2 YCR010C transporter activity meiosis* membrane Accumulation of DYads; member of the TC 9.B.33 YaaH family of putative transporters transmembrane protein Null mutant is viable; forms predominantly asci containing 2 spores (dyads) whensporulated; required
ADY3 YDL239C protein binding protein complex assembly* spindle* YKL023W YLR072W YMR124W YOL083W YOR284W YAL028W YAR018C YBR072W YDL030W YDR148C YDR273W YER086W YGR268C YHR184W YKL103C YLR242C YLR423C YML042W YNR012W YOL091W YOR324C YPL049C YPL070W YPL124W YPL255W YLR098C YAL042W YDR176W YKL192C YNL201C YOR127W YC Accumulation of DYads. Mediates assembly of the Don1p-containing structure at the leading edge of th Null forms largely asci that contain 2 spores (dyads) when sporulated. Sporulation defect in ady3ady
ADY4 YLR227C structural molecule activity sporulation spindle pole body YML133C YOR089C Component of the meiotic outer plaque, a membrane-organizing center that assembles on the cytoplasmi
AEP2 YMR282C molecular_function unknown protein biosynthesis mitochondrion YOL123W YHR181W Required for the translation of OLI1 mRNA. basic hydrophilic 67.5 kDa protein non-conditional respiratory mutant; unable to express the mitochondrial OLI1 gene; pet mutant
AFG2 YLR397C ATPase activity response to drug intracellular YAR044W YJR091C YMR047C YLR074C YPR017C ATPase family gene similar to the CDC48 gene product Null mutant is inviable
AFG3 YER017C ATPase activity* protein complex assembly* mitochondrial inner membrane* YBR034C YBR247C YFL018C YMR089C ATPase family gene ATP dependent metalloprotease nuclear petite phenotype; loss of repspiratory competence
AFR1 YDR085C receptor signaling protein activity signal transduction during conjugation with cellular fusion* shmoo tip YPL242C YMR059W coordinates regulation of alpha-factor receptor signalling and induction of morphogenesis during con cytoskeletal protein|similar to arrestins defect in alpha-factor-stimulated morphogenesis
AFT2 YPL202C specific RNA polymerase II transcription factor activity transcription initiation from Pol II promoter* nucleus Activator of Iron (Fe) Transcription Null: Deletion of AFT2 exacerates iron deficiency of AFT1 disruption.
AGA1 YNR044W cell adhesion receptor activity agglutination during conjugation with cellular fusion cell wall (sensu Fungi) anchorage subunit of a-agglutinin a-agglutinin anchorage subunit mating defect in liquid medium
AGA2 YGL032C cell adhesion receptor activity agglutination during conjugation with cellular fusion cell wall (sensu Fungi) YGR257C adhesion subunit of a-agglutinin a-agglutinin adhesion subunit Null mutant is viable and shows mating defect
AGC1 YPR021C transporter activity transport mitochondrial inner membrane Aspartate glutamate carrier Aspartate glutamate mitochondrial carrier Null: viable. Other phenotypes: not viable on minimal medium supplemented with acetate or oleate
AGP1 YCL025C amino acid transporter activity amino acid transport plasma membrane YIR038C YJL062W broad substrate range permease which transports asparagine and glutamine with intermediate specifici amino acid permease Null mutant is viable; resistant to the amino acid analog gamma-hydroxyaspartate, decreased growth o
AGP2 YBR132C hydrogen:amino acid symporter activity response to osmotic stress* endoplasmic reticulum membrane* The acronym may be misleading. AGP2 has been shown to be a carnitine permease, not a general amino a plasma membrane carnitine transporter Null mutant is viable; loss of growth on some amino acids as nitrogen source (leu, thr) in a strain
AGP3 YFL055W amino acid transporter activity amino acid transport plasma membrane YOR076C The acronym may be misleading. AGP3 has not been shown to be a general amino acid permease with broa Null mutant is viable; loss of growth on some amino acids as nitrogen source (leu, thr) in a strain
AHA1 YDR214W chaperone activator activity response to stress* cytoplasm YJL030W YIL038C YOL052C YDR523C YBR217W YDR138W YPR110C YER173W YHR030C YOL139C YDL059C YDL101C YOL094C YOR212W YAL015C Activator of Heat Shock Protein 90 ATPase Hsp90 system cochaperone; Aha1 binds to the middle domain of Hsp90 and improves client protein activ Null: knockout viable
AHC1 YOR023C molecular_function unknown nucleosome disassembly Ada2/Gcn5/Ada3 transcription activator complex YLR424W YCR082W YDL030W YOL009C YJL187C YLR200W YGR078C YNL153C YEL003W YML094W Ada Histone acetyltransferase complex component Ada histone acetyltransferase complex component Null mutant is viable
AHP1 YLR109W thioredoxin peroxidase activity regulation of redox homeostasis* cytoplasm YNL312W YHR135C YMR059W YLR340W YGL090W YMR022W YJL141C YDR369C thioredoxin peroxidase EC 1.11.1.-|alkyl hydroperoxide reductase hypersensitive to tert-butyl hydroperoxide
AI1 Q0050 endonuclease activity* mRNA processing* mitochondrion YER142C Mobile mitochondrial group II intron of COX1 which is involved in pre-mRNA splicing and in deletion intron-specific reverse transcriptase activity|maturase aI1 unable to excise adjacent aI2 intron; reduced intron mobility
AI2 Q0055 RNA binding* RNA splicing mitochondrion Mobile mitochondrial group II intron of COX1 which is involved in pre-mRNA splicing and in deletion endonuclease (putative)|intron-specific reverse transcriptase activity|maturase aI2 defective in aI1 and aI2 intron mobility
AI3 Q0060 endonuclease activity biological_process unknown mitochondrion Mobile group I intron of mitochondrial COX1 I-SceIII endonuclease activity|encoded by the 3' part of the aI3 intron Mutations that block aI3 splicing cause defects in respiration and accumulate I-SceIII endonuclease.
AI4 Q0065 endonuclease activity RNA splicing mitochondrion intron of mitochondrial COX1 I-SceII endonuclease activity|encoded by the aI4 intron Mutations that block aI4 splicing cause defects in respiration; other mutations affect intron mobili
AI5_ALPHA Q0070 endonuclease activity movement of group I intron mitochondrion Intron of mitochondrial COX1, aI5-alpha DNA endonuclease involved in intron homing
AI5_BETA Q0075 molecular_function unknown biological_process unknown mitochondrion Intron of mitochondrial COX1, aI5-beta
AIP1 YMR092C actin filament severing activity response to osmotic stress* nucleus* YNL138W YLR102C YBR101C YPL263C YLL050C Protein localizes to actin cortical patches. Probable binding site on actin lies on front surface of actin cortical patch component Null mutant is viable
AIR1 YIL079C molecular_function unknown mRNA-nucleus export nucleus* YDR432W YNL004W YML056C YOR204W YOL115W YAL041W YMR216C arginine methyltransferase-interacting RING finger protein
AIR2 YDL175C molecular_function unknown mRNA-nucleus export nucleus YNR073C YDR432W YOR204W YCR077C YDR023W YPR191W YGR165W YMR303C YMR125W YOL115W YPL093W arginine methyltransferase-interacting RING finger protein
AKR1 YDR264C palmitoyltransferase activity endocytosis* membrane YAL028W YPL242C YAL041W YJR086W YOR212W YDR103W YHR135C YNL154C YOR043W YOR101W YBR200W YDL226C Negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; i ankyrin repeat-containing protein Null mutant is viable, exhibits slow growth, abnormal morphology, and partial activation of pheromon
ALA1 YOR335C alanine-tRNA ligase activity alanyl-tRNA aminoacylation cytoplasm YPR111W YNL135C YNL244C YBR055C Cytoplasmic alanyl-tRNA synthetase gene null mutant is inviable; allele cdc64-1: arrest of proliferation at the regulatory step Start, inhib
ALD2 YMR170C aldehyde dehydrogenase activity aldehyde metabolism* cytoplasm Expression induced in response to high osmotic stress. NAD+ is preferred coenzyme. aldeyhde dehydrogenase ald2 ald3 double mutants show reduced growth rate with ethanol as the sole carbon source.
ALD3 YMR169C aldehyde dehydrogenase activity response to stress* cytoplasm Expression induced in response to heat shock, oxidative and osmotic stress. NAD+ is preferred coenzy aldehyde dehydrogenase ald2 ald3 double mutants show reduced growth rate with ethanol as the sole carbon source.
ALD4 YOR374W aldehyde dehydrogenase (NAD) activity ethanol metabolism mitochondrion YHR026W YLR447C Glucose repressed. Utilizes NADP+ or NAD+ as a coenzyme equally well. (sold by SIGMA under the catal aldehyde dehydrogenase
ALD5 YER073W aldehyde dehydrogenase activity electron transport mitochondrion YPL257W YEL042W YGL181W YPR086W YML032C Utilizes NADP+ as the preferred coenzyme. Activated by K+. aldehyde dehydrogenase
ALD6 YPL061W aldehyde dehydrogenase activity acetate biosynthesis cytoplasm YNL039W Utilizes NADP+ as the preferred coenzyme. Activated by Mg2+. aldehyde dehydrogenase Null mutant is viable, grows at approximately one-third the rate of wild-type, unable to grow on eth
ALF1 YNL148C co-chaperone activity post-chaperonin tubulin folding pathway* nucleus* alpha-tubulin foldin; protein implicated in folding of alpha tubulin tubulin folding cofactor B Null mutant is viable, benomyl super-sensitive, alf1 tub1 mutants are inviable
ALG1 YBR110W beta-1,4-mannosyltransferase activity N-linked glycosylation integral to membrane YDL055C beta-1,4-mannosyltransferase beta-1,4-mannosyltransferase Null mutant is inviable
ALG11 YNL048W alpha-1,2-mannosyltransferase activity protein amino acid glycosylation endoplasmic reticulum* Specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-Glycosylation inte Null mutant displays poor growth and temperature-sensitive lethality
ALG2 YGL065C glycolipid mannosyltransferase activity oligosaccharide-lipid intermediate assembly endoplasmic reticulum YER103W glycosyltransferase glycosyltransferase Null mutant is inviable, mutants accumulate Man1-2GlcNAc2 and arrest at G1
ALG5 YPL227C dolichyl-phosphate beta-glucosyltransferase activity N-linked glycosylation endoplasmic reticulum membrane YIL097W YJL026W YEL002C YGL022W UDP-glucose:dolichyl-phosphate glucosyltransferase UDP-glucose:dolichyl-phosphate glucosyltransferase underglycosylation of carboxypeptidase Y
ALG6 YOR002W transferase activity, transferring hexosyl groups protein amino acid glycosylation* endoplasmic reticulum YDL096C YAL023C YDL095W YFL036W YGL226C-A YOR085W Required for glucosylation in the N-linked glycosylation pathway glucosyltransferase Null mutant is viable and defective in protein glycosylation.
ALG7 YBR243C UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity N-linked glycosylation endoplasmic reticulum YER081W ER protein that transfers Glc-Nac-P from UDP-GlcNac to Dol-P UDP-N-acetyl-glucosamine-1-P transferase (GPT) Asparagine-linked glycosylation deficient; Null mutant is inviable
ALG8 YOR067C oligosaccharyl transferase activity dolichol-linked oligosaccharide biosynthesis* endoplasmic reticulum membrane YLR358C YFL036W YGL226C-A YOR085W YCR044C YDR074W YHR030C YJL095W YLR087C YOR035C YOR080W adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein glycosyl transferase Null mutant is viable, secretes under-glycosylated proteins
ALG9 YNL219C mannosyltransferase activity protein amino acid glycosylation* endoplasmic reticulum YGR149W catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides mannosyltransferase accumulation of lipid-linked Man6GlcNAc2; hypoglycosylation of secreted proteins
ALK1 YGL021W protein serine/threonine kinase activity mitosis nucleus YLR133W leucine zipper (putative), membrane protein (putative) haspin
ALO1 YML086C D-arabinono-1,4-lactone oxidase activity response to oxidative stress mitochondrion D-arabinono-1,4-lactone oxidase D-arabinono-1,4-lactone oxidase Null mutant is viable, shows increased sensitivity towards oxidative stress
ALP1 YNL270C basic amino acid transporter activity basic amino acid transport plasma membrane Homologous to permeases Can1p and Lyp1p basic amino acid permease
ALR1 YOL130W di-, tri-valent inorganic cation transporter activity di-, tri-valent inorganic cation transport* plasma membrane YGL024W YNL086W YIL009W YLR291C YGL025C aluminium resistance ion transporter (putative) Null mutant is inviable; overexpression increases resistance to aluminum and gallium toxicity
ALR2 YFL050C di-, tri-valent inorganic cation transporter activity di-, tri-valent inorganic cation transport* plasma membrane YLR453C aluminium resistance ion transporter (putative) Null mutant is viable, overexpression increases resistance to aluminum and gallium toxicity
AMA1 YGR225W molecular_function unknown sporulation (sensu Saccharomyces)* anaphase-promoting complex Required for sporulation, highly induced during sporulation; activator of meiotic anaphase promoting Null mutant is viable; homozygous null mutant does not sporulate but does not exhibit any vegetative
AME1 YBR211C molecular_function unknown biological_process unknown spindle pole body YBR107C YGR179C YKL002W YLR052W YDR394W associated with microtubules and essential microtubule stability regulator Null: Null mutant is inviable; localizes to microtubules and SPB region, ame1-1 arrests in G2/M, mut
AMN1 YBR158W protein binding negative regulation of exit from mitosis* nucleus* YDR111C YHR064C YGR285C YGR163W Antagonist of MEN (Mitotic Exit Network)
Chromosome STability
AMS1 YGL156W alpha-mannosidase activity carbohydrate metabolism vacuolar membrane YOL083W YOL082W YPR110C YKL103C vacuolar alpha mannosidase alpha mannosidase null mutant is viable
ANB1 YJR047C translation initiation factor activity translational initiation ribosome hypusine containg protein; ANB1 is expressed under anaerobic conditions and repressed under aerobic translation initiation factor eIF-5A, anaerobically expressed form null mutant is viable; a double mutant containing disruptions of both ANB1 and and the highly homolo
ANP1 YEL036C mannosyltransferase activity N-linked glycosylation mannosyltransferase complex* YHR080C YOL038W YJR075W YPL050C YML077W YPL094C YPL031C Mannan 8; Protein of the endoplasmic reticulum with a role in retention of glycosyltransferases in t Null mutant has altered mannoprotein glycosylation and a defect in N-linked outerchain glycan mannos
ANT1 YPR128C adenine nucleotide transporter activity peroxisome organization and biogenesis* cytoplasm* adenine nucleotide transporter Null: growth defect on medium-chain length fatty acids.
APC1 YNL172W protein binding* ubiquitin-dependent protein catabolism* anaphase-promoting complex YLR102C YDL008W YLR127C YDR118W YOR249C YKL022C YHR166C YFR036W YBL084C YGL240W YHR135C anaphase-promoting complex component ubiquitin ligase subunit
APC11 YDL008W protein binding* ubiquitin-dependent protein catabolism* anaphase-promoting complex YLR102C YLR127C YDR118W YOR249C YKL022C YHR166C YFR036W YBL084C YGL240W YNL172W subunit of the Anaphase Promoting Complex; all known APC subunits co-immunoprecipitate with epitope- anaphase promoting complex (APC) subunit Null mutant is inviable at 25 C
APC2 YLR127C protein binding* ubiquitin-dependent protein catabolism* anaphase-promoting complex YER179W YLR102C YDR118W YOR249C YKL022C YHR166C YFR036W YBL084C YGL240W YNL172W YER095W YGR052W YLR079W YDL008W subunit of the Anaphase Promoting Complex; all known APC subunit co-immunoprecipitate with epitope-t anaphase promoting complex (APC) subunit Null mutant is inviable at 25 deg. C; ts mutants arrest in metaphase due to defect in the degradatio
APC4 YDR118W protein binding* ubiquitin-dependent protein catabolism* anaphase-promoting complex YLR102C YOR249C YKL022C YHR166C YFR036W YBL084C YGL240W YNL172W YDL008W YLR127C subunit of the Anaphase Promoting Complex; all known APC subunits co-immunoprecipitate with epitope- anaphase promoting complex (APC) subunit Null mutant is inviable at 25 C
APC5 YOR249C protein binding* ubiquitin-dependent protein catabolism* anaphase-promoting complex YLR102C YKL022C YHR166C YFR036W YBL084C YGL240W YNL172W YDL008W YLR127C YDR118W subunit of the Anaphase Promoting Complex; all known APC subunits co-immunoprecipitate with epitope- anaphase promoting complex (APC) subunit Null mutant is inviable at 25 C
APC9 YLR102C protein binding* ubiquitin-dependent protein catabolism* anaphase-promoting complex YKL022C YHR166C YFR036W YBL084C YGL240W YML092C YNL176C YNL172W YDL008W YLR127C YDR118W YOR249C YMR092C YNL298W required for structural stability and the incorporation of Cdc27p into the APC. anaphase promoting complex (APC) subunit Null mutant is viable at 37 C but show delay in entry into anaphase at 37 C
APE2 YKL157W leucyl aminopeptidase activity peptide metabolism cytoplasm* YPR168W YHR114W YJL078C YMR307W YBR055C Removal of intron fused YKL158W and YKL157W (Davis et al.(2000) NAR 28:1700-6) aminopeptidase yscII Null mutant is viable
APE3 YBR286W aminopeptidase activity vacuolar protein catabolism vacuole (sensu Fungi) YDR311W YPL200W YGL100W Aminopeptidase yscIII aminopeptidase yscIII Null mutant is viable but exhibited reduced vacuolar aminopeptidase activities and could not hydroly
APL5 YPL195W molecular_function unknown Golgi to vacuole transport AP-3 adaptor complex YJL024C YGR261C YBR288C YGL019W YLR039C YLR262C Delta-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to clathrin assembly complex AP-3 adaptin component delta-like subunit Null mutant is viable, rescues yck1,yck2 double mutant
APL6 YGR261C molecular_function unknown Golgi to vacuole transport AP-3 adaptor complex YBR288C YHR174W YPL195W YPL115C YLR039C YLR262C beta3-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to clathrin assembly complex beta adaptin component (putative) Null mutant is viable, null rescues yck1 yck2 double mutant
APM1 YPL259C clathrin binding vesicle-mediated transport AP-1 adaptor complex YBL104C YPR029C YKL135C YKL010C YPR159W YNL132W YHR027C YPR016C YLR328W YER165W YPL043W YOL010W YLR196W YPL093W YCL059C YNL308C YOL077C YHR052W YBR221C YLR329W medium subunit of the clathrin-associated protein complex clathrin associated protein complex medium subunit Null mutant is viable, enhances the slow growth and late Golgi sorting defects of a chc1-ts mutant
APM2 YHL019C clathrin binding vesicle-mediated transport AP-1 adaptor complex YFR045W YPR029C YKL135C YBR019C homologous to the medium chain of mammalian clathrin-associated protein complex Null mutant is viable
APM3 YBR288C molecular_function unknown Golgi to vacuole transport AP-3 adaptor complex YBR014C YOR089C YGR261C YPL195W YPL016W YHR135C YNL154C YBR097W YDR323C YDR495C YGL095C YML097C YOR036W YLR262C Mu3-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to t clathrin associated protein complex medium subunit Null mutant is viable, even combined with apm1 and apm2
APM4 YOL062C molecular_function unknown intracellular protein transport AP-2 adaptor complex YFL045C YBL037W YFR049W Clathrin associated protein, medium subunit clathrin associated protein complex medium subunit
APN1 YKL114C DNA-(apurinic or apyrimidinic site) lyase activity DNA repair* nucleus* YOR264W YJR057W major apurinic/apyrimidinic endonuclease/3'-repair diesterase major apurinic/apyrimidinic endonuclease/3'-repair diesterase hypersensitive to both oxidative and alkylating agents that damage DNA; higher rate of spontaneous m
APN2 YBL019W phosphodiesterase I activity* DNA repair nucleus YEL009C AP endonuclease 2, homolog of human HAP1 and E. coli exoIII AP endonuclease The apn2 null mutant is viable and is not MMS sensitive. The apn1 apn2 null mutant, however, is extr
APP1 YNL094W molecular_function unknown actin cytoskeleton organization and biogenesis actin cortical patch (sensu Saccharomyces)* YAL049C YLL050C YHR179W YCR088W YPL004C YDR155C YKL085W YGR196C YMR105C YNL025C YJR082C YLR429W YBR133C YDR235W YOR368W YDR388W YNL243W YBL106C YJL187C Actin Patch Protein Unknown Null: Viable. Other phenotypes: Unknown
APS3 YJL024C molecular_function unknown Golgi to vacuole transport AP-3 adaptor complex YPL195W sigma3-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase t Null mutant is viable, rescues yck1,yck2 double mutant
AQR1 YNL065W monocarboxylic acid transporter activity* drug transport* plasma membrane A(acids, azoles) Q(quinidine, quinine) Resistance multidrug resistance transporter Null mutant is viable, but exhibits increased susceptibility to low-chain organic acids (C2-C6), azo
AQY1 YPR192W water channel activity water transport plasma membrane Aquaporin aquaporin Null mutant is viable and exhibits improved viability when grown under hypo-osmolar or hyper-osmolar
AQY2 YLL052C water channel activity water transport plasma membrane* YMR094W aquaporin water channel in yeast MIP family member|aquaporin (putative)
ARA1 YBR149W aldo-keto reductase activity* carbohydrate metabolism cytosol YDL211C YNL128W YBR055C D-arabinose dehydrogenase D-arabinose dehydrogenase Null mutant is viable but cannot produce D-arabinono-1,4-lactone, a precursor of D-erythroascorbic a
ARC1 YGL105W tRNA binding tRNA-nucleus export* cytoplasm* YGL245W YKL205W YGR264C YCR002C YBR217W YMR059W YBR017C YML095C associated with tRNA and amino acyl-tRNA synthetases; has affinity for quadruplex nucleic acids Null mutant is viable, leads to slow growth and reduced MetRS activity; arc1- mutants are synthetic
ARC15 YIL062C structural molecule activity* actin cortical patch assembly mitochondrial membrane* YJR065C YLR370C YKL013C YNR035C YBR234C YDL029W Arp complex subunit Null mutant exhibits severe growth defects. Cells with mutations in Arp2 and Arc15 are defective in
ARC18 YLR370C structural constituent of cytoskeleton actin filament organization Arp2/3 protein complex YJR065C YOR361C YKL013C YNR035C YDL029W YGR240C YIL062C YJR091C YBR234C YJR043C YNL192W YBR023C YLR330W YJL099W YBL061C Arp2/3 complex subunit
ARC19 YKL013C structural molecule activity actin cortical patch assembly Arp2/3 protein complex YIL062C YLR370C YNR035C YJR065C YDL029W YBR234C YDR063W Arp complex subunit Null mutant is viable, but exhibits severe growth defects
ARC35 YNR035C structural molecule activity cell growth and/or maintenance Arp2/3 protein complex YJR065C YKL013C YDL029W YBR234C YIL062C YLR370C YHR114W YGL208W YDL225W Arp complex subunit Null mutant exhibits severe growth defects; synthetic lethal with vma2.
ARC40 YBR234C structural constituent of cytoskeleton actin filament organization Arp2/3 protein complex YNL040W YLR241W YBL062W YLR111W YJR065C YDR129C YNL298W YHR030C YJL095W YOR035C YHR064C YJR075W YPL043W YLR370C YKL013C YNR035C YIL062C YML069W YMR309C YNL233W YBR023C YBL061C YLR330W YJL099W YHR142W YNL322C YEL031W YER083C YBR200W YER155C YMR109W YE Arp2/3 complex subunit, 40 kilodalton Null mutant is inviable
ARD1 YHR013C peptide alpha-N-acetyltransferase activity protein amino acid acetylation cytoplasm YBR084W YMR116C YGR254W YHR023W YDL040C YGR090W YPR141C YPR135W YJR075W YDL049C YGR166W YJL062W subunit of the major N alpha-acetyltransferase; complexes with Nat1p N alpha-acetyltransferase major subunit|complexes with Nat1p inability to respond to alpha-factor, enter stationary phase or sporulate, required for full repress
ARE1 YCR048W sterol O-acyltransferase activity sterol metabolism endoplasmic reticulum YCL026C-A YLR427W YLR242C Acyl-CoA cholesterol acyltransferase (sterol-ester synthetase) acyl-CoA cholesterol acyltransferase (sterol-ester synthetase) Null mutant is viable, slightly reduces in vivo and in vitro ergosterol esterification. Deletion of
ARE2 YNR019W sterol O-acyltransferase activity sterol metabolism endoplasmic reticulum YDL006W YOR381W YLR242C Acyl-CoA cholesterol acyltransferase (sterol-ester synthetase) acyl-CoA cholesterol acyltransferase (sterol-ester synthetase) Null mutant is viable; greatly reduces in vivo and in vitro ergosterol esterification (to 15 - 35 %
ARF1 YDL192W ARF small monomeric GTPase activity ER to Golgi transport* cytosol* YGR130C YDL137W YGL206C YMR059W YMR094W YHR188C YDR477W YPR110C YDR320C YDR182W YPL051W YJR070C YBR164C implicated in signal transduction and intracellular protein transport to or within the Golgi apparat ADP-ribosylation factor Null mutant is viable and shows slow growth, cold sensitivity and sensitivity to normally sublethal
ARF2 YDL137W ARF small monomeric GTPase activity ER to Golgi transport* cytosol* YDR007W YDL192W YHR188C YPR110C YGR052W ADP-ribosylation factor 2 ADP-ribosylation factor 2 Null mutant is viable
ARG1 YOL058W argininosuccinate synthase activity arginine biosynthesis* cytosol YNL189W YDR388W arginosuccinate synthetase arginosuccinate synthetase Arginine requiring
ARG2 YJL071W amino-acid N-acetyltransferase activity arginine biosynthesis* mitochondrial matrix YBR130C First step in ornithine biosynthesis pathway acetylglutamate synthase
ARG3 YJL088W ornithine carbamoyltransferase activity arginine biosynthesis* cytosol YDL017W Sixth step in arginine biosynthesis ornithine carbamoyltransferase Arginine requiring
ARG4 YHR018C argininosuccinate lyase activity arginine biosynthesis cytosol YNL189W YGL137W YNL244C argininosuccinate lyase argininosuccinate lyase Arginine requiring
ARG5,6 YER069W N-acetyl-gamma-glutamyl-phosphate reductase activity* arginine biosynthesis* mitochondrial matrix YLR214W N-acetyl-gamma-glutamyl-phosphate reductase and acetylglutamate kinase N-acetyl-gamma-glutamyl-phosphate reductase and acetylglutamate kinase Arginine requiring
ARG8 YOL140W acetylornithine transaminase activity arginine biosynthesis* mitochondrial matrix Acetylornithine aminotransferase acetylornithine aminotransferase Arginine requiring
ARG80 YMR042W DNA binding* positive regulation of transcription from Pol II promoter* nucleus YML099C YER022W Regulator of arginine-responsive genes with ARG81 and ARG82 transcription factor Arginine requiring
ARG81 YML099C transcription cofactor activity arginine metabolism* nucleus YML014W YMR042W YCL040W YGR040W Regulator of arginine-responsive genes with ARG80 and ARG82 zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type Null mutant is viable
ARG82 YDR173C inositol/phosphatidylinositol kinase activity arginine metabolism* nucleus Regulator of arginine-responsive genes with ARG80 and ARG81 dual specificity inositol 1,4,5-trisphosphate 6-kinase/inositol 1,4,5,6-tetrakisphosphate 3-kinase ( Null mutant is viable but requires arginine at 23C; growth defect at 30C; inviable at 37C; null is d
ARH1 YDR376W NADPH-adrenodoxin reductase activity iron ion homeostasis* mitochondrial inner membrane YIR024C YCR093W adrenodoxin oxidoreductase homolog adrenodoxin oxidoreductase homolog Null mutant is inviable
ARK1 YNL020C protein serine/threonine kinase activity protein amino acid phosphorylation* actin cortical patch (sensu Saccharomyces) YDR259C YGR241C YJL174W actin regulating kinase serine/threonine kinase (putative) Null mutant is viable and shows slight delocalisation of actin cytoskeleton
ARL1 YBR164C small monomeric GTPase activity protein-vacuolar targeting* soluble fraction YDR203W YKL118W YNL043C YNL296W YLR242C YCR044C YDL100C YER083C YER122C YJR032W YDL077C YDL192W YDR108W YDR136C YDR137W YDR162C YDR202C YGL005C YGR105W YHL031C YHR012W YJL154C YJR033C YKL119C YKR001C YKR020W YLR261C YLR447C YML071C YMR004W YMR054W YM Encodes a regulator of membrane traffic. Hydrolyzes GTP; myristylated; in soluble fraction. Part of ADP-ribosylation factor-like protein 1 Null mutant is viable
ARL3 YPL051W small monomeric GTPase activity intracellular protein transport soluble fraction* YKL206C YPR053C YGR242W YKL118W YER122C YJR032W YDR310C YDL077C YDL192W YDR108W YDR136C YDR137W YGL005C YHL031C YKR020W YLR261C YML071C YNL041C YNL051W YNL297C YOL018C YOR068C YOR069W YOR132W YKR030W YER044C YGL183C YDR320C YEL042W YGL020C YLR039C YL Similar to ADP-ribosylation factor. Part of the carboxypeptidase Y pathway. Null mutant is viable, displays cold-sensitive growth
ARN1 YHL040C siderochrome-iron transporter activity iron-siderochrome transport endosome* Transporter that specifically recognizes siderophore-iron chelates and is expressed under conditions
ARN2 YHL047C siderochrome-iron transporter activity iron ion homeostasis* plasma membrane* Siderophore transporter for triacetylfusarinine C triacetylfusarinine C transporter YHL047c disrupted cells are unable to take up and utilize iron from triacetylfusarinine C und fusige
ARO80 YDR421W specific RNA polymerase II transcription factor activity positive regulation of transcription from Pol II promoter nucleus YDL030W
ARP1 YHR129C structural constituent of cytoskeleton mitotic anaphase B dynactin complex YGL217C YNL271C YLR200W YNL153C YEL003W YMR198W YNL189W YHR012W YMR294W YPL269W YOR098C YLR305C YPL174C YCR065W YEL061C YER016W YER056C-A YER114C YGL124C YGL216W YGR078C YGR229C YLR210W YLR373C YML094W YNR051C YOR349W YPR141C YJR008W YJR091C YBR200W actin-related protein of the dynactin complex Null mutant is viable, but both null mutations and overexpression lead to defects in spindle orienta
ARP10 YDR106W molecular_function unknown biological_process unknown cytoplasm YHR129C YLR222C actin-related protein
ARP2 YDL029W structural constituent of cytoskeleton* actin filament organization mitochondrion* YJR029W YDR018C YGL250W YLR111W YBL062W YLL013C YJR065C YDR129C YNL243W YDR388W YNL298W YJR064W YNL271C YCL037C YHR030C YJL095W YOR035C YJR075W YLR370C YKL013C YNR035C YIL062C YBR234C YNL233W YBR023C YBL061C YLR330W YJL099W YHR142W YNL322C YEL031W YE Involved in endocytosis and membrane growth and polarity actin related protein cells with mutations in Arp2 and Arc15 are defective in mitochondrial movement.
ARP3 YJR065C structural constituent of cytoskeleton* actin filament organization Arp2/3 protein complex YKL013C YNR053C YIL062C YLR370C YNR035C YPR086W YDL029W YBR234C YCR088W actin-related gene Mutations in Arp3 lead to defects in actin-patch motility and a rearrangement of the cortical actin
ARP4 YJL081C chromatin binding* regulation of transcription from Pol II promoter* nucleus* YOR244W YDL002C YJL098W YDR146C 54.8 kDa actin-related protein 54.8 kDa protein|actin related protein Null mutant is inviable
ARP5 YNL059C molecular_function unknown protein-vacuolar targeting nucleus Actin-related protein. Part of the carboxypeptidase Y pathway. actin related protein
ARP6 YLR085C molecular_function unknown protein-vacuolar targeting cytoplasm YDL033C YDR360W YGR071C YLR374C YML090W YNL296W YPL182C YBR059C YNL153C YEL003W YER122C YOR216C YLR268W YDR108W YDR137W YNL041C YCR065W YER016W YGR078C YML094W YOR349W YAL013W YBR036C YBR120C YBR175W YCL061C YDL074C YER007W YFL001W YGL086W YGL174W YG Actin-related protein. Part of the carboxypeptidase Y pathway.
ARP7 YPR034W general RNA polymerase II transcription factor activity chromatin modeling nucleus* YGR040W involved in transcriptional regulation actin related protein|chromatin remodeling Snf/Swi complex subunit Null mutant is viable, exhibits typical swi/snf phenotypes, including growth defects on media contai
ARP8 YOR141C molecular_function unknown biological_process unknown nucleus YDL002C YDR420W actin-related protein
ARP9 YMR033W general RNA polymerase II transcription factor activity chromatin modeling nucleus* YBR289W involved in transcriptional regulation actin related protein|chromatin remodeling Snf/Swi complex subunit Null mutant is viable, exhibits typical swi/snf phenotypes, including growth defects on media contai
ARR1 YPR199C RNA polymerase II transcription factor activity positive regulation of transcription from Pol II promoter nucleus YMR325W Similar to transcriptional regulatory elements YAP1 and cad1 Null mutant is viable, confers arsenite and arsenate hypersensitivity
ARR3 YPR201W arsenite transporter activity arsenite transport integral to plasma membrane YLR171W Putative membrane protein involved in arsenite transport Overexpression confers arsenite but not arsenate resistance
ARV1 YLR242C molecular_function unknown sterol transport* endoplasmic reticulum* YCR048W YNR019W YDL239C YHR007C YBR164C ARE2 Required for Viability 1. similar to Nup120p and C.elegans R05H5.5 protein Protein involved in sterol distribution temperature sensitive, anaerobically inviable, polyene antibiotic sensitive, inviable in the absence
ARX1 YDR101C molecular_function unknown ribosomal large subunit biogenesis cytoplasm* YER006W YAL007C YER036C YER126C YAL029C YHR170W YFR031C-A YGR245C YBR267W YKR081C YNL110C YLR074C YPR017C
ASC1 YMR116C molecular_function unknown biological_process unknown cytoplasm YNL308C YGL120C YLR197W YAR007C YGR145W YOR056C YHR013C YAR014C YAR018C YCL059C YDL040C YOR361C YER171W YOR116C YJL080C YPL106C YGR162W YGR090W YJR014W YGR285C YBR023C YLR330W YGR166W YGR229C WD repeat protein (G-beta like protein) that interacts with the translational machinery G-beta like protein Null mutant is viable. Null mutation suppresses the absence of growth of a cyp1- strain in anaerobio
ASE1 YOR058C microtubule binding mitotic anaphase B* spindle microtubule* YDR149C YLL049W YLR254C YMR299C YLR386W YNL271C YER155C YNL153C YEL003W YMR294W YPL174C YEL061C YER016W YGR078C YML094W YPR141C YHR129C YCR086W YDR130C YDR424C YDR488C YKL048C YKR054C YOR269W YPL155C YPR119W YDR150W YCL029C YHR191C YLR200W essential for anaphase spindle elongation spindle midzone component Null mutant is viable but temperature sensitive.
ASF1 YJL115W histone binding DNA damage response, signal transduction resulting in induction of apoptosis chromatin assembly complex YJR140C YIL070C YPL153C YJL026W YGR180C YMR200W YMR190C YNL298W YPR141C YOL006C YLR103C YNL250W YBR094W YAL013W YMR263W anti-silencing protein that causes depression of silent loci when overexpressed
ASG7 YJL170C molecular_function unknown conjugation with cellular fusion plasma membrane YER153C YGL070C an a-specific gene that is induced to a higher expression level by alpha factor Null mutant is viable
ASH1 YKL185W specific transcriptional repressor activity pseudohyphal growth* nucleus Zinc-finger inhibitor of HO transcription which is asymmetrically localized to the daughter cell nuc Mutant ash1 daughters can transcribe HO and switch mating type
ASI1 YMR119W ubiquitin-protein ligase activity ubiquitin-dependent protein catabolism endoplasmic reticulum membrane YIR038C YER039C YJR058C Amino acid Sensor-Independent (ASI) genes encode membrane proteins Asi1p, Asi2p and Asi3p. Asi1p and
ASI2 YNL159C molecular_function unknown ubiquitin-dependent protein catabolism integral to membrane YOR128C YNL159C YER022W Amino acid Sensor-Independent (ASI) genes encode membrane proteins Asi1p, Asi2p and Asi3p.
ASI3 YNL008C ubiquitin-protein ligase activity ubiquitin-dependent protein catabolism endoplasmic reticulum membrane YJR091C YNL260C Amino acid Sensor-Independent (ASI) genes encode membrane proteins Asi1p, Asi2p and Asi3p. Asi1p and
ASK1 YKL052C structural constituent of cytoskeleton mitotic spindle assembly (sensu Saccharomyces) condensed nuclear chromosome kinetochore* YLR288C YKR083C YMR077C Associated with Spindles and Kinetochores Null mutant is inviable
ASM4 YDL088C structural molecule activity mRNA-nucleus export* nuclear pore YMR153W YML031W Suppressor of thermosensitive mutations in the DNA polymerase delta gene nuclear pore complex subunit Null mutant is viable in some strain backgrounds (including CEN.PK2); however, in the FY1679 genetic
ASP1 YDR321W asparaginase activity asparagine catabolism intracellular YDR321W YGL095C YLR347C YML064C YPL070W Asparaginase I, intracellular isozyme asparaginase I|intracellular isozyme Aspartic acid requiring
ASP3-1 YLR155C asparaginase activity asparagine catabolism* endoplasmic reticulum* nitrogen catabolite-regulated cell-wall L-asparaginase II nitrogen catabolite-regulated cell-wall L-asparaginase II
ASP3-2 YLR157C asparaginase activity asparagine catabolism* periplasmic space (sensu Fungi) YNL070W YPR163C nitrogen catabolite-regulated cell-wall L-asparaginase II nitrogen catabolite-regulated cell-wall L-asparaginase II
ASP3-3 YLR158C asparaginase activity asparagine catabolism* periplasmic space (sensu Fungi) YER175C YLR295C nitrogen catabolite-regulated cell-wall L-asparaginase II nitrogen catabolite-regulated cell-wall L-asparaginase II
ASP3-4 YLR160C asparaginase activity asparagine catabolism* periplasmic space (sensu Fungi) nitrogen catabolite-regulated cell-wall L-asparaginase II nitrogen catabolite-regulated cell-wall L-asparaginase II
AST1 YBL069W protein transporter activity protein-membrane targeting extrinsic to membrane YGL008C YBL061C Protein involved in targeting of plasma membrane [H+]ATPase multicopy AST1 suppresses pma1 alleles defective for targeting
AST2 YER101C molecular_function unknown biological_process unknown cytoplasm YBL050W Protein involved in targeting of plasma membrane [H+]ATPase in high copy number, suppresses a pma1 ts mutant that is mis-routed to the vacuole at the restrictiv
ATC1 YDR184C molecular_function unknown response to stress* nucleus YLR319C YIR009W YGL070C interacts with AIP3, localized to the nucleus
ATE1 YGL017W arginyltransferase activity ubiquitin-dependent protein catabolism* cytoplasm YJL098W arginyl-tRNA-protein transferase arginyl-tRNA-protein transferase Null mutant is viable, but unable to degrade substrates of the N-end rule pathway that start with re
ATF1 YOR377W alcohol O-acetyltransferase activity fermentation cell fraction YGL127C YHR178W Alcohol acetyltransferase alcohol acetyltransferase
ATF2 YGR177C alcohol O-acetyltransferase activity steroid metabolism cytoplasm YGR172C Alcohol acetyltransferase alcohol acetyltransferase
ATG1 YGL180W protein serine/threonine kinase activity autophagy cytosol YML112W YPR185W Required for autophagy protein kinase Defective in autophagy; loses viability more rapidly than wild type during nitrogen starvation; defe
ATG10 YLL042C ubiquitin-like conjugating enzyme activity protein-vacuolar targeting* cytoplasm YBR217W YJR091C Involved in autophagy; protein-conjugating enzyme involved in the Apg12p-Apg5p conjugation pathway protein-conjugating enzyme Defective autophagy, apg10-1 allele shows reduced viablility under starvation conditions
ATG11 YPR049C molecular_function unknown protein-vacuolar targeting* extrinsic to membrane YGR113W YBR217W YDR228C Oligomeric, coiled-coil, peripheral membrane protein Oligomeric, coiled-coil, peripheral membrane protein required for stable binding of precursor API to cvt9 is defective in maturation of the vacuolar protein, aminopeptidase I and exhibits minor defects
ATG12 YBR217W molecular_function unknown protein-vacuolar targeting* membrane fraction YOR086C YGL245W YNL208W YHR020W YHR033W YLR423C YHR027C YDL029W YGR240C YKL104C YGL016W YIL128W YMR058W YMR159C YGL105W YMR056C YBR166C YDR127W YBR011C YGL234W YKL145W YJL138C YER021W YMR319C YEL060C YFR004W YLR216C YDR214W YHR076W YPR108W YDR394W YB autophagy Null mutant is viable, defective in autophagy
ATG13 YPR185W protein binding protein-vacuolar targeting* extrinsic to membrane YNL086W YEL013W YGL180W YGR253C YGR120C YHR128W autophagy Defective in autophagy
ATG14 YBR128C molecular_function unknown autophagy membrane fraction YDL185W YPL120W YER081W YHR005C Required for autophagy Null mutant is viable but defective in autophagy.
ATG15 YCR068W lipase activity autophagy* integral to membrane* YER019W Cytoplasm to vacuole targeting mutant. essential for intravacuolar lysis of autophagic bodies. amino lipase (putative) cvt17 is defective in lysis of autophagic vesicles after delivery to the vacuole. Null mutant is sta
ATG16 YMR159C molecular_function unknown autophagy membrane fraction YFL040W YFL068W YOR212W YMR159C YDR510W YMR048W YPL149W YGR097W YLR347C YPL070W YBR217W YLR288C YOR098C YML064C autophagy Null mutant is viable, defective in autophagy
ATG17 YLR423C kinase activator activity autophagy cytoplasm YCR082W YJR024C YMR124W YOR232W YDR148C YLR423C YPL124W YGR120C YDR022C YDR383C YER092W YNL078W YNL182C YPR179C YKR083C YAL032C YBR270C YCL032W YCL063W YDL239C YDR052C YDR176W YDR259C YDR311W YDR357C YDR473C YER127W YFR008W YGL127C YGL237C YGR113W YG required for activation of Apg1 protein kinase required for activation of Apg1 protein kinase|Null mutant is viable and has defect in autophagy
ATG18 YFR021W molecular_function unknown protein-vacuolar targeting* cytosol YDL047W YOL086C YFR040W YNL242W YLR222C YGL190C YPL258C YDR034C Required for cytoplasm to vacuole targeting of proaminopeptidase I and starvation induced autophagy (NMR1)Null mutant is viable; arrests with 2C DNA content after shift to sporulation medium.
ATG19 YOL082W protein binding protein-vacuolar targeting cytoplasm* YCL031C YER007W YFR049W YGL156W YHR113W YHR114W YML092C YNL037C YNL189W YOR302W YPL070W YPL091W YKL103C YDR122W YDR311W YOR115C YDR207C YOR353C Cytoplasm to Vacuole Targeting; Mutant is defective in import of aminopeptidase I through the cytopl Receptor for biosynthetic cytoplasm to vacuole targeting Null: viable, unable to target vacuolar aminopeptidase I and to vacuoles, both under growing and nit
ATG2 YNL242W molecular_function unknown protein-vacuolar targeting* extrinsic to membrane YFR021W Defective in autophagy; required for sporulation peripheral membrane protein The null mutant is viable but blocked in autophagy, pexophagy and import of Ape1 by the cytoplasm to
ATG20 YDL113C lipid binding protein-vacuolar targeting* membrane YLR424W YHR022C YPL174C YJL036W YFR040W YBL025W Cytoplasm to vacuole targeting PX domain-containing protein that binds Apg17 and Cvt13, and is required for import of precursor Ape Null: The cvt20 mutant accumulates precursor Ape1 but is normal for autophagy.. Other phenotypes: A
ATG21 YPL100W molecular_function unknown vacuolar protein processing/maturation cytosol* Maturation of pro-AmInopeptidase I (proAPI) defective; protein similar to Aut10p and YGR223Cp with t mai1 null is viable; mai1 aut10 ygr223c triple deletion strain does not grow on a specific acetate m
ATG27 YJL178C protein kinase regulator activity vesicle organization and biogenesis membrane YGL229C type II transmembrane protein
ATG4 YNL223W microtubule binding protein-vacuolar targeting* microtubule associated complex YFL037W YML085C YBL078C YAR019C Involved in autophagy. Interacts with Tub1p and Tub2p and forms a complex with Aut7p. Required for s anchor protein|mediates attachment of autophagosomes to microtubules Null mutant is viable but lacks autophagocytosis: i.e. starvation-induced protein transport to the v
ATG5 YPL149W molecular_function unknown protein-vacuolar targeting* cytosol YAL012W YMR058W YMR159C YBR217W YJL167W YLR390W-A Involved in autophagy reduced viability upon nutrient starvation; defective in autophagy
ATG8 YBL078C microtubule binding protein-vacuolar targeting* microtubule associated complex YOL083W YNL223W YNR007C YHR171W Forms a protein complex with Aut2p to mediate attachment of autophagosomes to microtubules. Defectiv similar to LC3, a microtubule-associated protein from rat Null mutant is viable but lacks autophagocytosis and is unable to sporulate. AUT7 is a suppressor of
ATG9 YDL149W molecular_function unknown protein-vacuolar targeting* cytoplasm* YPR041W YLR065C Integral membrane protein integral membrane protein Null mutant is viable but blocked in autophagy and aminopeptidase I import into vacuole. Temperature
ATH1 YPR026W alpha,alpha-trehalase activity response to stress* vacuole (sensu Fungi) Null mutant is viable; increased tolerance to dehydration, freezing, and toxic levels of ethanol
aminobutyric acid-glycine vesicular transporters Gln (Asn), Ile (Leu), Tyr transporter
AVT2 YEL064C transporter activity transport endoplasmic reticulum YIR034C YNR058W YOR242C YDL226C YBR103W related to the neuronal gamma -aminobutyric acid-glycine vesicular transporters transporter
AVT3 YKL146W neutral amino acid transporter activity neutral amino acid transport vacuole YJR091C YOR264W related to the neuronal gamma -aminobutyric acid-glycine vesicular transporters Gln (Asn), Ile (Leu), Tyr transporter
AVT4 YNL101W neutral amino acid transporter activity neutral amino acid transport vacuole YDL047W related to the neuronal gamma -aminobutyric acid-glycine vesicular transporters Gln (Asn), Ile (Leu), Tyr transporter
AVT6 YER119C amino acid transporter activity amino acid transport vacuole YKL055C YGL127C YMR047C related to the neuronal gamma -aminobutyric acid-glycine vesicular transporters Asp, Glu transporter
AVT7 YIL088C transporter activity transport vacuole related to the neuronal gamma -aminobutyric acid-glycine vesicular transporters transporter
AXL1 YPR122W metalloendopeptidase activity bud site selection* integral to membrane* YKL011C YPR111W determinant in axial budding pattern of haploid cells, involved in processing of a-factor human insulin-degrading endoprotease homolog (putative) Null mutant is viable; exhibits reduced a-factor expresion; haploid mutants show bipolar budding pat
AXL2 YIL140W molecular_function unknown bud site selection* bud neck* involved in polarity establishment/cellular polarization during budding AXL2 can serve as a multicopy suppressor of rho3 and is required for the haploid axial budding patte
AYR1 YIL124W acylglycerone-phosphate reductase activity phosphatidic acid biosynthesis cytoplasm* YLR295C YLR447C YGL137W YBR017C Subcellular location of Ayr1p: lipid particles and endoplasmic reticulum of the yeast 1-acyl dihydroxyacetone phosphate reductase Null mutant is viable. ybr159w/ayr1 double mutant is inviable.
AZF1 YOR113W DNA binding* regulation of transcription, DNA-dependent* nucleus probable transcription factor, suppressor of mutation in the nuclear gene for the core subunit of mi null mutant is viable
AZR1 YGR224W transporter activity transport membrane MFS-MDR
BAG7 YOR134W signal transducer activity* small GTPase mediated signal transduction intracellular YDR192C Structural homolog of SAC7 GTPase activating protein (GAP) Null mutant is viable; overexpression suppresses sac7 null mutation
BAP2 YBR068C amino acid transporter activity amino acid transport plasma membrane YOR133W YJL129C YKR050W contains 12 predicted transmembrane domains amino acid permease for leucine, valine, and isoleucine (putative) reduced uptake of leucine, isoleucine, and valine
BAP3 YDR046C amino acid transporter activity amino acid transport plasma membrane branched-chain amino acid permease valine transporter
BAR1 YIL015W aspartic-type endopeptidase activity protein catabolism periplasmic space (sensu Fungi) extracellular protease synthesized in a-cells that cleaves and inactivates alpha factor protease|synthesized in a-cells; cleaves and inactivates alpha factor MATa bar1 cells are supersensitive to the G1 arrest induced by alpha factor
BAS1 YKR099W RNA polymerase II transcription factor activity transcription from Pol II promoter* nucleus YIR009W YLR058C YGR229C YGL242C Transcription factor regulating basal and induced activity of histidine and adenine biosynthesis gen transcription factor
BAT1 YHR208W branched-chain-amino-acid transaminase activity branched chain family amino acid biosynthesis* mitochondrial matrix BAT1 highly expressed during logarithmic phase and is repressed during stationary phase, whereas BAT branched-chain amino acid transaminase|highly similar to mammalian ECA39, which is regulated by the Null mutant is viable; ILV auxotrophy in bat1 bat2 double mutant
BAT2 YJR148W branched-chain-amino-acid transaminase activity branched chain family amino acid biosynthesis* cytoplasm YHR152W YER022W YJL174W BAT1 highly expressed during logarithmic phase and is repressed during stationary phase, whereas BAT branched-chain amino acid transaminase Null mutant is viable; ILV auxotrophy in bat1 bat2 double mutants
BBC1 YJL020C myosin I binding actin cytoskeleton organization and biogenesis actin cortical patch (sensu Saccharomyces) YLR235C YML094C-A YDR129C YBL007C YDR155C YLR330W YBR200W YNL153C YGR078C YML094W YBL002W YLR258W YKL007W YIL034C YPL161C YNL098C YGR200C YPL086C YIL084C YOL133W YNL271C YLR200W YEL003W YCR009C YDR388W shows synthetic fitness defect with bni1 mutants and associates with the Bee1p-Vrp1p-Myo3/5p complex
BBP1 YPL255W structural constituent of cytoskeleton microtubule nucleation spindle pole body YBR270C YDL239C YEL062W YFR049W YHL004W YHL006C YLR392C YML064C YML092C YMR199W Involved in mitotic cell cycle and meiosis Null mutant is inviable; cells depleted of Bbp1p are defective in nuclear segregation, bud formation
BCK1 YJL095W MAP kinase kinase kinase activity protein amino acid phosphorylation* intracellular YOR008C YOR231W YPL140C YPL084W YBL105C YMR304W YHR082C YHR030C YBR015C YNL271C YBR234C YDL029W YPL031C YNL298W YNL233W YOR326W YLR200W YNL153C YML094W YNL250W YNL192W YBR023C YLR330W YJL099W YHR142W YMR307W YDR420W YJR075W YGR166W YJL062W YBL061C YG bypass requirement for protein kinase C homolog MEKK Null mutants are temperature-sensitive and exhibit cell lysis, which can be rescued by 1M sorbitol;
BCS1 YDR375C ATPase activity aerobic respiration mitochondrial inner membrane Mitochondrial protein of the CDC48/PAS1/SEC18 ATPase family, required for expression of functional R ATPase (AAA family) Gross reduction in the Rieske iron-sulfur subunit
BCY1 YIL033C cAMP-dependent protein kinase inhibitor activity response to stress* nucleus* YHR083W YLR347C YNL189W YPR086W YJL164C YIL061C YPL203W YKL166C YIL035C YIL128W YHR135C YMR022W YNL093W YJR017C YBL106C Involved in heat shock resistance, glycogen accumulation, and sporulation cAMP-dependent protein kinase regulatory subunit Null mutant is viable; sra1 mutants are associated with reduction of glycogen accumulation, temperat
BDF1 YLR399C transcription regulator activity sporulation (sensu Saccharomyces) nucleus YOR338W YIL002C YDR410C YNL244C YDL070W YDR328C YHR181W Required for sporulation, possible component of chromatin; affects synthesis of snRNA two bromodomains Null mutant is viable; defect in sporulation and spore formation, reduced rate of vegetative growth,
BDF2 YDL070W molecular_function unknown biological_process unknown nucleus YLR399C YGL063W YBR009C YGL075C YOL131W YER133W bromodomain protein, homolog of BDF1 BDF1 homolog|bromodomain protein Null mutant is viable in FY1679, RAY3A-D, and CEN.PK2 backgrounds, and synthetic lethal with bdf1
BDH1 YAL060W (R,R)-butanediol dehydrogenase activity butanediol fermentation cytoplasm YER081W (2R,3R)-2,3-butanediol dehydrogenase
BDP1 YNL039W RNA polymerase III transcription factor activity transcription initiation from Pol III promoter transcription factor TFIIIB complex YGL250W YOL115W YPL061W RNA polymerase III Transcription factor TFIIIB (90 kDa subunit; also called TFIIIB90 or B'' or B''90 TFIIIB 90 kDa subunit Null mutant is inviable; tfc5 mutant suppresses mutations in the class III transcription system
BEM1 YBR200W protein binding establishment of cell polarity (sensu Saccharomyces)* bud neck* YFL039C YHL007C YDR103W YJL157C YEL043W YAL041W YER155C YER114C YHR129C YDR264C YCR038C YOR188W YGR152C YBL085W YLR229C YIL118W YKR055W YGL233W YJL187C YGR134W YNL271C YJL020C YER016W YBR234C YDL029W YKL190W YPL031C YNL298W YKL079W YOR326W YLR200W YN SH3-domain protein that binds Cdc24p, Ste5p and Ste20p, and the Rsr1p/Bud2p/Bup5p GTPase Null mutant is viable; exhibits a defect in polarization in vegetative cells, exhibits decreased exp
BEM2 YER155C signal transducer activity* cell wall organization and biogenesis* intracellular YFL039C YHR023W YOR188W YOR326W YNL079C YDL047W YAR014C YGL130W YBL038W YBR251W YNL061W YPR088C YNL201C YNL207W YDL059C YOL087C YAL041W YBR200W YDR129C YNL271C YBR234C YDL029W YHR007C YFL037W YPL031C YNL298W YDL225W YKL079W YHR030C YOR269W YOR058C YE Protein with role in bud emergence rho GTPase activating protein (GAP) randomized bud-site selection at 26 degrees C and defective bud emergence and growth at 37 degrees C
BEM3 YPL115C signal transducer activity* establishment of cell polarity (sensu Saccharomyces)* intracellular YIL055C YNL298W YGR261C YGR270W YDR141C YGR040W YGR078C YNL153C YML094W Gtpase-activating protein activity toward the essential bud-site assembly GTPase Cdc42 rho GTPase activating protein (GAP) Null mutant is viable.
BET1 YIL004C v-SNARE activity ER to Golgi transport* endoplasmic reticulum membrane* YDR100W YKR068C YLR295C YML077W YER157W Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golg
BET3 YKR068C molecular_function unknown ER to Golgi transport TRAPP YML077W YLR268W YDR108W YLR342W YGR166W YDR407C YMR218C YBR254C YDR246W YDR472W YOR115C YNL272C YNL287W YFL005W YLR026C YBL050W YBR080C YFL038C YIL004C YDR189W Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Go transport protein particle (TRAPP) component Null mutant is inviable
BET5 YML077W molecular_function unknown ER to Golgi transport TRAPP YDR108W YIL004C YGR166W YDR407C YMR218C YBR254C YDR246W YDR472W YOR115C YPR017C YBR093C YEL036C YKR068C YLR078C YDL058W YFL038C YLR268W Bet5p/18kD component of TRAPP TRAPP 18kDa component Null mutant is inviable
BFA1 YJR053W GTPase activator activity conjugation with cellular fusion* spindle pole body YLR200W YNL153C YEL003W YNL238W YPL269W YER016W YGR078C YML094W YPR141C YMR319C YLR389C YGL121C YCL029C YNL250W YOR026W YPR135W YLR078C YML064C YDR150W YOR326W YEL061C YPL241C YLR103C YDL017W Byr four alike Null mutant is viable; mutants are sensitive to microtubule inhibitors, exhibit defects in mitotic c
BFR1 YOR198C RNA binding meiosis* polysome* YLR128W YKR030W YLR453C Multicopy suppressor of BFA (Brefeldin A)-induced lethality; implicated in secretion and nuclear seg Null mutant is viable; increase in cell ploidy; defective in nuclear segregation, bud formation, cyt
BGL2 YGR282C glucan 1,3-beta-glucosidase activity cell wall organization and biogenesis cell wall (sensu Fungi) YDL042C YBR017C YDL225W YDL047W YKR026C Cell wall endo-beta-1,3-glucanase cell wall endo-beta-1,3-glucanase Null mutant is viable
BI2 Q0110 nuclease activity RNA splicing mitochondrion Mrna maturase encoded from partially processed COB mRNA mRNA maturase bI2
BI3 Q0115 RNA binding Group I intron splicing mitochondrion Mitochondrial mRNA maturase bI3 encoded from partially processed COB mRNA that terminates with the i mRNA maturase bI3 Null mutant is viable.
BI4 Q0120 RNA binding Group I intron splicing mitochondrion Mitochondrial mRNA maturase bI4 encoded from partially processed COB mRNA that terminates with the i mitochondrial mRNA maturase bI4 Null mutant is viable.
BIG1 YHR101C molecular_function unknown cell wall biosynthesis (sensu Fungi) endoplasmic reticulum* YMR200W YBR229C bad in glucose or big cells Null mutant is viable but shows very slow growth on glucose, cells are big and accumulate increased
BIK1 YCL029C microtubule binding mitotic anaphase B* spindle pole body* YML085C YDR360W YML094C-A YJL030W YCR077C YLR200W YNL153C YEL003W YLR039C YPL269W YCR065W YEL061C YER016W YGR078C YML094W YOR349W YER007W YGL086W YGR188C YML124C YPL241C YIR009W YFL037W YMR138W YOR026W YBL027W YDR289C YER096W YFR019W YGL031C YGL173C Microtubule-associated protein required for microtubule function during mating and mitosis Null mutant is viable, bik1 mutants exhibit bilateral defects in karyogamy
BIM1 YER016W structural constituent of cytoskeleton mitotic spindle checkpoint* spindle pole body* YDR149C YGL211W YGL217C YNL170W YML094C-A YPL017C YDR360W YGR228W YLL049W YMR299C YNL136W YPL102C YNL298W YLR386W YML085C YJL030W YBR200W YLR200W YNL153C YEL003W YLR262C YMR294W YPL174C YEL061C YGL216W YGR078C YGR229C YLR373C YML094W YNR051C YOR349W Bim1p and Kar9p together make up the cortical microtubule-capture site. delays the exit from mitosis Null mutant is viable, causes cold sensitivity, benomyl supersensitivity, aberrant microtubule morph
BIO3 YNR058W adenosylmethionine-8-amino-7-oxononanoate transaminase activity biotin biosynthesis cytoplasm YEL064C YEL070W YLR105C YCR092C YJR035W YDR488C YJL128C biotin biosynthesis 7,8-diamino-pelargonic acid aminotransferase (DAPA) aminotransferase
BIO4 YNR057C dethiobiotin synthase activity biotin biosynthesis cytoplasm dethiobiotin synthetase dethiobiotin synthetase
BIO5 YNR056C permease activity biotin biosynthesis* plasma membrane transmembrane regulator of KAPA/DAPA transport transmembrane regulator of KAPA/DAPA transport
BIR1 YJR089W molecular_function unknown chromosome segregation condensed nuclear chromosome kinetochore YGR140W YDR328C YDR415C YDL017W baculoviral IAP repeat-containing protein
BLM3 YFL007W molecular_function unknown biological_process unknown membrane YML092C YGL011C YML109W YDR227W bleomycin resistance involved in protecting the cell against bleomycin damage Null mutant is viable and sensitive to bleomycin; codominant expression of hypersensitivity to letha
BMH1 YER177W DNA binding pseudohyphal growth* nucleus YFR017C YIL028W YER114C YDR216W YLR258W YDL117W YDR017C YDR028C YBL034C YDR001C YPR030W YDR006C YPL032C YIL159W YDR099W YDR062W YGL115W YNL189W YEL061C YPR141C YGR078C YNL153C YEL003W YML094W YDR052C Brain Modulosignalin Homolog member of conserved eukaryotic 14-3-3 gene family Null mutant is viable; bmh1 bmh2 double mutant is inviable; (in strain Sigma-1278b, required for pse
BMH2 YDR099W DNA binding pseudohyphal growth* nucleus YDR001C YPR030W YER177W YBR001C YNL267W YGL252C YAL017W YNL042W YBL043W YDR062W YBL066C YLR453C YDR017C Brain Modulosignalin Homolog member of conserved eukaryotic 14-3-3 gene family Null mutant is viable; bmh1 bmh2 double mutant is inviable; (in strain Sigma-1278b, required for pse
BMS1 YPL217C GTP binding rRNA processing* nucleus* YCL059C YNL061W YCR057C YOR080W BMH1 sensitive Null mutant is inviable; a temperature-sensitive allele exhibits a synthetic growth defect with bmh1
BNA1 YJR025C 3-hydroxyanthranilate 3,4-dioxygenase activity nicotinamide adenine dinucleotide biosynthesis cytoplasm YML108W YLR288C biosynthesis of nicotinic acid 3-hydroxyanthranilic acid dioxygenase Null mutant is viable, nicotinic acid auxotroph. Deletion results in significant rDNA silencing defe
BNA2 YJR078W tryptophan 2,3-dioxygenase activity nicotinamide adenine dinucleotide biosynthesis cytoplasm Biosynthesis of Nicotinic Acid Tryptophan 2,3-dioxygenase Null: Nicotinic acid auxotroph. Other phenotypes: Deletion of the gene is co-lethal with the deletio
BNI1 YNL271C cytoskeletal regulatory protein binding establishment of cell polarity (sensu Saccharomyces)* bud neck* YBL062W YDR149C YKR047W YMR299C YNL119W YPL102C YGR228W YLL049W YOR322C YBL007C YNL298W YLR319C YOR122C YHR030C YJL095W YNL233W YBR023C YBL061C YLR330W YHR142W YBR200W YER155C YLR200W YDR162C YKR020W YLR262C YMR294W YPL174C YGR229C YLR373C YHR129C YD Protein involved in cytoskeletal control and required for proper bipolar budding pattern; interacts formin, involved in spindle orientation Null mutant is viable, bni1 bnr1 double deletion mutants are temperature sensitive and are deficient
BNI4 YNL233W protein binding cytokinesis contractile ring (sensu Saccharomyces) YPL066W YDR388W YNL271C YJL095W YBL061C YLR337C YJR118C YDR162C YGR229C YNR051C YBR260C YCR009C YLR342W YDL117W YCR002C YBL047C YKL032C YLL021W YML115C YBR234C YDL029W YER133W YGR014W YDL225W YKL079W YHR030C YOR326W bud neck involved required to link Chs3p and Chs4p to the septins Null mutant is viable, shows delocalized chitin, elongated buds, enlarged bud necks
BNI5 YNL166C molecular_function unknown cytokinesis* bud neck* YDR136C YDR368W YGR078C YNL153C YML094W bud neck involved; localizes to mother-bud neck in a septin-dependent manner; bni5 shows synthetic e Null: Null mutant is viable, interacts genetically with CDC3, CDC10, CDC11, and CDC12 (septin) genes
BNR1 YIL159W cytoskeletal protein binding actin filament organization* contractile ring (sensu Saccharomyces) YNL271C YOR122C YKR055W YMR032W YER177W Bni1p-related protein, helps regulate reorganization of the actin cytoskeleton, potential target of Null mutant is viable; bni1 bnr1 double mutant exhibits severe temperature sensitive growth
BOI1 YBL085W phospholipid binding establishment of cell polarity (sensu Saccharomyces)* bud neck* YER114C YLR229C YIL118W YKR055W YML109W YBR238C YBR200W Involved in bud growth Null mutant is viable.
BOI2 YER114C phospholipid binding establishment of cell polarity (sensu Saccharomyces)* bud neck* YEL043W YNL298W YBR200W YOR188W YIL118W YKR055W YOR370C YER124C YIR039C YAL041W YJR091C YER177W YBL085W YHR129C YMR294W YPL174C YKR054C YDR488C Protein which binds Bem1p and contains a proline-rich sequence, an SH3 domain, and a pleckstrin homo Null boi1 boi2 mutants become large round cells or lysed with buds, display defects in bud formation
BOS1 YLR078C v-SNARE activity ER to Golgi transport endoplasmic reticulum membrane YML077W YJR053W YGL147C YML055W YMR047C YLR268W YFL038C YMR257C BOS1 encodes a v-SNARE; Bos1p is localized to the ER membrane and is necessary for vesicular transpo v-SNARE Null mutant is inviable
BPL1 YDL141W biotin-[acetyl-CoA-carboxylase] ligase activity* protein modification cytoplasm* Biotin:apoprotein ligase biotin:apoprotein ligase Null mutant is inviable.
BPT1 YLL015W bilirubin transporter activity* bilirubin transport* vacuolar membrane (sensu Fungi) YDL138W bile pigment transporter ABC transporter|highly homologous to human MRP1 and to C. elegans mrp-1 Null mutant is viable but lacks approximately 40% of the trasport activity of unconjugated bilirubin
BRE1 YDL074C ubiquitin-protein ligase activity chromatin silencing at telomere* nucleus YHR149C YPL055C YPR086W YHR007C YPL031C YJL168C YOR144C YLR039C YLR262C YLR085C YNL250W YLR330W YAL013W YMR263W putative coiled-coil protein with RING-finger and myosin-like domains null mutant is sensitive to brefeldin A
BRE2 YLR015W chromatin binding* transcription* nuclear chromatin YDR469W YAR003W YBR175W YBR272C YHR119W YHR007C YJL168C YLR039C YLR262C YPL174C YLR085C YNL250W putative transcription factor, contains a PHD finger motif; homology to D. melanogaster Ash2p compass (complex proteins associated with Set1p) component Null: null mutant is sensitive to brefeldin A
BRE4 YDL231C molecular_function unknown endocytosis integral to membrane YCR016W contains several putative trans-membrane domains null mutant is sensitive to brefeldin A
BRF1 YGR246C RNA polymerase III transcription factor activity transcription initiation from Pol III promoter transcription factor TFIIIB complex YER148W YNR003C YGR047C RNA polymerase III transcription factor with homology to TFIIB RNA polymerase III transcription factor|similar to TFIIB Null mutant is inviable
BRN1 YBL097W molecular_function unknown mitotic chromosome segregation* nucleus* YLR373C BaRreN, a gene with sequence similarity to Drosophila barren and Xenopus XCAP-H, and a functional ho Null mutant is inviable; chromosome loss in temperature-sensitive mutants and cells overexpressing B
BRO1 YPL084W intracellular transporter activity ubiquitin-dependent protein catabolism* cytoplasm* YPR173C YJL095W YHR030C BCK1-like resistance to osmotic shock Temperature-sensitive growth defect, sensitive to caffeine and respond abnormally to nutrient limita
BRR1 YPR057W RNA binding spliceosome assembly small nuclear ribonucleoprotein complex YFL017W-A YMR125W YDL084W YLR103C Protein involved in snRNP biogenesis spliceosomal snRNP component in brr1 mutants, newly synthesized snRNAs are destabilized and 3'-end processing is slowed
BRR2 YER172C pre-mRNA splicing factor activity* U2-type spliceosome conformational change to release U4 and U1 snRNP U5* YIL061C YMR240C YBR055C YJR068W RNA helicase-related protein required for pre-mRNA splicing; Snurp 246 kDa protein (Snurp = Small nu DEIH-box ATPase Null mutant is inviable; stabilized splicing intermediates which contain a mutant hammerhead cis-tar
BRR6 YGL247W molecular_function unknown mRNA-nucleus export* nuclear membrane Bad Response to Refrigeration nuclear envelope protein
BRX1 YOL077C rRNA primary transcript binding* ribosomal large subunit assembly and maintenance nucleolus YPL043W YDR060W YGR090W YKR081C YNL110C YHR066W YGR103W YMR049C YLR196W YNL061W YPL259C Essential nucleolar protein required for biogenesis of the 60S ribosomal subunit
BSD2 YBR290W molecular_function unknown protein-vacuolar targeting* endoplasmic reticulum YNL153C YML094W metal homeostasis protein; putative membrane protein suppressor of oxygen toxicity in sod1 mutants, increased sensitivity to copper and cadmium toxicity,
BSP1 YPR171W molecular_function unknown actin cytoskeleton organization and biogenesis bud neck* YBR187W YBL007C YOL015W YKL007W YGL181W Binding protein of Synaptojanin Polyphosphoinositide phosphatase domain; may function to link synapt
BST1 YFL025C molecular_function unknown ER-associated protein catabolism* endoplasmic reticulum* YLR039C YLR262C Negatively regulates COPII vesicle formation Null mutant is viable, suppresses sec13 null mutants, and shows defects in ER retention and cargo so
BTN2 YGR142W molecular_function unknown intracellular protein transport* cytosol YOR232W YNL141W YGL137W Gene/protein whose expression is elevated in a btn1 minus/Btn1p lacking yeast strain. Null mutant is viable; expression of BTN2 is elevated in yeast lacking BTN1. btn2delta strains demon
BTT1 YDR252W chaperone activity nascent polypeptide association nascent polypeptide-associated complex YHR193C YGR134W YJR055W beta subunit of the nascent-polypeptide-associated complex (NAC); homologous to human BTF3b; Negativ Null mutant is viable
BUB1 YGR188C protein binding* protein amino acid phosphorylation* nucleus* YOR026W YOR047C YER016W YKL079W YCL029C YLR085C YEL061C YPR141C YDR332W YER007W YPL241C YPR135W YMR078C YCL016C YDL003W YPL008W YLR200W YNL153C YEL003W YML094W YMR048W YDR052C YOR349W checkpoint gene involved in permitting entry into mitosis depending upon the assembly state of micro Mutants are unable to recover from transient loss of spindle function. Overexpression of BUB1 rescue
BUB2 YMR055C GTPase activator activity mitotic spindle checkpoint spindle pole body YGR153W YNL335W YMR055C YER143W YPL040C YHR061C YLR212C YER016W YDR309C YDR150W YCL029C YPL269W YOR326W YEL061C YPR141C YPL241C YPR135W YHR191C YLR200W YGR078C YNL153C YEL003W YML094W YMR048W YLR103C YDL017W Protein required for cell cycle arrest in response to loss of microtubule function Reduces the cell cycle delay which accompanies activation of a conditionally dicentric chromosome
BUB3 YOR026W molecular_function unknown mitotic spindle checkpoint condensed nuclear chromosome kinetochore Q0092 YGR188C YLR258W YJL013C YEL061C YER016W YJR053W YCL029C YPR141C YDR332W YOR265W YPR135W YMR078C YDL003W YLR200W YGR078C YNL153C YEL003W YML094W Protein required for cell cycle arrest in response to loss of microtubule function Null mutant is viable, but grows slowly and exhibits benomyl supersensitivity
BUD13 YGL174W molecular_function unknown bud site selection nucleus YGL216W YMR012W YIR005W YLR016C YLR418C YLR085C Null mutant is viable; diploid null mutants exhibit unipolar budding and elongate phenotype.
BUD14 YAR014C molecular_function unknown cellular morphogenesis during vegetative growth bud neck* YHR064C YGR285C YER155C YMR116C YER133W YOL154W YPL204W YLR096W YLR039C YLR262C YPR141C YGR078C YNL322C Null mutant is viable; random budding in diploid null mutants
BUD16 YEL029C molecular_function unknown bud site selection cytoplasm Null mutant is viable; random budding in diploid null mutants.
BUD2 YKL092C signal transducer activity* polar budding* intracellular YPL095C YIL117C YAL040C YPL256C GTPase-activating protein (GAP) for Rsr1p/Bud1p GTPase activating protein (GAP) for Rsr1p/Bud1p Null mutant is viable, with random bud site selection in all cell types
BUD20 YLR074C molecular_function unknown bud site selection nucleus YCR072C YJL122W YBL044W YGL068W YFL006W YIR003W YLL050C YMR303C YPR016C YLR196W YPL093W YHR052W YHR179W YDR155C YKL085W YNR053C YJR144W YGL120C YIL070C YNL182C YBL002W YER126C YDL051W YKL009W YNL002C YGR245C YDR101C YER006W YGR103W YHR085W YHR197W YK Null mutant is viable; random budding in diploid null mutants
BUD21 YOR078W snoRNA binding processing of 20S pre-rRNA small nucleolar ribonucleoprotein complex YNL320W YCR057C YDR315C YDL110C part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); U3 snoRNP protein Null mutant is viable; random budding in diploid null mutants; null has both reduced growth and redu
BUD22 YMR014W molecular_function unknown bud site selection nucleus YOR264W Null mutant is viable; random budding in diploid null mutants
BUD3 YCL014W molecular_function unknown cytokinesis* contractile ring (sensu Saccharomyces) YIL104C YJR092W YBL038W YGR220C YJR091C YPR086W YHR197W cell cycle regulated protein required for axial bud formation; co-assembles with Bud4p at bud sites Null mutant is viable; bipolar budding pattern in all cell types
BUD4 YJR092W GTP binding bud site selection* contractile ring (sensu Saccharomyces) YCL014W co-assembles with Bud3p at bud sites Null mutant is viable, haploids have dipolar budding, normally they have axial budding, no effects o
BUD5 YCR038C signal transducer activity* pseudohyphal growth* bud neck* YDR532C YEL061C YAL036C YDL065C YHR119W YBR200W GTP/GDP exchange factor for Rsr1 protein GTP/GDP exchange factor for Rsr1 protein bud5 mutants select bud sites randomly
BUD6 YLR319C cytoskeletal regulatory protein binding establishment of cell polarity (sensu Saccharomyces)* actin cap (sensu Saccharomyces)* YGL015C YLR319C YMR117C YLL021W YLR313C YLR362W YMR186W YFL039C YDR184C YNL271C YNL298W YLR229C YDR150W actin interacting rotein Null mutant is viable; mutants exhibit severe disruption of the actin cytoskeleton; deletion strains
BUD8 YLR353W molecular_function unknown pseudohyphal growth* bud tip* YBR027C YMR047C marks and directs bud emergence to the distal pole of diploid cells A bud8 bud9 double mutant buds almost exclusively from the proximal pole
BUD9 YGR041W molecular_function unknown bud site selection bud neck YPL251W YGR041W YDR316W among a group of genes whose products are necessary for bud-site selection; likely involvement in po In null mutants bipolar-budding cells bud preferentially at distal pole
BUL1 YMR275C protein binding protein monoubiquitination* plasma membrane YER125W YPL140C YLR418C BUL1p is putatively involved in specifying ubiquitination substrates by binding ubiquitin ligase RSP Null mutant is viable, but at high temperature a minichromosome is unstable; respiration deficiency
BUR6 YER159C transcription co-repressor activity negative regulation of transcription from Pol II promoter nucleus YDR397C YHR114W Homolog of DRAP1 (NC2alpha) transcriptional regulator Null mutant is viable, but grows very poorly
BZZ1 YHR114W molecular_function unknown actin filament organization* cytoplasm* YAL064W YBL109W YDL172C YDR042C YDR056C YDR319C YER079W YFL012W YGR031W YGR110W YHL044W YJL065C YJL086C YJL152W YKL177W YKR032W YLL054C YLR112W YML131W YNL092W YOR059C YOR175C YDR148C YPL124W YFL018C YCR044C YOL082W YDL100C YNR035C YOL018C YPL174C YL Associated with LAS17p/Bee1p Mutant viable
CAC2 YML102W molecular_function unknown DNA repair* chromatin assembly complex* YDL099W YPR018W YKL113C Involved in DNA-replication-linked nucleosome assembly; homologous to the p60 subunit of the Human C chromatin assembly factor-I (CAF-I) p60 subunit Null mutant is viable, but is sensitive to UV irradiation
CAD1 YDR423C RNA polymerase II transcription factor activity positive regulation of transcription from Pol II promoter* nucleus YMR047C Transcriptional activator involved in resistance to 1,10-phenanthroline; member of yeast Jun-family basic leucine zipper transcription factor Cadmium resistance; increased thermo-tolerance under starvation conditions
CAF120 YNL278W molecular_function unknown regulation of transcription from Pol II promoter CCR4-NOT complex YLR216C CCR4 Associated Factor 120 kDa Null mutant is viable
CAF130 YGR134W molecular_function unknown regulation of transcription from Pol II promoter CCR4-NOT complex YAL021C YCR093W YNR052C YDR252W YBR200W CCR4 Associated Factor 130 kDa Null mutant is viable
CAF16 YFL028C ATP-binding cassette (ABC) transporter activity regulation of transcription, DNA-dependent cytoplasm* YIL106W CCR4 associated factor ABC ATPase Null mutant is viable
CAF20 YOR276W translation regulator activity negative regulation of translation mRNA cap complex YKR048C YOL139C YER027C YDR482C binds to eIF-4E, the mRNA cap-binding protein, and represses cap-dependent translation initiation by 20 kDa protein|functional and limited sequence similarity to EAP1|functionally analogous to mammalia Null mutant is viable and grows faster; deletion of CAF20 partially suppresses mutations in translat
CAF4 YKR036C protein binding regulation of transcription, DNA-dependent CCR4-NOT complex YBL029W YJR064W YJL014W YBR039W YPR088C YIL142W YLR206W YHR001W YDR212W YDR188W CCR4 associated factor CCR4 transcriptional complex component Null mutant is viable
CAF40 YNL288W molecular_function unknown regulation of transcription from Pol II promoter CCR4-NOT complex YAL021C YCR093W YNR052C YER022W YPR086W YNL091W YLR200W YGR078C YML094W CCR4 Associated Factor 40 kDa Null mutant is viable
CAK1 YFL029C protein kinase activity protein amino acid phosphorylation* cytoplasm YBR160W YDR279W YPR054W binds and phosphorylates Cdc28p cyclin-dependent kinase-activating kinase Null mutant is inviable; temperature-sensitive mutant confers a G2 delay accompanied by low Cdc28p p
CAM1 YPL048W translation elongation factor activity regulation of translational elongation cytosolic ribosome (sensu Eukarya) YBR118W Calcium and phospholipid binding protein homologous to translation elongation factor 1-gamma (EF-1ga calcium and phospholipid binding protein homologous to translation elongation factor 1-gamma (EF-1ga Null mutant is viable under normal growth conditions
CAN1 YEL063C basic amino acid transporter activity* basic amino acid transport plasma membrane YGR057C YPL139C YOR345C arginine permease arginine permease Canavanine resistance
CAP1 YKL007W F-actin capping activity cell wall organization and biogenesis* actin cortical patch (sensu Saccharomyces)* YER071C YIR003W YIL086C YIL034C YDR309C YPR171W YHR114W YFR016C YDR129C YJL020C YDR162C YLR229C YMR294W YPL174C YOR269W YDR150W YCR009C YDR388W capping - addition of actin subunits capping protein Null mutant is viable; severe deficit of actin cables and increased number of actin spots in the mot
CAP2 YIL034C F-actin capping activity cell wall organization and biogenesis* actin cortical patch (sensu Saccharomyces)* YBR096W YBR277C YCL022C YCL056C YDL165W YAL014C YBR119W YBR173C YBR188C YBR201W YBR264C YBR291C YCL009C YCL035C YKL007W YBL049W YFR016C YDR424C YDR245W YJL020C YDR162C YLR229C YPL174C YDR150W YLR200W YGR078C YEL003W YML094W YCR009C YDR388W capping - addition of actin subunits capping protein beta subunit Null mutant is viable, exhibits abnormal actin distribution (including loss of actin cables); round,
CAR1 YPL111W arginase activity arginine catabolism to ornithine cytosol YFL012W YKL085W YNL189W YKL104C YBR011C YEL034W YPL111W YPL160W YGR136W YHR114W YLR347C YML064C YMR235C arginase arginase Null mutant is viable but defective in arginine catabolism
CAR2 YLR438W ornithine-oxo-acid transaminase activity arginine catabolism cytoplasm YLR328W YHL025W YGR010W YLR236C YPL204W YPL150W YHR135C YPL022W YBR217W YPR165W YNL244C YMR059W YGR262C YLR186W YLL019C YIR005W YHR169W YJR017C ornithine aminotransferase ornithine aminotransferase Catabolism of arginine defective
CAT2 YML042W carnitine O-acetyltransferase activity carnitine metabolism mitochondrion* YNL046W YML042W YMR038C YDL239C YGL187C YJR091C YLR014C YNL189W YOL075C Carnitine O-acetyltransferase, peroxisomal and mitochondrial carnitine O-acetyltransferase Null mutant is viable; cat2 cit2 double mutants cannot grow on oleate.
CAT5 YOR125C molecular_function unknown ubiquinone metabolism mitochondrial inner membrane YJL068C YDR243C YGL192W YBL045C may encode a protein involved in one or more monoxygenase or hydroxylase steps of ubiquinone biosynt may encode a protein involved in one or more monoxygenase or hydroxylase steps of ubiquinone biosynt Null mutant is viable, results in complete loss of glucose derepression affecting gluconeogenic key
CAT8 YMR280C specific RNA polymerase II transcription factor activity positive regulation of transcription from Pol II promoter* nucleus YOR047C CAT8 controls the key enzymes of gluconeogenesis in S. cerevisiae. zinc-cluster protein involved in activating gluconeogenic genes; related to Gal4p Null mutant is viable but unable to grow on non-fermentable carbon sources due to failure to derepre
CAX4 YGR036C pyrophosphatase activity N-linked glycosylation* integral to endoplasmic reticulum membrane YDR318W YKL190W CAX4p contains 3 short stretches of amino acids that are characteristic for a wide variety of phosph contains 3 short stretches of amino acids that are characteristic for a wide variety of phosphatases Null mutant is viable with severely affected growth rate, hypo-N-glycosylation of secretory proteins
CBC2 YPL178W pre-mRNA splicing factor activity nuclear mRNA splicing, via spliceosome commitment complex* YMR125W YIL061C YDR432W YNL189W YLR347C YDL087C YPL190C YHR086W YNL251C YML049C YLR275W YDR240C YGR013W YGL049C YML117W YBR119W YDR034C cap binding complex nuclear cap binding complex subunit mutants exhibit promiscuous 3'-end formation; sae-1 mutation causes temporary cell cycle arrest in m
CBF1 YJR060W DNA binding* methionine biosynthesis* nucleus* YMR168C YKL049C YNL232W YKL089W YIR017C YNL103W YAL021C YGL244W YGR140W YPL153C YOR070C YLR039C YLR262C centromere binding factor; binds in vivo to CDE I sites in centromeres (and some promoters), and ind basic helix-loop-helix protein Null mutant is viable, but grows slowly and causes partial loss of centromere function (increased ch
CBF2 YGR140W DNA bending activity* chromosome segregation condensed nuclear chromosome kinetochore YNL307C YKL089W YJR060W YJR089W 110 kd component (Cbf3a) of the multisubunit 'Cbf3' kinetochore protein complex, which binds to the centromere binding factor CBF3 110 kDa subunit Null mutant is inviable
CBF5 YLR175W pseudouridylate synthase activity rRNA modification* small nucleolar ribonucleoprotein complex YPL043W YCL059C YMR309C YLR197W YNL307C YDR496C YIL104C YGL049C YMR290C YDL014W YGR162W YAL035W YPL012W YNL124W YLR134W YMR205C YBR247C YHR089C YJL033W YDL208W YCR057C YBL032W YER022W YMR047C YLR233C YDL213C major low affinity 55 kDa Centromere/microtubule binding protein major low affinity 55 kDa centromere/microtubule binding protein Null mutant is inviable
CBK1 YNL161W protein kinase activity cellular morphogenesis during conjugation with cellular fusion* nucleus* YDL029W YLR447C YEL060C YIL076W YDR293C YOR007C YEL030W YMR304W YBR018C YNL007C YIL129C YFL034C-B YIL106W YIR016W cell wall biosynthesis kinase. required for efficient apical growth, proper mating projection morpho serine/threonine protein kinase Null mutation is viable; shows alpha factor resistance; in liquid culture large aggregates of cells
CBP1 YJL209W mRNA binding aerobic respiration* mitochondrion Protein required for COB mRNA stability or 5' processing. required for translation of COB RNAs. Null mutant is viable, unable to respire due to degradation of mitochondrially encoded cytochrome b
CBP2 YHL038C pre-mRNA splicing factor activity Group I intron splicing mitochondrion YDL213C Protein required for splicing of COB aI5 intron Null mutant is viable
CBP3 YPL215W molecular_function unknown protein complex assembly mitochondrial membrane YAR069C YIL061C YDL043C YCL058C YJR042W YLR200W Protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex) reduced levels of a subset of subunit polypeptides of the coenzyme QH2-cytochrome c reductase comple
CBP4 YGR174C molecular_function unknown protein complex assembly mitochondrial membrane YOL115W Essential for the expression and activity of ubiquinol-cytochrome c reductase Inability to respire, pleiotropic reduction in steady state levels of four subunits of ubiquinol-cyt
CBP6 YBR120C molecular_function unknown protein biosynthesis mitochondrion YJR082C YBR017C YKR026C YLR085C YLR200W Translational activator of COB mRNA translational activator of COB mRNA Null mutant is viable, repiratory deficiency with concomitant loss of cytochrome b
CBR1 YIL043C cytochrome-b5 reductase activity electron transport microsome cytochrome b reductase cytochrome b reductase
CBS1 YDL069C translation factor activity, nucleic acid binding protein biosynthesis mitochondrial inner membrane YEL003W translational activator of cytochrome b translational activator of cytochrome B Null mutant is viable
CBS2 YDR197W molecular_function unknown protein biosynthesis mitochondrial inner membrane Translational activator of COB mRNA; soluble protein cytochrome b translational activator Null mutant is viable, exhibits a mitochondrial apocytochrome b mRNA translational defect
CCA1 YER168C tRNA adenylyltransferase activity tRNA modification nucleus* YHR174W YPL022W tRNA nucleotidyltransferase (tRNA CCA-pyrophosphorylase) tRNA nucleotidyltransferase (tRNA CCA-pyrophosphorylase)
CCC1 YLR220W molecular_function unknown iron ion homeostasis* Golgi apparatus* YER029C Functions in the homeostasis of both calcium and manganese ions transmembrane Ca2+ transporter (putative) Wild-type complements csg1 (calcium sensitive-group) mutants when overexpressed. Deletion of CCC1 re
CCC2 YDR270W copper-exporting ATPase activity intracellular copper ion transport* Golgi trans face YNL259C YBR036C copper-transporting P-type ATPase with similarity to human Menkes and Wilsons genes Null mutant is viable, exhibits defects in respiration and iron uptake
CCE1 YKL011C endodeoxyribonuclease activity DNA recombination mitochondrial inner membrane YPR122W YIL066C YBR278W YKR026C YPL283C YMR201C cruciform cutting endonuclease cruciform cutting endonuclease Null mutant is viable, exhibits a higher than normal frequency of appearance of petite cells
CCH1 YGR217W calcium channel activity calcium ion transport plasma membrane YLR342W YGR229C calcium channel calcium channel (putative) Null mutant is viable; exhibits reduced growth rate, viability and calcium uptake; exhibits a defect
CCL1 YPR025C general RNA polymerase II transcription factor activity* transcription initiation from Pol II promoter* transcription factor TFIIH complex YDR460W YBR081C YPR016C YDL108W YOR173W YDR508C YLR373C YER171W YKR086W essential for cell proliferation TFIIK subunit, a subcomplex of transcription factor TFIIH|cyclin Null mutant is inviable
CCP1 YKR066C cytochrome-c peroxidase activity response to oxidative stress mitochondrion* Cytochrome-c peroxidase cytochrome c peroxidase
CCR4 YAL021C 3'-5' exoribonuclease activity regulation of transcription from Pol II promoter* cytoplasm* YDL165W YCR093W YDR190C YGR134W YGR092W YML032C YDR188W YNL288W YGL195W YNR052C YGR086C YGR155W YOR027W YGR184C YCL028W YJL127C YGR116W YLR150W YER068W YJR060W YDL160C YGL178W carbon catabolite repression; transcriptional regulator for some glucose-repressed genes including A 95 kDa containing leucine rich tandem repeats reduced levels of ADH2 expression under both glucose and ethanol growth conditions; temperature sens
CCT2 YIL142W chaperone activity protein folding* cytoplasm* YJR070C YLR200W YJL014W YLR105C YDR212W YDL047W YDL080C YMR054W YGL116W YBL049W YBR198C YDR075W YKR036C YNL317W YGR040W YOR230W YDR142C YGL190C YGL137W YLL011W YOR212W YDL156W YDR030C YJL106W YLR196W YDL143W YEL003W cytoplasmic chaperonin of the Cct ring complex related to Tcp1p; subunit beta Null mutant is inviable; some mutant alleles exhibit defects in microtubule and actin assembly.
CCT3 YJL014W chaperone activity protein folding* cytoplasm* YLR200W YDR212W YGL116W YBL049W YBR198C YDR075W YER173W YKR036C YOR230W YDR142C YGL190C YLL011W YOR212W YDL156W YMR106C YLR196W YDL143W YEL003W YIL142W YBR234C Homolog of mammalian CCT family of chaperonin proteins; required for assembly of microtubules and ac gamma chaperonin subunit Defects in microtubule and actin assembly in vivo, abberant chromosome segregation, supersensitivity
CCT4 YDL143W chaperone activity protein folding* cytoplasm* YFL039C YJL014W YIL142W YDR212W YHR211W YKR026C subunit of the TRiC/CCT complex; cytoplasmic chaperonin subunit required for actin cytoskeleton asse Null mutant is inviable; cct4 mutant exhibit allele-specific non-complementing interactions with dif
CCT5 YJR064W chaperone activity protein folding* cytoplasm* YNR016C YDL029W YKL095W YGL116W YBR198C YPL151C YKR036C YDR142C YGL190C YLL011W YOR212W YMR106C YNL317W YLR196W Required for assembly of microtubules and actin in vivo chaperonin subunit epsilon subunit
CCT6 YDR188W chaperone activity protein folding* cytoplasm* YAL021C YMR028W YPL151C YKR036C YOR230W YDR142C YGL190C YDL047W YGL137W YDR128W YLL011W YOR229W YOR212W YDR030C YNL317W YMR049C YLR196W cytoplasmic chaperonin of the Cct ring complex (previously called TCP1 or TRiC), distantly related t Null mutant is inviable; overexpression suppresses a TOR2 dominant nagative allele
CCT7 YJL111W chaperone activity protein folding* cytoplasm* YJL111W YMR028W Required for assembly of microtubules and actin in vivo chaperonin containing T-complex subunit seven component
CCT8 YJL008C chaperone activity protein folding* cytoplasm* YDR127W YDL029W YJL074C YOR117W YAL041W Required for assembly of microtubules and actin in vivo chaperonin containing T-complex subunit eight component
CCW12 YLR110C molecular_function unknown cell wall organization and biogenesis* cell wall (sensu Fungi) YLR453C YBR023C YLR330W YHR142W YLR332W YBL061C YCR009C YDR388W cell wall mannoprotein Null mutant is viable and shows decrease in mating efficiency and defect in agglutination
CCW14 YLR390W-A structural constituent of cell wall cell wall organization and biogenesis cell wall (sensu Fungi) YPL149W YOL132W Secretory Stress Response protein cell wall mannoprotein Null mutant is viable but causes increased sensitivities to calcofluor white, Congo red, and zymolya
CCZ1 YBR131W guanyl-nucleotide exchange factor activity protein-vacuolar targeting* membrane* YDL043C YDR150W YGR229C Calcium Caffeine Zinc sensitivity Null mutant is viable, but is sensitive to caffeine, calcium and zinc; no sporulation in homozygous
CDA1 YLR307W chitin deacetylase activity spore wall assembly (sensu Saccharomyces) chitosan layer of spore wall Required for proper formation of the ascospore wall chitin deacetylase Null mutant is viable, mutants spores disrupted for both cda1 and cda2 fail to emit natural fluoresc
CDA2 YLR308W chitin deacetylase activity spore wall assembly (sensu Saccharomyces) chitosan layer of spore wall YGL084C Required for proper formation of the ascospore wall chitin deacetylase Null mutant is viable, mutant spores disrupted for both cda1 and cda2 fail to emit natural fluoresce
CDC1 YDR182W molecular_function unknown DNA repair* integral to membrane YDL192W YCR044C Protein that affects bud emergence, intrachromosomal recombination, and nuclear division Null mutant is inviable
CDC10 YCR002C structural constituent of cytoskeleton* cell wall organization and biogenesis* septin ring (sensu Saccharomyces) YFL018C YGL105W YHR107C YDL225W YNL312W YLR314C YJR076C YDR324C YBR055C YDR507C YNL233W Cell division cycle blocked at 36 degree C septin abnormal cell-wall deposition and bud growth, inability to complete cytokinesis, failure to form the
CDC11 YJR076C structural constituent of cytoskeleton* cell wall organization and biogenesis* shmoo tip* YHR033W YHR107C YOR284W YHR027C YDR218C YCR002C YMR012W YGL049C YGR162W YCL043C YNL088W YMR304W YLR314C YDR507C YPL161C YML109W Involved in proper bud growth 10 nm filament component of mother-bud neck abnormal cell-wall deposition and bud growth, inability to complete cytokinesis, failure to form the
CDC12 YHR107C structural constituent of cytoskeleton* cell wall organization and biogenesis* cytoplasm* YKL056C YGL245W YNL271C YML056C YFL045C YBR130C YBR260C YJR076C YHR107C YDL225W YHR060W YER091C YGL062W YHR043C YNL073W YHR044C YLR147C YPL241C YLR314C YCR002C YBL061C YHR030C YDR507C YPL161C YNL298W YHR061C YDR309C Involved in proper bud growth 10 nm filament component of mother-bud neck|septin abnormal cell-wall deposition and bud growth, inability to complete cytokinesis, failure to form the
CDC13 YDL220C single-stranded DNA binding telomere maintenance* nuclear telomere cap complex YDR155C YEL030W YDR082W YGL256W YMR284W YPL153C YMR106C YAL035W Regulator of telomere replication. Recruits telomerase to the telomere. Required for G2/M transition single-stranded TG1-3 telomere G-tails binding protein
CDC14 YFR028C protein phosphatase activity protein amino acid dephosphorylation* nucleus* YHR064C YBR039W YHR128W YDR298C YER133W YNL014W YDR171W YOR032C YPR069C YBR126C YGR094W YKL150W YDR226W YPR183W YGL115W YDR453C YKL016C YFR028C YJR063W YJR091C YMR049C YAR019C A phosphatase required for mitotic exit; Cdc14p is in the nucleolus until liberated by the FEAR and protein phosphatase Null mutant is inviable; ts mutant arrests at late anaphase with phenotypes similar to cdc5 mutants
CDC15 YAR019C protein kinase activity protein amino acid phosphorylation* bud neck* YDL185W YNL223W YGR152C YGR092W YIL106W YFR028C YMR001C YPR111W YOR101W YML064C YHR169W YNL098C YLR079W Promotes the exit from mitosis by directly switching on the kinase activity of Dbf2. Required for mi protein kinase domain Null mutant inviable, arrests in G2; buds at distal instead of axial position, undergoes autolysis w
CDC16 YKL022C protein binding* ubiquitin-dependent protein catabolism* anaphase-promoting complex YHR166C YFR036W YBL084C YGL240W YDR386W YDR369C YNL172W YDL008W YLR127C YDR118W YOR249C YLR102C A component of anaphase-promoting complex required for the G2/M transition in mitosis and degradatio metal-binding nucleic acid-binding protein, interacts with Cdc23p and Cdc27p to catalyze the conjuga Null mutant is inviable; sensitive to caffeine; cdc16 mutants are unable to progress through the G(s
CDC19 YAL038W pyruvate kinase activity glycolysis* cytosol YNL307C YOR226C Required for START A in the cell cycle and sporulation pyruvate kinase Null mutant is inviable. cdc19 mutants are pyruvate kinase deficient and show cell division cycle bl
CDC2 YDL102W delta DNA polymerase activity lagging strand elongation* delta DNA polymerase complex YBR094W YMR075C-A YCL061C YMR048W YNL307C YNL273W YJR006W YER173W YJR068W YBR098W YDR004W YFR010W YJR043C YMR307W YNL291C YOL093W YOR368W YPL194W Essential for mitotic and meiotic DNA synthesis, dispensable for meiotic spindle pole body duplicati DNA polymerase III catalytic (delta) subunit Null mutant is inviable. cdc2 mutants arrest at the mononucleate stage with duplicated spindle pole
CDC20 YGL116W enzyme activator activity ubiquitin-dependent protein catabolism* anaphase-promoting complex YJR064W YJL030W YKL085W YJL014W YPL140C YJL013C YIL142W YDR212W YKL101W YEL061C Required for onset of anaphase anaphase promoting complex (APC) subunit Null mutant is inviable; conditional alleles show cell cycle arrest in G2
CDC21 YOR074C thymidylate synthase activity DNA dependent DNA replication* nucleus YPR086W YPL093W Cell division cycle blocked at 36 degree C thymidylate synthase defective in continued replication during S phase of the cell cycle; temperature-sensitive thymidyla
CDC23 YHR166C protein binding* ubiquitin-dependent protein catabolism* anaphase-promoting complex YBR270C YBL084C YPL124W YLR127C YKL022C YFR036W YGL240W YEL034W YDR448W YLR451W YDR260C YER161C YNL172W YDL008W YDR118W YOR249C YLR102C Required for mitosis and RNA synthesis unable to complete G(sub)2/M transition
CDC24 YAL041W signal transducer activity* establishment of cell polarity (sensu Saccharomyces)* nucleus* YOR212W YBR200W YER155C YJL008C YER114C YKL080W YPL161C YOR188W YJL157C YGR152C YLR229C YJL187C YLR206W YLR357W YGR221C YIL079C YNL007C YGL052W YGL127C YGR268C YKL130C YMR298W YDR264C Calcium-binding protein involved in polarity establishment and maintenance; required for bud emergen guanine nucleotide exchange factor (a.k.a. GDP-release factor) for cdc42 temperature sensitive mutation affecting bud formation and localized cell surface growth at a restri
CDC25 YLR310C Ras guanyl-nucleotide exchange factor activity regulation of cell cycle* cytoplasm* YLL016W YLL024C YNL098C YPL240C YAL005C YBL075C YER103W Cell division cycle blocked at 36 degree C adenylate cyclase regulatory protein Null mutant is inviable; arrests at G(sub)1; low levels cAMP and decreased levels of Mg2+-dependent
CDC26 YFR036W protein binding* ubiquitin-dependent protein catabolism* anaphase-promoting complex YKL022C YHR166C YBL084C YGL240W YLL051C YJR091C YNL172W YDL008W YLR127C YDR118W YOR249C YLR102C YPR141C YPR135W YHR191C YMR078C YBR023C YDR420W Component of anaphase-promoting complex; required for ubiquitination of Clb2p and Clb3p, is a nuclea thermosensitive cell growth (lethal at high temperature)
CDC27 YBL084C protein binding* ubiquitin-dependent protein catabolism* anaphase-promoting complex YGL240W YHR166C YNL172W YDL008W YLR127C YDR118W YOR249C YLR102C YFR036W YKL022C Protein required for cell cycle anaphase promoting complex (APC) subunit Null mutant is inviable. Some conditional alleles overreplicate their DNA.
CDC28 YBR160W cyclin-dependent protein kinase activity protein amino acid phosphorylation* nucleus* YGL178W YFL029C YMR199W YKL014C YKR077W YPL014W YPL070W YHR030C YHR027C YNL189W YKL048C YPR119W YKL145W YFR030W YIL050W YHL007C YMR012W YAL040C YPL256C YDR212W YBR135W YIR031C YFR015C YDL017W YGL073W YFR052W YDL020C YGR274C YNL064C YLR079W YER059W YN Catalytic subunit of the main cell cycle cyclin-dependent kinase cyclin-dependent protein kinase arrests at G1/S transition
arrests at G2/M transition
CDC3 YLR314C structural constituent of cytoskeleton* cell wall organization and biogenesis* shmoo tip* YDR507C YJR076C YHR107C YDL225W YCR002C YCR053W YDR158W YLR027C YJL060W Involved in proper bud growth Null mutant is inviable; other mutants show abnormal cell-wall deposition and bud growth, inability
CDC31 YOR257W structural constituent of cytoskeleton microtubule nucleation* nuclear pore* YNL188W YHR102W Required for spindle pole body duplication and mitosis in meiosis II; calcium-binding protein compon nuclear pore complex subunit|spindle pole body calcium-binding protein component Null mutant is inviable. cdc31 mutants form reductional dyads with unduplicated spindle pole bodies
CDC33 YOL139C translation initiation factor activity translational initiation* nucleus* YOR204W YER165W YDR214W YDL051W YBL004W YMR125W YGL049C YGR162W YGL115W YNL262W YLR371W YHL034C YOR276W YKL204W YMR246W YER090W YNL147W YDL087C YBL032W YLR288C YDL025C YMR104C YMR059W YLR427W YJL098W YDL101C YML064C YDR365C YJR007W YJL005W YDR386W YD Required for START A of cell cycle and sporulation mRNA cap binding protein eIF-4E Null mutant is inviable. cdc33 mutants arrest at G(sub)1. cdc33 has normal cAMP pools and is not sup
CDC34 YDR054C ubiquitin-protein ligase activity* ubiquitin-dependent protein catabolism* nucleus* YDR328C YLL039C YLR079W YIL046W YDR139C YPR066W YLR306W YPL003W YFL009W YDL132W YJR090C YJL194W YGL070C YPL256C YNL236W ubiquitin-conjugating enzyme, E2 ubiquitin-conjugating enzyme overexpression confers resistance to xenobiotics (methylmercury, mercuric chloride, and p-chloromerc
CDC36 YDL165W 3'-5' exoribonuclease activity regulation of transcription from Pol II promoter* nucleus* YNL315C YPR072W YGL127C YIL034C YKL002W YLR125W YAL021C YDR448W YGR014W Required for Start B in mitosis and for meiosis I spindle pole body separation basal transcription inhibitor|transcriptional regulator Null mutant is viable, cdc36 mutant arrests in G(sub)1; forms shmoo morphology at restrictive temper
CDC39 YCR093W 3'-5' exoribonuclease activity regulation of transcription from Pol II promoter* nucleus* YIL038C YPR072W YPL235W YGR134W YNL288W YNR052C YDL145C YGL137W YOR110W YER068W YOL133W YJL141C YAL021C YDR376W Required for Start B in mitosis and spindle pole body separation at meiosis I basal transcription inhibitor|transcriptional regulator Null mutant is inviable; arrests in G(sub)1 at pachytene at the mononucleate stage with duplicated,
CDC4 YFL009W protein binding* ubiquitin-dependent protein catabolism* nucleus* YDL132W YDR328C YLR079W YJL194W YDR054C Init. of DNA synthesis & spindle pole body separation; dispensable for both mitotic and meiotic spin ubiquitin ligase subunit Null mutant is inviable. cdc4 mutants arrest in meiosis at the mononucleate stage with duplicated sp
CDC40 YDR364C pre-mRNA splicing factor activity* nuclear mRNA splicing, via spliceosome* nuclear pore* YMR213W YAL032C YKL095W Required for proper timing of DNA synthesis at all temperatures and completion of DNA synthesis at a beta transducin family Null mutant is viable, temperature sensitive at 36 degrees celsius, arrests at the mononucleate stag
CDC42 YLR229C signal transducer activity* establishment of cell polarity (sensu Saccharomyces)* plasma membrane* YDL135C YBR077C YGL211W YGR151C YNL298W YNL271C YLR319C YPL242C YCR077C YMR303C YAL041W YBR200W YER149C YBR171W YDR310C YKL007W YIL034C YPL161C YGR200C YPL086C YOR188W YJL157C YGR152C YBL085W YHL007C YHR111W YMR312W YPL101W YER111C YLL021W YDR126W YH Budding blocked at 36 degree C in ts mutant Rho subfamily of Ras-like proteins Null mutant is inviable; temperature sensitive mutations unable to form buds and display delocalized
CDC43 YGL155W signal transducer activity* establishment of cell polarity (sensu Saccharomyces)* intracellular YKL019W may participate in a ras-like C-terminus modification of proteins involved in nuclear division and b protein geranylgeranyltransferase type 1 polypeptide subunit temperature sensitive mutants unable to form buds and display delocalized cell-surface deposition
CDC45 YLR103C DNA binding DNA replication initiation* replication fork* YLR274W YBR202W YBR277C YJR070C YLR235C YMR166C YOR024W YGL127C YJL030W YCR077C YEL003W YLR268W YML094W YPR141C YBR036C YCL061C YGL086W YGL244W YLR055C YOL064C YOR043W YOR123C YPL055C YCR086W YJR140C YMR048W YMR039C YPR135W YDR289C YFR019W YGL173C YM Cdc45p assembles into a complex with Cdc46p/Mcm5p chromosomal DNA replication initiation protein required for minichromosome maintenance and chromosomal DNA replication
CDC46 YLR274W chromatin binding* DNA replication initiation* cytoplasm* YEL032W YBR202W YLR103C YGL201C YOR080W Member of complex that acts at ARS's to initiate replication Null mutant is inviable; at nonpermissive temperature cdc46(ts) mutants arrest with a large bud and
CDC47 YBR202W chromatin binding* DNA replication initiation* nucleus* YBR202W YIL150C YLR274W YEL032W YGL001C YLR103C YDL029W Essential for initiation of DNA replication Null mutant is inviable, at nonpermissive temperature cdc47(ts) mutants arrest with a large bud and
CDC48 YDL126C ATPase activity ubiquitin-dependent protein catabolism* nucleus* YDR049W YNL271C YDR028C YDR337W YBR170C YGL246C YBL058W YGR048W YDL190C YKL213C YBL103C YDR037W YGR078C Microsomal protein of CDC48/PAS1/SEC18 family of ATPases; full length homology to mammalian protein Null mutant is inviable
CDC5 YMR001C protein serine/threonine kinase activity protein amino acid phosphorylation* nucleus* YNL175C YLR347C YJL019W YAL047C YFL008W YDL003W YIL026C YJL074C YDR229W YNL092W YDR386W YBR060C YIL106W YAR019C CDC5 is dispensable for premeiotic DNA synthesis and recombination, but required for tripartite syna protein kinase Null mutant is inviable. cdc5(ts) mutants form synaptonemal complexes lacking central elements and a
CDC50 YCR094W transcription regulator activity G1 phase of mitotic cell cycle* late endosome* YGL090W YJR091C cell division cycle mutant Null mutant is cold-sensitive and sensitive to MMS and HU
CDC53 YDL132W structural molecule activity* ubiquitin-dependent protein catabolism* nuclear ubiquitin ligase complex* YLR128W YDR274C YDL006W YNL055C YEL060C YPL258C YDR328C YAL040C YPL256C YLR134W YMR199W YDL017W YLR079W YIL046W YFL009W YJR090C YJL194W YDR054C YGR087C YLR100W YLR368W YGL249W YBR280C YLR097C YJL149W YOR080W YOL133W YLR352W YDR306C YML088W acts together with Cdc4p and Cdc34p to control the G1-S phase transition, assists in mediating the p Cells arrest in G1 with active Cln kinases but no Clb-associated Cdc28p kinase activity
CDC54 YPR019W chromatin binding* DNA replication initiation* nucleus* YDL029W YDR143C YBR060C YNL261W essential for initiation of DNA replication; homolog of S. pombe CDC21 Null mutant is inviable; at nonpermissive temperature cdc54(ts) mutants arrest with a large bud and
CDC6 YJL194W protein binding* pre-replicative complex formation and maintenance pre-replicative complex YBR160W YKL145W YDR196C YDL132W YDR054C YFL009W Protein involved in initiation of DNA replication pre-initiation complex component arrest at initiation of S phase
CDC60 YPL160W leucine-tRNA ligase activity leucyl-tRNA aminoacylation cytoplasm YPL111W YNL244C YPR110C YCR079W cytosolic leucyl tRNA synthetase leucine--tRNA ligase arrest at START point of cell cycle upon shift to restrictive temperature
CDC7 YDL017W protein serine/threonine kinase activity protein amino acid phosphorylation* nucleoplasm YBL023C YCR022C YCR050C YEL023C YFR057W YNR048W YOR006C YGL250W YJR070C YKL056C YLR235C YOR027W YLR386W YJL030W YGL019W YJR032W YDR032C YGL086W YLR055C YPR119W YJR140C YJL138C YMR055C YHR191C YCL016C YJR053W YML016C YML032C YMR078C YDR363W YDL160C YL Required for mitotic DNA synthesis but dispensable for premeiotic DNA synthesis and spindle pole bod Cdc7p-Dbf4p kinase complex catalytic subunit Null mutant is inviable. cdc7 mutant arrests at G(sub)1/S phase with duplicated spindle pole bodies
CDC73 YLR418C Pol II transcription elongation factor activity RNA elongation from Pol II promoter transcription elongation factor complex YDL033C YDR334W YEL033W YER084W YER139C YLR168C YLR269C YML012C-A YNL140C YNL198C YPL182C YPR084W YCL037C YOR089C YCR077C YOR080W YNL025C YEL031W YER122C YOR216C YLR268W YDR137W YHL031C YGL020C YLR039C YLR262C YEL061C YLR373C YIL128W YPL069C YAL013W accessory factor associated with RNA polymerase II by affinity chromatography Mutations affect cell growth and the abundance of transcripts from a subset of genes
CDC8 YJR057W thymidylate kinase activity DNA repair* nucleus* YDR438W YDR458C YKL098W YLR235C YMR198W YLR268W YGL020C YCL061C YCR086W YGL173C YKL032C YDR453C YER173W YBR098W YPL194W YHR178W YLR234W YNL299W YMR190C YDR446W YDR452W YDR490C YER167W YJR034W YKL113C YKL114C YNL218W YNL229C YNL241C YOR304W Essential for mitotic DNA synthesis. Required for premeiotic DNA synthesis, synaptonemal complexes, thymidylate kinase Null mutant is inviable. cdc8 mutants are defective in continued replication during S phase of the c
CDC9 YDL164C DNA ligase (ATP) activity DNA recombination* replication fork YOR378W YEL030W YLR276C YBR088C YGL207W YHR178W Essential for mitosis and meiosis, dispensable for intragenic recombination, but required for haploi DNA ligase cell division cycle blocked at 36 degrees, increased sensitivity to ultraviolet radiation and bleomy
CDH1 YGL003C enzyme activator activity ubiquitin-dependent protein catabolism* nucleus* YHR152W YLR079W YMR048W CDC20 homolog 1 required for Clb2 and Ase1 degradation Null mutant is viable but defective in Clb2p and Ase1p degradation; deletion of cdh1 causes pheromon
CDS1 YBR029C phosphatidate cytidylyltransferase activity phosphatidylglycerol biosynthesis* mitochondrion* CDP-diacylglycerol synthase, CTP-phosphatidic acid cytidylyltransferase, CDP-diglyceride synthetase phosphatidate cytidylyltransferase Null mutant is inviable
CEF1 YMR213W pre-mRNA splicing factor activity nuclear mRNA splicing, via spliceosome spliceosome complex YDR416W YCR063W YLR423C YGL120C YML049C YLR275W YDR364C YLR117C YBR065C YMR288W YLL036C YNR011C YER013W YAL032C YPL151C YPR101W YKL173W YDL209C YGL128C YGR278W YHR165C homolog of S. pombe cdc5+. c-Myb DNA binding motif at amino terminus is required for cellular growth protein complex component associated with the splicing factor Prp19p Null mutant is inviable, arrests in G2/M, exhibits abnormal nuclear morphologies. Essential for mRNA
CEG1 YGL130W mRNA guanylyltransferase activity mRNA capping nucleus YHR121W YMR309C YER155C YKR001C YGL120C YMR012W YDL014W YAL035W YNL088W YBL075C YER103W YNL030W YBR221C YGL207W YPL228W YOL145C YBR079C YOL078W YIL131C YDL140C mRNA guanylyltransferase (mRNA capping enzyme), alpha subunit mRNA capping enzyme alpha subunit|mRNA guanylyltransferase Null mutant is inviable
CEM1 YER061C 3-oxoacyl-acyl-carrier protein synthase activity hexadecanal biosynthesis mitochondrion YPL073C homology with beta-keto-acyl synthases beta-keto-acyl synthase homolog Null mutant is viable; exhibits respiratory-deficient growth
CEP3 YMR168C DNA bending activity* mitotic spindle checkpoint condensed nuclear chromosome kinetochore YJR060W Cbf3 kinetochore complex binds CDE III centromere element; Cep3p contains an N-terminal Zn2Cys6 type Cbf3 kinetochore protein complex subunit b Null mutant is inviable; mutations within the zinc finger domain result in cells that exhibit a G2-M
CET1 YPL228W polynucleotide 5'-phosphatase activity mRNA capping nucleus YGL130W Interacts with Ceg1p, the mRNA capping enzyme alpha subunit; removes gamma-phosphate from triphospha RNA 5'-triphosphatase|mRNA capping enzyme beta subunit (80 kDa) Null mutant is inviable
CFT1 YDR301W cleavage/polyadenylation specificity factor activity mRNA polyadenylation* mRNA cleavage factor complex* YGR240C YER133W YLR115W YKR002W YNL317W YAL043C YDR195W YMR061W YGR156W YKL059C YLR277C YJR093C YPR107C Functions in cleavage of 3'-ends of pre-mRNAs, prior to polyadenylation; 23.5% identical to the 160- 150 kDa protein associated with polyadenylation factor 1 (PF I)|cleavage factor II (CF II) component Null mutant is inviable
CFT2 YLR115W cleavage/polyadenylation specificity factor activity mRNA polyadenylation* mRNA cleavage factor complex* YER133W YKR002W YNL317W YAL043C YGR156W YKL059C YLR277C YJR093C YHL035C YPR107C YJL033W YDR228C YDR195W YMR061W YDR301W cleaves pre-mRNAs prior to polyadenylation; homologous to both the 73- and 100-kDa subunits of mamma 105 kDa protein associated with polyadenylation factor 1 (PF I)|cleavage factor II (CF II) component Null mutant is inviable
CGR1 YGL029W molecular_function unknown rRNA processing* nucleolus YNL243W Coiled-coil growth-regulated. May contribute to compartmentalization of nucleolar constituents. coiled-coil protein Null mutant is inviable; CGR1 expression is down-regulated in the postdiauxic growth phase
CHA4 YLR098C transcription factor activity regulation of transcription, DNA-dependent* nucleus YDR034C YPL130W YDL076C YDL239C Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain DNA binding transcriptional activator of CHA1 Unable to grow with serine or threonine as the sole nitrogen source, suppresses ilv1 mutant by causi
CHC1 YGL206C structural molecule activity vesicle-mediated transport clathrin vesicle coat YGR241C YIL094C YGR167W YHR161C YKR026C YHR108W YOR181W YPL106C YBR169C YDL192W vesicle coat protein Clathrin heavy chain Null mutant is viable, but is slow-growing and shows defects in mating, sporulation and vesicle ultr
CHD1 YER164W ATPase activity* chromatin modeling* transcription elongation factor complex YGL019W YKR001C YNL030W YIL035C YOR039W YOR304W YOR061W YBR245C YOR319W YPR135W YCL016C Sole S. cerevesiae member of CHD gene family containing Chromodomain, Helicase domain, and DNA-bindi transcriptional regulator Null mutant is viable, resistant to 6-azauracil
CHK1 YBR274W protein kinase activity protein amino acid phosphorylation* nucleus YLR152C YNL234W YKL104C YJL036W YLR258W YIL084C YDR217C YPR124W YMR255W YER171W YER081W YNR013C YLR103C YDL017W YDR052C checkpoint kinase 1; homolog of the S. pombe and mammalian Chk1 checkpoint kinases protein kinase Mutants are defective in the DNA damage checkpoint operating at metaphase
CHL1 YPL008W DNA helicase activity chromosome segregation nucleus YOL150C YJL030W YLR200W YNL153C YML094W YCL061C YGL086W YGR188C YPR119W YDR254W YPL018W YDR318W YJR135C YJL013C YLR381W YDR014W YLR315W YPR046W YJL092W YKL113C YOR014W YOR144C YER016W YEL061C YPR141C YDR332W YHR191C YMR078C YCL016C YDL003W YGR078C YE Required for mitotic chromosome segregation, needed for wild-type levels of meiotic recombination an deah box protein|kinetochore protein Null mutant is viable, ts mutants mis-segregate chromosomes at permissive temperature leading to inc
CHL4 YDR254W DNA binding chromosome segregation condensed nuclear chromosome kinetochore YBR107C YEL077C YIL111W YER016W YEL061C YPR141C YPR135W YDL003W YPL008W YJL030W YLR200W YGR078C YNL153C YEL003W YML094W YOR349W Protein necessary for stability of ARS-CEN plasmids; suggested to be required for kinetochore functi Null mutant is viable. Some authors report a temperature-senstive deletion allele, while others fine
CHO1 YER026C CDP-diacylglycerol-serine O-phosphatidyltransferase activity phosphatidylserine biosynthesis endoplasmic reticulum YMR153W phosphatidylserine synthase phosphatidylserine synthase The null mutant is viable but grows slowly on minimal medium. The growth rate of the null mutant on
CHO2 YGR157W phosphatidylethanolamine N-methyltransferase activity phosphatidylcholine biosynthesis endoplasmic reticulum YKL190W YPL031C YOR070C YGR166W YBR229C First step in the methylation pathway for phosphatidylcholine biosynthesis phosphatidyl-ethanolamine N-methyltransferase Null mutant is viable and accumulates phosphatidylethanolamine and has reduced levels of phosphatidy
CHS1 YNL192W chitin synthase activity budding plasma membrane* YBR209W YDL206W YDR248C YDR314C YEL033W YFR045W YGL081W YIL110W YMR003W YNL087W YNL171C YNL179C YNL200C YNL203C YNL228W YNL235C YOR322C YPL261C YPR053C YJL095W YLR370C YEL031W YER149C YHR012W YJL154C YMR123W YOR069W YOR132W YKR042W YAL013W YOR043W YP disrupts mating and sporulation efficiently chitin synthase 1 Null mutant is viable
CHS2 YBR038W chitin synthase activity response to osmotic stress* contractile ring (sensu Saccharomyces) YCL022C YHR123W YPL020C YPR106W chitin synthase 2 chitin synthase 2 disruption results in loss of well-defined septa and in growth arrest
CHS3 YBR023C chitin synthase activity response to osmotic stress* contractile ring (sensu Saccharomyces) YBR077C YDL032W YDL033C YLR111W YLR338W YNL171C YDR129C YBL007C YDR388W YNL298W YNL271C YMR089C YJL095W YLR087C YOR035C YFR036W YGL240W YLR370C YBR023C YBL061C YLR337C YJR118C YMR116C YKR020W YGR229C YNR051C YPL069C YPL055C YNL079C YLR342W YFR019W YJ Required for chitin synthesis. Enzyme responsible for the hyperaccumulation of chitin in response to chitin synthase 3 Null mutant exhibits reduced chitin levels, lack of chitin synthase III activity in vitro, derepress
CHS5 YLR330W molecular_function unknown conjugation with cellular fusion* cytoplasm YDL033C YDL206W YFR045W YGL081W YGL152C YLR111W YNL171C YDR129C YBL007C YNL298W YOR089C YOL009C YCR077C YJL095W YLR087C YKL010C YLR370C YER149C YJL183W YLR268W YMR116C YKR020W YGR229C YCR009C YDL074C YPL055C YDR378C YPL161C YNL079C YLR342W YFR019W YJ Involved in chitin synthase III activity, also required for homozygosis in the first stages of matin Null mutant is viable, cells exhibit a strong mating defect; sensitive to Calcofluor, reduced amount
CHS7 YHR142W molecular_function unknown ER to Golgi transport* endoplasmic reticulum membrane YLR111W YDR129C YBL007C YDR388W YNL298W YNL271C YFL036W YHR030C YJL095W YOR035C YLR337C YGR229C YKL127W YNL079C YLR342W YJL148W YDL117W YLR425W YBL047C YML115C YDR245W YNL329C YGR135W YJR073C YLR110C YKR082W YIL121W YDR318W YJL131C YBR234C YDL029W YK The seventh gene identified that is involved in chitin synthesis; involved in Chs3p export from the Null mutant is viable but exhibit reduced chitin synthesis due to a severe reduction of Chitin Synth
CIC1 YHR052W protein binding, bridging protein catabolism nucleolus* YNL132W YNL061W YKL172W YDR194C YOR206W YBR142W YOR310C YMR229C YER006W YPL043W YHR066W YDR060W YKR081C YNL110C YGR103W YMR049C YMR093W YOR005C YOR080W YOR272W YIL035C YNL230C YNL175C YDL213C YER133W YLR074C YPL131W YPL259C Core interacting component 1 Null: lethal. Other phenotypes: cic1-2 ts mutant stabilizes F-box proteins.
CIK1 YMR198W microtubule motor activity meiosis* spindle pole body* YPR141C YDR022C YMR012W YBR234C YFL037W YHR129C YDR332W YMR078C YCL016C YCL061C YNL273W YJR057W YOR025W YJR075W YLR113W chromosome instability and karyogamy; CIK1 is important for proper organiziatio Kar3-binding protein Null mutant is viable but is defective in both karyogamy and chromosome maintenance and does not sho
CIN1 YOR349W co-chaperone activity post-chaperonin tubulin folding pathway* microtubule YML085C YPL269W YGL086W YGR188C YPR135W YOL012C YDR254W YHR191C YPL018W YDR318W YJL013C YGL190C YFL037W YER016W YHR129C YMR294W YPL174C YKR054C YDR424C YDR488C YMR299C YDR150W YCL029C YLR085C YPL155C YEL061C YML124C YOR265W YPL241C YMR138W YMR078C YC Protein involved in chromosome segregation, required for microtubule stability tubulin folding cofactor D Null mutant is viable, exhibits cold sensitivity for viability; defect in nuclear migration and nucl
CIN5 YOR028C RNA polymerase II transcription factor activity regulation of transcription from Pol II promoter* nucleus YER022W YGL154C YGR167W YGR211W YJL057C YLR373C YLR446W YLR447C YNL092W YLR247C Protein involved in silencing bZIP (basic-leucine zipper) protein|can activate transcription from a promoter containing a Yap reco Null mutant is viable and suppresses the cold sensitivity of yap1 mutants
CIN8 YEL061C microtubule motor activity mitotic chromosome segregation* kinesin complex* YDR149C YLL049W YNL298W YJL030W YER155C YLR200W YNL153C YEL003W YMR294W YPL174C YGR078C YGR229C YLR210W YML094W YOR349W YHR129C YER007W YGL086W YGR188C YML124C YPL241C YCR086W YKL048C YKR054C YOR269W YPL155C YPR119W YMR048W YMR138W YCL029C YOR026W YP Kinesin-related protein involved in establishment and maintenance of mitotic spindle Null mutant is viable; cin8 dyn1 and cin8 kip1 double deletion mutants are inviable
CIS3 YJL158C structural constituent of cell wall cell wall organization and biogenesis plasma membrane* YJR030C YLR226W cik1 suppressor similar to Hsp150p and Pir1p, Pir2p, and Pir3p Null mutant is viable; CIS3 is a high copy suppressor of cik1 deletion mutants
CIT1 YNR001C citrate (Si)-synthase activity tricarboxylic acid cycle* mitochondrion* YER022W YLR447C citrate synthase. Nuclear encoded mitochondrial protein. citrate synthase Null mutant is viable; disruption of both CIT1 and CIT2 result in glutamate auxotrophy and poor grow
CIT2 YCR005C citrate (Si)-synthase activity glutamate biosynthesis* peroxisome YCR005C YJL042W YPL245W non-mitochondrial citrate synthase citrate synthase Null mutant is viable; disruption of both CIT1 and CIT2 result in glutamate auxotrophy and poor grow
CIT3 YPR001W citrate (Si)-synthase activity tricarboxylic acid cycle* mitochondrial matrix YER103W Mitochondrial isoform of citrate synthase citrate synthase Null mutant shows severely reduced growth on the respiratory substrate glycerol in a delta cit1 back
CKI1 YLR133W choline kinase activity phosphatidylcholine biosynthesis cytosol YGL021W YMR139W choline kinase choline kinase Null mutant is viable
CLA4 YNL298W protein serine/threonine kinase activity protein amino acid phosphorylation* actin cap (sensu Saccharomyces) YBL062W YBR174C YML094C-A YPL047W YLR386W YNL271C YLR319C YLR102C YHR030C YJL095W YBR023C YBL061C YLR330W YJL099W YHR142W YBR200W YER155C YER149C YNL153C YPL174C YGR229C YML094W YBR175W YDR424C YHR200W YHR152W YPL161C YGR200C YNL206C YHL007C YHR107C Involved in localizing cell growth with respect to the septin ring Ste20p homolog|protein kinase Null mutant is viable, possesses a cytokinesis defect; cla4 cln1 cln2 strains are inviable; cla4 ste
CLB2 YPR119W cyclin-dependent protein kinase, intrinsic regulator activity G2/M transition of mitotic cell cycle* nucleus* YDR412W YHR035W YKR048C YER111C YBR160W YBR135W YBR024W YDR025W YNL135C YDR386W YNR022C YOR264W YJL187C YOR058C YEL061C YPR135W YHR191C YMR078C YCL016C YPL008W YDL017W YNL250W Involved in mitotic induction B-type cyclin Null mutant is viable (lethal in combination with clb1 mutation)
CLB5 YPR120C cyclin-dependent protein kinase, intrinsic regulator activity G1/S transition of mitotic cell cycle* nucleus YJL048C YKR077W YOR066W YPL269W YDR130C YBR160W YLR079W YNL309W YER032W YMR232W YDR122W YMR036C YER105C YOR264W YJR091C YBR135W YPR135W YCL016C YLR103C role in DNA replication during S phase; additional functional role in formation of mitotic spindles B-type cyclin Null mutant is viable, but has an extended S phase
CLC1 YGR167W structural molecule activity vesicle-mediated transport clathrin vesicle coat YGR241C YHR161C YOR028C YGL206C YDR320C Clathrin light chain clathrin light chain Null mutant is viable but slow-growing and shows defects in receptor-mediated endocytosis, maturatio
CLF1 YLR117C molecular_function unknown nuclear mRNA splicing, via spliceosome* spliceosome complex YDR412W YDR416W YBR188C YML049C YLL036C YAL032C YPR101W YKL173W YJR050W YMR213W YMR240C YBR065C YGL120C YHR165C YFL017W-A YKL095W YBR190W YBR244W YBL050W SYnthetic lethal with cdcForty; Crooked neck Like Factor, an ortholog of the Drosophila crooked neck pre-mRNA splicing factor Null mutant is inviable; clf1 alleles show synthetic lethality with cdc40/prp17 and are defective in
CLG1 YGL215W cyclin-dependent protein kinase, intrinsic regulator activity cell cycle cyclin-dependent protein kinase holoenzyme complex YMR047C YPL031C YPR159W cyclin-like protein that interacts with Pho85p in affinity chromatography Null mutant is viable
CLN1 YMR199W cyclin-dependent protein kinase, intrinsic regulator activity regulation of CDK activity nucleus* YBR160W YPL255W YMR105C YPL256C YBR135W YGR211W YJR091C YAL040C YDL132W role in cell cycle START G1 cyclin Null mutant is viable, exhibits G1 arrest
CLN2 YPL256C cyclin-dependent protein kinase, intrinsic regulator activity regulation of CDK activity* nucleus* YBR039W YBR160W YEL030W YBR135W YDR054C YAL040C YMR199W YDL132W YKL092C YNL192W role in cell cycle START G1 cyclin Null mutant is viable, exhibits G1 arrest; dominant mutation advances the G(sub)1- to S- phase trans
CLN3 YAL040C cyclin-dependent protein kinase, intrinsic regulator activity G1/S transition of mitotic cell cycle* nucleus YPL014W YDL047W YFR040W YOR269W YJL157C YJL013C YLL021W YPL256C YMR199W YNL064C YDL132W YER167W YOL145C YJL098W YKR028W YJR132W YKL092C YBR160W role in cell cycle START; involved in G(sub)1 size control G1 cyclin Null mutant is viable; dominant mutation causes alpha-factor resistance and small cell size; chromos
CLP1 YOR250C cleavage/polyadenylation specificity factor activity mRNA polyadenylation* mRNA cleavage factor complex YBL075C YMR061W YDR228C YGL044C YDL195W cleavage/polyadenylation factor IA subunit; interacts with Pcf11p in the 2-hybrid system cleavage and polyadenylation factor CF I component involved in pre-mRNA 3'-end processing Null mutant is inviable
CLU1 YMR012W molecular_function unknown translational initiation* cytoplasm* YGL130W YBR017C YDR148C YBR142W YER171W YER095W YBR143C YGR274C YBL039C YDR266C YGL174W YCR084C YPR015C YJR076C YMR059W YIR001C YJL157C YGR067C YBR160W YML064C YBR136W YMR198W YDL043C YAL036C YBR055C YMR106C YER133W YAL015C YOL006C CLU1 is similar to the Dictyostelium cluA gene Sometimes copurifies with translation initiation factor eIF3, but apparently not required for transl Null mutant is viable, growth is normal, mitochondrial network is collapsed to one side of the cell
CMD1 YBR109C calcium ion binding cytoskeleton organization and biogenesis* cytoplasm* YDR356W YML094C-A YMR111C YLL050C YOR035C YDR155C YMR105C YMR109W YBR130C YDR032C YBL076C YBR011C YOR326W YBL047C YEL034W YGR094W YJR104C YGL043W YAL029C YGL106W YML057W YKL129C YGL141W YLL040C YKL210W YKL067W YNL281W YOL016C YFR014C YLR433C master regulator of calcium mediated signalling calmodulin Null mutant is inviable
CMK1 YFR014C calmodulin-dependent protein kinase I activity protein amino acid phosphorylation* cytoplasm YKL119C YBR109C Calmodulin-dependent protein kinase calmodulin-dependent protein kinase Null mutant is viable
CMP2 YML057W calcium-dependent protein serine/threonine phosphatase activity cell ion homeostasis* cytoplasm YPR108W YNL047C YKL081W YNL037C YNL290W YKL190W YLR096W YHR082C YLR342W YBR109C calmodulin binding protein homologous to mammalian calcineurin calcineurin subunit A Null mutant is viable (no obvious phenotype)
CNA1 YLR433C calcium-dependent protein serine/threonine phosphatase activity cell wall organization and biogenesis* cytoplasm YGR263C YDL186W YHR182W YOR324C YIR009W YNL047C YLR147C YBR109C YLR453C YKL190W YLR342W calmodulin binding protein homologous to mammalian calcineurin calcineurin subunit A Null mutant is viable (no obvious phenotype)
CNB1 YKL190W calcium-dependent protein serine/threonine phosphatase activity cell wall organization and biogenesis* cytoplasm YKL118W YKL212W YHR026W YAL023C YLR087C YPR159W YNL322C YER083C YBR200W YJL183W YPL234C YDR136C YDR137W YGR105W YKL119C YKR001C YLR261C YLR447C YNL238W YLR262C YGR229C YPL069C YKL080W YLR342W YAL026C YML115C YHR060W YMR307W YDL020C YHR039C-A YJR073C Type 2B protein phosphatase; regulatory B subunit of calcineurin calcineurin regulatory B subunit|type 2B protein phosphatase Null mutant is viable, Li+ and Na+ sensitive, cnb1 fks1 and cnb1 vma3 double mutants are inviable
CNE1 YAL058W molecular_function unknown ER-associated protein catabolism integral to endoplasmic reticulum membrane YNL171C YNR036C YGL084C YNL064C YKL194C YKL197C YOR236W YNL322C Functions in endoplasmic reticulum protein quality control calnexin and calreticulin homolog Null mutant is viable, increase of cell-surface expression of ste2-3p, increase in secretion of hete
CNM67 YNL225C structural constituent of cytoskeleton microtubule nucleation spindle pole body* YBR184W chaotic nuclear migration; predicted mass is 67kDa Null mutant is viable but shows slow growth and a nuclear migration defect
CNS1 YBR155W chaperone activity protein folding cytoplasm YPL240C YJR032W YMR186W YGR234W YGR187C YEL030W YLR355C YDR463W YER081W YJR091C cyclophilin seven suppressor Null mutant is inviable; overexpression of CNS1 restores normal growth and Hsp90 activity in a cpr7
COB Q0105 ubiquinol-cytochrome-c reductase activity aerobic respiration* respiratory chain complex III (sensu Eukarya) Cytochrome b cytochrome b Null mutant is viable and unable to grow on nonfermentable carbon sources
COF1 YLL050C actin filament severing activity actin filament organization* actin cortical patch (sensu Saccharomyces) YFL039C YNL138W YLR059C YGR233C YGL195W YLR429W YMR092C YGL179C YGL241W YJL005W YLR453C YPR033C YNL094W YJR090C YMR059W YFR016C YOR080W YML064C YLR074C YBR109C YGR080W yeast cortical cytoskeleton component; mammalian cofilin homolog actin binding and severing protein|cofilin Null mutant is inviable
COG1 YGL223C molecular_function unknown intra-Golgi transport* Golgi transport complex YDR034C YNL041C Conserved Oligomeric Golgi complex 1
Com
COG2 YGR120C protein binding ER to Golgi transport* soluble fraction* YGR119C YMR025W YNL041C YNL086W YOR158W YDL058W YER157W YFL038C YPR185W YAL034W-A YFR002W YDR311W YLR423C YNR025C YOR353C YPR105C Conserved Oligomeric Golgi complex 2
Sec Null mutant shows severe growth defect at 30 degrees and is inviable at 21 degrees; sec35-1 allele i
COG3 YER157W protein transporter activity ER to Golgi transport* soluble fraction* YOR216C YLR268W YGR120C YIL004C YFL038C YDR189W YDL058W YKL196C YDL005C YLR295C Conserved Oligomeric Golgi complex 3
sec Strains carrying the null allele are extremely slow growing; they display a severe growth defect at
COG4 YPR105C molecular_function unknown intra-Golgi transport* Golgi transport complex YMR181C YOR164C YOR331C YLR423C YPR191W YGR120C YLR315W YHR060W YGL153W YIL144W YGL145W Conserved Oligomeric Golgi complex 4
Com
COG5 YNL051W molecular_function unknown intra-Golgi transport Golgi transport complex YJR082C YPL051W YOR070C YLR039C YLR262C YBR164C YDR126W Conserved Oligomeric Golgi complex 5
Com
COG6 YNL041C molecular_function unknown intra-Golgi transport Golgi transport complex YDR115W YLR386W YGR120C YDR229W YIL144W YGL172W YGL223C YJL191W YPL051W YOR070C YLR039C YLR262C YLR085C YBR164C YDR126W Conserved Oligomeric Golgi complex 6
Com
COG7 YGL005C molecular_function unknown intra-Golgi transport Golgi transport complex YGR119C YLR453C YPL051W YOR070C YLR039C YLR262C YBR164C YDR126W Conserved Oligomeric Golgi complex 7
Com
COG8 YML071C molecular_function unknown intra-Golgi transport Golgi transport complex YNL265C YPL051W YOR070C YLR039C YLR262C YJR075W YDL049C YBR164C YDR126W Conserved Oligomeric Golgi complex 8
dep
COP1 YDL145C molecular_function unknown ER to Golgi transport* COPI vesicle coat YPL222W YDR216W YKL211C YBR039W YEL060C YIL076W YNL287W YJL117W YGL137W YFR051C YPL010W YDR238C YCR093W YER122C YNL284C YCR012W YKL108W YJL157C YDL043C YIL147C YJL187C YGL081W YBL056W YOL087C YMR106C alpha subunit of the coatamer complex; gamma-alpha-COP coatomer complex gamma-alpha-COP alpha subunit Null mutant is inviable; other cop1 alleles show secretion and protein sorting defects
COQ1 YBR003W trans-hexaprenyltranstransferase activity ubiquinone metabolism mitochondrion YJR022W YER022W hexaprenyl diphosphate synthesis hexaprenyl pyrophosphate synthetase respiratory defective
COQ2 YNR041C prenyltransferase activity* ubiquinone metabolism mitochondrial inner membrane YLR222C YLR373C YLR330W transfers polyprenyl group to p-hydroxybenzoic acid (the aromatic ring precursor of CoQ) para hydroxybenzoate: polyprenyl transferase Null mutant is viable but is respiratory defective and lacks PHB:polyprenyltransferase activity
COQ3 YOL096C hexaprenyldihydroxybenzoate methyltransferase activity ubiquinone metabolism* mitochondrion* 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase Null mutant is viable, fails to grow on H2O2; fails to grow on glycerol
COQ4 YDR204W molecular_function unknown ubiquinone metabolism mitochondrial inner membrane Involved in ubiquinone biosynthesis. encodes component of the coenzyme Q biosynthetic pathway Unable to produce ubiquinone, hypersensitivity to polyunsaturated fatty acid treatment
COQ5 YML110C ubiquinone biosynthesis methyltransferase activity aerobic respiration* mitochondrion YGL115W co-enzyme Q deficient C-methyltransferase (putative) Null mutant is viable, respiratory deficient, petite.
COQ6 YGR255C ubiquinone biosynthesis monooxygenase activity ubiquinone metabolism mitochondrion* Involved in ubiquinone biosynthesis monooxygenase Unable to produce ubiquinone, hypersensitivity to polyunsaturated fatty acid treatment
COR1 YBL045C ubiquinol-cytochrome-c reductase activity aerobic respiration respiratory chain complex III (sensu Eukarya) YPR191W YLR090W YMR047C YPL204W YKL095W YGL137W YIL061C YMR059W YPR054W YOR125C YMR036C YML064C YDL179W YDR339C YDR388W YLR442C 44 kDa core protein of yeast coenzyme QH2 cytochrome c reductase coenzyme QH2 cytochrome c reductase 44 kDa core protein subunit deficiency in cytochrome b; slow growth on glycerol
COS10 YNR075W molecular_function unknown endocytosis cytoplasm* YLL012W Protein with strong similarity to subtelomerically-encoded proteins such as Cos5p, Ybr302p, Cos3p, C
COS8 YHL048W molecular_function unknown response to unfolded protein nuclear membrane YKL079W Protein with similarity to subtelomerically-encoded proteins such as Cos5p, Ybr302p, Cos3p, Cos1p, C
COT1 YOR316C di-, tri-valent inorganic cation transporter activity* zinc ion homeostasis* vacuole (sensu Fungi) Protein involved in cobalt accumulation; dosage dependent suppressor of cobalt toxicity Null mutant is viable, yet increased sensitivity to cobalt
COX1 Q0045 cytochrome-c oxidase activity aerobic respiration respiratory chain complex IV (sensu Eukarya) cytochrome-c oxidase subunit I cytochrome c oxidase subunit I unable to grow on nonfermentable carbon sources
COX10 YPL172C protoheme IX farnesyltransferase activity heme a biosynthesis mitochondrial inner membrane YER063W YJR075W Required for an essential posttranslational stage in assembly of cytochrome oxidase farnesyl transferase (putative) mutant lacks cytochrome oxidase activity and cytochromes a and a3 and is respiratory-defective
COX11 YPL132W molecular_function unknown aerobic respiration mitochondrial inner membrane YLR330W Mitochondrial membrane protein required for insertion of Cu(B) and magnesium during assembly of cyto deficient in cytochrome oxidase; sensitive to photoactivated 3-carbethoxypsoralen, UV light, radiomi
COX12 YLR038C cytochrome-c oxidase activity cytochrome c oxidase biogenesis respiratory chain complex IV (sensu Eukarya) YML125C essential during assembly for full cytochrome c oxidase activity cytochrome c oxidase subunit VIb Null mutant is viable, grows poorly at room temperature, fails to grow on glycerol/ethanol media at
COX13 YGL191W enzyme regulator activity* aerobic respiration respiratory chain complex IV (sensu Eukarya) Modulates cytochrome c oxidase activity cytochrome c oxidase subunit VIa|may specifically interact with ATP Null mutant is viable, shows slightly reduced growth rate on nonfermentable carbon sources
COX14 YML129C molecular_function unknown aerobic respiration* integral to membrane* YOR110W Mitochondrial membrane protein, required for assembly of cytochrome c oxidase mitochondrial membrane protein Nuclear respiration deficient, lack cytochromes a and a3 and detectable cytochrome oxidase activity
COX15 YER141W molecular_function unknown cytochrome c oxidase biogenesis* mitochondrial inner membrane cytochrome oxidase assembly factor cytochrome oxidase assembly factor fail to synthesize cytochrome oxidase
COX16 YJL003W molecular_function unknown aerobic respiration* mitochondrial inner membrane YNL098C Cytochrome oxidase assembly Required for assembly of cytochrome oxidase Null: viable, respiration deficient
COX17 YLL009C copper ion transporter activity cytochrome c oxidase biogenesis* cytosol* YBR024W YJR091C YBR037C YBL050W Involved in copper metabolism and assembly of cytochrome oxidase cysteine-rich protein Null mutant is viable, respiratory defective, rescued by addition of copper to growth media and/or h
COX18 YGR062C molecular_function unknown cytochrome c oxidase biogenesis mitochondrial inner membrane* YDL193W Mitochondrial inner membrane protein, required for export of the Cox2p C terminus from the mitochond Null mutant is viable, respiratory deficient due to inactivity of cytochrome oxidase
COX19 YLL018C-A metal ion transporter activity cytochrome c oxidase biogenesis* cytosol* cytochrome oxidase gene 19. Clone containing this region complements respiratory deficient mutants o Mutants are respiratory deficient.
COX2 Q0250 cytochrome-c oxidase activity aerobic respiration respiratory chain complex IV (sensu Eukarya) subunit II of cytochrome c oxidase cytochrome c oxidase subunit II respiration-deficient
COX20 YDR231C chaperone activity aerobic respiration* mitochondrial inner membrane COX: cytochrome oxidase, 20: 20th gene involved in cytochrome oxidase activity required for maturation and assembly of cytochrome oxidase subunit II Null mutant is respiratory-deficient and has no cytochrome oxidase activity or accumulation of precu
COX3 Q0275 cytochrome-c oxidase activity aerobic respiration respiratory chain complex IV (sensu Eukarya) Cytochrome-c oxidase subunit III, mitochondrially-coded cytochrome c oxidase subunit III|mitochondrially encoded Null mutant is viable and unable to grow on nonfermentable carbon sources
COX4 YGL187C cytochrome-c oxidase activity aerobic respiration respiratory chain complex IV (sensu Eukarya) YML042W YGL213C YDL067C YBR133C subunit IV of cytochrome c oxidase cytochrome c oxidase subunit IV Null mutant is viable and unable to grow on nonfermentable carbon sources
COX5A YNL052W cytochrome-c oxidase activity aerobic respiration respiratory chain complex IV (sensu Eukarya) YDL067C One of two genes (COX5A and COX5B, both nuclear-encoded) coding for subunit V of cytochrome c oxidas cytochrome c oxidase chain Va Null mutant is viable, respires at 10-15% of the wild-type rate due to the presence of COX5B; cox5a
COX5B YIL111W cytochrome-c oxidase activity anaerobic respiration respiratory chain complex IV (sensu Eukarya) YDR254W YLR295C Cytochrome-c oxidase chain Vb cytochrome c oxidase chain Vb Null mutant is viable
COX6 YHR051W cytochrome-c oxidase activity aerobic respiration respiratory chain complex IV (sensu Eukarya) YDL067C YNL061W subunit VI of cytochrome c oxidase cytochrome c oxidase subunit Null mutant is viable, sensitive to H2O2
COX7 YMR256C cytochrome-c oxidase activity aerobic respiration respiratory chain complex IV (sensu Eukarya) subunit VII of cytochrome c oxidase cytochrome c oxidase subunit VII Null mutant is viable, lacks cytochrome c oxidase activity and haem a/a3 spectra; respiratory defici
COX8 YLR395C cytochrome-c oxidase activity aerobic respiration respiratory chain complex IV (sensu Eukarya) YFR008W Cytochrome-c oxidase chain VIII cytochrome c oxidase chain VIII Null mutant is viable, deficient in cellular respiration and cytochrome C oxidase activity
COX9 YDL067C cytochrome-c oxidase activity aerobic respiration respiratory chain complex IV (sensu Eukarya) YGL187C YNL052W YHR051W YDR318W Plays role in cytochrome c oxidase holoenzyme assembly or stability cytochrome c oxidase subunit VIIa Lacks functional cytochrome c oxidase holoenzyme
COY1 YKL179C molecular_function unknown Golgi vesicle transport Golgi membrane YPL022W CASP Of Yeast
CPA1 YOR303W carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity arginine biosynthesis cytosol YOR039W YNL036W YER022W YJR091C YLR197W YMR134W YDR260C Carbamoyl phosphate synthetase, arginine specific arginine specific|carbamoyl phosphate synthetase Null mutant is viable
CPA2 YJR109C carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity arginine biosynthesis cytosol YER095W YBL039C YBR217W YJR068W YMR106C YHR169W carbamyl phosphate synthetase carbamyl phosphate synthetase Null mutant is viable
CPR1 YDR155C peptidyl-prolyl cis-trans isomerase activity protein metabolism histone deacetylase complex YKR105C YPL235W YNL030W YBR103W YIL112W YOR290C YCR033W YER081W YDL220C YJL020C YNL094W YFL014W YJR090C YNL244C YMR059W YOR319W YDL101C YMR036C YML095C YML064C YDR510W YKL103C YIR005W YNL157W YLR074C YBR109C YLR200W YEL003W cyclophilin peptidyl-prolyl cis-trans isomerase cyclophilin|peptidyl-prolyl cis-trans isomerase (PPIase) Null mutant is viable
CPR3 YML078W peptidyl-prolyl cis-trans isomerase activity protein folding mitochondrion YML064C cyclophilin-3 (cyclosporin-sensitive proline rotamase-3) cyclophilin|peptidyl-prolyl cis-trans isomerase (PPIase) Null mutant is viable, unable to grow on L-lactate at 37 degrees C
CPR4 YCR069W peptidyl-prolyl cis-trans isomerase activity biological_process unknown membrane cyclophilin homolog cyclophilin|peptidyl-prolyl cis-trans isomerase (PPIase) suppressor of cdc65
CPR5 YDR304C peptidyl-prolyl cis-trans isomerase activity biological_process unknown cytoplasm* YDL100C Cyclophilin D, Peptidyl-prolyl cis-trans isomerase D cyclophilin D|peptidyl-prolyl cis-trans isomerase (PPIase) Null mutant is viable
CPR6 YLR216C chaperone activity* protein folding cytoplasm YOR154W YOR220W YMR303C YPL240C YNL278W YDR353W YHR074W YIR037W YKL057C YDR523C YBR217W YGL137W YDR398W YGR262C YHR030C YDR128W YDR394W YJR017C YKL166C YNL330C YDR162C YNR032W YDL105W YMR294W YPL174C YDR150W YPR141C a cyclophilin related to the mammalian CyP-40; physically interacts with RPD3 gene product cyclophilin 40|peptidyl-prolyl cis-trans isomerase (PPIase) Null mutant is viable, has normal growth rate
CPR7 YJR032W chaperone activity* response to stress cytosol YNL330C YBR155W YBR234C YDL029W YPL051W YOR070C YLR200W YGR078C YNL153C YEL003W YML094W YDL017W YBR164C a cyclophilin related to the mammalian CyP-40; physically interacts with RPD3 gene product cyclophilin 40|peptidyl-prolyl cis-trans isomerase (PPIase) Null mutant is viable, but grows slowly
CPS1 YJL172W Gly-X carboxypeptidase activity proteolysis and peptidolysis* vacuole (sensu Fungi) YGR285C carboxypeptidase yscS carboxypeptidase yscS Null mutant is viable; leucine auxotroph
CPT1 YNL130C diacylglycerol cholinephosphotransferase activity phosphatidylcholine biosynthesis endoplasmic reticulum Phospholipid biosynthesis sn-1,2-diacylglycerol cholinephosphotransferase Null mutant is viable, cpt1 ept1 double deletion mutants are viable
CRC1 YOR100C carnitine/acyl carnitine carrier activity fatty acid metabolism mitochondrion* YGR240C YGR056W YBR195C carnitine carrier carnitine transporter Null mutant is viable
CRD1 YDL142C cardiolipin synthase activity lipid biosynthesis* mitochondrial membrane YPL174C Cardiolipin synthase cardiolipin synthase Null mutant is viable, exhibits growth defects in galactose and glycerol/ethanol media
CRH1 YGR189C molecular_function unknown biological_process unknown cell wall (sensu Fungi)* YDL100C YDR034C YNL092W congo red hypersensitive cell wall protein Null mutant is viable and hypersensitive to Congo Red and Calcofluor White
CRM1 YGR218W protein carrier activity mRNA-nucleus export* nucleus YDR102C YER004W YFL068W YGL149W YMR124W YPL056C YMR235C YCR077C YOR184W YPL120W YGR178C YJR083C YKL143W YML007W YDL065C YDR229W YKL068W YGR119C YBL031W YDR016C YDR192C YEL015W YER062C YGL170C YJL210W YJR134C YLR151C YLR436C YML120C YNL164C YOL149W YO Involved in nuclear export chromosome region maintenance protein Null mutant is inviable; a temperature sensitive crm1 allele shows defects in nuclear protein export
CRN1 YLR429W microtubule binding* actin filament organization* actin cortical patch (sensu Saccharomyces) YDR328C YPL032C YNL094W YBR143C YLL050C YDL195W Crn1p associates with the Arp2/3 complex and inhibits WA- and Abp1-activated actin nucleation in the Dictyostelium and human actin-binding protein coronin homolog Overexpression of CRN1 causes growth arrest and redistribution of Arp2p and Crn1p into aberrant acti
CRP1 YHR146W DNA binding biological_process unknown nucleus Cruciform DNA Binding Protein 1 Cruciform DNA binding protein Null: Null mutant is viable and shows no growth defects
CRS5 YOR031W copper ion binding response to metal ion cytoplasm YGR035C Metallothionein-like protein metallothionein-like protein Null mutant is viable, exhibits increased sensitivity to copper toxicity
CRZ1 YNL027W transcription factor activity regulation of transcription, DNA-dependent* nucleus* YNR018W YJR132W YER120W YHR207C YPL204W YLR342W calcineurin responsive zinc-finger transcription factor Null mutant is viable
CSE1 YGL238W importin-alpha export receptor activity protein-nucleus export nuclear membrane YNL189W YLR293C YDR170C YNL236W homologue of human CAS; specific exportin for Srp1p; required for accurate mitotic chromosome segreg Null mutant is inviable
CSE2 YNR010W RNA polymerase II transcription mediator activity transcription from Pol II promoter* mediator complex YOR174W YNL055C YOL139C YDL005C YOL135C YBL093C YBR253W YGL127C Protein required for accurate mitotic chromosome segregation RNA polymerase II mediator subcomplex component Null mutant is viable, accumulates large-budded cells, results in significant increase in chromosome
CSE4 YKL049C centromeric DNA binding mitotic chromosome segregation condensed nuclear chromosome, pericentric region* YJR060W Required for proper kinetochore function; may be involved in assembly of a CEN-specific chromatin st similar to histone H3 and to human centromere protein CENP-A Null mutant is inviable; cse4-1 mutant causes increased non-disjunction of chromosome with mutated C
CSG2 YBR036C molecular_function unknown calcium ion homeostasis integral to endoplasmic reticulum membrane YBR265W YDL015C YMR272C YDR270W YDR062W YDR208W YDR297W YKL203C YER093C YPL231W YMR296C YNL330C YOL004W YPL057C YOR070C YLR085C YLR103C Required for growth in high (>25mM) calcium, contains 9 or 10 putative membrane spanning regions required for mannosylation of inositolphosphorylceramide (IPC) Null mutant is viable but Ca2+-sensitive; a presumed point mutant is sensitive to Ca2+ levels greate
CSI1 YMR025W molecular_function unknown adaptation to pheromone during conjugation with cellular fusion* signalosome complex YER137C YLR423C YGR120C YNR052C YDL216C YDR179C COP9 signalosome interactor Interactor with COP9 signalosome (CSN) complex
CSL4 YNL232W 3'-5' exoribonuclease activity 35S primary transcript processing* nuclear exosome (RNase complex)* YIR035C YCR035C YOR001W YOL021C YGR158C YHR069C YDL111C YGR195W YOR076C YDR280W YGR095C YJR060W Represses the replication of double-stranded RNA viruses, protecting the host from the otherwise let Null mutant is inviable, csl4-1 exhibits double mutant inviability in combination with cbf1(cep1) de
CSM1 YCR086W molecular_function unknown meiotic chromosome segregation nuclear membrane YKL077W YDR412W YOR281C YOL020W YDL089W YDL214C YER106W YKR010C YLR291C YGR155W YDR439W YML095C YGL175C YHR152W YDR061W YOR264W YPL093W YHR061C YDR309C YOR098C YML109W YOR058C YEL061C YLR200W YGR078C YNL153C YEL003W YML094W YLR103C YNL250W YJR057W YB Chromosome segregation in meiosis Null: missegregates chromosomes in meiosis
CSN12 YJR084W molecular_function unknown adaptation to pheromone during conjugation with cellular fusion signalosome complex YFL017W-A YPR182W YMR048W YJR075W subunit of COP9 signalosome (CSN) COP9 signalosome (CSN) subunit
CSN9 YDR179C molecular_function unknown adaptation to pheromone during conjugation with cellular fusion* signalosome complex YMR025W YDL216C YJR015W YDL147W YKR060W YHR005C subunit of Cop9 Signalosome (CSN) COP9 signalosome (CSN) subunit
CSR1 YLR380W phosphatidylinositol transporter activity cell wall organization and biogenesis* cytoplasm chs5 spa2 rescue; isolated as a multicopy suppressor of the lethality of chs5 spa2 double mutant at Null mutant is viable
CSR2 YPR030W molecular_function unknown cell wall organization and biogenesis* nucleus YGR087C YOR043W YDR099W YER177W YLR342W chs5 spa2 rescue; overexpression rescues the lethality of chs5 spa2 at 37 degrees Null mutant is viable
CST6 YIL036W specific RNA polymerase II transcription factor activity transcription initiation from Pol II promoter* nucleus Chromosome STability; contains an ATF/CREB-like bZIP domain; transcriptional activator; interacts wi basic leucine zipper (bZIP) transcription factor Overexpression of CSTs induces chromosome loss
CTA1 YDR256C catalase activity oxygen and reactive oxygen species metabolism peroxisomal matrix YGL153W YMR314W YLR347C YNL189W catalase A catalase A Null mutant is viable and heat sensitive
CTF13 YMR094W DNA bending activity* centromere/kinetochore complex maturation condensed nuclear chromosome kinetochore YDL192W YDR328C YLL052C YOR359W YDR034C 58 kd component (Cbf3c) of the multisubunit 'Cbf3' kinetochore protein complex, which binds to the C Null mutant is inviable
CTF18 YMR078C molecular_function unknown sister chromatid cohesion DNA replication factor C complex YGL217C YPL205C YNL298W YGL127C YJL030W YFR036W YER095W YNL153C YEL003W YMR198W YLR261C YGR078C YML094W YOR349W YCL061C YGL086W YGR188C YKL048C YPR119W YMR048W YER116C YNL250W YOR026W YOL012C YOR195W YNL307C YHR191C YJL013C YLR085C YGL163C YML032C YM Chromosome transmission Null mutant is viable, exhibits increased level of spontaneous mitotic recombination, slow growth, a
CTF19 YPL018W protein binding chromosome segregation* nucleus* YBR107C YHR102W YCL039W YER016W YEL061C YPR141C YPR135W YDL003W YPL008W YJL030W YLR200W YGR078C YNL153C YEL003W YML094W YOR349W Chromosome Transmission Fidelity kinetochore protein Null mutant is viable
CTF3 YLR381W protein binding chromosome segregation condensed nuclear chromosome kinetochore YAR035W YBR107C YER016W YEL061C YPR141C YPR135W YDL003W YPL008W YJL030W YLR200W YGR078C YNL153C YEL003W YML094W kinetochore-related protein
CTF4 YPR135W DNA binding DNA repair* nucleus YBR100W YLR235C YPL017C YPL144W YPR015C YBL007C YNL298W YGL127C YJL030W YFR036W YER095W YER083C YNL153C YEL003W YLR268W YGR078C YGR229C YML094W YNR051C YCL061C YGL086W YGL244W YGR188C YPL055C YPR119W YHR200W YER019W YMR048W YER116C YNL250W YOR026W YG Has a role in regulating DNA replication complexes. DNA polymerase alpha binding protein Null mutant is viable but shows increase in the rate of mitotic chromosome loss, increased mitotic r
CTF8 YHR191C molecular_function unknown sister chromatid cohesion DNA replication factor C complex YLR235C YPR045C YNL298W YGL127C YJL030W YFR036W YNL153C YEL003W YEL061C YER016W YGR078C YGR229C YML094W YCL061C YGL086W YGL244W YPL055C YPR119W YMR048W YER116C YNL250W YGL173C YMR055C YOL012C YOR058C YOR195W YLR085C YGL163C YDR335W YML032C YNL273W YP (putative) kinetochore protein
CTK1 YKL139W protein kinase activity* protein amino acid phosphorylation* nucleus YDL047W YDR432W YNL004W YNL132W YML112W YBR009C YJL006C YLR403W YBR169C YDR168W YCL011C YLR418C YGR166W putative kinase subunit of the kinase complex that phosphorylates the RPO21 CTD (carboxy-terminal do kinase subunit of RNA polymerase II carboxy-terminal domain kinase I Null mutations in each of the CTK1, CTK2, and CTK3 genes cause slow growth, cold-sensitivity, floccu
CTK2 YJL006C cyclin-dependent protein kinase, intrinsic regulator activity protein amino acid phosphorylation* nucleus YKL139W YML112W YLR330W cyclin-related subunit of the kinase complex that phosphorylates the RPO21 CTD (carboxy-terminal dom RNA polymerase II C-terminal domain kinase beta subunit, similar to cyclin Null mutations in each of the CTK1, CTK2, and CTK3 genes cause slow growth, cold-sensitivity, floccu
CTK3 YML112W cyclin-dependent protein kinase activity protein amino acid phosphorylation* nucleus YDR190C YJL006C YKL210W YDR169C YKL139W YGL180W CTD kinase-I gamma subunit RNA polymerase II C-terminal domain kinase gamma subunit, similar to cyclin-dependent kinase Null mutations in each of the CTK1, CTK2, and CTK3 genes cause slow growth, cold-sensitivity, floccu
CTL1 YMR180C polynucleotide 5'-phosphatase activity RNA processing nucleus* YNL154C CET1-Like Gene #1 (CET1 = capping enzyme triphosphatase 1) RNA triphosphatase Null mutant is viable at 15/30/37C, on media lacking inositol, and on media containing 15nM caffeine
CTM1 YHR109W [cytochrome c]-lysine N-methyltransferase activity protein modification cytosol YGR071C YJL010C cytochrome c trimethylase cytochrome c methyltransferase lack of trimethylation of cytochrome C Lys72
CTP1 YBR291C tricarboxylate carrier activity mitochondrial citrate transport mitochondrial inner membrane YIL034C citrate transport protein citrate tranporter Null mutant is viable
CTR1 YPR124W copper uptake transporter activity protein biosynthesis* plasma membrane YBR274W YGL137W High affinity copper transporter into the cell, probable integral membrane protein copper transport protein Null mutant is viable, deficient in ferrous iron uptake
CTR2 YHR175W copper uptake transporter activity* intracellular copper ion transport* vacuolar membrane (sensu Fungi) YLR288C Putative low-affinity copper transport protein ctr2 mutants display a high level of resistance to toxic copper concentrations. CTR2 overexpression
CTR3 YLR411W copper uptake transporter activity copper ion import integral to plasma membrane YBR126C YNL221C integral membrane protein that functions in high affinity copper transport copper transporter Null mutant is viable, grows slower than w.t. under conditons of copper limitation on non-fermentabl
CTR9 YOL145C Pol II transcription elongation factor activity* transcription from Pol II promoter* nucleus* YGL019W YHR012W YGL244W YOR123C YIL094C YJR138W YIL035C YOR039W YOR061W YLR418C YBR279W YGL130W YOR326W YGL207W YJR091C YAL040C CTR9 is required for normal CLN1 and CLN2 G1 cyclin expression Null mutant is viable, loses chromosomes and shows temperature sensitivity
CTS1 YLR286C chitinase activity cytokinesis, completion of separation endoplasmic reticulum* YNL329C Endochitinase endochitinase Null mutant is viable; exhibits a defect in cell separation
CTT1 YGR088W catalase activity response to stress cytoplasm YNL189W cytoplasmic catalase T catalase T Null mutant is viable and heat sensitive
CUE1 YMR264W protein binding ER-associated protein catabolism* integral to endoplasmic reticulum membrane YGL083W YHR007C Cue1p assembles with Ubc7p. Cue1p recruits Ubc7p to the cytosolic surface of the endoplasmic reticul Ubc7p binding and recruitment protein Null mutant is viable and shows stabilization of ER degradation substrates
CUE4 YML101C molecular_function unknown biological_process unknown cytoplasm YDL100C YJR102C Contains one CUE domain which is the ubiquitin-binding domain
CUP1-1 YHR053C copper ion binding response to copper ion cytosol YKL023W required for cell growth at high copper concentrations. copper binding metallothionein Copper resistance
CUP1-2 YHR055C copper ion binding response to copper ion cytosol required for cell growth at high copper concentrations. copper binding metallothionein Copper resistance
CUP2 YGL166W ligand-regulated transcription factor activity transcription initiation from Pol II promoter* nucleus YML092C YNL189W YML006C YOR210W YLL028W YJL154C YKR011C YOR220W Upregulates metallothionein (CUP1) expression in response to Cu2+ transcriptional activator Null mutant is sensitive to Cu2+
CUP5 YEL027W hydrogen ion transporter activity protein-vacuolar targeting* hydrogen-transporting ATPase V0 domain YKL190W YDR126W vacuolar ATPase V0 domain subunit c (17 kDa) 17 kDa|VO sector subunit|dicyclohexylcarbodiimide binding subunit|proteolipid|vacuolar ATP synthase Null mutant is viable, petite, copper sensitive
CUP9 YPL177C specific RNA polymerase II transcription factor activity transcription initiation from Pol II promoter* nucleus homeobox domain similar human proto-oncogene PBX1 DNA binding protein (putative) Null mutant is viable, associated with loss of copper resistance
CUS1 YMR240C protein binding* spliceosome assembly snRNP U2 YDL030W YOR123C YJL203W YML049C YMR125W YDL043C YER029C YLR147C YLR117C YMR288W YPL151C YPL213W YLR090W YOR117W YBR112C YOR319W YGL035C YFL017W-A YPR182W YBR152W YER172C YPL016W cold sensitive U2 snRNA Suppressor U2 snRNP protein suppresses cold sensitivity of a U2 G53A cs mutant
CUS2 YNL286W RNA binding nuclear mRNA splicing, via spliceosome snRNP U2 YDL043C cold sensitive U2 snRNA Supressor Null mutant is viable, enhances U2 mutations; mutations in this gene suppress the cold sensitive phe
CWC15 YDR163W molecular_function unknown biological_process unknown spliceosome complex Complexed with Cef1p
CWC2 YDL209C molecular_function unknown nuclear mRNA splicing, via spliceosome spliceosome complex YLR426W YMR213W YAL032C YHR165C YPR182W YKL095W Complexed with Cef1p Null: required for pre-mRNA splicing
CWC21 YDR482C molecular_function unknown biological_process unknown spliceosome complex YOR276W YAL016W YGL028C YJR091C Complexed With Cef1p
CWC22 YGR278W molecular_function unknown biological_process unknown spliceosome complex YGR049W YMR213W YAL032C YHR165C YKL095W Complexed with Cef1p
CWC23 YGL128C molecular_function unknown biological_process unknown spliceosome complex YMR213W YGL120C YAL032C YHR165C Complexed with Cef1p
CWC24 YLR323C molecular_function unknown biological_process unknown spliceosome complex YDR315C Complexed with Cef1p
CWC25 YNL245C molecular_function unknown biological_process unknown spliceosome complex YIL046W Complexed with Cef1p
CWC27 YPL064C molecular_function unknown biological_process unknown spliceosome complex YGL127C YIL128W Complexed with Cef1p
CWH41 YGL027C mannosyl-oligosaccharide glucosidase activity cell wall organization and biogenesis endoplasmic reticulum membrane YBR235W YCR044C YJL095W YLR087C YPR159W YDL006W YGL020C YGL084C YGL115W YGL200C YPL213W YIL022W YMR214W YER022W YHR030C YMR307W YNL322C Glucosidase I, involved in assembly of cell wall beta 1,6 glucan; an ER type II integral membrane N- glucosidase I Null mutant is viable, associated with K1 killer toxin-resistant phenotype and a 50% reduction in th
CWH43 YCR017C molecular_function unknown cell wall organization and biogenesis* bud neck*
CWP1 YKL096W structural constituent of cell wall cell wall organization and biogenesis cell wall (sensu Fungi) cell wall protein, involved in O and N glycosylation, acceptor of B1-6 glucan. cell wall mannoprotein Null mutant is viable, has increased sensitivities to calcoflour white and congo red
CWP2 YKL096W-A structural constituent of cell wall cell wall organization and biogenesis* cell wall (sensu Fungi) major constituent of the cell wall containing GPI-anchor, plays a role in stabilizing the cell wall, cell wall mannoprotein Null mutant is viable, displays increased sensitivity to Congo red, calcofluor white, and Zymolyase
CYB2 YML054C L-lactate dehydrogenase (cytochrome) activity electron transport mitochondrial intermembrane space YNR017W Expression is repressed by glucose and anaerobic conditions, is induced by L-lactate and is regulate L-lactate cytochrome c oxidoreductase|cytochrome b2 Null mutant is viable but is deficient in cytochrome b2 and L-lactate dehydrogenase activity and is
CYB5 YNL111C electron transporter activity sterol biosynthesis microsome cytochrome b5 cytochrome b5 Null mutant is viable, cyb5 mutations suppress ketoconazole hypersensitivity of a P450 reductase def
CYC1 YJR048W electron carrier activity electron transport mitochondrial intermembrane space YHR098C YLR288C YNL334C iso-1-cytochrome c iso-1-cytochrome c Cytochrome c deficiency
CYC2 YOR037W molecular_function unknown mitochondrial intermembrane space protein import* mitochondrion YCL056C YDR450W YOR299W YPR086W Involved in import of cytochrome c into mitochondria cytochrome c mitochondrial import factor Null mutant is viable. Deletion of CYC2 leads to accumulation of apocytochrome c in the cytoplasm; s
CYC3 YAL039C holocytochrome-c synthase activity cytochrome c-heme linkage mitochondrial intermembrane space cytochrome c heme lyase (CCHL) cytochrome c heme lyase (CCHL) Cytochrome c deficiency
CYC7 YEL039C electron carrier activity electron transport mitochondrial intermembrane space YGR078C iso-2-cytochrome c iso-2-cytochrome c Null mutant is viable
CYC8 YBR112C transcription co-activator activity* negative regulation of transcription nucleus YDR043C YCR084C YIL061C YDL194W YMR240C General repressor of transcription (with Tup1p); mediates glucose repression Null mutant is viable; high level constitutivity for invertase, clumpiness, temperature-sensitive gr
CYR1 YJL005W adenylate cyclase activity meiosis* plasma membrane YFL039C YNL138W YJL026W YDR028C YGR233C YOL139C YBR142W YBL038W YLL050C YMR059W YGR092W Required for START A of cell cycle, and glucose and nitrogen repression of sporulation adenylate cyclase Null mutant is inviable. cyr1 transiently arrests in G1 and sporulates precociously. N-terminal doma
CYS4 YGR155W cystathionine beta-synthase activity cysteine biosynthesis cytoplasm YCR086W YJR045C YHR170W YNL189W YPL204W YGL081W YJL173C YMR059W YGR040W YER161C YHR135C YBR088C YML064C YIL066C YAL021C YLR442C encodes the first enzyme in cysteine biosynthesis. catalyzes the first committed step of transsulfur cystathionine beta-synthase Null exhibits vacuolar acidification defects; cys2 and cys4 mutations are linked together and cooper
CYT1 YOR065W electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity mitochondrial electron transport, ubiquinol to cytochrome c* mitochondrial inner membrane* YOL073C Cytochrome c1 cytochrome c1
CYT2 YKL087C holocytochrome-c synthase activity cytochrome c-heme linkage mitochondrial intermembrane space YLR285W links heme covalently to apocytochrome c1 cytochrome c1 heme lyase (CC1HL)
DAD1 YDR016C structural constituent of cytoskeleton mitotic spindle assembly (sensu Saccharomyces) condensed nuclear chromosome kinetochore* YGL044C YGR113W YGR218W YKL002W YKR037C YGL061C YAL036C Duo1 And Dam1 interacting; localized to intranuclear spindles and spindle pole bodies Null mutant is inviable; temperature-sensitive mutant arrests with large buds and a short mitotic sp
DAD2 YKR083C structural constituent of cytoskeleton mitotic spindle assembly (sensu Saccharomyces) condensed nuclear chromosome kinetochore* YBR137W YLR423C YDR353W YKL052C YDR201W Duo1 And Dam1 interacting; Helper of AsK1 Null mutant is inviable
DAD3 YBR233W-A protein binding mitosis spindle* Hypothetical ORF identified by homology. See FEBS Letters [2000] 487:31-36.
DAD4 YDR320C-A protein binding mitosis spindle*
DAL1 YIR027C allantoinase activity allantoin catabolism intracellular YNL252C allantoinase allantoinase Allantoin degradation deficient
DAL3 YIR032C ureidoglycolate hydrolase activity allantoin catabolism membrane YIR032C YBR126C ureidoglycolate hydrolase ureidoglycolate hydrolase Null mutant is viable
DAL4 YIR028W allantoin permease activity allantoin transport membrane allantoin transport allantoin permease Null mutant is viable, lacks allantoin transport capability
DAL5 YJR152W allantoate transporter activity allantoate transport plasma membrane allantoate permease allantoate permease Null mutant is viable, unable to transport allontoate or ureidosuccinate
DAL7 YIR031C malate synthase activity allantoin catabolism cytoplasm YBR160W allantoin pathway malate synthase 2 Null mutant is viable
DAL80 YKR034W transcription factor activity transcription* nucleus YDR520C YER047C YHR060W YLR376C YNL021W YKR034W YJL110C Negative regulator of multiple nitrogen catabolic genes GATA family transcriptional repressor Null mutant is viable, deficient in allantoin degradation
DAL81 YIR023W specific RNA polymerase II transcription factor activity regulation of transcription from Pol II promoter* nucleus Positive regulator of multiple nitrogen catabolic genes transcriptional activator for allantoin and GABA catabolic genes, contains a Zn[2]-Cys[6] fungal-typ Null mutant is viable, unable to degrade allantoin
DAL82 YNL314W transcriptional activator activity transcription initiation from Pol II promoter* nucleus YOR047C YNL314W Positive regulator of allophanate inducible genes positive transcriptional regulator loss of induction for allantoin degradation pathways
DAM1 YGR113W structural constituent of cytoskeleton mitotic spindle assembly (sensu Saccharomyces) condensed nuclear chromosome kinetochore* YGL079W YJL064W YLR424W YPR045C YLR423C YPR049C YPR046W YIL144W YDR016C YKR037C YLR329W YGL061C YMR308C YDR034C Duo1 And Mps1 interacting. Localized to intranuclear spindles and spindle pole bodies. Key Ipl1p tar Null mutant is inviable
DAN1 YJR150C molecular_function unknown sterol transport cell wall (sensu Fungi) Delayed Anaerobic cell wall mannoprotein|induced during anaerobic growth Null mutant is viable
DAN2 YLR037C molecular_function unknown biological_process unknown cell wall (sensu Fungi) YJR091C YKL130C YLR183C Delayed anaerobic gene putative cell wall protein unknown
DAN3 YBR301W molecular_function unknown biological_process unknown cell wall (sensu Fungi) YMR047C YLR330W delayed anaerobic gene putative cell wall protein unknown
DAN4 YJR151C molecular_function unknown biological_process unknown cell wall (sensu Fungi) Delayed Anaerobic Gene cell wall mannoprotein unknown
DAP1 YPL170W molecular_function unknown sterol metabolism membrane YGL008C YLR289W YDR311W YHR007C damage response protein related to membrane progesterone receptor sterol-binding protein (putative) Null mutant exhibits sensitivity to MMS, elongated telomeres, elevated petite formation, partial arr
DAP2 YHR028C dipeptidyl-peptidase and tripeptidyl-peptidase activity protein processing vacuolar membrane (sensu Fungi) Dipeptidyl aminopeptidase B (DPAP B) dipeptidyl aminopeptidase B (DPAP B) Null mutant is viable and lacks dipeptidyl aminopeptidase yscV activity
DBF2 YGR092W protein kinase activity protein amino acid phosphorylation* bud neck* YKL061W YLR424W YJR072C YNR052C YDR394W YDL147W YDL185W YHR152W YDL160C YIL106W YBR126C YLR079W YGL137W YDR146C YJL005W YOR117W YOR317W YPR160W YAR019C YPR111W YAL021C YDL047W YCL029C YPL155C YPR141C YLR113W Kinase required for late nuclear division. Cdc15 promotes the exit from mitosis by directly switchin Null mutant is viable, dbf1 dbf20 null mutants are inviable; mutants show dumb-bell phenotype
DBF4 YDR052C protein serine/threonine kinase activity protein amino acid phosphorylation* nucleoplasm YDR052C YDL062W YLR235C YLR423C YNL153C YGR078C YML094W YIL128W YGR188C YJR140C YPR135W YGL173C YHR191C YCL016C YER177W YML115C YDR363W YGL129C YOR027W YER173W YOR368W YBL008W YBR215W YBR274W YDR217C YHR178W YLR234W YLR288C YPL024W YCR031C YHR154W YK Required for Cdc7 kinase activity Cdc7p-Dbf4p kinase complex regulatory subunit Null mutant is inviable; conditional alleles cause cell cycle arrest at the G1/S transition; dumbbel
DBP10 YDL031W ATP dependent RNA helicase activity 35S primary transcript processing* nucleolus YER006W YPR016C YNL061W YHR066W YKR081C YNL110C YGR103W YOR080W YIL035C Dead box protein 10 Null mutant is inviable
DBP2 YNL112W RNA helicase activity biological_process unknown bud neck YMR080C YFR031C-A YDL195W YBL032W YIL035C ATP-dependent RNA helicase of DEAD box family ATP dependent RNA helicase|dead box protein Null mutant is inviable
DBP3 YGL078C ATP dependent RNA helicase activity 35S primary transcript processing* nucleolus ATP-dependent RNA helicase CA3 of the DEAD/DEAH box family ATP dependent RNA helicase|dead/deah box protein CA3 Null mutant is viable
DBP5 YOR046C RNA helicase activity mRNA-nucleus export cytoplasm* YBR027C YDL011C YMR255W Dead-Box protein 5 RNA helicase dbp5(ts) strains exhibit rapid, synchronous accumulation of poly(A)+ RNA in nuclei when shifted to t
DBP6 YNR038W ATP dependent RNA helicase activity 35S primary transcript processing* nucleolus YKR024C Dead Box Protein 6 RNA helicase (putative) Null mutant is inviable; Dbp6p depletion leads to decreased production of the 27S and 7S precursors,
DBP7 YKR024C ATP dependent RNA helicase activity 35S primary transcript processing* nucleolus YNR038W YLR233C YHR082C YNL175C YDL213C YDR215C YLR342W Dead-box protein RNA helicase (putative) Null mutant is viable but shows slow growth
DBP8 YHR169W ATP dependent RNA helicase activity 35S primary transcript processing nucleolus YKL075C YDL086W YHR027C YHR179W YMR105C YGR240C YJL026W YJL138C YLR438W YJR109C YIL125W YNL014W YDR238C YER070W YPR121W YAR019C YCR057C Dead-Box Protein 8, ATP-dependent helicase involved in rRNA processing dead box protein Null mutant is inviable
DBP9 YLR276C ATP dependent RNA helicase activity 35S primary transcript processing* nucleolus YBR269C YPL043W YMR308C YDR060W YKR081C YHR066W YDL164C Dead-Box Protein 9 Null mutant is inviable
DBR1 YKL149C RNA lariat debranching enzyme activity RNA catabolism* nucleus YGR072W RNA lariat debranching enzyme RNA lariat debranching enzyme Null mutant is viable; reduces Ty1 transposition frequency; defective in the process of intron turno
DCC1 YCL016C molecular_function unknown sister chromatid cohesion DNA replication factor C complex YLR123C YLR235C YNL298W YJL030W YER095W YNL153C YMR198W YER016W YML094W YOR349W YPR141C YCL061C YER007W YGL086W YGL244W YGR188C YPL241C YPR119W YHR200W YER019W YMR048W YNL206C YNL250W YGL173C YOL012C YOR195W YJL013C YGL163C YBR231C YML032C YMR224C YN Defective in sister Chromatid Cohesion benomyl sensitive and defective in sister chromatid cohesion
DCI1 YOR180C dodecenoyl-CoA delta-isomerase activity fatty acid beta-oxidation peroxisomal matrix YGL153W YLR284C YDL116W YFL018C YGR263C Delta(3,5)-delta(2,4)-dienoyl-CoA isomerase delta(3,5)-delta(2,4)-dienoyl-CoA isomerase
DCP1 YOL149W mRNA binding* mRNA catabolism* cytoplasmic mRNA processing body YCR077C YDR378C YGL173C YJL124C YBL026W YPR189W YLR438C-A YER112W YER146W YNL147W YNL118C YBR094W YEL015W YGR218W YMR047C YOR167C YPL204W YGL213C YLR398C YDL160C YDR206W YJR022W YLR264W Decapping protein involved in mRNA degradation Null mutant is viable.|Null mutant is inviable in the FY1679 background, but viable, though grows sl
DCP2 YNL118C mRNA binding* mRNA catabolism* nucleus* YOL149W YEL015W YJR022W YMR080C YML091C YJL124C YDR060W YPL204W YCR077C YJR023C Mrna Decapping. essential suppressor of the respiratory deficiency of a pet mutant
DCW1 YKL046C molecular_function unknown cell wall biosynthesis (sensu Fungi) membrane fraction* Defective Cell Wall. N-glycosylated, GPI-anchored membrane protein.
DDC1 YPL194W molecular_function unknown meiosis* condensed nuclear chromosome YDL033C YNL298W YPR141C YDR225W YMR038C YOR368W YLR288C YKL113C YPR024W YOL094C YPL029W YNR072W YOR146W YIR008C YPR135W YHR191C YMR078C YCL016C YMR048W YCL061C YNL273W YJR043C YDL102W YLR103C YDL017W YJR057W DNA damage checkpoint gene Null mutant is viable, sensitive to DNA damage and defective in delaying G1-S and G2-M transistion a
DDI1 YER143W SNARE binding ubiquitin-dependent protein catabolism* plasma membrane YJR141W YNR071C YGL044C YMR055C DNA Damage Inducible; binds to T- and V- snare complexes Null mutant is viable
DED1 YOR204W RNA helicase activity translational initiation cytoplasm YDR388W YDL175C YIL079C YOL139C ATP-dependent RNA helicase of DEAD box family; suppressor of a pre-mRNA splicing mutation, prp8-1 Null mutant is inviable
DED81 YHR019C ATP binding* asparaginyl-tRNA aminoacylation cytoplasm YGL106W YHR204W YNL244C YKL095W YOR080W YIR005W YBR055C Asparaginyl-tRNA synthetase asparaginyl-tRNA synthetase
DEF1 YKL054C molecular_function unknown ubiquitin-dependent protein catabolism* nucleus YCR079W YMR106C RNA polymerase II DEgradation Factor 1 Rad26-interacting protein Null: slow growth. Other phenotypes: unable to degrade RNAPII in response to UV-damage. def1delta an
DEG1 YFL001W pseudouridylate synthase activity RNA processing nucleus* YDL153C YLR085C Similar to rRNA methyltransferase (Caenorhabditis elegans) and hypothetical 28K protein (alkaline en Null mutant is viable, but demonstrates depressed growth rate
DER1 YBR201W molecular_function unknown ER-associated protein catabolism endoplasmic reticulum membrane YGL070C YIL034C YLR288C Degradation in the Endoplasmic Reticulum Null mutant is viable, but blocks ER-degradation of target proteins
DFR1 YOR236W dihydrofolate reductase activity folic acid and derivative metabolism cytosol YAL058W dihydrofolate reductase dihydrofolate reductase Null mutant is viable, has an auxotrophic growth requirement for the C1 metabolites dTMP, adenine, h
DGA1 YOR245C diacylglycerol O-acyltransferase activity triacylglycerol biosynthesis* lipid particle YGR228W YOR097C YGL053W YBL050W DiacylGlycerol Acyltransferase Acyl-CoA : diacylglycerol acyltransferase
DHH1 YDL160C protein binding deadenylation-dependent decapping* cytoplasm* YCR077C YGR178C YER125W YAL021C YNR052C YEL015W YOL149W YCL030C YJL124C YNL147W YPR110C YDR170C YER081W YER140W YLR373C YGL137W YMR106C YBL105C YJR122W YGR092W YDL017W YBL026W Putative RNA helicase of DEAD box family Null mutant is viable, but grows poorly
DHR2 YKL078W RNA helicase activity ribosome biogenesis nucleolus YDL014W YGL137W DEAH-box protein involved in ribosome synthesis Required for 18S ribosomal RNA synthesis Null: essential|Null mutant is inviable
DIA1 YMR316W molecular_function unknown pseudohyphal growth* cytoplasm YER125W YDR189W may be involved in invasive growth, pseudohyphal growth Null mutant is viable and causes invasive growth in haploids and pseudohyphal growth in diploids
DIB1 YPR082C pre-mRNA splicing factor activity nuclear mRNA splicing, via spliceosome small nuclear ribonucleoprotein complex YBR055C YNL147W YGR091W YFL017W-A YPR182W YKR086W Homolog of S. pombe dim1+ 17 kDa U4/U6.U5 associated protein Null mutant is inviable
DIC1 YLR348C dicarboxylic acid transporter activity dicarboxylic acid transport mitochondrial membrane YBL113C mitochondrial dicarboxylate transport protein dicarboxylate transport protein
DID2 YKR035W-A molecular_function unknown protein-vacuolar targeting cytoplasm Doa4-independent degradation; Rad52 Inhibitor (Fifty Two Inhibitor) class E vacuolar-protein sorting and endocytosis factor Overexpression causes growth inhibition and G2 arrest in rad52 and cdc9 mutants; null mutants are ca
DID4 YKL002W protein binding late endosome to vacuole transport* cytoplasm* YBR197C YBR242W YBR262C YCL049C YDL162C YDR063W YEL057C YEL068C YEL074W YER079W YER084W YER121W YGR035C YLR108C YOR284W YDL165W YLR423C YER044C YMR117C YER092W YOR047C YFL034C-B YGR020C YDR016C YBR091C YBR106W YBR211C YDL127W YDR290W YDR408C YEL049W class E vacuolar-protein sorting and endocytosis factor secretion of vacuolar proteins; canavanine-hypersensitive; temperature-sensitive; suppresses defects
DIE2 YGR227W dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity N-linked glycosylation* endoplasmic reticulum membrane YGR064W YOL009C YFL036W YGL226C-A YOR085W De-repression of ITR1 Expression glucosyltransferase Null mutant is viable
DIG1 YPL049C transcription factor binding invasive growth nucleus YPL049C YDR036C YDR480W YGR040W YBL016W YHR084W YBL017C YDL239C YFR049W YNL189W YML064C Down-regulator of Invasive Growth, Regulator of Sterile Twelve, binds Fus3 and Ste12 MAP kinase-associated protein Null mutant is viable, shows abnormal bud morphology; dig1 dig2 double mutants show constitutive mat
DIG2 YDR480W transcription factor binding invasive growth nucleus YGR040W YBL016W YLR304C YPL020C YPL049C YHR084W YHR039C Down-regulator of Invasive Growth, Regulator of Sterile Twelve MAP kinase-associated protein Null mutant is viable; dig1 dig2 double mutants show constitutive mating pheromone specific gene exp
DIM1 YPL266W rRNA (adenine-N6,N6-)-dimethyltransferase activity rRNA modification* nucleolus YJL078C YDL060W YGR090W YNL207W YBR017C Dimethyladenosine transferase, (rRNA(adenine-N6,N6-)-dimethyltransferase),reponsible for m6[2]Am6[2] dimethyladenosine transferase Null mutant is inviable
DIN7 YDR263C nuclease activity DNA repair mitochondrion YOR214C DNA-damage inducible gene
DIP2 YLR129W snoRNA binding processing of 20S pre-rRNA small nucleolar ribonucleoprotein complex YCR057C YGR090W YJL069C YLR222C part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); DOM34 Interacting Protein U3 snoRNP protein
DIP5 YPL265W amino acid transporter activity* amino acid transport plasma membrane YGR165W YLR222C dicarboxylic amino acid permease dicarboxylic amino acid permease Null mutant is viable, exhibits loss of L-aspartate and L-glutamate uptake
DIS3 YOL021C 3'-5' exoribonuclease activity 35S primary transcript processing* nuclear exosome (RNase complex)* YCR035C YOR001W YGR158C YHR069C YDL111C YGR195W YOL142W YGR095C YHR081W YNL232W YLR163C YDR280W YGR090W YLR293C YKR086W Possible component of RCC1-Ran pathway 3'-5' exoribonuclease complex subunit Null mutant is inviable
DJP1 YIR004W co-chaperone activity peroxisome matrix protein import cytosol DnaJ-like protein required for Peroxisome biogenesis; Djp1p is located in the cytosol Null mutant is viable but shows partial mislocalisation of peroxisomal matrix proteins to the cytoso
DLD1 YDL174C D-lactate dehydrogenase (cytochrome) activity aerobic respiration* mitochondrial inner membrane mitochondrial enzyme D-lactate ferricytochrome c oxidoreductase D-lactate ferricytochrome c oxidoreductase Null mutant is viable and cannot grow on media containing lactate as the sole carbon source
DLD2 YDL178W D-lactate dehydrogenase (cytochrome) activity biological_process unknown mitochondrial matrix D-lactate dehydrogenase, located in mitochondrial matrix Null mutant is viable
DLD3 YEL071W D-lactate dehydrogenase (cytochrome) activity lactate metabolism cytoplasm* YPR165W YKL103C D-lactate dehydrogenase D-lactate dehydrogenase
DMC1 YER179W single-stranded DNA binding* meiosis* nucleus* YNL013C YER179W YPL235W YKL211C YLR067C YNL055C YDL148C YLR134W YPR183W YDR146C YLR044C YIL144W YGR085C YJL125C YNR016C YFL016C YBR073W YOR191W YNL189W YOR285W YLR127C YML064C YIL105C Dispensable for double strand breaks, synaptonemal complexes, gene conversion in return to growth as meiosis-specific protein related to RecA and Rad51p. Dmc1p colocalizes with Rad51p to discrete subnu Null mutant is viable. dmc1 accumulates synaptonemal complex-related dense body, has processed doubl
DNA2 YHR164C ATP dependent DNA helicase activity* DNA repair* nucleus YHR122W YAR007C YDR499W DNA replication helicase DNA replication helicase Null mutant is inviable
DNF1 YER166W phospholipid-translocating ATPase activity intracellular protein transport plasma membrane Drs2 Neo1 Family Potential aminophospholipid translocase viable. drs2 dnf1 mutant grows slowly, massively accumulates intracellular membranes, and exhibits a
DNF2 YDR093W phospholipid-translocating ATPase activity intracellular protein transport plasma membrane Drs2 Neo1 Family Potential aminophospholipid translocase
DNF3 YMR162C phospholipid-translocating ATPase activity intracellular protein transport trans-Golgi network transport vesicle Drs2 Neo1 Family Potential aminophospholipid translocase
DNL4 YOR005C DNA ligase (ATP) activity double-strand break repair via nonhomologous end-joining nucleus YDR198C YPL110C YGL146C YPR016C YHR052W YIL125W YGR103W YKR081C YNL110C YDR225W YNL061W YLR304C YGL111W YAL025C YOR272W YGL090W DNA ligase IV homolog ATP dependent DNA ligase Null mutant is viable, deficient in non-homologous double-strand end joining
DNM1 YLL001W GTPase activity mitochondrial fission mitochondrial outer membrane YPL204W YJL141C YJL112W YOR098C YDR150W YGR078C YEL003W YML094W Involved in receptor-mediated endocytosis and mitochondrial organization. Required for the cortical similar to dynamin GTPase Null mutant is viable, shows mating defects consistent with a delay in receptor-mediated endocytosis
DOA4 YDR069C endopeptidase activity* protein deubiquitination* proteasome complex (sensu Eukarya) YBR221C YAR003W YBL064C YER022W YHR114W YLL039C deubiquitinating enzyme; vacuole biogenesis gene ubiquitin isopeptidase Null mutant is viable, but exhibits uncoordinated DNA replication
DOC1 YGL240W enzyme regulator activity ubiquitin-dependent protein catabolism* anaphase-promoting complex YFL039C YLR127C YKL022C YHR166C YFR036W YNL172W YDL008W YDR118W YOR249C YLR102C YBL084C YKL113C YBR023C YLR342W YGR229C Doc1p and Cdc26p are associated with the anaphase-promoting complex and are involved in the degradat Null mutant is viable, grows slowly and forms colonies in which most of the cells have large buds an
DOG2 YHR043C 2-deoxyglucose-6-phosphatase activity response to stress* cytoplasm YLR423C YHR107C 2-deoxyglucose-6-phosphate phosphatase 2-deoxyglucose-6-phosphate phosphatase
DON1 YDR273W molecular_function unknown meiosis* spindle* YDL239C YFR052W prospore membrane localizing protein
DOT1 YDR440W protein-lysine N-methyltransferase activity chromatin silencing at telomere* nucleus YLR418C YLR330W YMR307W YDR420W YGR166W involved in meiosis and transcriptional silencing Null mutant is viable, bypasses meiotic arrest of zip1 mutant, and shows decreased silencing at telo
DOT5 YIL010W thioredoxin peroxidase activity regulation of redox homeostasis nucleus YGL181W YLR288C Derepression Of Telomeric silencing
homologous to 4 other S.c. thioredoxin peroxidases EC 1.11.1.-
DPB11 YJL090C epsilon DNA polymerase activity DNA replication initiation* replication fork YHR170W YGR162W YKL108W YDL116W YHR179W Part of the DNA polymerase II complex, acts in a checkpoiint pathway during S-phase DNA polymerase II complex Null mutant is inviable; conditional allele demonstrates defective S-phase progression
DPB2 YPR175W epsilon DNA polymerase activity lagging strand elongation* replication fork YNL262W YDR121W YNL334C YMR078C YBR278W YBL002W YER083C YMR106C DNA polymerase epsilon, subunit B DNA polymerase epsilon subunit B Null mutant is inviable; conditional mutant shows defects in DNA replication
DPB3 YBR278W epsilon DNA polymerase activity lagging strand elongation* replication fork YIL006W YMR290C YDR448W YNL262W YDR121W YPR175W YKL011C YJR091C YLR181C YLR103C C and C' subunits of DNA polymerase II DNA polymerase II C and C' subunits Null mutant is viable, shows increased spontaneous mutation rate
DPB4 YDR121W epsilon DNA polymerase activity lagging strand elongation* epsilon DNA polymerase complex YPR175W YBR278W YBL002W YLR447C YLR103C DNA Polymerase B (II), 4th subunit DNA polymerase II (epsilon) 4th subunit Null mutant is viable
DPM1 YPR183W transferase activity, transferring glycosyl groups* N-linked glycosylation* endoplasmic reticulum* YDL226C YDR311W YOR285W YER179W YFR028C dolichol phosphate mannose synthase dolichol phosphate mannose synthase Null mutant is inviable
DPP1 YDR284C diacylglycerol pyrophosphate phosphatase activity* phospholipid metabolism vacuolar membrane (sensu Fungi) contains a novel phosphatase sequence motif found in a super family of phosphatases including mammal diacylglycerol pyrophosphate phosphatase Null mutant is viable, does not exhibit any obvious growth defects
DPS1 YLL018C aspartate-tRNA ligase activity protein biosynthesis cytoplasm YHR056C YOR282W YBR017C YBR055C Aspartyl-tRNA synthetase, cytosolic aspartyl-tRNA synthetase
DRS1 YLL008W ATP dependent RNA helicase activity 35S primary transcript processing* nucleolus YPR016C YNL061W YPL043W YKR081C YNL110C YHR066W YGR103W YNL175C YDL213C nucleolar DEAD-box protein required for synthesis of 60S ribosomal subunits ATP dependent RNA helicase (putative) Null mutant is inviable; cold sensitive mutant with a deficit of 60S ribosomal subunits
DRS2 YAL026C ATPase activity* intracellular protein transport* Golgi membrane* YPL146C YAL053W YNL271C YKL190W YKL079W YLR039C YPL155C YGR078C YML094W YNL322C cation transport (E1-E2) ATPase family member P-type ATPase, potential aminophospholipid translocase Null mutant is viable, cold sensitive with perturbed late Golgi function; drs2 arf1 double mutants a
DSE2 YHR143W glucan 1,3-beta-glucosidase activity cell wall organization and biogenesis* cell wall (sensu Fungi)* Daugher Specific Expression 2
DSK2 YMR276W protein degradation tagging activity spindle pole body duplication (sensu Saccharomyces) nucleus YNL281W YDL190C YML034W Required with RAD23 for duplication of the spindle pole body ubiquitin-like protein Null mutant is viable
DSL1 YNL258C molecular_function unknown retrograde (Golgi to ER) transport endoplasmic reticulum YKR022C YLR440C YBL052C YFL021W YHR056C YLR457C YGL145W dsl1 mutations are suppressed by a dominant allele of SLY1, called sly1-20
DSS4 YPR017C guanyl-nucleotide exchange factor activity* secretory pathway membrane fraction* YJL122W YPL093W YFL005W YFL038C YDR101C YGR103W YLR397C YMR246W YER031C YML077W YJR022W YLR039C YLR262C dominant suppressor of sec4 GDP dissociation factor for Sec4p Null mutant is viable
DST1 YGL043W positive transcription elongation factor activity meiotic recombination* nucleoplasm YOR151C YJR132W YBR109C YLR418C YDL049C Transcription elongation factor S-II
Meiotic DNA recombination factor RNA polymerase II elongation factor|Transcription elongation factor S-II (TFIIS)|transcription elong Null mutant is viable; reduced induction of DNA strand transfer; sensitivity to 6-azauracil
DTR1 YBR180W multidrug transporter activity* spore wall assembly (sensu Saccharomyces)* prospore membrane YDR034C dityrosine transporter MFS-MDR dityrosine transporter MFS-MDR Null: Null mutant is viable; bisformyl dityrosine accumulates in cytoplasm of spores; spore wall dit
DUO1 YGL061C structural constituent of cytoskeleton mitotic spindle assembly (sensu Saccharomyces) condensed nuclear chromosome kinetochore* YER016W YDR529C YDR016C YKR037C YGR113W YJL179W Death Upon Overexpression Null mutant is inviable; overexpression arrests cells at large budded stage
DUR3 YHL016C urea transporter activity urea transport plasma membrane Urea active transport protein Null mutant is viable; urea degradation deficient
DYN1 YKR054C motor activity mitotic chromosome segregation* spindle pole body* YGL217C YNL271C YLR200W YNL153C YEL003W YPL269W YLR305C YCR065W YEL061C YER016W YER114C YGL124C YGL216W YGR078C YML094W YOR349W YPR141C YAL024C YBR009C YFL037W YOR058C YOR326W Dynein heavy chain of cytoplasmic dynein Null mutant is viable, demonstrates misalignment of the spindle relative to the bud neck during cell
DYN2 YDR424C microtubule motor activity microtubule-based process* cell YGL217C YNL271C YLR200W YNL153C YEL003W YPL269W YEL061C YGL124C YGL216W YGR078C YML094W YOR349W YIL034C YDR488C YNL298W YER016W YOR058C YOR326W putative light chain of dynein dynein light chain (putative) Null mutant is viable
EAF3 YPR023C histone acetyltransferase activity regulation of transcription from Pol II promoter* histone acetyltransferase complex YFL024C YOR244W YNL330C YOL004W YDL138W YLR200W YGR078C YNL153C YEL003W YML094W YAL013W Esa1p-Associated Factor
EAP1 YKL204W molecular_function unknown negative regulation of translation mRNA cap complex YOL139C YGL137W YNL154C YCR009C YDR388W Translation initiation factor eIF-4E associated protein functionally analogous to mammalian 4E-BPs
functional and limited sequence similarity to CAF20 Mutant is temperature sensitive and partially resistant to rapamycin
EBP2 YKL172W molecular_function unknown rRNA processing nucleolus YKR081C YHR066W YGR103W YMR049C YNL175C YHR052W YNL230C EBNA1-binding protein homolog nucleolar protein Null mutant is inviable
EBS1 YDR206W molecular_function unknown telomerase-dependent telomere maintenance nucleus YJL030W YOR047C YER027C YBR057C YOL149W EST1-like bcy1 Suppressor
ECI1 YLR284C dodecenoyl-CoA delta-isomerase activity fatty acid beta-oxidation peroxisome YGL153W YNL189W YPL070W YOR180C YML064C enoyl-CoA isomerase d3,d2-Enoyl-CoA Isomerase Null mutant is viable but fails to metabolize unsaturated fatty acids
ECM10 YEL030W heat shock protein activity protein-mitochondrial targeting mitochondrion YDL164C YDL220C YIL095W YCR084C YNL161W YMR106C YML058W YBR155W YNL230C YDL059C YPL256C YJR035W YJR062C YDL017W YAL015C ExtraCellular Mutant A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent
ECM11 YDR446W molecular_function unknown cell wall organization and biogenesis nucleus YDR510W YJR057W ExtraCellular Mutant A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent
ECM16 YMR128W RNA helicase activity processing of 20S pre-rRNA* nucleolus* YNL097C YIL084C YPL139C YBR247C YCL059C YBR251W YCR057C YDR280W YGR195W YGR090W part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); ExtraCellular Mutant
U3 snoRNP protein A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent
ECM22 YLR228C RNA polymerase II transcription factor activity sterol biosynthesis nucleus involved in cell wall biogenesis (putative) Null mutant is viable; sensitive to caffeine; Tn3 insertion mutant demonstrates hypersensitivity to
ECM32 YER176W RNA helicase activity* regulation of translational termination polysome YER122C DNA Helicase; identified as an ExtraCellular Mutant; homology exists between ECM32 and two other ide DNA helicase I Null mutant is viable; A Tn3 insertion into this gene causes hypersensitivity to the cell surface po
ECM33 YBR078W molecular_function unknown cell wall organization and biogenesis plasma membrane YOL133W YHR030C ExtraCellular Mutant A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent
ECM38 YLR299W protein-glutamine gamma-glutamyltransferase activity cell wall organization and biogenesis* intracellular YOL137W ExtraCellular Mutant; cik1 suppressor gamma-glutamyltransferase homolog Null mutant is viable. A Tn3 insertion into this gene causes hypersensitivity to the cell surface po
ECM40 YMR062C amino-acid N-acetyltransferase activity* cell wall organization and biogenesis* mitochondrial matrix ExtraCellular Mutant acetylornithine acetyltransferase A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent
ECM7 YLR443W molecular_function unknown cell wall organization and biogenesis integral to membrane YDL013W YMR307W Involved in cell wall maintenance A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent
ECO1 YFR027W acetyltransferase activity DNA repair* nuclear chromatin YHR114W Establishment of COhesion Null mutant is inviable; temperature-sensitive allele prematurely separates sister chromatids, and s
EDE1 YBL047C molecular_function unknown endocytosis bud neck* YDR348C YNL243W YCR030C YPL204W YOL054W YPL153C YOL087C YBR109C YNL298W YHR030C YNL233W YBR023C YLR330W YHR142W YLR342W YJR075W YBL061C EH domain protein involved in endocytosis Null mutant is viable; diploid null mutants exhibit random budding.
EFB1 YAL003W translation elongation factor activity translational elongation ribosome YBR118W YKL081W YML064C GDP/GTP exchange factor for Tef1p/Tef2p translation elongation factor EF-1beta Null mutant is inviable
EFT1 YOR133W translation elongation factor activity translational elongation ribosome YDR385W YBR068C translation elongation factor 2 (EF-2) translation elongation factor 2 (EF-2) Null mutant is viable (eft1 eft2 double mutant is lethal)
EFT2 YDR385W translation elongation factor activity translational elongation ribosome YFR051C YOR133W YPR159W translation elongation factor 2 (EF-2) translation elongation factor 2 (EF-2) Null mutant is viable (eft1 eft2 double mutant is lethal)
EGD1 YPL037C chaperone activity nascent polypeptide association nascent polypeptide-associated complex YKL095W YMR059W YIL035C YLR039C YLR262C beta subunit of the nascent-polypeptide-associated complex (NAC); homologous to human BTF3b; GAL4 en pol II transcribed genes regulator Null mutant is viable; reduced induction of galactose-regulated genes upon shift from glucose to gal
EGD2 YHR193C chaperone activity nascent polypeptide association nascent polypeptide-associated complex YML062C YDR252W YJR091C YLR295C YPL204W YPR111W YHR030C YMR049C GAL4 enhancer protein, homolog of human alpha NAC subunit of the nascent-polypeptide-associated comp GAL4 enhancer protein|nascent-polypeptide-associated complex human alpha NAC subunit homolog Null mutant is viable
EGT2 YNL327W cellulase activity cytokinesis cell wall (sensu Fungi) YLL039C cell-cycle regulation protein, may be involved in the correct timing of cell separation after cytoki
EHT1 YBR177C molecular_function unknown lipid metabolism lipid particle alcohol acyl transferase alcohol acyl transferase Null mutant is viable, temperature sensitive, and contains higher amounts of phosphatidylinositol, p
ELA1 YNL230C transcriptional elongation regulator activity RNA elongation from Pol II promoter transcription elongation factor complex YER077C YLR423C YML056C YNL132W YLR196W YPL093W YHR052W YPL004C YGR090W YGR103W YKR081C YDR496C YOL041C YLR136C YDL014W YPL012W YEL030W YGR086C YPL001W YDR381W YKL172W YDR194C YMR049C YJL141C YOR272W YOR017W YLR432W YFR001W YJR091C similar to mammalian elongin A, interacts with elongin C elongin A transcription elongation factor
ELC1 YPL046C transcriptional elongation regulator activity RNA elongation from Pol II promoter transcription elongation factor complex YJR052W similar to mammalian elongin C, interacts with elongin A elongin C transcription elongation factor
ELM1 YKL048C protein kinase activity* protein amino acid phosphorylation* contractile ring (sensu Saccharomyces) YDL185W YJR113C YBR160W YJR090C YNL271C YFL037W YER016W YOR058C YOR326W YEL061C YMR078C YLR200W YGR078C YNL153C YEL003W YML094W YLR342W YGR229C cell morphology protein kinase formation of expanded, branched chains of elongated cells; grow invasively under the surface of agar
ELO1 YJL196C fatty acid elongase activity fatty acid elongation, unsaturated fatty acid membrane YNL192W Elongase I extends C12-C16 fatty acyl-CoAs to C16-C18 fatty acids elongase Null mutant is viable, but shows no growth on media supplemented with less than 16-C saturated fatty
ELP2 YGR200C Pol II transcription elongation factor activity regulation of transcription from Pol II promoter transcription elongation factor complex YPL086C YLR384C YPL101W YHR187W YJR127C YNL271C YJL020C YER016W YNL298W YLR229C YOR326W YAL013W ELongator Protein 2; 90kD subunit; has WD40 repeats RNA polymerase II Elongator subunit Null mutant is viable but grows slowly and shows slow adaptation to growth on new media; ts- (39 C);
ELP3 YPL086C Pol II transcription elongation factor activity* regulation of transcription from Pol II promoter transcription elongation factor complex* YGR200C YNL271C YJL020C YLR229C YER016W YOR326W YAL013W YMR263W elongator protein; histone and other protein acetyltransferase; has sequence homology to known HATs RNA polymerase II Elongator subunit|histone acetyltransferase Null mutant is viable but grows slowly and shows slow adaptation to growth on new media; ts- (39^*C)
ELP4 YPL101W Pol II transcription elongation factor activity regulation of transcription from Pol II promoter cytoplasm* YGR200C YLR229C YNL271C YER016W YOR326W YAL013W YDR126W ELongator Protein 4; 50kD subunit. Homolog of ATPases, yet with substitutions of amino acids critica RNA polymerase II Elongator protein subunit Null: Slow adaptation to growth on new media;
ts- (39 oC); sensitive to 1 M NaCl; insensitive t
ELP6 YMR312W Pol II transcription elongation factor activity regulation of transcription from Pol II promoter transcription elongation factor complex YLR327C YHR187W YNL298W YLR229C YNL271C YER016W YLR200W YGR078C YNL153C YEL003W YML094W YAL013W YDR126W ELongator Protein 6; 30kD subunit. Homolog of ATPases, yet with substitutions of amino acids critica RNA polymerase II Elongator protein subunit Null:Slow adaptation to growth on new media;
ts- (39 oC); sensitive to 1 M NaCl; insensitive to
EMG1 YLR186W molecular_function unknown processing of 20S pre-rRNA* nucleus* YER030W YHR179W YPL004C YLR438W YGR233C YBR247C YCL059C YCR057C YGR090W Essential for Mitotic Growth ribosome biogenesis Null: Lethal
EMI2 YDR516C molecular_function unknown biological_process unknown cytoplasm YCL040W YGR169C YJR091C YNL032W Early Meiotic Induction Null: Required for IME1 induction and sporulation.
EMP24 YGL200C molecular_function unknown ER to Golgi transport* endoplasmic reticulum* YML012W YAR002C-A YAL007C YDL147W YGL058W YNL192W YBR023C YLR330W YMR307W YDR420W YLR113W YPR159W YHR181W YLR057W YGL027C type I transmembrane protein, component of COPII-coated, ER-derived transport vesicles type I transmembrane protein Null mutant is viable
EMP46 YLR080W molecular_function unknown ER to Golgi transport Golgi membrane YMR083W YOL131W Evidence suggests that Emp46p and Emp47p are required for the export of specific glycoprotein cargo homolog of the Golgi protein Emp47p Null: viable
EMP47 YFL048C molecular_function unknown ER to Golgi transport Golgi apparatus* 47 kDa type I transmembrane protein localized to the Golgi 47 kDa type I transmembrane protein localized to the Golgi Null mutant is viable
EMP70 YLR083C transporter activity transport membrane fraction* YDR383C YLR295C YLR039C YLR262C identified as a 24 kDa cleavage product in endosome-enriched membrane fractions
ENA1 YDR040C ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism sodium ion transport plasma membrane YAL028W YDL153C YMR047C Plasma membrane Na+ pump; P-type ATPase P-type ATPase Na+ pump|plasma membrane ATPase Null mutant is sensitive to Na+
ENA2 YDR039C ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism sodium ion transport plasma membrane plasma membrane protein; putative Na+ pump; P-type ATPase P-type ATPase Na+ pump|plasma membrane ATPase|plasma membrane protein Null mutant is viable and sensitive to Na+, Li+, and alkaline pH
ENA5 YDR038C ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism sodium ion transport plasma membrane YDR380W Na(+) ATPase Na+ ATPase
ENB1 YOL158C ferric-enterobactin transporter activity ferric-enterobactin transport integral to membrane* Siderophore transporter for enterobactin; AFT1 regulon enterobactin transporter Null mutants are viable but are unable to take up and utilize iron from enterobactin
END3 YNL084C cytoskeletal adaptor activity actin filament organization* actin cortical patch (sensu Saccharomyces) YPL174C YIR006C YOR181W YER022W YDL029W YCR009C YDR388W Required for endocytosis and organization of the cytoskeleton Null mutant is viable and defective in endocytosis
ENO1 YGR254W phosphopyruvate hydratase activity gluconeogenesis* cytoplasm* YNR036C YJR045C YHR013C YBL105C enolase I enolase I Null mutant is viable
ENO2 YHR174W phosphopyruvate hydratase activity gluconeogenesis* soluble fraction* YIL091C YPR053C YGR261C YER168C YNL006W YOL135C YLR196W YGL044C YEL031W YNL127W YLR265C enolase enolase Null mutant is inviable
ENP1 YBR247C snoRNA binding processing of 20S pre-rRNA* nucleus* YNL132W YOL010W YCL059C YGR090W YOR056C YDL148C YGR081C YKL143W YBL004W YDL014W YPL012W YLR175W YMR128W YLR186W YHR148W YNL075W YJR002W YLR180W YLL011W YDL060W YDR449C YMR093W YPR144C YBL056W YCR057C YNL207W YPL204W YBR017C YNL244C YOR080W YIL061C YE Essential nuclear protein 57 kDa protein with an apparent MW of 70 kDa by SDS-PAGE (putative) Null mutant is inviable
ENT1 YDL161W cytoskeletal adaptor activity actin filament organization* actin cortical patch (sensu Saccharomyces) YLR116W YLR206W YIR006C YOR111W epsin N-terminal homology-containing protein Null mutant is viable, synthetically lethal with ent2 (YLR206w). ent1/2 double mutants have endocyto
ENT2 YLR206W cytoskeletal adaptor activity actin filament organization* actin cortical patch (sensu Saccharomyces) YGR169C YKR036C YDL161W YAL041W YBL106C epsin N-terminal homology-containing protein Null mutant is viable; synthetically lethal with ent1 (YDL161w). ent2/1 double mutants have endocyto
ENT3 YJR125C cytoskeletal adaptor activity actin filament organization* actin cortical patch (sensu Saccharomyces)* YOR111W epsin N-terminal homology-containing protein unknown
ENT4 YLL038C cytoskeletal adaptor activity actin filament organization* actin cortical patch (sensu Saccharomyces) YPL161C YPL242C YLR039C YLR262C epsin N-terminal homology-containing protein unknown
ENT5 YDR153C clathrin binding Golgi to endosome transport cytoplasm* YLR039C YLR262C Epsin N-Terminal homology-containing protein
EPL1 YFL024C histone acetyltransferase activity regulation of transcription from Pol II promoter* histone acetyltransferase complex YFL039C YHR099W YDR359C YNL030W YPR023C YOR244W YNL107W YEL018W YJL098W Enhancer of Polycomb-Like (from D. melanogaster). Subunit of the Nucleosomal Acetyltransfera NuA4 histone acetyltransferase complex component Null mutant is inviable.
EPS1 YIL005W protein disulfide isomerase activity protein-ER retention endoplasmic reticulum membrane YLR295C YPR086W
EPT1 YHR123W ethanolaminephosphotransferase activity phosphatidylethanolamine biosynthesis endoplasmic reticulum YIR038C YEL017W YBR038W sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase Null mutant is viable
ERD1 YDR414C molecular_function unknown protein-ER retention membrane YPL031C YHR030C YOR070C YLR113W YNL322C Protein required for retention of luminal ER proteins disruption of the retention system for ER proteins; defects in the Golgi-dependent modification of g
ERD2 YBL040C HDEL sequence binding protein-ER retention integral to endoplasmic reticulum membrane ER protein retention HDEL receptor Null mutant is inviable
ERF2 YLR246W palmitoyltransferase activity protein-membrane targeting* integral to endoplasmic reticulum membrane YJR146W Mutation has an Effect on Ras Function. Implicated in signaling pathway. Null mutant is viable, but has a synthetic growth defect in the absence of RAS2; Deletion of ERF2 re
ERG1 YGR175C squalene monooxygenase activity ergosterol biosynthesis endoplasmic reticulum* YNL311C squalene epoxidase; an essential enzyme in the ergosterol-biosynthesis pathway; catalyzes the epoxid squalene monooxygenase Null mutant is inviable when cells are grown under aerobic conditions; erg1 null mutants are viable
ERG10 YPL028W acetyl-CoA C-acetyltransferase activity ergosterol biosynthesis cytosol YPR165W YGR223C YNL244C YPL026C YBR055C induced under stress conditions acetoacetyl CoA thiolase Nul mutant is inviable; other mutants are ergosterol biosynthesis defective or nystatin resistant
ERG11 YHR007C sterol 14-demethylase activity ergosterol biosynthesis endoplasmic reticulum YHR045W YPR090W YBL007C YLR242C YHR030C YEL031W YER083C YER155C YDR310C YHR012W YKR001C YGL020C YOR070C YDL074C YLR015W YMR272C YBR121C YNL231C YJR073C YDL155W YOR275C YML013W YER031C YBR283C YMR022W YMR264W YPL170W cytochrome P450 lanosterol 14a-demethylase Null mutant is inviable, erg11 null inviability is suppressed by deletion of ERG3; erg11 mutants are
ERG12 YMR208W mevalonate kinase activity ergosterol biosynthesis cytosol mevalonate catabolism mevalonate kinase Null mutant is inviable and unable to grow vegetatively or germinate spores; mutants exhibit increas
ERG13 YML126C hydroxymethylglutaryl-CoA synthase activity ergosterol biosynthesis mitochondrion* YNL119W YFL039C YIL094C YLR180W YKL125W YDL188C YJR091C YMR059W involved in mevalonate synthesis 3-hydroxy-3-methylglutaryl coenzyme A synthase
ERG2 YMR202W C-8 sterol isomerase activity ergosterol biosynthesis endoplasmic reticulum YGL127C YJR091C YCR034W YNL271C sterol biosynthesis C-8 sterol isomerase synthetic lethal with vma2.
ERG20 YJL167W dimethylallyltranstransferase activity* ergosterol biosynthesis* cytosol YDL186W YNL244C YJR035W YBR055C YPL149W YDR369C May be rate-limiting step in sterol biosynthesis pathway farnesyl diphosphate synthetase (FPP synthetase) Null mutant is inviable
ERG24 YNL280C C-14 sterol reductase activity ergosterol biosynthesis endoplasmic reticulum YDL153C YHR114W sterol C-14 reductase sterol C-14 reductase Null mutant appears to be inviable in some genetic backgrounds and conditionally lethal in others; e
ERG25 YGR060W C-4 methyl sterol oxidase activity ergosterol biosynthesis plasma membrane* YJL202C YGL001C YDR113C membrane-bound non-heme di-iron oxygenase involved in lipid metabolism. C-4 sterol methyl oxidase Null mutant is inviable
ERG26 YGL001C C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity ergosterol biosynthesis endoplasmic reticulum* YGR060W YBR202W one of three enzymatic activities required for the conversion of 4,4-dimethylzymosterol to zymostero C-3 sterol dehydrogenase
ERG27 YLR100W 3-keto sterol reductase activity ergosterol biosynthesis endoplasmic reticulum* YGL137W YDL132W YBL005W 3-keto sterol reductase 3-keto sterol reductase
ERG28 YER044C molecular_function unknown ergosterol biosynthesis endoplasmic reticulum membrane YDR034C YKL002W YPL051W YNL322C Transmembrane domain containing protein which may facilitate protein-protein interactions between th Null mutant is viable; random budding in diploid null mutants; null cells have an unusual sterol con
ERG3 YLR056W C-5 sterol desaturase activity ergosterol biosynthesis endoplasmic reticulum YHR128W YIL074C YOL099C YOR167C YNL271C C-5 sterol desaturase C-5 sterol desaturase Null mutant is inviable; suppresses syringomycin resistant mutant; sensitive to photoactivated 3-car
ERG4 YGL012W delta24(24-1) sterol reductase activity ergosterol biosynthesis endoplasmic reticulum Sterol C-24 reductase sterol C-24 reductase Null mutant is viable
ERG5 YMR015C C-22 sterol desaturase activity ergosterol biosynthesis endoplasmic reticulum cytochrome P450 involved in C-22 denaturation of the ergosterol side-chain cytochrome P450|involved in C-22 denaturation of the ergosterol side-chain Null mutant is viable
ERG6 YML008C sterol 24-C-methyltransferase activity ergosterol biosynthesis endoplasmic reticulum* YCL023C YDL089W YHR114W YOR097C YPL020C YPR113W YMR059W ergosterol synthesis The null mutant is viable, cannot methylate ergosterol precursors at C-24, and lacks ergosterol. The
ERG7 YHR072W lanosterol synthase activity ergosterol biosynthesis plasma membrane* carries out complex cyclization step of squalene to lanosterol in sterol biosynthesis pathway 2,3-oxidosqualene-lanosterol cyclase Null mutant is inviable
ERG8 YMR220W phosphomevalonate kinase activity ergosterol biosynthesis* cytosol Involved in isoprene and ergosterol biosynthesis pathways 48 kDa phosphomevalonate kinase Null mutant is inviable
ERG9 YHR190W farnesyl-diphosphate farnesyltransferase activity ergosterol biosynthesis endoplasmic reticulum YIR038C YMR153W YLR453C squalene synthetase squalene synthetase Null mutant is inviable
ERI1 YPL096C-A GTPase inhibitor activity small GTPase mediated signal transduction endoplasmic reticulum
ERO1 YML130C electron carrier activity protein folding* endoplasmic reticulum YLR342W YLR208W YML067C YAL042W YDR021W YJL002C YCR057C essential, FAD-dependent oxidase of protein disulfide isomerase Null mutant is inviable; in ero1-1(ts) mutants newly synthesized carboxypeptidase Y is retained in t
ERP1 YAR002C-A molecular_function unknown ER to Golgi transport COPII-coated vesicle YNL030W YGL200C YML012W YAL007C YGR132C YJR091C Emp24p/Erv25p related protein p24 protein involved in membrane trafficking null mutant is viable; delayed transport of Gas1p and invertase
ERP2 YAL007C molecular_function unknown ER to Golgi transport COPII-coated vesicle YPL211W YDR127W YLR342W YDR101C YMR290C YGL200C YER110C YML012W YDR087C YAR002C-A Emp24p/Erv25p related protein 2 p24 protein involved in membrane trafficking null mutant is viable; delayed transport of Gas1p
ERP3 YDL018C molecular_function unknown secretory pathway integral to membrane Emp24p/Erv25p related protein 2 p24 protein involved in membrane trafficking
ERP4 YOR016C molecular_function unknown secretory pathway integral to membrane Emp24p/Erv25p related protein 4 p24 protein involved in membrane trafficking
ERP5 YHR110W molecular_function unknown secretory pathway integral to membrane Emp24p/Erv25p related protein 5 p24 protein involved in membrane trafficking
ERP6 YGL002W molecular_function unknown secretory pathway integral to membrane Emp24p/Erv25p related protein 6 p24 protein involved in membrane trafficking
ERS1 YCR075C L-cystine transporter activity L-cystine transport integral to membrane Suppressor of ERD1 mutation; seven transmembrane domain protein
ERV1 YGR029W thiol oxidase activity iron ion homeostasis* mitochondrion* Protein forms dimers in vivo and in vitro, contains a conserved YPCXXC motif at carboxyl-terminal, b sulfhydryl oxidase Null mutant is inviable; mutants demonstrate defects in mitochondrial biogenesis
ERV14 YGL054C molecular_function unknown ER to Golgi transport* endoplasmic reticulum membrane* YLL043W YNL201C YLR039C YLR262C ER-derived vesicles 14 kDa protein found on ER-derived vesicles Null mutant is viable but exhibits defects in sporulation (diploids) and bud site selection (haploid
ERV15 YBR210W molecular_function unknown axial budding integral to membrane Putative ER vesicle protein with similarity to Erv14p
ERV2 YPR037C thiol oxidase activity protein thiol-disulfide exchange microsome YDL100C YPR156C Essential for Respiration and Vegetative growth 2. Protein forms dimers in vivo/vitro, contains a co Deletion of ERV2 or depletion of Erv2p by regulated gene expression is not associated with any detec
ERV25 YML012W molecular_function unknown ER to Golgi transport COPII-coated vesicle YLR124W YAR002C-A YAL007C YGL142C YGL200C COPII coat component of certain ER-derived vesicles vesicle coat component Null mutant is viable, displays a selective defect in transport of secretory proteins from the ER to
ERV29 YGR284C molecular_function unknown ER to Golgi transport COPII-coated vesicle YMR060C ER Vesicle protein of 29 kDa (apparent MW) ER-Golgi transport vesicle protein Null mutant is viable.
ERV41 YML067C molecular_function unknown ER to Golgi transport integral to endoplasmic reticulum membrane* YML130C YAL042W ER vesicle protein Null mutant is viable.
ERV46 YAL042W molecular_function unknown ER to Golgi transport integral to endoplasmic reticulum membrane* YDL239C YML067C YML130C ER vesicle protein of 46 kDa ER-Golgi transport vesicle protein Null mutant is viable but cold sensitive.
ESA1 YOR244W histone acetyltransferase activity regulation of transcription from Pol II promoter* histone acetyltransferase complex YKR021W YFL039C YHR099W YOL086C YML007W YDR359C YPR023C YNL107W YJL081C YFL024C YDR271C YJL098W contains amino-terminal chromodomains; Essential SAS family Acetyltransferase sharing homology with NuA4 complex component|acetyltransferase in the SAS gene family Null mutant is inviable
ESBP6 YNL125C transporter activity* transport mitochondrion* YDL153C YLR196W Protein with similarity to mammalian monocarboxylate transporters MCT1 and MCT2 monocarboxylate permease (putative)
ESC1 YMR219W molecular_function unknown chromatin silencing at telomere nucleus Establishes Silent Chromatin. May be a component of a redundant pathway that functions to localize s
ESC2 YDR363W molecular_function unknown chromatin silencing at HML and HMR (sensu Saccharomyces) nucleus YBR099C YBR174C YGR071C YLR235C YLR374C YCL037C YLR373C YOR123C YJR140C YNL106C YDR279W YPL057C YFR010W YJR043C YDL020C YHR031C YJL092W YOL006C YPL024W YMR190C YAR002W YHR167W YNL218W YJL176C YDR386W YOR076C YAR003W YMR080C YGR072W YOR191W YBR228W YH Establishes Silent Chromatin
ESC8 YOL017W molecular_function unknown chromatin silencing nucleus YBR245C YLR039C YLR262C Establishes Silent Chromatin 8 Null: Viable, HMR silencing defect
ESP1 YGR098C cysteine-type endopeptidase activity regulation of exit from mitosis* nucleus* YDR113C YGR163W Esp1 promotes sister chromatid separation by mediating dissociation from the chromatin of the cohesi separase Null mutant is inviable, produces extra spindle pole bodies, shows disrupted cell cycle control
ESS1 YJR017C peptidyl-prolyl cis-trans isomerase activity mRNA processing* nucleus YHR033W YML010W YHR027C YGR090W YLR216C YLR438W YGR253C YLR106C YNL014W YIL033C YGR186W YIL021W YLL026W YDR343C YDL140C YDR457W YPR086W Mitotic regulator; structurally and functionally homologous to human PIN1 peptidyl-prolyl cis-trans isomerase (PPIase) Null mutant is inviable; arrest phenotype of mitotic arrest and nuclear fragmentation
EST1 YLR233C RNA binding* telomerase-dependent telomere maintenance nucleus* YER077C YKL014C YGR160W YAL028W YNL132W YLR196W YKR081C YDR496C YPL012W YCL043C YJL019W YNL229C YDR194C YOR319W YJL109C YLR175W YDR087C YOR201C YKR024C YGL201C YKL020C YML038C YLR006C YLR200W Est1p binds the telomerase RNA and also directly interacts with Cdc13p which binds single-stranded t Telomere elongation protein
EST2 YLR318W telomeric template RNA reverse transcriptase activity telomerase-dependent telomere maintenance nucleus* YLR039C YLR262C YLR085C Contributes to the catalytic activity of telomerase and to other aspects of telomerase assembly and telomerase reverse transcriptase Null mutant is viable, exhibits progressively shorter telomeres, cellular senescence and a telomeras
EST3 YIL009C-A telomerase activity telomerase-dependent telomere maintenance nucleus* YML092C ever shorter telomeres 20.5 kDa 181aa protein Null mutant shows progressively shorter telomeres and cellular senescence; telomerase activity is st
ETR1 YBR026C enoyl-acyl-carrier protein reductase activity aerobic respiration* mitochondrion Involved in mitochondrial fatty acid biosynthesis 2-enoyl thioester reductase, E.C. 1.3.1.- Null mutant is viable but is respiratory-deficient
EUG1 YDR518W protein disulfide isomerase activity protein folding endoplasmic reticulum YCL043C ER protein functionally likely involved in interacting with nascent polypeptides in the ER protein disulfide isomerase homolog Null mutant is viable
EXG1 YLR300W glucan 1,3-beta-glucosidase activity cell wall organization and biogenesis* cell wall (sensu Fungi) YMR049C YOL126C Has a broad specificity for beta-1,3-linkages as well as beta-1,6-linkages, and also for other beta- exo-1,3-beta-glucanase Null mutant is viable, displays modest increase in killer toxin sensitivity and beta 1,6-glucan leve
EXG2 YDR261C glucan 1,3-beta-glucosidase activity biological_process unknown cell wall (sensu Fungi) Exo-1,3-b-glucanase exo-1,3-beta-glucanase Null mutant is viable
EXO1 YOR033C exonuclease activity* mismatch repair nucleus YOL090W YJR091C YKL113C YOL006C Protein that complements a drug-hypersensitive mutation. EXO1 plays a structural role in MMR and sta exonuclease Mutants demonstrate sensitivity to cycloheximide, bleomycin, actinomycin D, 5-fluorouracil, and seve
EXO70 YJL085W protein binding establishment of cell polarity (sensu Saccharomyces)* actin cap (sensu Saccharomyces)* YLR247C 70 kDa exocyst component protein; the exocyst proteins are required for exocytosis late in the secre exocyst complex 70 kDa component Null mutant is inviable
EXO84 YBR102C molecular_function unknown nuclear mRNA splicing, via spliceosome* actin cap (sensu Saccharomyces)* YNR046W YGL233W YLR166C YER008C YDR166C YIL068C YPR055W YML097C exocyst complex component; homolog in rat brain called rExo84.
pre-mRNA splicing factor. Null mutant is inviable, defective in secretion
FAA1 YOR317W long-chain-fatty-acid-CoA ligase activity lipid metabolism* lipid particle YBR064W YBR239C YJR091C YLR373C YBR017C YDL047W YCR079W YGR092W YKR026C cellular lipid metabolism and protein N-myristolation long chain fatty acyl:CoA synthetase Null mutant is viable as long as fatty acid synthase (fas) complex is active
FAA2 YER015W long-chain-fatty-acid-CoA ligase activity lipid metabolism* peroxisome YDR146C acyl-CoA synthetase (long-chain fatty acid CoA ligase) (fatty acid activator 2), activates endogenou acyl-CoA synthetase (fatty acid activator 2) Not essential for vegetative growth when fatty acid synthase (fas) is active
FAA4 YMR246W long-chain-fatty-acid-CoA ligase activity lipid metabolism* cytoplasm* YDR129C YHR136C YLR019W YNL088W YLR291C YDR398W YPR017C YOL139C YOL133W YOL126C YDL047W YML064C YLR195C acyl-CoA synthetase (long-chain fatty acid CoA ligase) (fatty acid activator 2), activates imported long chain fatty acyl:CoA synthetase|long-chain fatty acid:CoA ligase Not essential for vegetative growth when fatty acid synthase (fas) is active
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase activity response to stress* vacuolar membrane YOL135C YDL047W YNL271C YDR162C YER016W YNL298W YOR269W YDR150W YCL029C YOR326W YLR200W YGR078C YNL153C YEL003W YML094W YLR103C YBR023C YLR330W YBL061C YNL322C May regulate vacuole homeostasis. Catalyzes formation of phosphatidylinositol-3,5-bisphosphate via p 1-phosphatidylinositol-3-phosphate 5-kinase Null mutant is temperature-sensitive. Mutation causes pleiotropic effects on nuclear migration and o
FAD1 YDL045C FMN adenylyltransferase activity FAD biosynthesis cytoplasm YGL127C YLR295C Flavin adenine dinucleotide (FAD) synthetase, which performs second step in synthesis of FAD from ri FAD synthetase Null mutant is inviable
FAL1 YDR021W ATP dependent RNA helicase activity 35S primary transcript processing nucleolus YNL271C YDR021W YML130C YJR007W YER127W Similar to eukaryotic initiation factor eIF4a; required for pre-rRNA processing at sites A0, A1, and RNA helicase (putative)|dead box protein Null mutant is inviable; when Fal1p is depleted, either in a temperature-sensitive fal1-1 mutant or
FAP7 YDL166C molecular_function unknown processing of 20S pre-rRNA* nucleus YLR222C YCL059C YLR208W Nuclear protein involved in oxidative stress response
FAR1 YJL157C cyclin-dependent protein kinase inhibitor activity signal transduction during conjugation with cellular fusion* nucleus* YOR212W YDR394W YMR012W YMR304W YDL145C YNR031C YBR200W YEL016C YPL022W YAL040C YLR229C YAL041W Factor arrest protein Cdc28p kinase inhibitor
FAS1 YKL182W acyl-carrier protein S-malonyltransferase activity* fatty acid biosynthesis cytosol* pentafunctional enzyme consisting of the following domains : acetyl transferase, enoyl reductase, de acetyl transferase|dehydratase|enoyl reductase|malonyl/palmityl transferase|pentafunctional enzyme Null mutant is viable
FAS2 YPL231W holo-acyl-carrier protein synthase activity* fatty acid biosynthesis* fatty-acid synthase complex YBR036C YIL038C Trifunctional enzyme fatty acid synthase alpha subunit Fatty acid synthetase deficient
FAT1 YBR041W long-chain-fatty-acid-CoA ligase activity* lipid transport* plasma membrane* YDL153C YGR229C Putative membrane-bound long-chain fatty acid transport protein homologous to mouse fatty acid trans fatty acid transporter Null mutant is viable, but is Ole- in presence of cerulenin (i.e., unable to grow on YPD supplemente
FBA1 YKL060C fructose-bisphosphate aldolase activity gluconeogenesis* cytoplasm* YOL135C YOR116C YNL127W YLR295C Low Temperature-responsive aldolase Null mutant is viable, lacks aldolase enzymatic activity and fails to grow in media containing as a
FBP1 YLR377C fructose-bisphosphatase activity gluconeogenesis cytosol YLR377C YLR347C YML064C YML121W YNL189W YPL169C fructose-1,6-bisphosphatase fructose-1,6-bisphosphatase unable to grow with ethanol
FBP26 YJL155C fructose-2,6-bisphosphate 2-phosphatase activity* gluconeogenesis cytosol YBR043C fructose-2,6-bisphosphatase fructose-2,6-bisphosphatase Null mutant lacks fructose-2,6-biphosphatase activity but can grow on glucose, fructose, galactose,
FCP1 YMR277W protein phosphatase activity* transcription* nucleus YCR079W Encodes a carboxy-terminal domain (CTD) phosphatase essential for dephosphorylation of RNA polymeras TFIIF interacting component of CTD phosphatase
FCY2 YER056C cytosine-purine permease activity purine transport* plasma membrane purine-cytosine permease purine-cytosine permease Null mutant is viable
FCY21 YER060W cytosine-purine permease activity biological_process unknown integral to membrane identical to FCY2 purine-cytosine permease
FCY22 YER060W-A cytosine-purine permease activity biological_process unknown integral to membrane identical to FCY2 purine-cytosine permease
FDH1 YOR388C formate dehydrogenase activity formate catabolism* cytosol YBL039C YER022W YER081W Protein with similarity to formate dehydrogenases
FEN1 YCR034W fatty acid elongase activity sphingolipid biosynthesis* endoplasmic reticulum* YMR202W YLR372W YOR049C YCR009C YDL017W YLR342W Elongase II elongates palmitoyl-CoA and stearoyl-CoA up to C22 fatty acids, and is also involved in 1,3-beta-glucan synthase subunit (putative) ELO1 homolog Null mutant is viable; slow growth; fenpropimorph resistant; resistant to a pneumocandin B0 analog (
FEN2 YCR028C pantothenate transporter activity pantothenate transport plasma membrane Fenpropimorph resistance gene. Protein shows similarity to Dal5p and members of the allantoate perme Plasma Membrane H+-Pantothenate Symporter Null mutant is viable
FES1 YBR101C adenyl-nucleotide exchange factor activity protein biosynthesis cytosol* YBR014C YKL171W YLR194C YPL136W YJL117W YDR171W YKR059W YLR074C YMR092C YHL021C YLL062C YMR173W YOL011W facteur d'Echange pour ssa1p (French for "Ssa1p Exchange Factor") Hsp70 nucleotide exchange factor Null mutant is thermosensitive. Other phenotypes: cycloheximide sensitive.
FET3 YMR058W multicopper ferroxidase iron transport mediator activity high affinity iron ion transport plasma membrane YER022W YLR291C YBR217W YKL189W YDL029W YPL149W YAL015C FET3 encodes a ferro-O2-oxidoreductase that is part of the high-affinity iron transport system multicopper oxidase The null mutant is viable but defective for high affinity Fe(II) uptake. The null mutant is inviable
FET4 YMR319C iron ion transporter activity intracellular copper ion transport* integral to plasma membrane YGR173W YDR200C YJL164C YJL128C YJR053W YLR222C YBR217W YBL036C YLR238W YER075C YLR427W YLR248W YGR040W YNL061W YGR252W YIL061C YER117W Putative transmembrane low-affinity Fe(II) transporter low affinity Fe2+ transport protein Mutant lacks low affinity Fe(II) transport but has more active high affinity Fe(II) transport activi
FET5 YFL041W multicopper ferroxidase iron transport mediator activity iron ion transport membrane fraction YBR207W ferrous iron transport multicopper oxidase|type 1 integral membrane protein overexpression of FET5 suppresses a fet3 null mutant.
FHL1 YPR104C transcription factor activity rRNA processing* nucleus YDR510W YDR225W YBR009C YDR174W YKR026C Putative transcriptional regulator of rRNA-processing genes domain similar to the fork head DNA-binding domain found in the developmental fork head protein of D Null mutant shows reduced growth rate and lower rRNA content
FIG1 YBR040W molecular_function unknown cellular morphogenesis during conjugation with cellular fusion* cell wall (sensu Fungi)* YCL040W Factor-Induced Gene 1: expression is induced by the mating pheromones, a and alpha factor; required integral membrane protein Null mutant is viable, deficient in mating
FIG2 YCR089W molecular_function unknown cellular morphogenesis during conjugation with cellular fusion* cell wall (sensu Fungi) YNL192W Factor-Induced Gene 2: expression is induced by the mating pheromones, a and alpha factor; required GPI-anchored cell wall protein (putative) Null mutant is viable, deficient in mating under non-optimal conditions
FIG4 YNL325C polyphosphoinositide phosphatase activity cellular morphogenesis during conjugation with cellular fusion extrinsic to membrane FIG4 expression is induced by mating factor. Null mutant is viable, mating defective
FIN1 YDR130C protein binding biological_process unknown nucleus* YER133W YPR120C YOR058C Cell cycle-dependent filament between nuclei cell cycle-dependent filament between nuclei Null mutant is viable; overproduction is lethal in haploids and strongly inhibits growth in diploids
FIP1 YJR093C cleavage/polyadenylation specificity factor activity mRNA polyadenylation* mRNA cleavage and polyadenylation specificity factor complex YCL046W YML030W YMR061W YLR115W YKR002W YNL317W YAL043C YGR156W YKL059C YLR277C YPR107C YDR301W YLR221C YJL033W YNL092W YER133W YCL032W component of a pre-mRNA polyadenylation factor that interacts with poly(A) polymerase polyadenylation factor I (PF I) Null mutant is inviable. At restrictive temperature, a temperature-sensitive mutant shows shortening
FIS1 YIL065C molecular_function unknown mitochondrial fission mitochondrial outer membrane YJR091C YLR321C Involved in mitochondrial division outer mitochondrial membrane protein required to localize Dnm1p and Mdv1p during mitochondrial divis Null mutant is viable, mitochondrial fission blocked, mitochondrial membranes form nets
FIT1 YDR534C molecular_function unknown siderochrome transport cell wall (sensu Fungi) YPR191W YGL127C FIT1, FIT2, and FIT3 code for mannoproteins that are incorporated into the cell wall via glycosylpho Cell wall protein involved in iron uptake Impaired siderophore-iron uptake, activation of the major iron-dependent transcription factor AFT1.
FIT2 YOR382W molecular_function unknown siderochrome transport cell wall (sensu Fungi) YDR380W FIT1, FIT2, and FIT3 code for mannoproteins that are incorporated into the cell wall via glycosylpho Cell wall protein involved in iron transport impaired siderophore-iron uptake, activation of the major iron -dependent transcription factor, AFT1
FIT3 YOR383C molecular_function unknown siderochrome transport cell wall (sensu Fungi) YER086W FIT1, FIT2, and FIT3 code for mannoproteins that are incorporated into the cell wall via glycosylpho Cell wall protein involved in iron transport impaired siderophore iron uptake, activation of the major iron-dependent transcription factor, AFT1
FKH1 YIL131C transcription factor activity pseudohyphal growth* nucleus YMR144W YGR017W YLR291C YGL019W YGR196C YJR144W YNL272C YNL042W YBR009C YDR224C YBR160W YDL014W YOL004W YIL035C YOR039W YNL229C YGL130W YOR061W YDR087C YKR026C YJL076W YPL237W YJL197W YGR083C YJR007W YIR002C YDL056W YDR279W YHL027W forkhead protein forkhead protein
FKH2 YNL068C transcription factor activity pseudohyphal growth* nucleus YMR303C YBL002W YOL004W YGL150C YNL298W Fork Head homolog two forkhead protein
FKS1 YLR342W 1,3-beta-glucan synthase activity cell wall organization and biogenesis* actin cap (sensu Saccharomyces)* YBL062W YGL046W YGL081W YGL196W YJL046W YLR021W YLR338W YMR073C YNL171C YOL003C YPL041C YPL144W YPL261C YBL007C YDR388W YNL271C YOR035C YGL240W YBL061C YER155C YJR118C YJL183W YDL006W YDR137W YKR020W YNR051C YKL048C YHR200W YDR378C YPL161C YBL105C YJ Required for viability of calcineurin mutants 1,3-beta-D-glucan synthase Null mutant is viable, demonstrates slow growth, hypersensitivity to FK506 and cyclosporin A, sensit
FLO1 YAR050W cell adhesion molecule activity flocculation cell wall (sensu Fungi) FLO5- and FLO8-determined flocculation are considerably less sensitive to mannose than FLO1-determin Flocculation
FLO5 YHR211W cell adhesion molecule activity flocculation cell wall (sensu Fungi) YDR131C YJL038C YPL027W YJR091C YOR360C YDL143W FLO5- and FLO8-determined flocculation are considerably less sensitive to mannose than FLO1-determin flocculin|similar to flocculation protein Flo1p Mutations in FLO5 appear to have no effect on filamentous growth.
FLO8 YER109C specific RNA polymerase II transcription factor activity pseudohyphal growth* nucleus* YGL070C Nuclear protein required for diploid filamentous growth, haploid invasive growth and flocculation; n transcriptional activator of FLO1 (putative) Null mutant is viable; wild-type gene is required for flocculation and for pseudo-hyphal growth
FLR1 YBR008C multidrug transporter activity response to toxin integral to plasma membrane YMR047C Fluconazole Resistance 1 major facilitator transporter Null mutant is viable; overexpression confers resistance to fluconazole, cycloheximide, 4-nitroquino
FLX1 YIL134W flavin-adenine dinucleotide transporter activity mitochondrial transport mitochondrion YDR532C Nuclear-encoded mitochondrial protein involved in transport of flavine into mitochondria FAD carrier protein Null mutant is viable and unable to grow on nonfermentable carbon sources
FMC1 YIL098C molecular_function unknown protein complex assembly mitochondrion YPR180W Formation of Mitochondrial Complexes Assembly factor of ATP synthase in heat stress Null mutant is viable and shows growth deficiency on non-fermentable carbon sources at 37 degrees C
FMN1 YDR236C riboflavin kinase activity* FMN biosynthesis mitochondrial inner membrane* YDR398W Riboflavin kinase riboflavin kinase
FMO YHR176W monooxygenase activity protein folding endoplasmic reticulum membrane catalyzes the O2- and NADPH-dependent oxidations of biological thiols, including oxidation of glutat flavin-containing monooxygenase
FMS1 YMR020W amine oxidase activity* pantothenate biosynthesis* cytoplasm YHR178W YOR075W YPL244C Multicopy suppressor of fenpropimorph resistance (fen2 mutant), shows similarity to Candida albicans putatitive amine oxidase Null mutant is viable
FMT1 YBL013W methionyl-tRNA formyltransferase activity translational initiation* mitochondrion Formyl-Methionyl-tRNA Transformylase (consistent with name of bacterial homologs) methionyl-tRNA transformylase Null mutant is viable and lacks mitochondrial formyl-Met-tRNA
FOB1 YDR110W ribosomal DNA (rDNA) binding DNA recombination* nucleolus YDR412W YIL061C YAL028W YPL093W YBR119W YLR095C YGL127C YHL004W YER161C YML064C YDR026C YDR235W YPL153C The gene product is essential for both DNA replication fork blocking and recombinational hotspot act DNA replication fork blocking protein Loss of replication fork blocking and recombinational hotspot activities.
FOL1 YNL256W 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity* folic acid and derivative biosynthesis cytoplasm folic acid synthesis dihydro-6-hydroxymethylpterin pyrophosphokinase|dihydroneopterin aldolase|dihydropteroate synthetase essential, induces pseudohyphal growth
FOL2 YGR267C GTP cyclohydrolase I activity folic acid and derivative biosynthesis cytoplasm YGR267C YLR347C YML064C YNL189W YPL003W YKL210W YHR135C YJR090C YHR030C YIR034C YOL087C YMR106C First enzyme in biosynthetic pathway for folic acid and tetrahydrobioptern GTP-cyclohydrolase I Folinic acid requiring
FOX2 YKR009C 3-hydroxyacyl-CoA dehydrogenase activity* fatty acid beta-oxidation peroxisomal matrix peroxisomal multifunctional beta-oxidation protein multifunctional beta-oxidation protein mutant lacks 2-enoyl-CoA hydratase and D-3-hydroxyacyl-CoA dehydrogenase activities
FPR2 YDR519W peptidyl-prolyl cis-trans isomerase activity biological_process unknown endoplasmic reticulum membrane binds the immunosuppressant drug FK506 FKBP13 (FK506 binding protein)|peptidyl-prolyl cis-trans isomerase (PPIase) Null mutant is viable
FPR3 YML074C peptidyl-prolyl cis-trans isomerase activity biological_process unknown nucleolus YPL204W YER133W YOR080W YDR386W YIL061C YIL035C binds the immunosuppressant drugs, FK506 and rapamycin, and is localized to the nucleolus; binds to peptidyl-prolyl cis-trans isomerase (PPIase) Null mutant is viable; overexpression gives no phenotype except is growth inhibitory in fpr1 mutant;
FPR4 YLR449W peptidyl-prolyl cis-trans isomerase activity biological_process unknown nucleus YBR119W YJL023C YNL061W YLR196W YKR081C YIL050W YLR453C YMR049C YER041W YER133W Homolog of homolog of the nucleolar FKBP, Fpr3 peptidyl-prolyl cis-trans isomerase (PPIase) Null mutant is viable
FPS1 YLL043W transporter activity* transport* cytoplasm* YGL054C YPL192C YHR158C YHR030C YNL192W YLR330W YLR342W YPR159W YLR332W YBL061C YGR229C YKL037W Suppressor of tps1/fdp1 and member of the MIP family of transmembrane channels; may be involved in g glycerol channel protein Null mutant is viable
FRE1 YLR214W ferric-chelate reductase activity iron ion transport* plasma membrane YER069W Ferric (and cupric) reductase cupric reductase|ferric reductase Null mutant is viable, fre1-1 mutants are deficient in the uptake of ferric iron and are extremely s
FRE2 YKL220C ferric-chelate reductase activity iron ion transport* plasma membrane Ferric reductase, similar to Fre1p ferric reductase
FRE3 YOR381W ferric-chelate reductase activity iron ion homeostasis* plasma membrane* YNR019W YBR139W similar to FRE2 ferric reductase transmembrane component 3
E.C. 1.6.99.13
FRE4 YNR060W ferric-chelate reductase activity iron-siderochrome transport plasma membrane similar to FRE2
FRQ1 YDR373W calcium ion binding biological_process unknown membrane YDL218W YOR136W YHR060W YGL153W YGL098W YOR003W YGR082W Product of gene unknown
FRS2 YFL022C phenylalanine-tRNA ligase activity phenylalanyl-tRNA aminoacylation cytoplasm* YDL193W YGR169C YLR060W YMR059W YMR284W YKR026C Phenylalanyl-tRNA synthetase, beta subunit, cytoplasmic phenylalanine-tRNA ligase subunit
FTR1 YER145C iron ion transporter activity high affinity iron ion transport plasma membrane YDR307W YIL056W YJL001W YER081W high-affinity iron transporter, primarily expressed under oxygenated conditions. iron permease Lacks high affinity iron uptake
FUI1 YBL042C uridine transporter activity uridine transport plasma membrane YER021W YBR021W YLR039C YJL062W uridine permease uridine permease Null mutant is viable, resistant to 5-fluorouridine and does not grow on media containing uridine as
FUM1 YPL262W fumarate hydratase activity tricarboxylic acid cycle* cytosol* YPR165W YMR291W YML095C Fumarase; converts fumaric acid to L-malic acid in the TCA cycle fumarase (fumarate hydralase) respiratory defective
FUN12 YAL035W translation initiation factor activity* translational initiation cytosolic small ribosomal subunit (sensu Eukarya) YGR102C YLR241W YOR361C YBR084W YMR309C YDR496C YDL014W YNL030W YDL220C YLR175W YGL130W YER036C YFR031C-A YPR041W YIR001C YLR427W YER142C YMR106C Functions in general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribos 97 kDa protein Null mutant is inviable
FUN26 YAL022C nucleoside transporter activity nucleoside transport membrane* YGL132W predicted membrane protein Null mutant is viable
FUN34 YNR002C transporter activity transport* membrane* Highly homologous to Ycr010p and similar to Yarrowia lipolytica glyoxylate pathway regulator GPR1 (s transmembrane protein (putative) Null mutant is viable. Other phenotype: defect in ammonia production in S.cerevisiae colonies
FUR4 YBR021W uracil permease activity uracil transport plasma membrane YOR128C YEL021W YBL042C uracil permease uracil permease Null mutant is viable
FUS1 YCL027W molecular_function unknown conjugation with cellular fusion plasma membrane* YIR014W YML058W YHR158C YMR047C YPL242C cell-surface protein required for cell fusion Null mutant is viable; in fus1 x fus1 matings there is an interruption of the mating process just be
FUS2 YMR232W molecular_function unknown plasma membrane fusion shmoo tip YCR009C YHL043W YHR158C YPR120C Involved in cell fusion during mating, also required for the alignment of parental nuclei before nuc Null mutant is viable, fus2 mutants have strong defects in karyogamy and fail to orient microtubules
FUS3 YBL016W MAP kinase activity protein amino acid phosphorylation* nucleus* YHR168W YIL169C YDR103W YDL159W YPL049C YDR469W YLR313C YLR362W YGL178W YDR480W YGL057C YNL053W YGL158W Required for the arrest of cells in G(sub)1 in response to pheromone and cell fusion during conjugat CDC28/cdc2 related protein kinase sterile; divide continuously in the presence of pheromones; form prezygotes with wild-type cells of
FYV8 YGR196C molecular_function unknown biological_process unknown cytoplasm YBR260C YGR253C YDL080C YLR200W YNL094W YIL131C Function required for Yeast Viability on toxin exposure Null phenotype is K1 killer toxin hypersensitive
FZF1 YGL254W transcription factor activity positive regulation of transcription from Pol II promoter* nucleus YGR047C YOR039W YHR215W YNL189W YGL154C involved in sulfite resistance contains five zinc fingers|transcription factor Null mutant is viable, sulfite sensitive. FZF1 is a high copy suppressor of grr1 mutants
FZO1 YBR179C GTPase activity mitochondrion organization and biogenesis* mitochondrial outer membrane YHR041C YDR142C may be involved in mitochondrial fusion Drosophila melanogaster fuzzy onions gene homolog|integral protein of the mitochondrial outer membra Null mutant is viable, exhibits a petite phenotype and fragmented mitochondrial morphology
GAA1 YLR088W GPI-anchor transamidase activity attachment of GPI anchor to protein integral to endoplasmic reticulum membrane YIR038C YHR215W ER protein essential for attaching GPI (glycosylphosphatidylinositol) to protein GPI:protein transamidase component (putative) Null mutant is inviable; temperature-sensitive mutant, after shifting to restrictive temperature, do
GAD1 YMR250W glutamate decarboxylase activity response to oxidative stress* cytoplasm glutamate decarboxylase glutamate decarboxylase
GAL11 YOL051W RNA polymerase II transcription mediator activity transcription from Pol II promoter mediator complex YOL148C YPL016W YOR290C YNL236W YDL005C YBL093C YBR253W YDR335W YBR081C YHR154W Regulates transcription of a diverse array of genes. Required for mating and sporulation. RNA polymerase II holoenzyme complex component|positive and negative transcriptional regulator of ge Null mutant is viable, exhibits reduced expression of Gal4 regulated genes
GAL2 YLR081W glucose transporter activity* galactose metabolism* plasma membrane YKR026C YLR270W YOR181W Galactose transport, also able to transport hexoses galactose permease Galactose non-utilizer
GAL3 YDR009W protein binding regulation of transcription, DNA-dependent* cytoplasm YML051W YOL133W Involved in galactose induction of GAL genes Galactose non-utilizer
GAL4 YPL248C transcriptional activator activity regulation of transcription, DNA-dependent* nucleus YML051W Positive regulator of GAL genes zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type Null mutant is viable, cannot utilize galactose as sole carbon source
GAL7 YBR018C UTP-hexose-1-phosphate uridylyltransferase activity galactose metabolism cytoplasm YER081W YNL161W YKL108W YPR054W YHR030C YGL137W YMR106C galactose-1-phosphate uridyl transferase galactose-1-phosphate uridyl transferase Null mutant is viable and cannot utilize galactose.
GAL80 YML051W transcription co-repressor activity regulation of transcription, DNA-dependent* nucleus* YBR020W YDR009W YPL248C inhibits transcription activation by Gal4p in the absence of galactose transcriptional regulator Null mutant is viable but has constitutive expression of the GAL genes.
GAL83 YER027C SNF1A/AMP-activated protein kinase activity protein amino acid phosphorylation* nucleus YGL115W YOR276W YGL208W YDR206W YDR477W Glucose repression protein Null mutant is viable
GAP1 YKR039W general amino acid permease activity amino acid transport integral to plasma membrane general amino acid permease general amino acid permease abolished activity of the general amino acid transport system
GAR1 YHR089C RNA binding rRNA modification* nucleolus* YKL014C YBR084W YPL043W YDL051W YDR496C YBL004W YDL213C YGL049C YPL012W YNL262W YLR175W YNL005C YDL208W YHR072W-A YGL122C YMR047C YBR017C YJR022W YNL061W YGL171W small nucleolar RNP proteins small nucleolar RNP protein Null mutant is inviable
GAS1 YMR307W 1,3-beta-glucanosyltransferase activity cell wall organization and biogenesis plasma membrane YAL053W YMR316C-A YMR317W YMR326C YPL041C YHR030C YJL095W YPR159W YNL322C YER155C YDL006W YDR136C YDR137W YDR162C YLR261C YGR229C YPL161C YOR008C YGR166W YBR229C YER111C YKL157W YML117W YDR293C YLR357W YLR371W YKR072C YNL294C YDR440W YGL110C YGL200C Glycophospholipid-anchored surface protein cell surface glycoprotein 115-120 kDa Null mutant is slow growing and exhibits cell wall defects.
GAS3 YMR215W molecular_function unknown biological_process unknown cell wall (sensu Fungi) YGL198W Hypothetical ORF
GAS4 YOL132W molecular_function unknown biological_process unknown cell wall (sensu Fungi) YLR390W-A YBR058C Hypothetical ORF
GAS5 YOL030W molecular_function unknown biological_process unknown cell wall (sensu Fungi) YJR003C YJR055W YCL019W Hypothetical ORF
GAT1 YFL021W specific RNA polymerase II transcription factor activity* transcription initiation from Pol II promoter* nucleus YGL011C YJR082C YLR068W YNL258C activator of transcription of nitrogen-regulated genes; inactivated by increases in intracellular gl transcriptional activator with GATA-1-type Zn finger DNA-binding motif Null mutant is viable. Required for expression of nitrogen catabolite repression-sensitive genes
GAT2 YMR136W transcription factor activity transcription nucleus Similar to GATA-family of DNA binding proteins
GAT3 YLR013W transcription factor activity transcription nucleus The amino acid sequence of this ORF is very homologous to that of GAT4/YIR013C.
GAT4 YIR013C transcription factor activity transcription nucleus YJL102W very short and so far mRNA can't be detected very short and so far mRNA can't be detected being investigated
GBP2 YCL011C RNA binding* telomere maintenance* nucleus YFL034C-B YDR381W YHR167W YML062C YLR432W YNL139C YDL084W YNL253W YDR138W YDR120C YNL189W YKL139W YDL213C G-strand Binding Protein
binds single-stranded telomeric repeat sequences in vitro; similar to Gb contains RNA recognition motifs Mutation alters the distribution of Rap1p, a telomere-associated protein, but has no effect on telom
GCD1 YOR260W translation initiation factor activity translational initiation ribosome* YDR211W YLR291C YER025W YLR044C YKR026C YPL237W YGR083C YJR007W YNL265C YLR447C YML095C general control of amino acid biosynthesis and cell cycle initiation gamma subunit|negative regulator in the general control of amino acid biosynthesis|translation initi affect growth rate under nonstarvation conditions
GCD10 YNL062C tRNA methyltransferase activity translational initiation* nucleus YOR361C YJL125C YPR086W First identified as negative regulator of GCN4 expression RNA-binding protein|subunit of tRNA(1-methyladenosine) methyltransferase, along with Gcd14p Null mutant is inviable. There are mutants available that show constitutive HIS4 transcription and s
GCD11 YER025W translation initiation factor activity translational initiation ribosome YLR215C YOL142W YOR260W YDR211W YPR110C YNL312W YLR291C YKL095W YJR007W YBR217W YML064C YDL059C YOR212W YKR026C YMR117C eIF2 is a heterotrimeric GTP-binding protein
SUI2 encodes the alpha subunit
SUI3 encodes th translational initiation factor eIF-2 gamma subunit Null mutant is inviable, gcd11 mutants have slower growth rate under nonstarvation conditions
GCD14 YJL125C tRNA methyltransferase activity tRNA methylation nucleus YER179W YFL052W YNL062C General Control Derepression subunit of tRNA(1-methyladenosine) methyltransferase, along with Gcd10p 3-Aminotriazole resistance; unconditional slow growth
GCD2 YGR083C translation initiation factor activity translational initiation ribosome* YCR084C YDR211W YOR260W YNL265C YLR291C YIL131C YJR007W YKR026C translation initiation factor eIF2B, 71 kDa (delta) subunit; translational repressor of GCN4 protein 71 kDa subunit (delta)|translation initiation factor eIF2B subunit|translational repressor of GCN4 p Null mutant is inviable; resistance to 5-methyltryptophan, 5-fluorotryptophan and canavanine; overri
GCD6 YDR211W translation initiation factor activity translational initiation ribosome* YLR291C YER025W YKR026C YPL237W YGR083C YJR007W YOR260W YNL265C YJL080C YAL009W Guanine nucleotide exchange factor, 81 kDa subunit translation initiation factor eIF-2B epsilon subunit Null mutant is inviable; non-null mutations increase GCN4 translation
GCD7 YLR291C translation initiation factor activity translational initiation ribosome* YCR076C YDR444W YHL018W YOR284W YLR386W YLR423C YPL070W YPL124W YKL205W YIL128W YMR058W YCR086W YER025W YEL013W YDR416W YDR448W YMR246W YLR245C YJR132W YGR024C YBR176W YMR052W YFR008W YKR026C YPL237W YGR083C YDR211W YOR260W YDR484W YGL181W YJL199C YO translation initiation factor eIF2b, 43 kDa subunit; negative regulator of GCN4 expression 43 kDa|negative regulator of GCN4 expression|translation initiation factor eIF2B subunit Null mutant is inviable; non-null mutants exhibit an increase in GCN4 translation
GCN1 YGL195W molecular_function unknown regulation of translational elongation cytosol* YFR009W YAL021C YAL059W YHR108W YBR017C YNL132W YBR142W YPL082C YJL050W YOR326W YAL029C YER171W YJL074C YLL050C YDL193W YOL133W YER100W YNL323W translational activator of GCN4 through activation of GCN2 in response to starvation translational activator of GCN4 through activation of GCN2 in response to starvation Null mutant is viable and sensitive to 3-aminotriazole
GCN2 YDR283C protein kinase activity protein amino acid phosphorylation* cytosolic ribosome (sensu Eukarya) YNL213C YOR308C YKL173W YBR055C YBL074C YGR091W YPR178W YLR409C Derepression of GCN4 expression eukaryotic initiation factor 2 alpha (eIF2-alpha) kinase Null mutant is viable, unable to grow on medium containing 3-aminotriazole (3-AT), a competitive inh
GCN20 YFR009W molecular_function unknown regulation of translational elongation cytosol* YGL195W YER171W YER095W YDR170C YLR058C Positive effector of the EIF-2-alpha kinase activity of GCN2; component of a heteromeric complex tha ATP-binding cassette (ABC) family Null mutant is viable and shows impaired derepression of GCN4 translation and reduced levels of eIF-
GCN3 YKR026C translation initiation factor activity translational initiation eukaryotic translation initiation factor 2B complex YJL215C YJR072C YDR342C YOR128C YLR291C YGL206C YKL211C YBR120C YER025W YOR047C YAL002W YLR289W YOR317W YLR081W YKL011C YKR026C YPL237W YGR083C YGL026C YFL022C YDR211W YOR260W YEL051W YDL143W YHL032C YJR019C YMR021C YOR190W YBL030C YMR145C YGR282C YB 34 KD alpha subunit of eIF2B eIF2B 34 kDa alpha subunit null mutants fail to derepress amino acid-regulated genes under conditions of amino acid starvation
GCN4 YEL009C DNA binding* regulation of transcription from Pol II promoter* nucleus YBL019W YPL038W YDL097C YHR145C transcriptional activator of amino acid biosynthetic genes transcriptional activator of amino acid biosynthetic genes The null mutant is viable but requires arginine on minimal medium and issensitive to 3-amino-1,2,4-t
GCN5 YGR252W histone acetyltransferase activity histone acetylation* SAGA complex YOR225W YDR448W YPL254W YDR176W YOL148C YBR081C YHR099W YMR319C YMR223W YHR041C YNL236W YCL010C YGL112C YBR253W YDR167W YPL016W YOR290C YBR289W YHR030C functions in the Ada and SAGA (Spt/Ada) complexes to acetylate nucleosomal histones histone acetyltransferase Null mutant is viable, sensitive to intra-S-phase DNA damage, and grows poorly on minimal media.
GCR1 YPL075W DNA binding* positive regulation of transcription from Pol II promoter* nucleus YNL216W YPL031C trans-acting positive regulator of the enolase and glyceraldehyde-3-phosphate dehydrogenase gene fam trans-acting positive regulator of the enolase and glyceraldehyde-3-phosphate dehydrogenase gene fam Null mutant has a severe growth defect when grown in the presence of glucose, but grows quite well o
GCR2 YNL199C transcriptional activator activity positive regulation of transcription from Pol II promoter* nucleus YIL061C YDL100C YMR139W YPR048W YPL031C YLR418C activates transcription of glycolytic genes; homologous to GCR1; may function in complex with Gcr1p transcription factor Null mutant is viable and has partial growth defect on glucose-containing media
GCS1 YDL226C ARF GTPase activator activity* ER to Golgi transport* cytoskeleton* YHR135C YNL154C YGR172C YDR264C YOR327C YPR183W YGL161C YOL129W YGL198W YBL098W YEL064C YER118C YJL151C YKL126W YKR088C YPR113W YDL153C YER123W Zn-finger-containing protein that functions as ADP-ribosylation factor GTPase-activating protein and ADP-ribosylation factor GTPase-activating protein (ARF GAP) Null mutant is cold-sensitive for reentry into mitotic cell cycle from stationary phase and shows in
GCV1 YDR019C glycine dehydrogenase (decarboxylating) activity one-carbon compound metabolism* mitochondrion Required for metabolizing glycine as a nitrogen source glycine decarboxylase complex T subunit Null mutant is viable but cannot use glycine as sole nitrogen source
GCV2 YMR189W glycine dehydrogenase (decarboxylating) activity one-carbon compound metabolism mitochondrion Glycine CleaVage system glycine cleavage system P subunit|glycine decarboxylase complex P subunit|glycine synthase P subunit Inability to convert glycine to serine (ser1 background); Inability to utilize glycine as a nitogen
GCV3 YAL044C glycine dehydrogenase (decarboxylating) activity one-carbon compound metabolism mitochondrion H-protein subunit of the glycine cleavage system glycine cleavage system H-protein subunit Null mutant is viable but does not grow if glycine is the sole nitrogen source
GDA1 YEL042W guanosine diphosphatase activity* protein amino acid glycosylation Golgi apparatus YJL152W YEL017W YER073W YLR250W YPR193C YPL051W converts nucleoside diphosphates to nucleoside monophosphates to recycle nucleosides and promote tra guanosine diphosphatase of Golgi membrane Null mutant is viable and has partial block in mannosylation of proteins and sphingolipids
GDH1 YOR375C glutamate dehydrogenase (NADP) activity glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+) nucleus* YJL124C YDR420W NADP-specific glutamate dehydrogenase NADP-specific glutamate dehydrogenase Null mutant is viable
GDH2 YDL215C glutamate dehydrogenase activity nitrogen metabolism soluble fraction YLR320W YBR196C YPR048W YLR432W NAD-dependent glutamate dehydrogenase NAD-dependent glutamate dehydrogenase Null mutant is viable, grows very poorly on glutamate as a nitrogen source
GDH3 YAL062W glutamate dehydrogenase activity glutamate biosynthesis nucleus* YLR267W YNL189W Involved in glutamate biosynthesis NADP-linked glutamate dehydrogenase Null mutant is viable
GDI1 YER136W RAB GDP-dissociation inhibitor activity vesicle-mediated transport membrane fraction* YOR089C YIR009W YFL005W YFL038C YLR362W YBR264C YER031C YPR180W YKR014C YGL210W YML001W YMR047C YLR262C YNL135C YJR035W Regulates vesicle traffic in secretory pathway by regulating dissociation of GDP from Sec4/Ypt/rab f GDP dissociation inhibitor Null mutant is inviable
GEA1 YJR031C ARF guanyl-nucleotide exchange factor activity ER to Golgi transport* Golgi vesicle YFR037C component of a complex guanine nucleotide exchange activity for the ADP-ribosylation factor ARF GDP/GTP exchange factor
GEA2 YEL022W ARF guanyl-nucleotide exchange factor activity ER to Golgi transport* Golgi vesicle YBR207W YDR062W Guanine-nucleotide Exchange on ARF ARF GTP/GDP exchange factor Null mutant is viable, synthetically lethal with gea1 null mutant
GEF1 YJR040W voltage-gated chloride channel activity cation homeostasis Golgi vesicle YBL086C YLR039C YLR262C Integral membrane protein highly homologous to voltage-gated chloride channels from humans, mice and transport protein involved in intracellular iron metabolism (putative) Null mutant is viable; cells grow slowly on rich media containing carbon sources utilized by respira
GFD1 YMR255W molecular_function unknown mRNA-nucleus export cytoplasm* YDR192C YOR046C YDL207W YGL122C YBR274W YGL112C YHR016C Great for FULL DEAD box protein activity Null mutant is viable; high copy suppressor of rat8-2|Null mutant is viable
GGA1 YDR358W molecular_function unknown Golgi to vacuole transport Golgi trans face YPR159W Golgi-localized, gamma-adaptin homology, Arf-binding. Interacts with Arf1p and Arf2p in a GTP-depend ARF-binding protein Single and double knockouts are viable at both 30 C and 37 C. Cells lacking GGA1, GGA2 exhibit defec
GGA2 YHR108W molecular_function unknown Golgi to vacuole transport Golgi trans face YGL206C YGL195W YIL094C YHR030C YBR229C Golgi-localized, gamma-adaptin homology, Arf-binding. Interacts with Arf1p and Arf2p in a GTP-depend ARF-binding protein Single and double knockouts are viable at both 30 C and 37 C. Cells lacking GGA1, GGA2 exhibit defec
GIC1 YHR061C small GTPase regulatory/interacting protein activity establishment of cell polarity (sensu Saccharomyces)* bud neck* YNL298W YCR086W YMR238W YPL161C YHR107C YML109W YKL082C YDR309C YCL032W YLR229C YMR055C Gtpase-interacting component 1 Null mutant is viable; gic1 gic2 double null is temperature sensitive at 33 degrees C
GIC2 YDR309C small GTPase regulatory/interacting protein activity establishment of cell polarity (sensu Saccharomyces)* bud tip* YNL298W YCR086W YMR238W YPL161C YHR107C YMR055C YML109W YKL082C YDR116C YCL032W YGR207C YLR229C YKL007W YHR061C YOR127W Gtpase-interacting component 2 Null mutant is viable and temperature sensitive at 37 degrees C; gic1 gic2 double null is temperatur
GIM3 YNL153C tubulin binding tubulin folding cytoplasm YEL003W YML094W YGR078C YLR200W YBR108W YDR149C YDR334W YDR360W YGR054W YKL118W YLL049W YLR089C YPL017C YBL007C YNL298W YLR386W YCR044C YHR030C YJL095W YJR075W YBR200W YER155C YMR109W YLR337C YBR171W YJL183W YJR117W YOR216C YJR032W YDR310C YHR012W YL Prefoldin subunit 4; putative homolog of subunit 4 of bovine prefoldin, a chaperone comprised of six bovine prefoldin subunit 4 homolog (putative) Null mutant is viable, super-sensitive towards the microtubule-depolymerizing drug benomyl, syntheti
GIM4 YEL003W tubulin binding tubulin folding cytoplasm YML094W YGR078C YCR082W YDR149C YDR334W YJR129C YKL118W YLL007C YLL049W YLR089C YNL140C YPL017C YPR050C YBL007C YNL298W YLR386W YCR044C YJR075W YDR155C YER155C YMR109W YER149C YLR337C YLR200W YJL014W YBR171W YJL183W YJR117W YOR216C YJR032W YHR012W YL Prefoldin subunit 2; putative homolog of subunit 2 of bovine prefoldin, a chaperone comprised of six bovine prefoldin subunit 2 homolog (putative) Null mutant is viable, sensitive to anti-microtubule drugs benomyl and nocadazole; synthetically let
GIM5 YML094W tubulin binding tubulin folding cytoplasm YBR108W YBR255W YDR149C YDR334W YDR360W YGR054W YHL029C YKL118W YLL007C YLL049W YLR089C YNL140C YPL017C YPL176C YPR050C YBL007C YNL298W YLR386W YHR030C YJL095W YJR075W YEL031W YER155C YMR109W YLR337C YLR200W YBR171W YJR117W YOR216C YJR032W YDR310C YH Prefoldin subunit 5; putative homolog of subunit 5 of bovine prefoldin, a chaperone comprised of six bovine prefoldin subunit 5 homolog (putative) Null mutant is viable, cold sensitive, benomyl and nocadazole sensitive and fails to grow on YPD+1.2
GIN4 YDR507C protein kinase activity protein amino acid phosphorylation* bud neck YJR076C YHR107C YKR048C YCR002C YLR314C YAL027W YMR139W YBR125C YNL271C Growth inhibitory gene serine/threonine kinase (putative) Null mutant is viable, exhibits a mild elongated bud phenotype and some cell clumping
GIP1 YBR045C protein phosphatase 1 binding spore wall assembly (sensu Saccharomyces) prospore membrane* YDR103W YER133W YIL045W YOR329C YGR169C YBR045C YER054C YLR263W YBL105C YOR178C Developmentally-regulated protein phosphatase 1 (Glc7) interacting protein which is required for spo sporulation defective
GIT1 YCR098C phospholipid transporter activity phospholipid transport plasma membrane YJL184W YLR447C member of the yeast sugar permease family, which consists of 34 proteins. permease involved in the uptake of glycerophosphoinositol (GroPIns) Null mutant is viable, exhibits decreased GroPIns transport
GLC7 YER133W protein phosphatase type 1 activity* meiosis* nucleolus* YBR099C YDR412W YJL042W YOR329C YDR130C YHR100C YOR315W YHR052W YKL085W YNL233W YLR258W YDR028C YMR012W YGR103W YLR134W YGL256W YFR015C YDR195W YJR093C YML074C YMR049C YPR160W YCL054W YGL111W YOR272W YIR006C YLR449W YDR301W YPL237W YJR007W YHR158C YB Glycogen accumulation. Gip1p-Glc7p phosphatase complex is required for proper septin organization an protein phosphatase type I Null mutant is inviable
GLC8 YMR311C enzyme activator activity glycogen biosynthesis cytoplasm YPL031C YER133W YDR436W Homolog of mammalian protein phosphatase inhibitor 2. protein phosphatase 1 (Glc7p) regulator Null mutant is viable; deletion of glc8 suppresses phenotypes of ipl1 and glc7 mutants. Gene disrupt
GLE1 YDL207W molecular_function unknown poly(A)+ mRNA-nucleus export nuclear pore YDL207W YDR192C YKL068W YER107C YMR047C YEL024W YMR255W YIL115C Polyadenylated-RNA-export factor; the HIV Rev protein may mimic function of Gle1 nuclear pore complex subunit|nuclear-export-signal (NES)-containing protein Null mutant is inviable
GLE2 YER107C structural molecule activity mRNA-nucleus export* nuclear pore YHL008C YNL189W YKL068W YDR192C YMR047C YEL024W YGL143C YDR300C YDL207W YGL092W Nuclear pore protein required for poly(A)+ RNA export, has beta-transducin (WD-40) repeats nuclear pore complex subunit|rae1 S. pombe homolog gle2 mutations exhibit double mutant inviability in combination with nup100 mutants
GLK1 YCL040W glucokinase activity carbohydrate metabolism cytosol YML099C YCL040W YDR516C YBR040W YNL189W Glucose phosphorylation glucokinase Null mutant is viable with no discernible difference from wild-type; hxk1, hxk2, glk1 triple null mu
GLN1 YPR035W glutamate-ammonia ligase activity nitrogen metabolism* cytoplasm YBR126C glutamine synthetase glutamine synthetase Glutamine synthetase non-derepressible
GLN3 YER040W transcription factor activity* positive regulation of transcription from Pol II promoter* nucleus* YGL181W YCL032W Responsible for nitrogen catabolite repression (NCR)-sensitive transcription. During nitrogen starva transcriptional activator of nitrogen-regulated genes Glutamine synthetase non-derepressible
GLN4 YOR168W glutamine-tRNA ligase activity amino acid activation cytoplasm glutaminyl-tRNA synthetase glutamine-tRNA ligase Null mutant is inviable
GLO2 YDR272W hydroxyacylglutathione hydrolase activity carbohydrate metabolism cytoplasm Cytoplasmic glyoxylase-II glyoxylase-II Null mutant is viable but shows increased sensitivity to methylglyoxal
GLO3 YER122C ARF GTPase activator activity ER to Golgi transport* ER-Golgi intermediate compartment YJL030W YNL287W YDL145C YGL137W YJR132W YDR238C YER176W YHR148W YBR234C YPL051W YLR039C YLR262C YLR418C YLR085C YBR164C Zinc-finger-containing protein with similarity to Gcs1p and Sps18p similar to Gcs1p and Sps18p|zinc finger protein
GLO4 YOR040W hydroxyacylglutathione hydrolase activity carbohydrate metabolism mitochondrion* YBR054W YNL092W Mitochondrial glyoxylase-II glyoxylase-II Null mutant is viable, but shows increased sensitivity to methylglyoxal
GLT1 YDL171C glutamate synthase (NADH) activity glutamate biosynthesis cell YBL023C YBL087C YPR086W YDL047W YMR117C Glutamate synthase (NADH) glutamate synthase (NADH) Null mutant is viable
GLY1 YEL046C threonine aldolase activity threonine catabolism* cytosol YEL046C YBR009C YNL189W YNL220W L-threonine aldolase that catalyzes cleavage of L-allo-threonine and L-threonine to glycine threonine aldolase Null mutant is viable, glycine auxotroph, gly1 null mutants are not glycine auxotrophs on ethanol me
GND1 YHR183W phosphogluconate dehydrogenase (decarboxylating) activity glucose metabolism cytoplasm YKL085W YGL216W YNL014W YPR110C YHR196W YPL126W YMR059W YBR114W YHR030C YER161C YHR135C YMR049C YEL056W 6-phosphogluconate dehydrogenase, decarboxylating; converts 6-phosphogluconate + NADP to ribulose-5- cannot grow on media containing D-glucono-delta-lactone as the sole carbon source
GND2 YGR256W phosphogluconate dehydrogenase (decarboxylating) activity glucose metabolism cytosol YPL126W YMR059W 6-phosphogluconate dehydrogenase, decarboxylating; converts 6-phosphogluconate + NADP to ribulose-5- 6-phosphogluconate dehydrogenase cannot grow on media containing D-glucono-delta-lactone as the sole carbon source
GNP1 YDR508C amino acid transporter activity* amino acid transport plasma membrane YOR123C YPR025C YLR373C YDL212W YLR342W YMR307W high-affinity glutamine permease high affinity glutamine permease Null mutant is viable but shows reduced glutamine transport and is therefore resistant to the glutam
GNT1 YOR320C acetylglucosaminyltransferase activity N-linked glycosylation Golgi medial cisterna N-acetylglucosaminyltransferase transferase capable of modification of N-linked glycans in the Golgi N-acetylglucosaminyltransferase
GON1 YAL048C molecular_function unknown vesicle-mediated transport integral to membrane Null mutant is viable but exhibits slightly reduced secretion of over-produced PrA. Null mutants als
GON5 YPL183W-A structural constituent of ribosome protein biosynthesis mitochondrion YLR103C Putative mitochondrial ribosomal protein
GOS1 YHL031C v-SNARE activity intra-Golgi transport* integral to membrane YLR026C YKL196C YKL006C-A YBL050W YPL051W YOR070C YLR039C YLR262C YLR418C YBR164C YDR126W SNARE protein with a C-terminal membrane anchor
GOlgi Snare
GOT1 YMR292W molecular_function unknown ER to Golgi transport* Golgi membrane Golgi Transport membrane protein Null mutant is viable but exhibits ER to Golgi transport defects in vitro. got1 is synthetically let
GPA1 YHR005C heterotrimeric G-protein GTPase activity signal transduction during conjugation with cellular fusion plasma membrane* YBR116C YHL026C YOR212W YDL100C YLR362W YOR178C YBR128C YJL080C YDR179C YMR069W YER020W Involved in the mating pheromone signal transduction pathway; component of pheromone response pathwa G protein alpha subunit|coupled to mating factor receptor The null mutation is inviable in haploids but not diploids. Gpa1 mutants exhibit specific defects in
GPD1 YDL022W glycerol-3-phosphate dehydrogenase (NAD) activity intracellular accumulation of glycerol cytoplasm YPL022W glycerol-3-phosphate dehydrogenase glycerol-3-phosphate dehydrogenase lethal under conditions of osmotic stress, unable to grow on glycerol
GPD2 YOL059W glycerol-3-phosphate dehydrogenase (NAD) activity glycerol metabolism cytosol YFL017C YBR058C YPL022W Involved in glycerol production via conversion of glyerol-3-phosphate and NAD+ to glycerol phosphate glycerol-3-phosphate dehydrogenase (NAD+) Null mutant is viable
GPH1 YPR160W glycogen phosphorylase activity glycogen catabolism cytoplasm YPL204W YHR196W YPR111W YER054C YML058W YNL250W YDL043C YGR092W YDR419W YBR055C YMR106C YGL115W YER133W YKL166C YAL017W Releases glucose-1-phosphate from glycogen glycogen phosphorylase Null mutant is viable; haploid cells contain higher levels of intracellular glycogen
GPI1 YGR216C molecular_function unknown GPI anchor biosynthesis membrane Participates in synthesis of N-acetylglucoaminylphosphatidylinositol, the first intermediate in synt Null mutant is viable but is temperature-sensitive for growth, for [3H]inositol incorporation into p
GPI10 YGL142C molecular_function unknown GPI anchor biosynthesis integral to membrane YML012W Involved in glycosyl phosphatidyl inositol synthesis; could be the target of the GPI synthesis inhib alpha 1,2 mannosyltransferase (putative) Null mutant is inviable but can be complemented by the homologous cDNA from humans that encodes the
GPI11 YDR302W phosphoethanolamine N-methyltransferase activity GPI anchor biosynthesis endoplasmic reticulum Glycosylphosphatidylinositol (GPI) assembly
GPI12 YMR281W N-acetylglucosaminylphosphatidylinositol deacetylase activity GPI anchor biosynthesis endoplasmic reticulum membrane N-acetylglucosaminylphosphatidylinositol de-N-acetylase N-acetylglucosaminylphosphatidylinositol de-N-acetylase Null mutation is inviable
GPI13 YLL031C phosphoethanolamine N-methyltransferase activity GPI anchor biosynthesis endoplasmic reticulum YHL015W Glycosylphosphatidylinositol (GPI) biosynthesis Null mutant is inviable; Gpi13p-depleted strains accumulate a GPI precursor whose glycan headgroup c
GPI16 YHR188C GPI-anchor transamidase activity attachment of GPI anchor to protein integral to endoplasmic reticulum membrane YJR015W YDL137W YDL192W YBR296C YNL092W Glycosyl Phosphatidyl Inositol 16 GPI transamidase component, human PIG-T homologue Null: inviable.
GPI17 YDR434W GPI-anchor transamidase activity attachment of GPI anchor to protein integral to endoplasmic reticulum membrane Glycosyl Phosphatidyl Inositol 17 GPI transamidase component, human PIG-S homologue Null Mutant:inviable
GPI8 YDR331W GPI-anchor transamidase activity attachment of GPI anchor to protein integral to endoplasmic reticulum membrane YER081W Protein involved in the attachment of glycosylphosphatidylinositol (GPI) anchors to proteins Null mutant is inviable
GPM1 YKL152C phosphoglycerate mutase activity gluconeogenesis* cytosol YDL090C YNL127W converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis phosphoglycerate mutase Required for sporulation
GPM2 YDL021W NOT phosphoglycerate mutase activity gluconeogenesis* cytoplasm* Similar to GPM1 (phosphoglycerate mutase); converts 3-phosphoglycerate to 2-phosphoglycerate in glyc Null mutant is viable, gpm2 gpm3 double deletion mutants exhibit no synthetic phenotypes
GPM3 YOL056W NOT phosphoglycerate mutase activity gluconeogenesis* cytosol YLR387C converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis phosphoglycerate mutase Null mutant is viable, gpm3 gpm2 double deletion mutants exhibit no synthetic phenotypes
GPR1 YDL035C G-protein coupled receptor activity pseudohyphal growth* plasma membrane YER020W G-protein-coupled receptor at plasma membrane; interactions in two-hybrid system with Gpa2p Null mutant is viable and grows normally
GPT2 YKR067W glycerol-3-phosphate O-acyltransferase activity phospholipid biosynthesis cytoplasm* YFR051C YGL137W Encodes a Glycerol-3-phosphate acyltransferase
GRD19 YOR357C protein binding protein localization cytosol Functions in Golgi retention. Grd19p contains the PX domain found in human SNX1 (Sorting Nexin-1). Localized predominantly to the Null mutant is viable but defective for retention of proteins in the trans-Golgi. grd19 null mutants
GRE1 YPL223C molecular_function unknown response to stress* cytoplasm Induced by osmotic stress Null mutant is viable and shows no phenotype in osmotic, ionic or oxidative stress
GRE2 YOL151W oxidoreductase activity* response to stress nucleus* YGR111W YLR196W induced by osmotic stress; similar to dihydroflavonol 4-reductase from plants Null mutant is viable.
GRH1 YDR517W molecular_function unknown mitotic spindle checkpoint cytoplasm Yeast (GR)ASP65 (H)omologue mammalian GRASP protein homolog Null: Null mutation is viable, exhibits defects in spindle checkpoint
GRR1 YJR090C protein binding* ubiquitin-dependent protein catabolism* nucleus* YBR284W YPR158W-B YLL050C YDR155C YGR240C YNL055C YKL048C YGL190C YBL002W YDR328C YMR032W YLR134W YDL132W YLL039C YGR087C YER043C YGR267C YDR054C F box protein with several leucine rich repeats Null mutant is viable, resistant to high levels of divalent cations, sensitive to sulfite, and defec
GRS1 YBR121C glycine-tRNA ligase activity glycyl-tRNA aminoacylation* cytoplasm* YNL244C YLR427W YBR055C YHR007C YNL192W YLR330W YLR342W Glycyl-tRNA synthase glycine-tRNA ligase
GRX1 YCL035C thiol-disulfide exchange intermediate activity* response to oxidative stress* cytoplasm YIL034C YMR059W Glutaredoxin EC 1.20.4.1|glutaredoxin Null mutant is viable but sensitive to oxidative stress. grx1 grx2 null mutants are viable but lack
GRX3 YDR098C thiol-disulfide exchange intermediate activity response to oxidative stress intracellular YGL071W YGL044C YGL220W YGR262C Member of a glutaredoxin subfamily in Sc together with GRX4 & GRX5. Sign. sequence diff. with the ot glutaredoxin Null mutant is viable and shows moderate sensitivity to oxidative stress and increased oxidation lev
GRX4 YER174C thiol-disulfide exchange intermediate activity response to oxidative stress intracellular YGL220W YGR262C Member of a glutaredoxin subfamily in Sc together with GRX3 & GRX5. Significant sequence diff. with glutaredoxin Null mutant is viable and shows moderate sensitivity to oxidative stress and increased oxidation lev
GRX5 YPL059W thiol-disulfide exchange intermediate activity response to osmotic stress* mitochondrial matrix YJL162C YNL047C YIL105C YMR032W YFL010C Member of glutaredoxin subfamily together w/GRX3, GRX4. Significant sequence diff. from other glutar glutaredoxin Null mutant is viable and shows high sensitivity to oxidative stress and increased sensitivity to os
GSC2 YGR032W 1,3-beta-glucan synthase activity cell wall organization and biogenesis* actin cap (sensu Saccharomyces)* YLR342W YJL034W Highly similar to FKS1 (GSC1). GSC2 and FKS1 encode redundant catalytic components of 1,3-beta-gluca 1,3-beta-D-glucan synthase catalytic component Null mutant is viable and shows partially reduced 1,3-beta-glucan synthase activity
GSF2 YML048W molecular_function unknown secretory pathway cytoplasm* YIR038C YDL100C YDL047W YML094W Glucose Signaling Factor A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent
GSG1 YDR108W molecular_function unknown ER to Golgi transport* TRAPP YGR234W YGR166W YDR407C YMR218C YBR254C YDR246W YDR472W YOR115C YIR040C YKR068C YML077W YPL051W YLR039C YLR262C YLR085C YBR164C Probably has role late in meiosis following DNA replication homozygous diploids do not sporulate (no asci)
GSH1 YJL101C glutamate-cysteine ligase activity glutathione biosynthesis* intracellular YPL031C encodes the first enzyme involved in glutathione biosynthesis gamma-glutamylcysteine synthetase Null mutant is viable, exhibits alteration of glutathione content and reduction in growth rate
GSH2 YOL049W glutathione synthase activity glutathione biosynthesis intracellular Glutathione Synthetase glutathione synthetase Null mutant is viable, growth was poor under aerobic conditions in minimum medium
GSP1 YLR293C RAN small monomeric GTPase activity rRNA processing* nucleus* YLR347C YJR074W YDR335W YGL097W YOL021C YMR308C YER052C YOR185C YDR002W YJL041W YOR160W YJR091C YBR017C YMR235C YDL193W YER161C YGR218W YER110C YGL238W maintenance of nuclear organization; homologous to mammalian Ran, a small nuclear GTPase of the ras GTP-binding protein Null mutant is inviable
GSP2 YOR185C RAN small monomeric GTPase activity nuclear organization and biogenesis nucleus YJR074W YOR171C YBR017C YLR293C YMR235C YOL128C YDL193W maintenance of nuclear organization; homologous to mammalian Ran, a small nuclear GTPase of the ras GTP-binding protein|Gsp1p homolog Null mutant is viable
GSY2 YLR258W glycogen (starch) synthase activity glycogen metabolism cytoplasm YLR258W YIL045W YLR273C YFR015C YJL137C YJL020C YER054C YER177W YOR026W YER133W YBR274W Highly similar to GSY1. GSY2 is the predominantly expressed glycogen synthase. Activity is probably glycogen synthase (UDP-glucose-starch glucosyltransferase) Null mutant is viable. Mutant lacking both GSY1 and GSY2 is viable but lacks glycogen synthase activ
GTR1 YML121W small monomeric GTPase activity phosphate transport nucleus* YML121W YLR377C YGR163W YHR114W YKR007W YLR295C YOL144W YNL113W Involved in the function of the Pho84 phosphate transporter small GTPase (putative) Null mutant is viable but grows slowly, is cold-sensitive, and has defects in phosphate uptake
GTR2 YGR163W small monomeric GTPase activity biological_process unknown nucleus* YCR015C YGR203W YPL235W YGL207W YBR158W YGR098C YKR007W YML121W (putative) small GTPase, similar to Gtr1 similar to Gtr1|small GTPase (putative)
GTS1 YGL181W molecular_function unknown sporulation (sensu Saccharomyces)* nucleus* YCR072C YDL233W YIL057C YNR068C YOR331C YOR333C YBR138C YAL004W YFR024C YOR284W YHR016C YBL007C YDR388W YAR018C YDR259C YGR241C YER047C YPL013C YPR171W YHR086W YER161C YER063W YER045C YJL141C YIR006C YIL052C YER073W YHR177W YIL010W YIL122W YOR140W YP Putative zinc-finger transcription factor Null mutant is viable; shows reduced lag phase
GTT1 YIR038C glutathione transferase activity glutathione metabolism endoplasmic reticulum YIR038C YLL060C YCL025C YDL089W YDR120C YDR371W YEL017W YER022W YGL225W YGR121C YGR149W YGR191W YHR123W YHR190W YIL023C YJL097W YLR026C YLR088W YML048W YMR119W YNL234W YOL065C YPL020C Glutathione Transferase glutathione transferase Null mutant is viable, heat shock sensitive at stationary phase
GTT2 YLL060C glutathione transferase activity glutathione metabolism cell YIR038C Glutathione Transferase glutathione transferase Null mutant is viable, heat shock sensitive in stationary phase
GUP1 YGL084C glycerol transporter activity glycerol catabolism* membrane YJR091C YLR308W YNL058C YLR039C YLR262C YBR023C YLR330W YJL099W YAL058W YGR166W YBL061C YCR009C YDR388W YNL322C YBR229C YGL027C Involved in active glycerol uptake glycerol transporter (putative)
GUP2 YPL189W molecular_function unknown biological_process unknown membrane YMR048W Involved in active glycerol uptake active glycerol transporter (putative)
GUT2 YIL155C glycerol-3-phosphate dehydrogenase activity carbohydrate metabolism* mitochondrion glycerol-3-phosphate dehydrogenase, mitochondrial glycerol-3-phosphate dehydrogenase Null mutant is viable, unable to utilize glycerol as a carbon source
GWT1 YJL091C molecular_function unknown GPI anchor biosynthesis membrane YER087C-B YMR047C GPI-anchored wall protein transfer 1 overexpression confers 1-[4-butylbenzyl]isoquinoline (BIQ)-resistant growth in S. cerevisiae.
GYP1 YOR070C Rab GTPase activator activity vesicle-mediated transport Golgi apparatus YER083C YJL183W YOR216C YLR268W YJR032W YDR310C YDR136C YDR162C YGL005C YHL031C YLR261C YML071C YNL041C YNL051W YLR039C YLR262C YBR036C YPL055C YPL057C YJR060W YMR272C YBR127C YGR157W YPR036W YBR164C YDR414C YJL004C YMR138W YHR007C YPL051W YDL049C YB Gtpase activating protein for Ypt1p GTPase activating protein (GAP) Null mutant is viable and shows no phenotype
GYP5 YPL249C Rab GTPase activator activity vesicle-mediated transport cytosol* YNL191W YOL131W YDR388W GAP for Ypt protein GTPase-activating protein Null: viable
GYP8 YFL027C Rab GTPase activator activity vesicle-mediated transport intracellular YER078C YHR115C YKL195W GAP for Ypt protein GTPase-activating protein Null: viable
GZF3 YJL110C specific RNA polymerase II transcription factor activity negative regulation of transcription from Pol II promoter* nucleus YNL021W YJL110C YCR014C YDL203C YJR091C YKR034W Dal80 homolog GATA zinc finger protein 3 homologous to Dal80 in structure and function Null mutant is partially NCR-insensitive
HAA1 YPR008W specific RNA polymerase II transcription factor activity transcription initiation from Pol II promoter nucleus YDR335W Homolog of Ace1 Activator
HAC1 YFL031W specific RNA polymerase II transcription factor activity regulation of transcription from Pol II promoter* nucleus YFL031W Transcription factor that is required for the unfolded protein-response pathway; binds to CRE motif; bZIP (basic-leucine zipper) protein Null mutant is viable but is sensitive to caffeine (suppressed by high-copy SRA5) and stresses that
HAL1 YPR005C molecular_function unknown transcription initiation from Pol II promoter* cytoplasm Protein induced by NaCl, KCl, or sorbitol; involved in halotolerance (tolerance to salt) polar 32 kDa cytoplasmic protein Null mutant is viable, shows decreased salt tolerance
HAL9 YOL089C specific RNA polymerase II transcription factor activity transcription initiation from Pol II promoter* nucleus involved in salt tolerance contains zinc finger|transcription factor (putative) Null mutant is viable, exhibits decreased salt tolerance and ENA1 expression; HAL9 overexpression in
HAP1 YLR256W specific RNA polymerase II transcription factor activity aerobic respiration* nucleus Activator of CYC1 and CYP3 transcription; positive regulator of cytochrome C genes CYC1 and CYC7 zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type Essential for anaerobic or heme deficient growth; Null mutant is viable, deficient in expression of
HAP2 YGL237C transcriptional activator activity transcription* nucleus* YGR146C YLR423C YMR153W YOR047C YOR358W YBL021C YDR277C YKL109W YLR200W YNL192W Global regulator of respiratory genes transcriptional activator protein of CYC1 (component of HAP2/HAP3 heteromer)
HAP3 YBL021C transcriptional activator activity transcription* CCAAT-binding factor complex YGL237C YOR358W YKL109W YHL006C YLR200W Regulates respiratory functions; encodes divergent overlapping transcripts transcriptional activator protein of CYC1 (component of HAP2/HAP3 heteromer)
HAP4 YKL109W transcriptional activator activity transcription* CCAAT-binding factor complex YGL237C YOR358W YBL021C Regulates respiratory functions; encodes divergent overlapping transcripts transcriptional activator protein of CYC1 (component of HAP2/HAP3 heteromer) hap4 point mutants or disruptions are unable to grow on non-fermentable carbon sources
HAP5 YOR358W transcriptional activator activity transcription* CCAAT-binding factor complex YOR047C YBL021C YDR277C YKL109W YGL237C YGR236C YLR200W YNL153C YEL003W YMR307W Regulates respiratory functions; subunit of a heterotrimeric complex required for CCAAT binding CCAAT-binding transcription factor component (along with Hap2p and Hap3p) Null mutant is viable
HAS1 YMR290C molecular_function unknown biological_process unknown nucleolus* YKL103C YER006W YLR175W YPR016C YAL007C YJL033W YER126C YBR142W YDL208W YNL061W YPL043W YHR088W YDR060W YKR081C YNL110C YHR066W YBR278W YGR103W YLR427W YGR040W YIL061C YML064C YDL213C YMR049C YIL035C Helicase Associated with SET1 RNA-dependent helicase (putative) Null mutant is inviable
HAT1 YPL001W H3/H4 histone acetyltransferase activity chromatin silencing at telomere* nucleus* YOR361C YMR309C YEL056W YBR079C YLL022C YBR009C YBR272C YBL023C YNL230C YLR103C histone acetyltransferase histone acetyltransferase Null mutant is viable
HAT2 YEL056W H3/H4 histone acetyltransferase activity chromatin silencing at telomere* nucleus* YPL001W YNL030W YHR183W YLL022C YDR233C YBR272C YLR200W YGR078C YLR103C subunit of histone acetyltransferase; may regulate activity of Hat1p, the catalytic subunit of histo histone acetyltransferase subunit Null mutant is viable
HBT1 YDL223C molecular_function unknown cellular morphogenesis during conjugation with cellular fusion shmoo tip YNL192W YBR023C YLR342W Hub1 target
HCA4 YJL033W ATP dependent RNA helicase activity 35S primary transcript processing nucleolus YCL037C YLR197W YER133W YOL041C YMR290C YDL014W YLR115W YKR002W YNL317W YAL043C YDR195W YMR061W YGR156W YLR277C YJR093C YOR310C YLR175W YNL016W YCR057C putative RNA helicase RNA helicase (putative) Null mutant is inviable. A Tn3 insertion into this gene causes hypersensitivity to the cell surface
HCM1 YCR065W specific RNA polymerase II transcription factor activity transcription initiation from Pol II promoter* nucleus YCR041W YFL037W YHR129C YMR294W YKR054C YDR150W YCL029C YLR085C YJL030W Dosage-dependent suppressor of cmd1-1 mutation; shows homology to fork head family of DNA-binding pr forkhead protein Null mutant is viable; exacerbates temperature-sensitivity of a cmd1-1 (calmodulin) mutant
HCR1 YLR192C translation initiation factor activity protein biosynthesis eukaryotic translation initiation factor 3 complex YBR079C YPR041W YDR091C YML064C YJR075W High Copy suppressor of RPG1 Substoichiometric component of eukaryotic translation initiation factor 3 (eIF3)
HCS1 YKL017C DNA helicase activity lagging strand elongation alpha DNA polymerase:primase complex YOR167C YOL108C DNA helicase 1 DNA helicase A
HDA1 YNL021W histone deacetylase activity regulation of transcription, DNA-dependent* histone deacetylase complex YPR179C YDR295C YPR016C YOL090W YKR034W YJL110C YHL006C component of histone deacetylase A histone deacetylase|shares sequence similarity with Rpd3p, Hos1p, Hos2p, and Hos3p Null mutant is viable; exhibits increased acetylation levels in core histones H3 and H4; exhibtis in
HEF3 YNL014W ATPase activity* translational elongation cytosolic ribosome (sensu Eukarya) YJR068W YHR183W YJL173C YMR059W YGR262C YCR079W YHR169W YJR017C YFR028C Translational elongation factor EF-3B Translation elongation factor 3 (EF-3)
HEK2 YBL032W mRNA binding telomerase-dependent telomere maintenance* cytoplasm* YMR310C YFR012W YBR084W YOL139C YMR125W YGL049C YML117W YGR162W YNL030W YNL112W YLR175W YPL237W YNL005C YML105C Heterogeneous nuclear RNP K-like gene Null: ASH1 mRNA is partially delocalized
HEM1 YDR232W 5-aminolevulinate synthase activity heme biosynthesis mitochondrial matrix First enzyme in heme biosynthetic pathway 5-aminolevulinate synthase Null mutant is viable; auxotroph for heme and methionine
HEM13 YDR044W coproporphyrinogen oxidase activity heme biosynthesis mitochondrial inner membrane YGL112C YNL189W YDR077W Oxygen-repressed, sixth step in heme biosynthetic pathway coproporphyrinogen III oxidase Null mutant is viable; auxotroph for heme and methionine
HEM14 YER014W protoporphyrinogen oxidase activity heme biosynthesis mitochondrion converts protoporphyrinogen IX to protoporphyrin IX (in synthesis of heme) protoporphyrinogen oxidase Null mutant is viable but is protoporphyrinogen oxidase deficient (heme deficiency and accumlation o
HEM15 YOR176W ferrochelatase activity heme biosynthesis mitochondrial inner membrane YER071C YDR226W YGR123C YHR062C YLR196W YJR042W YBR017C YDL134C YDR499W Performs last step in heme biosynthesis pathway, inserting ferrous iron into protoporphyrin IX ferrochelatase (protoheme ferrolyase) Null mutant is inviable in certain genetic backgrounds
HEX3 YDL013W DNA binding sporulation (sensu Saccharomyces)* nucleus YIL061C YDL030W YDR510W YER116C YNR031C YLR443W YLR006C YOR208W YJR091C YOR144C YPR135W YCL016C Protein involved in hexose metabolism null is synthetically lethal with sgs1 null
HFI1 YPL254W transcription cofactor activity transcription from Pol II promoter* SAGA complex YDR176W YOL148C YDR146C YDR448W YGR252W YBR081C YPL031C Transcription factor involved in global regulation of gene expression Ada/Gcn5 protein complex member|transcription factor Null mutant phenotypes similar to spt20/ada5 and spt7 mutants. Null mutant is viable, elongated cell
HFM1 YGL251C DNA helicase activity meiosis* nucleus YNL127W DNA helicase that functions in meiotic crossing over C4 zinc finger DNA-binding protein of low sequence specificity in vitro; Probable 119 kDa DNA/RNA he Null mutant is viable
HHF1 YBR009C DNA binding chromatin assembly/disassembly nuclear nucleosome YFR006W YPR077C YEL046C YBR084W YPR010C YGL019W YNL132W YGR240C YKR054C YGL190C YOR188W YLR106C YBL004W YPL001W YJR138W YLR239C YJR132W YDL058W YER093C YER110C YMR308C YLR180W YBL088C YMR021C YDL070W YMR176W YER065C YDR300C YGR170W YPR110C YDR303C YJ Histone H4 (HHF1 and HHF2 code for identical proteins) histone H4 (HHF1 and HHF2 code for identical proteins)
HHF2 YNL030W DNA binding chromatin assembly/disassembly nuclear nucleosome YGL190C YGL130W YER164W YDR155C YFL024C YAR002C-A YEL056W YBR272C YCR057C YLR176C YMR061W YJL074C YGR162W YBL032W YAL035W YKL067W YIL126W Histone H4 (HHF1 and HHF2 code for identical proteins) histone H4 (HHF1 and HHF2 code for identical proteins)
HHO1 YPL127C DNA binding regulation of transcription, DNA-dependent nucleus* YER142C YDR386W Histone H1 histone H1 Null mutant is viable; other phenotype: Increased basal expression of a CYC1-lacz reporter gene; nuc
HHT1 YBR010W DNA binding chromatin assembly/disassembly nucleus* YER142C YKL103C YIL035C Histone H3 (HHT1 and HHT2 code for identical proteins) histone H3 (HHT1 and HHT2 code for identical proteins) Null mutant is viable
HHT2 YNL031C DNA binding chromatin assembly/disassembly nuclear nucleosome YIL126W Histone H3 (HHT1 and HHT2 code for identical proteins) histone H3 (HHT1 and HHT2 code for identical proteins)
HIP1 YGR191W L-histidine transporter activity manganese ion transport* plasma membrane YLR283W YIR038C YPR181C YPL218W YIL109C histidine permease histidine permease requires supplementation with large amounts of histidine for growth
HIR1 YBL008W transcription co-repressor activity regulation of transcription from Pol II promoter nucleus* YBL008W YOR038C YGR063C YLR103C YDL017W YDR052C YAL013W Involved in cell-cycle regulation of histone transcription contains nuclear targeting signal|repressor protein (putative)|similar to Tup1p and mammalian retina Null mutant is viable, but HTA1-HTB1 transcription is derepressed and is no longer cell-cycle regula
HIR2 YOR038C transcription co-repressor activity regulation of transcription from Pol II promoter nucleus YDR477W YDR225W YBL008W YLR418C YLR103C Involved in cell-cycle regulation of histone transcription contains nuclear targeting signal|repressor protein (putative) Null mutant is viable, but HTA1-HTB1 transcription is derepressed and is no longer cell-cycle regula
HIR3 YJR140C transcription co-repressor activity G1/S-specific transcription in mitotic cell cycle nucleus YJL115W YNL312W YML058W YLR418C YLR103C YDL017W YDR052C YDR363W YAL013W Involved in cell-cycle regulation of histone transcription HTA1-HTB1 transcription is derepressed and is no longer cell-cycle regulated
HIS1 YER055C ATP phosphoribosyltransferase activity histidine biosynthesis cell involved in the first step of histidine biosynthesis ATP phosphoribosyltransferase Null mutant is viable and requires histidine
HIS2 YFR025C histidinol-phosphatase activity histidine biosynthesis cell Histidinolphosphatase histidinolphosphatase Null mutant is viable and requires histidine
HIS3 YOR202W imidazoleglycerol-phosphate dehydratase activity histidine biosynthesis cell YOR202W YPR016C imidazoleglycerol-phosphate dehydratase imidazoleglycerol-phosphate dehydratase Null mutant is viable and requires histidine
HIS4 YCL030C phosphoribosyl-ATP diphosphatase activity* histidine biosynthesis cell YML124C YDL160C YLR044C YLR180W YGR052W histidinol dehydrogenase histidinol dehydrogenase Null mutant is viable and requires histidine
HIS5 YIL116W histidinol-phosphate transaminase activity histidine biosynthesis cell responsive to control of general amino acid biosynthesis histidinol-phosphate aminotransferase Null mutant is viable and requires histidine
HIS6 YIL020C 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase ac histidine biosynthesis cell YLR295C phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase Null mutant is viable and requires histidine
HIS7 YBR248C imidazoleglycerol phosphate synthase activity histidine biosynthesis cell YOL102C glutamine amidotransferase:cyclase, also called imidazole glycerol phosphate synthase glutamine amidotransferase:cyclase|imidazole glycerol phosphate synthase (synonym) Null mutant is viable and requires histidine
HKR1 YDR420W molecular_function unknown cell wall organization and biogenesis* plasma membrane YNL171C YMR089C YJL095W YFR036W YMR123W YPL161C YNL064C YDR245W YDR440W YGL200C YKL041W YMR060C YGR159C YOL023W YOR141C YOR375C cell surface protein that may regulate cell wall beta-glucan synthesis and bud site selection; Hanse contains EF hand motif|type I transmembrane protein Null mutant is inviable; overexpression confers resistance to Hanenula mrakii killer toxin
HMF1 YER057C molecular_function unknown biological_process unknown nucleus* YNL189W YDL190C Homologous Mmf1p factor Null mutant grows faster than wild-type cells and has higher survival rate at 42.5c; overexpression
HMG1 YML075C hydroxymethylglutaryl-CoA reductase (NADPH) activity ergosterol biosynthesis endoplasmic reticulum membrane* YNR009W YOR102W Induces cell to assemble stacks of paired nuclear-associated membranes called karmellae. 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase isozyme Null mutant is viable, sensitive to compactin, a competitive inhibitor of HMG-CoA reductase; hmg1 hm
HMG2 YLR450W hydroxymethylglutaryl-CoA reductase (NADPH) activity ergosterol biosynthesis endoplasmic reticulum membrane* YOL113W Induces cells to assemble peripheral ER membrane arrays and short nuclear-associated membrane stacks 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase isozyme Null mutant is viable, sensitive to compactin, a competitive inhibitor of HMG-CoA reductase; hmg1 hm
HMI1 YOL095C ATP dependent DNA helicase activity mitochondrial genome maintenance mitochondrial matrix YPL270W Helicase in MItochondria
HMLALPHA1 YCL066W transcription co-activator activity regulation of transcription from Pol II promoter* nucleus YDR224C YBL002W YJR091C YLR288C transcription factor involved in the regulation of alpha-specific genes involved in the regulation of alpha-specific genes|transcription factor
HMLALPHA2 YCL067C transcription co-repressor activity regulation of transcription from Pol II promoter* nucleus YOL006C YLR288C Homeobox-domain containing protein which, in haploid cells, acts with MCM1 to repress a-specific gen
HMO1 YDR174W RNA polymerase I transcription factor activity* plasmid maintenance nucleus* YBR233W YAL027W YKL130C YKR092C YML098W YNL189W YPR104C YDL213C YLR074C YDR335W YIL013C YML015C YML064C one of seven HMG-box proteins of Saccharomyces cerevisiae. high mobility group (HMG) family Null mutant is viable, but grows slowly and shows higher than normal plasmid loss rate
HMRA1 YCR097W transcription co-repressor activity regulation of transcription, mating-type specific nucleus silenced copy of A1, which encodes a homeobox-domain containing protein that, together with alpha2, homeobox transcription factor Null mutant is viable; deletion of the expressed copy of A1 causes mating defect; diploids in which
HMT1 YBR034C protein-arginine N-methyltransferase activity mRNA-nucleus export* nucleus YDR432W YMR048W YGR118W YDR249C YER017C YGR165W YGR181W YIL061C YNL078W hnRNP methyltransferase arginine methyltransferase|mono- and asymmetrically dimethylating enzyme Null mutant is viable, hmt1 npl3-1 mutants are inviable
HMX1 YLR205C peroxidase activity* iron ion homeostasis membrane YJR091C Homology to heme oxygenases Null mutant is viable.
HNM1 YGL077C choline transporter activity choline transport plasma membrane choline transport protein; may also control uptake of nitrogen mustard transporter (permease) for choline and nitrogen mustard; share homology with UGA4 Null mutant is viable, but hyper-resistant to nitrogen mustard; ctr1,cho1 double null is inviable
HNT1 YDL125C hydrolase activity* nucleotide metabolism cytoplasm YER075C YJR091C Hint homolog, member of the histidine triad superfamily of nucleotide-binding proteins
HO YDL227C endonuclease activity mating-type switching/recombination* nucleus Homothallic switching homothallic switching endonuclease Null mutant is viable and cannot undergo mating type switching
HOC1 YJR075W alpha-1,6-mannosyltransferase activity* cell wall mannoprotein biosynthesis* mannosyltransferase complex YLR338W YNR005C YDR129C YBL007C YDR388W YOR089C YJL095W YLR087C YOR035C YPL050C YNL322C YEL031W YLR337C YMR198W YKR020W YML071C YNR051C YJL148W YBL047C YML115C YJR043C YAL002W YMR060C YJL176C YKR082W YJR084W YBR082C YJR145C YHR013C YGR133W YML097C YP Homologous to OCH1, an alpha-1,6-mannosyltransferase; Golgi-localized, type II integral membrane pro mannosyltransferase (putative) Null mutant is viable but is hypersensitive to calcofluor white and hygromycin B and has lowered res
HOF1 YMR032W cytoskeletal protein binding cytokinesis contractile ring (sensu Saccharomyces) YDR203W YNL271C YLR423C YBR260C YER144C YGR250C YJL039C YJR090C YNL152W YOR324C YPL059W YIL159W YCR054C YOR098C SH3 domain containing-protein required for cytokinesis Null mutant is defective in cytokinesis
HOG1 YLR113W MAP kinase activity protein amino acid phosphorylation* nucleus* YBL083C YLR358C YNL171C YNL296W YPR045C YMR089C YJL183W YMR198W YOR123C YGR092W YNL215W YDR359C YLR362W YMR272C YBR194W YDR363W-A YGL200C YLR398C YKL041W YKL194C YMR172W YML097C YDR414C YJL128C YDR497C YNL264C YPL180W YGL158W YLR248W YDL235C YGR058W Osmoregulation. Hog1p is activated under stress conditions when the cAMP cellular content is low. MAP kinase Null mutant is viable and unable to grow in high osmolarity media
HOL1 YNR055C transporter activity transport plasma membrane Putative ion transporter similar to the major facilitator superfamily of transporters ion transporter (putative)|similar to the major facilitator superfamily of transporters Null mutant is viable, unable to uptake histidinol or Na+. Gain-of-function mutations confer non-sel
HOP1 YIL072W DNA binding meiosis* condensed nuclear chromosome* YLR263W YOR351C Meiosis-specific protein involved in homologous chromosome synapsis and chiasmata formation DNA binding protein decreased levels of meiotic crossing over and intragenic recombination between markers on homologous
HOP2 YGL033W molecular_function unknown synapsis condensed nuclear chromosome YDR332W HOmologous Pairing meiosis-specific gene required for the pairing of similar chromosomes Null mutant is viable; homozygous hop2 null diploids arrest in meiotic prophase prior to the first m
HOR7 YMR251W-A molecular_function unknown response to stress cell wall (sensu Fungi)* hyperosmolarity-responsive gene
HOS1 YPR068C histone deacetylase activity regulation of transcription, DNA-dependent* histone deacetylase complex Protein with similarity to Hda1p, Rpd3p, Hos2p, and Hos3p
HOS2 YGL194C NAD-dependent histone deacetylase activity* regulation of transcription, DNA-dependent* histone deacetylase complex YBR103W YMR273C YLR200W YGR078C YML094W YAL013W YPL181W YMR263W Protein with similarity to Hda1p, Rpd3p, Hos1p, and Hos3p
HOS3 YPL116W histone deacetylase activity histone deacetylation nucleus* Protein with similarity to Hda1p, Rpd3p, Hos2p, and Hos1p
HOS4 YIL112W NAD-dependent histone deacetylase activity* histone deacetylation* histone deacetylase complex YDR155C YMR273C YBR103W YNL298W YJL168C
HOT1 YMR172W specific RNA polymerase II transcription factor activity regulation of transcription from Pol II promoter* nuclear chromosome YOR039W YIL035C YLR113W YGR078C YML094W high osmolarity induced transcription nuclear protein osmostress hypersensitivity
HPA2 YPR193C histone acetyltransferase activity histone acetylation cytoplasm YEL042W YML064C YNL189W YPL070W YCL032W Histone and other Protein Acetyltransferase; Has sequence homology to known HATs and NATs histone acetyltransferase Null mutant is viable and does not show any detectable phenotype
HPC2 YBR215W transcription regulator activity G1/S-specific transcription in mitotic cell cycle nucleus YLR453C YKL113C YLR418C YLR103C YDR052C Protein required for normal cell-cycle regulation of histone gene transcription highly charged basic protein altered cell cycle regulation of histone gene transcription; suppresses delta insertion mutations in
HPR1 YDR138W nucleic acid binding mRNA-nucleus export* THO complex YEL060C YDR214W YLR234W YOL006C YML062C YNR031C YNL139C YDL084W YKR010C YBR175W YCL011C YNL088W Hyperrecombination protein that suppresses intrachromosomal excision recombination Increased intrachromosomal recombination
HPR5 YJL092W DNA helicase activity DNA repair* nucleus YBR099C YLR235C YFL045C YIR009W YDR510W YNL250W YPR181C YGL163C YNL273W YPR164W YBR098W YJR043C YDR369C YHR031C YLR234W YPL024W YHR154W YMR190C YKL113C YOR144C YDR078C YDR386W YLR320W YIR002C YDL101C YOR355W YCR066W YPR135W YHR191C YMR078C YCL016C YP Required for proper timing of committment to meiotic recombination and the transition from Meiosis I DNA helicase Null mutant is viable, radiation (ultraviolet or ionizing sensitive), loss of function results in RA
HRB1 YNL004W molecular_function unknown protein-nucleus import nucleus* YOR160W YBR270C YJR082C YKL139W YIL079C an ORF of unknown function located in a centromeric region duplicated between chromosomes III and XI hypothetical RNA-binding protein
HRD1 YOL013C ubiquitin-protein ligase activity ER-associated protein catabolism endoplasmic reticulum membrane Ubiquitin-protein ligase for endoplasmic reticulum-associated degradation. Null mutant is viable, slows degradation of Hmg2p
HRD3 YLR207W ubiquitin-protein ligase activity ER-associated protein catabolism endoplasmic reticulum YPL022W HMG-CoA Reductase Degradation--the HRD complex is responsible for the endoplasmic reticulum (ER)-ass Null mutant is viable, slows degradation of Hmg2p
HRP1 YOL123W cleavage/polyadenylation specificity factor activity mRNA polyadenylation* nucleus* YFL018C YDR023W YMR061W YGL044C YDL060W YGL122C YMR064W YMR282C YDR350C YBR017C YCL032W Putative polyadenylated-RNA-binding protein located in nucleus; similar to vertebrate hnRNP A/B prot cleavage and polyadenylation factor CF I component involved in pre-mRNA 3'-end processing Null mutant is inviable; mutants can suppress temperature-sensitive alleles of npl3 (but not npl3 nu
HRR25 YPL204W protein kinase activity* DNA repair* nucleus YBR225W YOR215C YKL056C YER138C YLL013C YDR342C YOR232W YDL047W YBR247C YDR023W YER095W YHR179W YCR088W YPL004C YKL085W YBR011C YLR438W YHR193C YKL143W YNL272C YPR181C YBL051C YBL047C YER133W YER006W YBR009C YEL034W YDL065C YBL045C YGR086C YGR155W YM Similar to YCK1 and YCK2, two other casein kinase I isoforms; found primarily in nucleus; may be inv casein kinase I isoform Null mutant is viable but shows slow growth; hrr25-1 mutation results in sensitivity to continuous e
HRT1 YOL133W protein binding* ubiquitin-dependent protein catabolism* nucleus* YAR009C YLR035C-A YLL034C YIL001W YJL200C YHR027C YGR240C YCR093W YDR216W YBR208C YOR261C YGR218W YOR326W YJL020C YLR106C YEL034W YJL047C YGL195W YBR126C YMR246W YDL132W YLL039C YGL137W YLL040C YNL037C YLR289W YJL141C YOR341W YNL085W YPL036W YDR009W High level expression Reduces Ty3 Transposition Skp1-Cullin-F-box ubiquitin protein ligase (SCF) subunit Null mutant is inviable.
HSD1 YOR311C molecular_function unknown biological_process unknown integral to membrane* YDL049C ER membrane protein ER membrane protein Null mutant is viable, no other notable phenotype.
HSE1 YHL002W protein binding protein-vacuolar targeting endosome YNR005C YGR268C YDR259C YNR006W YNL015W YGR078C YEL003W YLR330W Has Symptoms of class E vps mutant Null: accumulates enlarged prevacuolar/endosomal compartment. Fails to sort proteins into the vacuol
HSF1 YGL073W transcription factor activity regulation of transcription from Pol II promoter* nucleus YBR160W heat shock transcription factor heat shock transcription factor Null mutant is inviable
HSH155 YMR288W mRNA binding spliceosome assembly snRNP U2 YML049C YMR213W YMR240C YDL087C YAL032C YFL017W-A YPR182W YBR152W U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice
HSH49 YOR319W RNA binding nuclear mRNA splicing, via spliceosome snRNP U2 YHR209W YDR155C YGL244W YML049C YBR103W YGR056W YER164W YPR188C YLR233C YNL135C YMR240C YJR022W YGL096W Human SAP Homolog 49. A yeast homolog of a human spliceosome associated protein (SAP) called SAP 49. mammalian splicing factor/U2 snRNP protein homolog
HSL1 YKL101W protein kinase activity protein amino acid phosphorylation* bud neck* YBR133C YNL132W YGL116W YPR135W YMR078C YCL016C YDL017W YNL250W Negative regulator of Swe1 kinase kinase domain similar to GIN4 and KCC4|serine-threonine kinase|similar to S. pombe cdr1/nim1 Null mutant is viable; synthetically lethal with histone H3 mutations; G2 delay
HSL7 YBR133C protein-arginine N-methyltransferase activity G2/M transition of mitotic cell cycle* bud neck YER087W YPL016W YJL187C YGL187C YNL094W YBR055C YKL101W YDL154W Negative regulator of Swe1 kinase Has homology to arginine methyltransferases Null mutant is viable; synthetically lethal with histone H3 mutations; G2 delay
HSP10 YOR020C chaperone activity protein folding mitochondrial matrix YDR412W YOR020C YBL056W YML092C YMR047C YNL173C YNL189W YLR335W YMR308C YML064C Homolog of E. coli GroES protein; regulates Hsp60, the yeast mitochondrial chaperonin, and is thereb heat shock protein 10 Null mutant is inviable; temperature-sensitive mutants are available
HSP104 YLL026W heat shock protein activity* response to stress* nucleus* YGR205W YDR172W YPL204W YHR196W YLR096W YOL094C YKL215C YJR062C YJR017C plays a major role in the acquisition of tolerance to a variety of stresses such as heat, ethanol, a heat shock protein 104 Null mutant is viable and defective in induced thermotolerance
HSP150 YJL159W structural constituent of cell wall cell wall organization and biogenesis cell wall (sensu Fungi) YBL044W YBR064W YDL023C YHR114W YNL321W Heat shock protein, secretory glycoprotein heat shock protein|secretory glycoprotein Null mutant is viable
HSP26 YBR072W chaperone activity* response to stress* nucleus* YDL239C YML064C YNL189W YPL169C heat shock protein 26 heat shock protein 26 Null mutant is viable; hsp26 hsp42 double deletion mutants are viable
HSP30 YCR021C heat shock protein activity response to stress* plasma membrane YJL068C YDL153C YLR453C Protein induced by heat shock, ethanol treatment, and entry into stationary phase; located in plasma
HSP42 YDR171W chaperone activity* response to stress* cytoplasm* YFR028C YML065W YNL007C YBR069C YBR101C YDR430C Similar to HSP26; expression is regulated by stress conditions Null mutant is viable; hsp42 hsp26 double deletion mutants are viable; hsp42 null mutants subjected
HSP60 YLR259C heat shock protein activity protein folding* mitochondrion 60 kDa heat shock protein chaperonin|groEL homolog Null mutant is inviable
HSP78 YDR258C chaperone activity* response to stress* mitochondrial matrix Similar to E. coli ClpB protein; involved in folding of some mitochondrial proteins heat shock protein 78 Null mutant is viable but in ssc1 mutant background gives rho- phenotype
HSP82 YPL240C chaperonin ATPase activity response to stress* cytoplasm YIR042C YLR362W YAL005C YKL117W YBR155W YGR123C YLR216C YLR310C YNL064C YOR027W 82 kDa heat shock protein; homolog of mammalian Hsp90 heat shock protein 90|mammalian Hsp90 homolog Null mutant is viable at 25 degrees C; ability to grow at higher temperatures varies with gene copy
HST1 YOL068C NAD-dependent histone deacetylase activity* transcriptional gene silencing nucleus* YOR043W YDR363W YBR103W YKL113C Homolog of SIR2 Overexpression restores transcriptional silencing in a sir2 mutant
HST2 YPL015C NAD-dependent histone deacetylase activity chromatin silencing at telomere cytoplasm Homolog of SIR2
HST3 YOR025W DNA binding chromatin silencing at telomere* nucleus YLR235C YML094C-A YOR082C YMR198W YJR043C YMR190C YKL113C YLR403W YDR191W YCL061C YLR103C Homolog of SIR2 hst3 hst4 double mutant has defects in telomeric silencing, cell cycle progression, radiation resist
HTA1 YDR225W DNA binding chromatin assembly/disassembly nuclear nucleosome YKR048C YPL043W YNL308C YLR222C YGR103W YBR009C YDR224C YOR038C YGL207W YGL241W YOR116C YPR190C YDR243C YMR061W YMR125W YER022W YGL127C YHL001W YLR074C YOL054W YPR104C YOR005C YLR247C YIL035C YDR332W YPR135W YHR191C YPL194W Histone H2A (HTA1 and HTA2 code for nearly identical proteins) histone H2A (HTA1 and HTA2 code for nearly identical proteins) Null mutant is viable
HTA2 YBL003C DNA binding chromatin assembly/disassembly nuclear nucleosome YCR057C YOL004W YOL054W YDL188C YBR017C YPL153C Histone H2A (HTA1 and HTA2 code for nearly identical proteins) histone H2A (HTA1 and HTA2 code for nearly identical proteins) Null mutant is viable. Deletion of the HTA2-HTB2 (TRT2) locus has no reported observable phenotypes,
HTB1 YDR224C DNA binding chromatin assembly/disassembly nuclear nucleosome YPR041W YCL066W YNL312W YIL131C YLR074C YOL054W YCR092C YBR083W YDR225W YOL108C YDR365C YKL103C YDL060W YIL066C YDL213C Histone H2B (HTB1 and HTB2 code for nearly identical proteins) histone H2B (HTB1 and HTB2 code for nearly identical proteins) Null mutant is viable
HTB2 YBL002W DNA binding chromatin assembly/disassembly nuclear nucleosome YPR010C YKR001C YKR048C YDR496C YNL262W YDR121W YOL006C YOR304W YBR245C YGL241W YPR175W YOR116C YPR190C YPL082C YMR091C YIL126W YCL066W YJL020C YGR054W YLR074C YHR197W YOL054W YJR090C YNL157W YBR114W YGR067C YER142C YMR036C YOL108C YNL068C YOL087C YD Histone H2B (HTB1 and HTB2 code for nearly identical proteins) histone H2B (HTB1 and HTB2 code for nearly identical proteins) Null mutant is viable. Deletion of the HTA2-HTB2 (TRT2) locus has no reported observable phenotypes,
HTL1 YCR020W-B molecular_function unknown regulation of cell cycle* RSC complex High-Temperature Lethal Null mutant is viable but shows temperature-sensitive lethality
HTS1 YPR033C histidine-tRNA ligase activity histidyl-tRNA aminoacylation cytoplasm* YLL050C YFR004W YOR190W YBR059C Nuclear gene that specifies two messages for cytoplasmic and mitochondrial forms histidine-tRNA ligase Certain mutations can be made to disrupt either cytoplasmic or mitochondrial form of Hts1p; loss of
HTZ1 YOL012C chromatin binding regulation of transcription from Pol II promoter* nuclear chromatin* YLR387C YJL019W YKR048C YLR288C YBR114W YJL168C YER016W YLR039C YLR262C YLR418C YCL029C YDR332W YML124C YPR135W YHR191C YMR078C YCL016C YJL030W YLR200W YGR078C YNL153C YEL003W YML094W YCL061C YNL273W YLR103C YHR181W YOR349W YAL013W YPL181W YMR263W Histone-related protein that can suppress histone H4 point mutation evolutionarily conserved member of the histone H2A F/Z family of histone variants Null mutant is viable at 28C; high copy suppressor of histone H4 point mutant affecting nucleosome s
HUA1 YGR268C molecular_function unknown biological_process unknown cytoplasm YDR388W YGR268C YAL041W YER125W YBR058C YDL239C YHL002W YML064C YOR124C YOR302W YOR138C YHR016C
HUB1 YNR032C-A protein tagging activity cellular morphogenesis during conjugation with cellular fusion* shmoo tip Similar to ubiquitin-like protein 8 of Arabidopsis thaliana and C. elegans ubiquitin-like modifier Null mutant is viable
HXK1 YFR053C hexokinase activity fructose metabolism cytosol YEL077C YER081W Glucose phosphorylation hexokinase I (PI) (also called hexokinase A) Null mutant is viable, is able to ferment fructose, and has little or no effect on glucose repressio
HXK2 YGL253W hexokinase activity fructose metabolism nucleus* YBR126C YLR200W YGR078C YNL153C YEL003W YML094W Glucose phosphorylation hexokinase II (PII) (also called hexokinase B) Null mutant is viable and can ferment fructose, but fails to show glucose repression at SUC2, CYC1,
HXT1 YHR094C glucose transporter activity* hexose transport plasma membrane YHR122W YDL194W Low-affinity glucose transporter whose expression is activated in the presence of glucose and inhibi hexose transporter Null mutant is viable
HXT10 YFL011W glucose transporter activity* hexose transport plasma membrane YMR004W high-affinity hexose transporter high affinity hexose transporter
HXT11 YOL156W glucose transporter activity* hexose transport plasma membrane YBR058C YOR299W High-affinity hexose transporter glucose permease Null mutant is viable, cycloheximide, sulfomethuron methyl, and 4-NQO (4-nitroquinoline-N-oxide) res
HXT13 YEL069C glucose transporter activity* hexose transport plasma membrane YPR110C YBL053W YGL249W high-affinity hexose transporter high affinity hexose transporter
HXT14 YNL318C galactose transporter activity hexose transport plasma membrane High-affinity hexose transporter hexose transporter
HXT15 YDL245C glucose transporter activity* hexose transport plasma membrane High-affinity hexose transporter hexose transporter
HXT16 YJR158W glucose transporter activity* hexose transport plasma membrane hexose transporter hexose permease
HXT17 YNR072W glucose transporter activity* hexose transport plasma membrane YLR147C YPL194W Hexose transporter hexose transporter
HXT2 YMR011W glucose transporter activity* hexose transport plasma membrane YDL194W hexose transporter high affinity hexose transporter-2 Null mutant is viable
HXT3 YDR345C glucose transporter activity* hexose transport plasma membrane YOR047C YDL194W Low-affinity glucose transporter low affinity glucose transporter Null mutant is viable but grows slowly on galactose; some mutant alleles confer sodium hypersensitiv
HXT4 YHR092C glucose transporter activity* hexose transport plasma membrane YDL194W hexose transporter high affinity glucose transporter Null mutant is viable
HXT5 YHR096C glucose transporter activity* hexose transport plasma membrane YLL020C YDL047W Member of superfamily of monosaccharide transporters hexose transporter Null mutant is viable
HXT6 YDR343C glucose transporter activity* hexose transport plasma membrane YER081W YKL193C YOL100W YBL036C YER125W YNL032W YER171W YLR019W YGR040W YOR181W YJR017C Repression of HXT6 expression by glucose requires SNF3 hexose transporter Null mutant is viable; snf3 hxt1 hxt2 hxt3 hxt4 hxt6 hxt7 mutant cannot grow on media containing glu
HXT7 YDR342C glucose transporter activity* hexose transport plasma membrane YDR034C YER048C YPL204W YCL039W YOL100W YBL036C YCR088W YJL173C YLR019W YLR340W YNL323W YOR181W YKR026C YMR049C Hexose transporter hexose transporter Null mutant is viable; snf3 hxt1 hxt2 hxt3 hxt4 HXT7 hxt7 mutant cannot grow on media containing glu
HXT8 YJL214W glucose transporter activity* hexose transport plasma membrane YNL192W High-affinity hexose transporter hexose permease
HXT9 YJL219W glucose transporter activity* hexose transport plasma membrane YLR447C High-affinity hexose transporter hexose permease Null mutant is viable, cycloheximide, sulfomethuron methyl, and 4-NQO (4-nitroquinoline-N-oxide) res
HYM1 YKL189W transcriptional repressor activity cytokinesis, completion of separation* intracellular YMR303C YKL010C YMR058W YDL065C YHR102W YFL016C Cbk1p and Hym1p regulate two distinct cell morphogenesis pathways: an ACE2-indep. pathway req'd for Null mutant is inviable
HYP2 YEL034W translation initiation factor activity translational initiation cytoplasm* YBR272C YOL069W YPL204W YOR043W YHR135C YDR394W YPL111W YMR284W YLR340W YOL133W YHR166C YBR055C YLR074C YBR109C YBR135W Translation initiation factor eIF-5A translation initiation factor eIF-5A Null mutant is viable; a double mutant containing disruptions of both HYP2 and and the highly homolo
HYR1 YIR037W thiol peroxidase activity* response to oxidative stress intracellular YMR047C YLR216C Hydroperoxide resistance conferring gene. Sensor and transducer of the hydroperoxide signal to Yap1. glutathione-peroxidase (putative) Null mutant is hypersensitive to oxidative stress
HYS2 YJR006W delta DNA polymerase activity lagging strand elongation* delta DNA polymerase complex YJR043C YDL102W YLR447C Putative role in DNA replication DNA polymerase delta 55 kDa subunit Null mutant is inviable
IBD2 YNL164C molecular_function unknown mitotic spindle checkpoint nucleus YGR218W YNL091W Inhibition of Bud Division Null: viable, sensitive to benomyl
ICL2 YPR006C methylisocitrate lyase activity propionate metabolism* mitochondrial matrix YLR447C 2-methylisocitrate lyase 2-methylisocitrate lyase Null mutant is viable
IDH1 YNL037C isocitrate dehydrogenase (NAD) activity tricarboxylic acid cycle* mitochondrial matrix YOL082W YOR136W YDR523C YLR097C YER020W YML057W YDR388W YHR030C YPL140C YGL137W YOL133W YMR106C YAL015C alpha-4-beta-4 subunit of mitochondrial isocitrate dehydrogenase 1 isocitrate dehydrogenase 1 alpha-4-beta-4 subunit Null mutant is viable, grows at a reduced rate on glycerol, lactate, and acetate
IDH2 YOR136W isocitrate dehydrogenase (NAD) activity tricarboxylic acid cycle* mitochondrion* YDR127W YBL022C YDR170C YDR373W YER022W YJL015C YNL037C YNL189W YPR110C YPR111W YGL208W YER171W YHR014W YGL158W YDR394W NAD+-dependent isocitrate dehydrogenase NAD-dependent isocitrate dehydrogenase Null mutant is viable
IDI1 YPL117C isopentenyl-diphosphate delta-isomerase activity ergosterol biosynthesis cytosol catalyzes activation step in isoprenoid biosynthetic pathway isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase) Null mutant is inviable
IDP1 YDL066W isocitrate dehydrogenase (NADP) activity glutamate biosynthesis* mitochondrion YMR047C Mitochondrial form of NADP-specific isocitrate dehydrogenase NADP-dependent isocitrate dehydrogenase Null mutant is viable
IDP2 YLR174W isocitrate dehydrogenase (NADP) activity glutamate biosynthesis* cytosol YNR065C YGR262C concerts isocitrate and NADP+ to 2-oxoglutarate, CO2, and NADPH NADP-dependent isocitrate dehydrogenase Null mutant is viable
IDP3 YNL009W isocitrate dehydrogenase (NADP) activity fatty acid beta-oxidation* cytoplasm* YLR295C peroxisomal NADP-dependent isocitrate dehydrogenase NADP-dependent isocitrate dehydrogenase Null mutant is viable but is unable to grow on polyunsaturated fatty acids as sole carbon source
IFM1 YOL023W RNA binding* translational initiation mitochondrion YDR420W YGR143W mitochondrial initiation factor 2 mitochondrial initiation factor 2 Null mutant is viable but is respiratory-deficient and has defects in mitochondrial protein synthesi
IKI1 YHR187W Pol II transcription elongation factor activity regulation of transcription from Pol II promoter transcription elongation factor complex* YGR200C YMR047C YMR312W RNA polymerase II Elongator associated protein Null mutant is viable but is insensitive to pGLK killer toxin; zymotoxin resistant; slow growth; the
IKI3 YLR384C Pol II transcription elongation factor activity* regulation of transcription from Pol II promoter transcription elongation factor complex* YDR461W YGR200C YER016W YLR418C YGR229C YAL013W YDR126W RNA polymerase II Elongator subunit Null mutant is viable; insensitive to pGKL killer toxin; zymotoxin resistant; slow growth; thermo-se
ILS1 YBL076C isoleucine-tRNA ligase activity protein biosynthesis cytosol YBR058C YDL100C YNL244C YPR110C YOR080W YBR055C YBR109C YLR016C cytoplasmic isoleucyl-tRNA synthetase isoleucine-tRNA synthetase Arrests in early G1 at nonpermissive temperature of 36 degrees C
ILV2 YMR108W acetolactate synthase activity branched chain family amino acid biosynthesis mitochondrion YDL059C YMR106C YNL128W acetolactate synthase acetolactate synthase Isoleucine-plus-valine requiring; Sulfometuron methyl resistance
ILV3 YJR016C dihydroxy-acid dehydratase activity branched chain family amino acid biosynthesis mitochondrion YPR165W catalyzes third step in common pathway leading to biosynthesis of branched-chain amino acids dihydroxyacid dehydratase Null mutant is viable and requires isoleucine and valine
ILV5 YLR355C ketol-acid reductoisomerase activity mitochondrial genome maintenance* mitochondrion YHR135C YBR155W YDR388W YHR030C YLR442C YDR499W branched-chain amino acid biosynthesis acetohydroxyacid reductoisomerase Isoleucine-plus-valine requiring
ILV6 YCL009C enzyme regulator activity* branched chain family amino acid biosynthesis mitochondrion YER094C YIL034C YLR288C acetolactate synthase regulatory subunit
IMD3 YLR432W IMP dehydrogenase activity GTP biosynthesis cytoplasm YDR469W YKR026C YDL215C YDR167W YLR427W YER142C YNL175C YOL115W YDR365C YDL213C YNL230C YBR055C YCL011C IMP dehydrogenase homolog IMP dehydrogenase homolog
IME1 YJR094C transcription regulator activity meiosis nucleus YDR207C YER022W YMR139W Transcriptional activator of meiotic gene expression. The null mutant is viable. Diploids homozygous for the null mutation lack premeiotic DNA synthesis a
IME2 YJL106W protein kinase activity protein amino acid phosphorylation* nucleus YIL142W YDR212W YJR091C YLR447C Positive regulator of meiosis, dispensable for mitosis, stimulates early, middle and late gene expre Null mutant is viable, homozygous null mutants are sporulation defective. High copy IME2 stimulates
IMG1 YCR046C structural constituent of ribosome protein biosynthesis mitochondrial ribosome YDL049C YNL284C YGR220C YGR091W YMR307W Required for respiration and maintenance of mitochondrial genome mitochondrial ribosomal protein Null mutant is viable; respiration deficient
IMG2 YCR071C structural constituent of ribosome protein biosynthesis mitochondrial large ribosomal subunit YNL284C YGR220C required for integrity of mitochondrial genome Null mutant is viable but shows respiratory deficiency and loss of wild-type mtDNA: conversion to rh
IMH1 YLR309C molecular_function unknown vesicle-mediated transport cytosol YLR309C YHR041C YHR114W YDL029W YLR039C YLR262C Encodes a protein implicated in protein transport; induced under stress conditions. Null mutant is viable; imh1 ypt6 double disruption causes growth inhibition
IML3 YBR107C molecular_function unknown chromosome segregation condensed nuclear chromosome kinetochore YDR383C YDR254W YPL018W YDR318W YJR135C YLR381W YBR211C YER081W YGL070C YER016W YEL061C YPR141C YPR135W YJL030W YLR200W YGR078C YNL153C YEL003W YML094W Increase Minichromosome Loss Null mutant is viable, but exhibits chromosome loss and abnormal chromosomal segregation
IMP1 YMR150C peptidase activity mitochondrial processing mitochondrial inner membrane peptidase complex Inner membrane protease (mitochondrial protein) inner membrane protease petite; unable to grow on non-fermentable carbon sources
IMP2 YMR035W peptidase activity mitochondrial processing mitochondrial inner membrane peptidase complex YLR368W YHR154W YDL049C YCL051W Inner membrane protease (mitochondrial protein) protease
IMP3 YHR148W snoRNA binding rRNA modification* small nucleolar ribonucleoprotein complex* YER122C YJR002W YBR247C YCL059C YCR057C YGR090W YCR099C part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); Interacts With Mpp10; Imp U3 snoRNP protein Null mutant is inviable. Depletion of Imp3p prevents the synthesis of mature 18S rRNA.
IMP4 YNL075W rRNA primary transcript binding rRNA modification* small nucleolar ribonucleoprotein complex* YJR002W YBR247C YCR057C part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); Interacts With Mpp10. Imp U3 snoRNP protein Null mutant is inviable
INH1 YDL181W enzyme inhibitor activity ATP synthesis coupled proton transport proton-transporting ATP synthase complex (sensu Eukarya) YDR318W ATPase inhibitor ATPase inhibitor Null mutant is viable; exhibits marked ATP hydrolysis in response to the uncoupler carbonylcyanide-m
INO2 YDR123C specific RNA polymerase II transcription factor activity positive regulation of transcription from Pol II promoter* nucleus YOL108C Transcription factor required for derepression of inositol-choline-regulated genes involved in phosp helix-loop-helix protein The null mutant is viable but auxotrophic for inositol and choline. The null mutant can also display
INO4 YOL108C specific RNA polymerase II transcription factor activity positive regulation of transcription from Pol II promoter* nucleus YMR317W YPL211W YKL135C YIL070C YBL002W YBR009C YDR224C YMR308C YDR324C YKL017C YDR123C YNL279W YLR262C Transcription factor required for derepression of inositol-choline-regulated genes involved in phosp basic helix-loop-helix (bHLH) protein The null mutant is viable but auxotrophic for inositol and choline. The null mutant expresses repres
INO80 YGL150C ATPase activity DNA repair* chromatin remodeling complex YDL002C YOR355W YNL068C Shows similarity to the Snf2p family of DNA-dependent ATPases Null mutant is viable but does not grow without inositol supplementation and does not grow with etha
INP51 YIL002C inositol-polyphosphate 5-phosphatase activity cell wall organization and biogenesis* membrane fraction YNL106C YIR006C YOR109W YLR399C Synaptojanin-like protein phosphatidylinositol 4,5-bisphosphate 5-phosphatase Null mutant is viable, has abnormal vacuoles
INP52 YNL106C inositol-polyphosphate 5-phosphatase activity cell wall organization and biogenesis* membrane fraction* YGR234W YNL055C YJL138C YPL032C YDR279W YCL028W YKR028W YER104W YPR173C YPR188C YOR109W YJR105W YDL230W YBL007C YIL002C YER016W YCL029C YDR332W YDR363W Synaptojanin-like protein inositol polyphosphate 5-phosphatase Null mutant is viable, has abnormal vacuoles
INP53 YOR109W inositol-polyphosphate 5-phosphatase activity cell wall organization and biogenesis* membrane fraction* YIL002C YNL106C YLR039C YLR262C Synaptojanin-like protein inositol polyphosphate 5-phosphatase Null mutant is viable but has abnormal vacuoles
INP54 YOL065C inositol-polyphosphate 5-phosphatase activity exocytosis endoplasmic reticulum YIR038C YMR153W YJL117W YDL204W YJR010C-A INositol polyphosphate 5-Phosphatase, fourth one identified; has homology to Type I mammalian inosit inositol polyphosphate 5-phosphatase
IOC2 YLR095C protein binding chromatin modeling nucleus YLR379W YDR110W YFR013W YOL060C YER094C YDL075W YDR445C YDR493W Iswi One Complex
IOC3 YFR013W protein binding chromatin modeling nucleus YLR095C YBR245C YBR089C-A YOL004W Iswi One Complex
IOC4 YMR044W protein binding chromatin modeling nucleus YIL061C Iswi One Complex
IPK1 YDR315C inositol/phosphatidylinositol kinase activity myo-inositol metabolism nucleus YJR117W YLR264W YLR323C YOR078W YER016W YNL273W YNL192W inositol polyphosphate kinase inositol 1,3,4,5,6-pentakisphosphate 2-kinase Null mutant is viable but is severely compromised in ability to produce IP6 (100x decrease); null ha
IPL1 YPL209C protein kinase activity chromosome segregation kinetochore microtubule* YOR084W YBR156C YEL061C Regulation of yeast chromosome segregation -- plays a crucial role in regulating kinetochore-microtu protein kinase temperature-sensitive mutant lacks proper chromosome segregation at non-permissive temperature
IPP1 YBR011C inorganic diphosphatase activity phosphate metabolism cytosol YDL203C YPL066W YGL120C YLR425W YLR371W YMR267W YPL204W YBR217W YPL111W YKL108W YHR030C YPL153C YJR062C YBR109C pyrophosphate phosphohydrolase, EC 3.6.1.1; catalyzes the rapid exchange of oxygens of Pi with water inorganic pyrophosphatase Null mutant is inviable
IPT1 YDR072C transferase activity, transferring phosphorus-containing groups mannosyl diphosphorylinositol ceramide metabolism membrane fraction YDR107C necessary for synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C) inositolphosphotransferase 1 Null mutant is viable but cannot synthesize M(IP)2C, instead accumulates the precursor, mannose-inos
IQG1 YPL242C cytoskeletal protein binding actin filament organization* contractile ring (sensu Saccharomyces) YLR428C YNL146W YFL039C YLL038C YCL027W YDR085C YLR229C YDR264C YKR086W Homolog of the mammalian IQGAP1 and 2 genes; probable regulator of cellular morphogenesis, inducing Null mutant is inviable (spores germinate, divide several times and lyse); cells are multinucleate a
IRA1 YBR140C Ras GTPase activator activity sporulation (sensu Saccharomyces)* membrane YNL098C YMR139W Inhibitory regulator of the RAS-cAMP pathway, negatively regulates cAPK by antagonizing CDC25 GTPase activating protein (GAP) Null mutant is viable, exhibits constitutive activation of the Ras/cyclic AMP (cAMP) pathway, heat s
IRE1 YHR079C protein serine/threonine kinase activity* protein amino acid phosphorylation* endoplasmic reticulum membrane* YDR532C YIL061C Involved in myo-inositol biosynthesis; implicated as the sensor of unfolded proteins in the ER that endoribonuclease|serine-threonine kinase|transmembrane protein Null mutant is viable, myo-inositol auxotroph; IRE1 is essential for viability under stress conditio
IRR1 YIL026C protein binding cytogamy* nuclear cohesin complex YFL008W YJL074C YER110C YMR313C YMR001C YDL003W Irregular; involved in sister chromatid cohesion cohesin complex subunit Null mutant is inviable; decreased transcription of mutant causes irregularity of zygotes, colonies,
ISA1 YLL027W molecular_function unknown iron ion transport mitochondrial matrix YGL189C YER131W YDL213C Iron Sulfur Assembly -- IscA/NifA homolog
ISA2 YPR067W molecular_function unknown iron ion transport mitochondrial intermembrane space YPR110C Iron Sulfur Assembly -- IscA/NifA homolog null mutant is viable; exhibits dependency on lysine and glutamate for growth, an increase in mitoch
ISM1 YPL040C isoleucine-tRNA ligase activity protein biosynthesis* mitochondrion YJL100W YMR055C nuclear encoded mitochondrial isoleucyl-tRNA synthetase isoleucine-tRNA ligase Null mutant is viable but is petite with defects in mitochondrial protein synthesis
IST3 YIR005W pre-mRNA splicing factor activity spliceosome assembly snRNP U2 YDR341C YMR057C YER148W YHR064C YDR155C YMR105C YGL174W YLR438W YHR019C YER043C YLR418C YJL099W U2 snRNP associated protein Null mutant is viable but exhibits slow growth and a pre-mRNA splicing defect in vivo and in vitro.
ISU1 YPL135W molecular_function unknown iron ion homeostasis* mitochondrion* YCL017C Iron-sulfur cluster nifU-like protein Null mutant is viable on YPD at 30 degrees C, and is synthetically lethal with isu2 null.
ISU2 YOR226C molecular_function unknown iron ion homeostasis* mitochondrial matrix YPL088W YAL038W Iron-sulfur cluster nifU-like protein Null mutant is viable on YPD at 30 degrees C, and is synthetically lethal with isu1 null.
ISW1 YBR245C ATPase activity chromatin modeling nucleus YKR001C YLR357W YOL004W YGL133W YFR037C YPR110C YPL082C YMR091C YFR013W YKR008W YCR052W YLR033W YOL017W YER164W YBL002W YLR163C YDL002C YBR089C-A YLR176C YOR304W has strong homology to Drosophila ISWI ATPase component of a four subunit chromatin remodeling complex Null mutant is viable, isw1 isw2 chd1 triple deletion mutants are synthetically temperature and form
ISW2 YOR304W ATPase activity chromatin modeling* nucleus YOL086C YLR347C YBR245C YGL133W YER164W YBL002W YDL002C YBR089C-A YLR176C YJR057W YAL013W has strong homology to Drosophila ISWI ATPase component of a two subunit chromatin remodeling complex Null mutant is viable, isw1 isw2 chd1 triple deletion mutants are synthetically temperature and form
ISY1 YJR050W pre-mRNA splicing factor activity nuclear mRNA splicing, via spliceosome spliceosome complex YLR297W YDR416W YLR117C YJR091C Interacts with Syf1p, Prp39p and Ypl213wp. Null mutant is viable and shows a partial splicing defect. isy1 prp19 double mutants are inviable. i
ITC1 YGL133W molecular_function unknown chromatin modeling* nucleus YBR245C YOR304W YDL002C YBR089C-A YLR176C YBR123C YNL298W YAL013W Imitation switch Two Complex 1 Null mutant is viable, but shows abnormal morphology and reduced mating efficiency when the disrupti
ITR1 YDR497C myo-inositol transporter activity myo-inositol transport membrane YLR113W member of sugar transporter superfamily myo-inositol transporter Null mutant is viable
ITR2 YOL103W myo-inositol transporter activity myo-inositol transport membrane YJL165C member of sugar transporter superfamily myo-inositol transporter Null mutant is viable
IVY1 YDR229W phospholipid binding secretory pathway vacuolar membrane (sensu Fungi) YJL017W YGL066W YGR218W YHR102W YMR047C YNL041C YMR001C Phospholipid-binding protein that interacts with Vpt7p and Vps33p
IWS1 YPR133C Pol II transcription elongation factor activity RNA elongation from Pol II promoter transcription elongation factor complex YGR116W YPR094W Interacts with Spt6 involved in transcriptional elongation Null: Null Mutant is Lethal.
IXR1 YKL032C DNA binding DNA repair nuclear chromosome YNL298W YNL233W YPL269W YJR057W YLR330W YLR342W YDL049C intrastrand crosslink recognition protein intrastrand crosslink recognition protein Null mutant is viable; exhibits decreased sensitivity to the anticancer drug, cisplatin
JAC1 YGL018C co-chaperone activity aerobic respiration* mitochondrion YJR104C YHR114W may be involved in assembly/maturation of mitochondrial iron-sulfur proteins E. coli Hsc20 co-chaperone protein homolog|J-protein co-chaperone family 20 kDa Null mutant is inviable; the jac1-1 mutation caused by a single amino acid deletion of Asp32 can sup
JEM1 YJL073W co-chaperone activity protein folding* endoplasmic reticulum* DnaJ-like protein of the endoplasmic reticulum membrane Null mutant is viable but has karyogamy defect; jem1 scj1 double mutant is temperature sensitive
JEN1 YKL217W lactate transporter activity lactate transport plasma membrane Repressed by glucose, induced by lactic acid; in high copy, weakly suppresses cpr3 null mutant pheno carboxylic acid transporter protein homolog deletion results in slow growth of yeast in synthetic medium supplemented with L-lactate and synergi
JNM1 YMR294W structural constituent of cytoskeleton mitotic anaphase B dynactin complex YGR294W YPR126C YGL217C YLR217W YNL271C YCR077C YLR200W YNL153C YEL003W YJL154C YPL269W YPL174C YCR065W YEL061C YER016W YER114C YGL216W YGR078C YGR229C YLR210W YML094W YOR349W YPR141C YHR129C YER007W YML124C YPL241C YLR216C YKL007W YAL024C YNL281W YG coiled-coil domain protein required for proper nuclear migration during mitosis (but not during conj
KAP104 YBR017C nuclear localization sequence binding protein-nucleus import* cytosol YDL063C YNL035C YKL212W YOR176W YBR247C YMR105C YOR098C YDR216W YOR259C YBR120C YGL105W YIL124W YMR012W YKL009W YNR069C YGL195W YGL256W YAL032C YGL172W YDR192C YLR293C YGR005C YOR317W YBR205W YER110C YEL051W YBL030C YMR145C YGR282C YKR046C YMR241W YG Karyopherin of 103,613 Da. Similar to yeast karyopherin beta (Kap95p; YLR347c) karyopherin beta 2 Null mutant is viable at 23 degrees C, but fails to germinate and dies at 30 C, shows severe nuclear
KAP114 YGL241W protein carrier activity protein-nucleus import nucleus* YER148W YBL002W YKR048C YLL050C YDR225W KAryoPherin (collective name for homologous family of nuclear transport receptors) of approximately The null mutant is viable.
KAP120 YPL125W structural constituent of nuclear pore protein-nucleus import cytoplasm* YER161C YDR502C karyopherin karyopherin
KAP122 YGL016W protein carrier activity protein-nucleus import* cytoplasm* YOR098C YLR335W YOR194C YKL058W YDL029W YBR217W YPR110C Member of the karyopherin-beta family with possible role in nuclear transport and regulation of plei karyopherin beta family member Null mutant is viable.
KAP123 YER110C protein carrier activity protein-nucleus import nucleus* YML007W YLR293C YMR308C YAL059W YAL007C YBR207W YBR009C YIL026C YBR017C YDR148C YDR062W YAL029C YER095W YBL087C YDR170C YBR143C YBR069C YKL081W YAL034C YNL313C YML094W Karyopherin of predicted MW 122.524 Da. Similar to Kap95p (YLR347C) and Kap104p *YBR017C). Ran bindi karyopherin beta 4 Null mutant is viable
KAP95 YLR347C protein carrier activity protein-nucleus import cytoplasm* YNL331C YPL124W YLR328W YNL044W YOR098C YMR159C YDR321W YML007W YFR047C YKR048C YHR216W YGL037C YPL111W YIL033C YKL068W YKL067W YDR353W YGL092W YBR176W YLR377C YGR267C YER023W YMR047C YGL040C YEL066W YGR144W YLR335W YDL055C YDR256C YDR418W YGL175C YO protein involved in nuclear import; required for the docking of import substrate to the nuclear memb karyopherin beta (importin 90) homolog (95 kDa) essential, ts mutant shows nuclear import defect
KAR1 YNL188W protein binding spindle pole body duplication (sensu Saccharomyces)* half bridge of spindle pole body YOR257W involved in spindle pole body duplication and karyogamy, interacts with Cdc31p, localizes to the spi Null mutant is inviable, kar1 mutants are karyogamy defective; defects in KAR1 block spindle pole bo
KAR2 YJL034W chaperone activity* SRP-dependent cotranslational membrane targeting, translocation* endoplasmic reticulum lumen YKL073W YOR254C YJR091C YGR032W Involved in translocation of nascent polypeptides across the ER membrane HSP70 family|mammalian BiP (GPR78) homolog null mutants are inviable; other mutants block karyogamy (nuclear fusion) during mating
KAR3 YPR141C microtubule motor activity* meiosis* spindle pole body* YIL090W YLL049W YLR217W YJL030W YFR036W YER155C YLR200W YNL153C YEL003W YEL061C YGR078C YML094W YCL061C YGL086W YGR188C YDR488C YLR216C YHR200W YMR048W YOR026W YGL173C YGR092W YMR055C YDR254W YOR195W YNL307C YHR191C YPL018W YDR318W YJR135C YBR107C YJ kinesin-like nuclear fusion protein kinesin-like nuclear fusion protein Null mutant is viable. Mutations in KAR3 are semidominant and cause pleiotropic effects affecting bo
KAR4 YCL055W transcription regulator activity meiosis* nucleus YGL036W YMR147W YNL196C YGL192W YBR057C May assist Ste12p in pheromone-dependent expression of KAR3 and CIK1 involved in karyogamy|transcription factor Defective in pheromone-induced expression of KAR3 and CIK1; therefore, defective in nuclear fusion b
KAR5 YMR065W molecular_function unknown karyogamy during conjugation with cellular fusion endoplasmic reticulum membrane YLR116W appears to be required for the completion of nuclear membrane fusion and may play a role in the orga coiled-coil membrane protein Null mutant is viable, mating defective, nuclear fusion defective
KAR9 YPL269W molecular_function unknown nuclear migration (sensu Saccharomyces) shmoo tip* YLR128W YDR149C YLL049W YLR200W YNL153C YEL003W YGR078C YML094W YPL155C YMR055C YPR046W YKL032C YOR233W YDR162C YPR120C YDL101C YHR129C YMR294W YPL174C YKR054C YDR424C YDR488C YMR299C YOR269W YDR150W YJR053W YCL029C YOR349W cortical protein required for cytoplasmic microtubule orientation; Bim1p and Kar9p make up the corti Null mutant is viable; cytoplasmic microtubule orientation defects, nuclear migration defects, benom
KCC4 YCL024W protein kinase activity protein amino acid phosphorylation* bud neck YKR048C YAL027W involved in septin organization S. pombe Nim1 homolog|protein kinase Null mutant is viable. Deletion of KCC4 causes moderate defects in bud formation at stationary phase
KEL1 YHR158C molecular_function unknown cellular morphogenesis* cytoplasm* YGR238C YMR181C YLL021W YOR047C YLL043W YMR232W YHR158C YJR122W YAL024C YAL016W YLR453C YLR096W YJL187C YER133W YBL105C YCL027W YHR030C protein contains six kelch repeats, contains leucine zipper patterns, similar to KEL2 and KEL3. Kel1 The null mutant is viable but shows a moderate defect in cell fusion during mating.
KEL2 YGR238C molecular_function unknown conjugation with cellular fusion bud neck* YHR030C YHR158C YOL069W YLR096W YBL105C protein containing six kelch repeats suspected of mediating binding interactions with actin; similar The null mutant is viable.
KEM1 YGL173C recombinase activity* 35S primary transcript processing* cytoplasm* YCR077C YDR378C YJL124C YHR170W YBL026W YLR398C YJR022W YGL213C YLR438C-A YER112W YER146W YNL147W YOL149W YER016W YLR039C YLR418C YCL029C YGL216W YPR141C YPR135W YHR191C YCL016C YLR200W YGR078C YML094W YLR103C YDR052C YML032C YJR057W Plays a role in cytoplasmic mRNA degradation. The disparate functions of Kem1p may belie a functiona 5'-3' exonuclease Kar1-1 nuclear-fusion-defect Enhancing Mutation. Null mutant grows poorly. muta
KEX1 YGL203C carboxypeptidase D activity protein processing Golgi trans face YNL322C Killer toxin and alpha factor precursor processing. Kex1p can cleave lys and arg residues from the C protease|similar to carboxypeptidase B Null mutant is viable and defective in killer expression
KEX2 YNL238W serine-type endopeptidase activity peptide pheromone maturation Golgi trans face YJR053W YLL040C YKL190W YLR039C YBR164C YNL322C prohormone processing; golgi localization marker, dispensable for meiotic recombination but partiall Ca2+-dependent serine protease Null mutant is viable and defective in killer expression
KGD1 YIL125W oxoglutarate dehydrogenase (lipoamide) activity tricarboxylic acid cycle* mitochondrial matrix YDR148C YFL018C YPL213W YFR049W YHR196W YDL147W YBR217W YMR235C YOR005C YFR016C YML064C YCR079W YHR169W alpha-ketoglutarate dehydrogenase alpha-ketoglutarate dehydrogenase Null mutant is viable but is deficient in alpha-ketoglutarate dehydrogenase, is therefore respirator
KGD2 YDR148C molecular_function unknown tricarboxylic acid cycle* mitochondrial matrix YFL018C YDR510W YMR012W YER110C YLR180W YFR049W YIL125W YDL239C YHR114W YKL010C YLR423C YMR047C YNL092W YNL189W YPL070W YDL225W YDR388W YMR308C dihydrolipoyl transsuccinylase component of alpha-ketoglutarate dehydrogenase complex in mitochondri alpha-ketoglutarate dehydrogenase complex dihydrolipoyl transsuccinylase component Null mutant is viable but is respiratory deficient (pet-), and its mitochondria are unable to cataly
KHA1 YJL094C potassium:hydrogen antiporter activity monovalent inorganic cation transport membrane YLR193C putative K+/H+ antiporter
KIN1 YDR122W protein kinase activity biological_process unknown membrane fraction YOL082W YNL035C YPR120C Serine/threonine protein kinase Null mutant is viable and shows no obvious phenotypes
KIN2 YLR096W protein kinase activity biological_process unknown membrane fraction YPR159W YGR047C YKL081W YNR052C YHR044C YML057W YKL210W YLL026W YHR158C YAR014C YGR238C YML006C YHR030C Serine/threonine protein kinase
KIN28 YDL108W general RNA polymerase II transcription factor activity* protein amino acid phosphorylation* transcription factor TFIIH complex YOR151C YDL140C YGL134W YPR025C YOR299W YER171W serine-threonine kinase, subunit of transcription factor TFIIK, a subcomplex of TFIIH Null mutant is inviable
KIN4 YOR233W protein kinase activity biological_process unknown cytoplasm YPL269W protein kinase protein kinase Null mutant is viable
KIP1 YBL063W structural constituent of cytoskeleton* microtubule nucleation* spindle pole body* YIL061C YPR141C YEL061C Mitotic spindle assembly kinesin related protein Null mutant is viable; kip1 cin8 double deletion mutants are inviable
KIP2 YPL155C microtubule motor activity nuclear migration (sensu Saccharomyces)* cytoplasmic microtubule* YGL127C YLR200W YNL153C YEL003W YEL061C YGR078C YML094W YOR349W YER007W YML124C YPL241C YGR092W YAL026C YER016W YOR058C YPL269W YOR326W kinesin-related protein kinesin related protein Null mutant is viable
KIP3 YGL216W microtubule motor activity mitotic spindle assembly (sensu Saccharomyces)* cytoplasmic microtubule* YDR149C YGL152C YLL049W YER016W YPR141C YKR054C YPR135W YGL173C YOR195W YHR191C YCL016C YMR078C YBL031W YGL174W YHR183W YDR162C YHR129C YMR294W YPL174C YDR424C YDR488C YMR299C YOR269W YDR150W Kinesin-related protein defective in pre-anaphase nuclear migration
KNH1 YDL049C molecular_function unknown beta-1,6 glucan biosynthesis cell wall (sensu Fungi)* YBR226C YDL033C YDR249C YGR064W YGR206W YHL005C YHR034C YLR282C YNL171C YPR197C YLR330W YJL154C YML071C YOR069W YOR070C YJL148W YKL032C YDL065C YJL174W YDL020C YLR350W YAL002W YGL043W YNL329C YGR135W YMR060C YIL121W YHR013C YGR133W YKL126W YLR360W YG 46% identical at amino acid level to Kre9p; located extracellularly KRE9 homolog Null mutant is viable; overexpression suppresses kre9 mutation; knh1 kre9 double mutant is inviable
KRE1 YNL322C structural constituent of cell wall cell wall organization and biogenesis cell wall (sensu Fungi) YAL053W YAL056C-A YBL083C YDR129C YCR044C YHR030C YOR035C YER165W YBR023C YBL061C YLR330W YER155C YJR118C YJL183W YJR117W YDL006W YDR162C YKR020W YNL238W YER044C YDR389W YMR238W YBR229C YFR019W YAL026C YPL065W YGL084C YGL168W YKL190W YJR073C YMR060C cell wall beta-glucan assembly Null mutant is viable, exhibits reduction in cell wall (1--6)-beta-glucan
KRE11 YGR166W molecular_function unknown ER to Golgi transport TRAPP YEL048C YNL171C YOR115C YMR089C YCR044C YJL095W YNL322C YJR118C YMR116C YKR020W YGR229C YLR373C YPL069C YDR407C YMR218C YBR254C YDR246W YDR472W YJL174W YGL084C YDR440W YKL139W YBL101C YNL329C YBR057C YKL041W YMR060C YOR312C YJL176C YGR157W YHR013C YO Involved in biosynthetic pathway for cell wall beta-glucans Null mutant is viable; killer toxin resistant; reduced levels of 1,6-beta-glucan in cell wall
KRE2 YDR483W alpha-1,2-mannosyltransferase activity O-linked glycosylation* Golgi apparatus YER081W N-glycosylation alpha-1,2-mannosyltransferase have altered N-linked glycosylation of proteins and grow slowly at 30 degrees; unable to grow at 37
KRE5 YOR336W UDP-glucose:glycoprotein glucosyltransferase activity beta-1,6 glucan biosynthesis endoplasmic reticulum YER022W appears to function early in (1,6)-beta-D-glucan synthesis pathway Null mutant is viable but has aberrant morphology, reduced levels of cell wall (1,6)-beta-glucan, an
KRE6 YPR159W glucosidase activity cell wall organization and biogenesis* integral to membrane* YBL053W YBR042C YDL206W YDR248C YEL047C YGL081W YGL196W YFL036W YOR080W YDR137W YGR105W YOR068C YGL244W YML115C YAL055W YGL200C YLL043W YPL192C YKL041W YJL176C YDR385W YIL052C YDR233C YGL135W YKL120W YDR358W YGL215W YLR018C YLR131C YLR165C YKL190W YD cell wall beta-glucan assembly beta-glucan synthase (putative) Null mutant is viable, slow growing, killer toxin-resistant, possesses half the normal level of wild
KRI1 YNL308C molecular_function unknown ribosome biogenesis nucleolus YIL105C YMR236W YOR299W YMR116C YLR427W YDR225W YOR080W YIL035C YNL175C YDR386W YDL213C YPR110C YPL259C KRRI-Interacting protein 1 Krr1p binding protein
KRR1 YCL059C molecular_function unknown rRNA processing* nucleolus YNL132W YMR116C YLR197W YGR145W YDL148C YBL004W YDL014W YDR299W YJL109C YPL217C YMR128W YLR186W YHR148W YJR002W YLL011W YDR449C YMR093W YPR144C YGL201C YLR409C YDR324C YER127W YPL126W YPR137W YDL166C YKR060W YLR175W YBR247C YCR057C YDL213C YPL259C Involved in cell division and spore germination Null mutant is inviable
KRS1 YDR037W lysine-tRNA ligase activity lysyl-tRNA aminoacylation cytoplasm YDL126C YPR056W YJL124C YNL135C YDR388W YBR055C lysyl-tRNA synthetase lysine-tRNA ligase Null mutant is inviable; mutants can show resistance to 5-methyltryptophan, 5-fluorotryptophan and c
KSP1 YHR082C protein serine/threonine kinase activity protein amino acid phosphorylation nucleus YNL192W YJL095W YDR127W YNL201C YAL016W YML057W YKR024C YKL045W YHR186C Serine/threonine kinase similar to casein kinase II and other serine/threonine protein kinases Null mutant is viable
KSS1 YGR040W MAP kinase activity protein amino acid phosphorylation* nucleus YJR072C YGL245W YDR239C YPR115W YHR033W YLR362W YDL159W YPL049C YPR010C YML099C YKL104C YDR190C YGL008C YMR319C YHR200W YDL097C YKR048C YIL142W YMR290C YGR155W YGL062W YGL178W YLL039C YER167W YOL078W YER093C YHR084W YLR304C YLR154C YDR343C YML123C YN Recovery from alpha factor arrest MAP kinase|involved in pheromone signal transduction
KTR1 YOR099W alpha-1,2-mannosyltransferase activity O-linked glycosylation* Golgi apparatus mannosyltransferase involved in O- and N-linked glycosylation type II transmembrane protein Null mutant is viable
KTR2 YKR061W mannosyltransferase activity N-linked glycosylation* Golgi apparatus May be involved in extracellular matrix assembly; involved in N-linked glycosylation of cell wall ma mannosyltransferase (putative)|type 2 membrane protein Null mutant is viable, with partial resistance to killer toxin
KTR3 YBR205W mannosyltransferase activity cell wall organization and biogenesis* membrane fraction YLR338W YMR060C YDR170C YBR017C YML115C YGL212W YHR105W YFL038C YPR107C YDL101C Putative alpha-1,2-mannosyltransferase alpha-1,2-mannosyltransferase (putative)
KTR4 YBR199W mannosyltransferase activity N-linked glycosylation Golgi apparatus Putative alpha-1,2-mannosyltransferase alpha-1,2-mannosyltransferase (putative)
KTR5 YNL029C mannosyltransferase activity cell wall organization and biogenesis* Golgi apparatus YPR041W Putative mannosyltransferase of the KRE2 family mannosyltransferase (putative) Null mutant is viable
KTR6 YPL053C mannosylphosphate transferase activity cell wall organization and biogenesis* membrane fraction YER022W YGL181W Similar to KRE2, mannosylphosphate transferase which may recognize any oligosaccharides with at leas mannosylphosphate transferase Null mutant is viable, hypersensitive to Calcofluor White and hygromycin B; shows less binding to Al
KTR7 YIL085C mannosyltransferase activity cell wall organization and biogenesis* Golgi apparatus YLR325C Putative mannosyltransferase of the KRE2 family Null mutant is viable
LAC1 YKL008C protein transporter activity ceramide biosynthesis* endoplasmic reticulum YMR298W YHL003C YNL107W YML064C Longevity-assurance gene 1 cognate (LAG1 cognate) LAG1 longevity gene homolog Null mutant is viable but exhibits synthetic lethality with mutations in lag1.
LAG1 YHL003C protein transporter activity replicative cell aging* endoplasmic reticulum YKL008C YMR047C YMR298W YKL008C Null mutant is viable
LAP3 YNL239W transcription regulator activity* response to antibiotic cytoplasm YLR222C YDR189W YML064C AKA bleomycin hydrolase. This protein may represent the first example of a eukaryotic DNA-binding pr aminopeptidase of cysteine protease family Null mutant is viable with no obvious growth defects but is leucine aminopeptidase deficient and hyp
LAP4 YKL103C aminopeptidase I activity vacuolar protein catabolism vacuole (sensu Fungi) YFL034W YKL103C YOL082W YDR155C YCL029C YDR224C YBR010W YOR332W YGL156W YEL071W YDL239C YGR119C YLR295C YML064C YMR290C YNL189W YOR302W YDR142C YAL034W-A YDR311W vacuolar aminopeptidase ysc1 vacuolar aminopeptidase ysc1 Leucine aminopeptidase deficient
LAS1 YKR063C molecular_function unknown establishment of cell polarity (sensu Saccharomyces)* nucleus YLR403W May regulate expression of genes involved in bud formation and morphogenesis Null mutant is inviable
LAS17 YOR181W cytoskeletal protein binding actin filament organization* cytoplasm* YLR337C YDR342C YBL007C YNL243W YDR388W YFL039C YHR027C YGL206C YLR447C YNL084C YBR085W YJL100W YHR133C YGR136W YFR052W YAL029C YLR081W YDR343C YML123C YMR241W YJL151C YHR114W YFR024C-A YIR012W YNR065C YBL017C YPL246C Homolog of human WASP, proline-rich protein actin assembly factor Null mutant is viable, demonstrates impaired budding and cytokenesis and severely disrupted cortical
LAS21 YJL062W transferase activity GPI anchor biosynthesis integral to plasma membrane* YBL104C YDL096C YPL080C YPR045C YJL095W YLR087C YJL148W YGL147C YDL065C YIL154C YBR076W YDR363W-A YBL101C YPL213W YHR013C YPL079W YBL042C YCL025C YOL044W YDL017W YJL099W Local Anesthetics Sensitive: involved in the attachment of glycosylphosphatidylinositol (GPI) anchor major facilitator superfamily (putative)|membrane protein (putative) Null mutant is viable but is temperature-sensitive. The las21-1 strain is sensitive to tetracaine, b
LAT1 YNL071W dihydrolipoamide S-acetyltransferase activity pyruvate metabolism mitochondrion YBR221C YDR430C YLR330W Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase component (E2) Null mutant is viable
LCB1 YMR296C serine C-palmitoyltransferase activity sphingolipid biosynthesis membrane fraction* YBR036C YDL052C YDR062W YDR365C YIL104C Serine palmitoyltransferase catalyses the committed step in sphingolipid synthesis, the condensation serine palmitoyltransferase component Null mutant is viable; auxotrophic for long-chain component of sphingolipids; homozygous lcb1 diploi
LCB2 YDR062W serine C-palmitoyltransferase activity sphingolipid biosynthesis membrane fraction* YHR020W YKL104C YGR218W YLR342W YER177W YIL094C YER110C YLR180W YEL022W YHL030W YDR502C YDR099W YBR017C YMR296C YJR077C YBR036C Serine palmitoyltransferase catalyses the committed step in sphingolipid synthesis, the condensation serine palmitoyltransferase component Auxotrophic for long-chain component of sphingolipids; some mutations can suppress the Ca2+-sensitiv
LCB3 YJL134W sphingosine-1-phosphate phosphatase activity sphingolipid biosynthesis* endoplasmic reticulum YGL053W Protein involved in incorporation of exogenous long chain bases in sphingolipids dihydrosphingosine-1-phosphate phophatase Null mutant is viable, has reduced rate of exogenous long chain base incorporation into sphingolipid
LCB4 YOR171C D-erythro-sphingosine kinase activity sphingolipid metabolism* endoplasmic reticulum* YER071C YOR185C YOR034C YHR178W YPL022W involved in sphingolipid biosynthesis sphingoid long chain base (LCB) kinase Null mutant is viable, exhibts 2-3% of wild-type LCB kinase activity; lcb4 is an extragenic suppress
LCB5 YLR260W D-erythro-sphingosine kinase activity response to heat* membrane fraction* involved in sphingolipid biosynthesis sphingoid long chain base (LCB) kinase Null mutant is viable, exhibits ~97% of wild-type LCB kinase activity; lcb4 lcb5 deletion mutants ex
LCD1 YDR499W protein binding* telomerase-dependent telomere maintenance* nuclear chromosome YOR176W YMR303C YML058W YBR009C YCL028W YLR355C YER070W YBR136W YHR164C YDR097C required for the DNA integrity checkpoint pathways; S. pombe Rad26 functional homolog (putative), ho Null mutant is inviable. Null mutant is rescued by deletion of SML1, but deletion of SML1 does not s
LCP5 YER127W RNA binding rRNA modification* small nucleolar ribonucleoprotein complex* YLR423C YDR299W YKR002W YDR021W YCL059C YJL069C Lethal with conditional pap1 allele Null mutant is inviable; there is also a temperature sensitive mutant defective in rRNA processing a
LEA1 YPL213W pre-mRNA splicing factor activity nuclear mRNA splicing, via spliceosome cytoplasm* YIR009W YMR240C YIL125W YAL032C YGR074W YFL017W-A YPR182W YBR152W YKL095W YER081W YNL192W YLR330W YJL062W YGL027C Looks Exceptionally like U2A Null mutant is viable but grows slowly and is temperature sensitive. Null mutant also exhibits defec
LEM3 YNL323W transcription regulator activity cell surface receptor linked signal transduction cytoplasm* YLR326W YHR199C YDR342C YDR212W YLR347C YGL195W YJR132W YLR447C YPL031C plays an important role in phospholipid translocation across the plasma membrane. membrane glycoprotein Null mutant sensitive to brefeldin A, shows increased glucocorticoid receptor activity in response t
LEO1 YOR123C Pol II transcription elongation factor activity transcription from Pol II promoter* transcription elongation factor complex* YOL131W YDR456W YOL145C YGL244W YBR058C YDR508C YMR240C YJL168C YLR418C YLR085C YLR103C YDR363W YLR113W YAL013W YPL181W YMR263W member of the RNA polymerase II-associated Paf1 complex Null mutant is viable
LEU1 YGL009C 3-isopropylmalate dehydratase activity leucine biosynthesis cytosol YOL086C LEU1 encodes the second enzyme in leucine biosynthesis. isopropylmalate isomerase Leucine requiring
LEU2 YCL018W 3-isopropylmalate dehydrogenase activity leucine biosynthesis cytosol YKL106W leucine biosynthesis beta-IPM (isopropylmalate) dehydrogenase Null mutant is viable, leucine auxotroph
LEU3 YLR451W specific RNA polymerase II transcription factor activity regulation of transcription from Pol II promoter* nucleus YHR166C Regulates genes involved in branched chain amino acid biosynthesis and in ammonia assimilation. Posi zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type Null mutant is viable, leaky leucine auxotroph
LEU4 YNL104C 2-isopropylmalate synthase activity leucine biosynthesis cytoplasm* YKL183W leucine biosynthesis alpha-isopropylmalate synthase (2-isopropylmalate synthase) Null mutant is viable, Leu+
LEU5 YHR002W coenzyme A transporter activity coenzyme A transport mitochondrial inner membrane mitochondrial carrier protein, involved in the accumulation of CoA in the mitochondrial matrix; homo Null mutant is viable; leu5 mutant is not a leucine auxotroph unless in a leu4 background; glycerol
LEU9 YOR108W 2-isopropylmalate synthase activity leucine biosynthesis mitochondrion YDR455C gene product responsible for alpha-isopropylmalate synthase II activity alpha-isopropylmalate synthase (2-isopropylmalate synthase)
LHP1 YDL051W RNA binding tRNA processing nucleus* YDR395W YOL139C YPR016C YHR089C YNL016W YPR088C YGR162W YLR074C YDR365C Protein homologous to human La (SS-B) autoantigen Null mutant is viable
LHS1 YKL073W chaperone activity protein transport* endoplasmic reticulum lumen YHR030C YOL087C YDR394W YJL034W Lumen HSP Seventy
Required for efficient translocation of protein precursors across the ER membr Hsp70 family
LIF1 YGL090W structural molecule activity double-strand break repair via nonhomologous end-joining nucleus YLR424W YLR288C YOR061W YCR094W YLR265C YLR109W YOR005C Ligase Interacting Factor 1; physically interacts with DNA ligase 4 protein (Lig4p) Null mutant is viable but is deficient in non-homologous double-strand break repair; inefficient in
LIN1 YHR156C protein binding biological_process unknown nucleus* YJR010W YHR165C YJR091C YMR235C LIN element of a link between sister chromatid cohesion, DNA replicarion and splicing Null: viable. Other phenotypes: none
LIP5 YOR196C catalytic activity fatty acid metabolism mitochondrion YDR344C YBL023C Involved in lipoic acid metabolism lipoic acid synthase Null mutant is viable; cannot synthesize lipoic acid; grows slowly on ethanol-rich media; barely gro
LOC1 YFR001W mRNA binding ribosomal large subunit biogenesis nucleus YPR016C YNL061W YGR103W YPL204W YDR386W YNL230C Localization of mRNA Mutant exhibits slow growth at 30C
LOS1 YKL205W tRNA binding* tRNA-nucleus export* nuclear matrix YGR074W YKL144C YLR291C YER100W YGL105W Nuclear pore protein involved in pre-tRNA splicing Null mutant is viable but is defective in pre-tRNA splicing at 37 degrees
LPD1 YFL018C dihydrolipoamide dehydrogenase activity L-serine biosynthesis* mitochondrial matrix* YJR051W YOR180C YIL125W YDR148C YBR221C YDR430C YGL063W YHR114W YOL123W YCR002C YDR388W YER017C an FAD flavoprotein which contains a pair of redox-active cysteines involved in the transfer of redu dihydrolipoamide dehydrogenase precursor (mature protein is the E3 component of alpha-ketoacid dehyd unable to utilize glycine as sole nitrogen source
LPE10 YPL060W magnesium ion transporter activity mitochondrial magnesium ion transport mitochondrial inner membrane YGR052W YLR373C mitochondrial protein with homology to MRS2
LPP1 YDR503C phosphatidate phosphatase activity phospholipid metabolism membrane YKL130C YER049W YNR074C Lipid phosphate phosphatase lipid phosphate phosphatase
LRE1 YCL051W transcription regulator activity* cell wall organization and biogenesis* cell wall (sensu Fungi) YMR035W YDL116W YPR086W involved in laminarase resistance Null mutant is viable; overexpression of both LRE1 and PBN1 confers resistance to laminarinase, whic
LRO1 YNR008W phospholipid:diacylglycerol acyltransferase activity triacylglycerol biosynthesis* endoplasmic reticulum YMR059W Lecithin cholesterol acyl transferase (LCAT) Related Orf phospholipid:diacylglycerol acyltransferase
E.C. 2.3.1.158 Null mutant is viable
LRP1 YHR081W molecular_function unknown double-strand break repair via nonhomologous end-joining* nuclear exosome (RNase complex) YOL021C YGR095C YNL092W Like an rRNA Processing protein. Homolog of mammalian C1D, which is a nuclear matrix protein involve
LRS4 YDR439W molecular_function unknown chromatin silencing at ribosomal DNA (rDNA) nucleus YCR086W YJR091C Loss of rDNA silencing loses rDNA silencing
LSB1 YGR136W molecular_function unknown biological_process unknown cytoplasm YBR108W YIL108W YNL189W YOR181W YPL111W YER125W YGR058W LAs17 Binding protein
LSB5 YCL034W molecular_function unknown actin filament organization* cell cortex LAs17 Binding protein
LSB6 YJL100W 1-phosphatidylinositol 4-kinase activity actin filament organization cytoplasm* YLR295C YOR181W YPL040C LAs17 Binding protein
LSC1 YOR142W succinate-CoA ligase (ADP-forming) activity tricarboxylic acid cycle* mitochondrion YBR160W YER171W YMR106C alpha subunit of succinyl-CoA ligase (synthetase; ATP-forming), a mitochondrial enzyme of the TCA cy Null mutant is viable but grows slowly on minimal glycerol or pyruvate; mutant suppresses idh2 null
LSC2 YGR244C succinate-CoA ligase (ADP-forming) activity tricarboxylic acid cycle* mitochondrion YPL118W beta subunit of succinyl-CoA ligase (synthetase; ATP-forming), a mitochondrial enzyme of the TCA cyc Null mutant is viable but grows slowly on minimal glycerol or pyruvate; mutant suppresses idh2 null
LSG1 YGL099W GTPase activity sporulation (sensu Saccharomyces)* cytoplasm Killer toxin REsistant Heterozygous diploid mutant exhibits haploinsufficiency K1 killer toxin resistance
LSM1 YJL124C RNA cap binding rRNA processing* cytoplasmic mRNA processing body* YNL147W YCR077C YDR378C YBL026W YDL160C YMR080C YLR438C-A YER112W YER146W YNL118C YDR037W YOL149W YGL173C YOR375C YER016W YLR418C YLR103C YLR342W Like Sm protein; the finding that Lsm1 contains the Sm consensus motifs and most closely resembles S Null mutant is viable but grows slowly at 23deg and 30deg, and is required for growth at 37deg; abse
LSM2 YBL026W pre-mRNA splicing factor activity nuclear mRNA splicing, via spliceosome* small nuclear ribonucleoprotein complex YLR438C-A YJL124C YER146W YDR378C YNL147W YCR077C YGL234W YDL097C YDL160C YLR275W YOL149W YGR158C YER112W YLR264W YOR167C YMR268C YJR022W YGR091W YHR165C YLR074C YGL173C Like Sm-D1 protein snRNA-associated protein, Sm class Null mutant is inviable
LSM3 YLR438C-A U6 snRNA binding nuclear mRNA splicing, via spliceosome* snRNP U6 YER146W YCR077C YDR378C YJR022W YER112W YBL026W YNL147W YOL149W YGL173C YJL124C Like Sm-D2 protein; contains Sm-like domain; coprecipitates with U4, U5 and U6 snRNAs. snRNP protein Null mutant is inviable
LSM4 YER112W pre-mRNA splicing factor activity nuclear mRNA splicing, via spliceosome* small nuclear ribonucleoprotein complex YDR378C YLR269C YCR077C YJL124C YMR304W YBR126C YOR039W YDR238C YJR022W YOL149W YER146W YNL147W YLR264W YOR167C YFL017W-A YGL173C YBL026W YLR438C-A Like Sm-D3 protein U6 snRNA associated protein Null mutant is inviable. LSM4p depleted cells have reduced levels of U6 snRNA
LSM5 YER146W pre-mRNA splicing factor activity nuclear mRNA splicing, via spliceosome* small nuclear ribonucleoprotein complex YCR077C YDR378C YBL026W YKL173W YBR055C YPR178W YLR438C-A YNL147W YOL149W YGL173C YJL124C YER112W YJR022W Like Sm-E protein snRNP protein Null mutant is viable.
LSM6 YDR378C pre-mRNA splicing factor activity nuclear mRNA splicing, via spliceosome small nuclear ribonucleoprotein complex YCR077C YER146W YNL147W YBL026W YER112W YGR091W YHR165C YLR295C YNL070W YOL153C YOL149W YGL173C YJL124C YLR438C-A YJR022W YLR418C YLR330W YLR342W Like Sm-F protein snRNP protein Null mutant is viable but grows slowly at 23deg and 30deg, and is required for growth at 37deg
LSM7 YNL147W U6 snRNA binding nuclear mRNA splicing, via spliceosome* snRNP U6 YLR438C-A YCR077C YOR308C YDR378C YJL124C YBL026W YDL160C YOL139C YLR275W YKL173W YER112W YER146W YBR055C YPR178W YMR268C YPR082C YDL098C YOL149W YGL173C YJR022W Like Sm-G protein snRNP protein Null mutant is viable but grows slowly at 23deg and 30deg, and is required for growth at 37deg
LSM8 YJR022W pre-mRNA splicing factor activity nuclear mRNA splicing, via spliceosome* nucleus* YGL117W YHR034C YHR035W YNL050C YBL026W YLR269C YCR077C YPR191W YPR016C YOR261C YNR053C YDR378C YPR017C YER029C YFR052W YDR228C YEL015W YOL149W YGR158C YDL111C YOR076C YOR319W YLR438C-A YER146W YNL147W YLR264W YDR277C YCL050C YOR167C YHR089C YNR050C Like Sm-B protein snRNP protein Null mutant is inviable
LSP1 YPL004C molecular_function unknown biological_process unknown cytoplasm YJR091C YPL157W YPL204W YDR200C YNL094W YPL150W YOL100W YPL022W YPL074W YMR059W YLR186W YNL230C YBR055C YDR490C Long chain base Stimulates Phosphorylation
LST4 YKL176C protein transporter activity vesicle-mediated transport* vesicle coat YOR080W YLR208W YOR167C YLR418C YGR143W YBL061C required for amino acid permease transport from the Golgi to the cell surface. involved in regulated very low activity of the nitrogen-regulated permeases Gap1p and Put4p on poor nitrogen sources; lst4
LST7 YGR057C protein transporter activity vesicle-mediated transport* vesicle coat YLR208W YKL015W YEL063C YIL109C Required for amino acid permease transport from the Golgi to the cell surface Reduced activity of the nitrogen-regulated permeases Gap1p and Put4p
LST8 YNL006W protein binding transport* Golgi membrane* YFR039C YHR174W YCR012W YER022W YMR106C YLR208W Required for amino acid permease transport from the Golgi to the cell surface Reduced activity of a broad set of amino acid permeases
LTE1 YAL024C guanyl-nucleotide exchange factor activity regulation of exit from mitosis bud YIR009W YNL098C YGR152C YIL106W YOR101W YML064C YHR158C YAL016W YLR229C YMR294W YKR054C YDR150W YPR141C YMR078C YCL016C YJR043C YLR103C YMR263W Gdp/GTP exchange factor required for growth at low temperatures lethal at low temperature (8 degrees C)
LUC7 YDL087C mRNA binding mRNA splice site selection snRNP U1 YIL061C YPR182W YOL139C YHR086W YML049C YLR275W YDR240C YGR013W YMR125W YGR162W YER029C YLR147C YMR288W YKL173W YML046W YKL012W YDR235W YLR298C YPL178W YFL017W-A YDR080W YGL112C Living Under Cap-binding complex expression Null mutant is inviable; luc7 mutants exhibit synthetic lethality with the Cap-Binding Complex
LYP1 YNL268W basic amino acid transporter activity basic amino acid transport plasma membrane lysine permease lysine permease
LYS1 YIR034C saccharopine dehydrogenase (NAD, L-lysine-forming) activity lysine biosynthesis, aminoadipic pathway cytoplasm* YNL055C YGL153W YGR267C YLR354C YEL064C YHR135C saccharopine dehydrogenase Lysine requiring
LYS12 YIL094C isocitrate dehydrogenase activity lysine biosynthesis cytoplasm* YLR103C YGL206C YOL145C YML126C YHR108W YDR062W YKR048C YMR308C YBL039C YNL313C YOR073W YDR388W YHR030C YPL140C YMR106C homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in th homo-isocitrate dehydrogenase Null mutant is viable but shows decreased growth in the absence of lysine
LYS14 YDR034C transcriptional activator activity lysine biosynthesis, aminoadipic pathway nucleus YBR144C YCR095C YDR131C YDR417C YDR438W YER064C YFR055W YGR111W YJL185C YLR063W YMR187C YPL102C YPL114W YPR136C YDR342C YLR098C YDR023W YJR075W YLR328W YDR259C YER044C YAR007C YKR048C YDL065C YIL045W YLR105C YHR060W YBR057C YDL155W YKL068W YGL223C YG Transcriptional activator of lysine pathway genes with 2-aminoadipate semialdehyde as co-inducer; sa Lysine requiring
LYS2 YBR115C L-aminoadipate-semialdehyde dehydrogenase activity lysine biosynthesis, aminoadipic pathway cytoplasm YGL154C YAL059W A key step in fungal biosynthesis of lysine, enzymatic reduction of alpha-aminoadipate at C6 to the alpha aminoadipate reductase Null mutant is viable, lysine auxotroph
LYS20 YDL182W homocitrate synthase activity lysine biosynthesis, aminoadipic pathway nucleus homocitrate synthase, highly homologous to YDL131W YDL131W (LYS21) homolog|homocitrate synthase Null mutant is viable, is able to grow on minimal media, and exhibits reduced but significant homoci
LYS21 YDL131W homocitrate synthase activity lysine biosynthesis, aminoadipic pathway nucleus YLR427W homocitrate synthase, highly homologous to YDL182W YDL182W (LYS20) homolog|homocitrate synthase
LYS4 YDR234W homoaconitate hydratase activity lysine biosynthesis, aminoadipic pathway mitochondrion* homoaconitase homoaconitase Lysine requiring
LYS5 YGL154C holo-acyl-carrier protein synthase activity lysine biosynthesis, aminoadipic pathway* cytoplasm YOR128C YOR028C YGL254W YBR115C Converts inactive apo-form of Lys2p (alpha-aminoadipate semialdehyde reductase) into catalytically a alpha aminoadipate reductase phosphopantetheinyl transferase Lysine requiring
LYS7 YMR038C superoxide dismutase copper chaperone activity intracellular copper ion transport cytosol YER083C YML042W YKL113C YLR418C YPR135W YHR191C YMR078C YCL016C YPL194W YNL250W YML032C YBR094W YGR229C Involved in lysine biosynthesis, oxidative stress protection copper chaperone for superoxide dismutase Sod1p Null mutant is viable, methionine and lysine auxotroph, pH and temperature sensitive; sensitive to s
LYS9 YNR050C saccharopine dehydrogenase (NADP, L-glutamate-forming) activity lysine biosynthesis, aminoadipic pathway cytoplasm YNL292W YNR046W YOR164C YLR453C YJR022W Seventh step in lysine biosynthesis pathway lysine auxotroph
MAC1 YMR021C specific RNA polymerase II transcription factor activity positive regulation of transcription from Pol II promoter* nucleus YBR009C YGR123C YGR144W YKR026C YLR200W YML094W metal-binding transcriptional activator metal-binding transcriptional activator Null mutant is viable, has a defect in the plasma membrane Cu(II) and Fe(III) reductase activity, ai
MAD1 YGL086W molecular_function unknown mitotic spindle checkpoint* nucleus* YER016W YDR150W YCL029C YLR085C YEL061C YPR141C YDR332W YML124C YER007W YPL241C YPR135W YHR191C YMR078C YCL016C YPL008W YLR200W YGR078C YNL153C YEL003W YML094W YMR048W YLR103C YDL017W YOR349W coiled-coil protein involved in spindle-assembly checkpoint
MAD2 YJL030W molecular_function unknown mitotic spindle checkpoint nuclear pore* YJL064W YML094C-A YPL017C YLR200W YNL153C YEL003W YCR065W YER016W YGR078C YML094W YOR349W YPR141C YNL098C YOL012C YDR254W YOR195W YPL018W YDR318W YJR135C YBR107C YLR381W YDR359C YPR046W YBR194W YGL060W YGL116W YDR206W YGR014W YER105C YGL229C YNL236W spindle checkpoint complex subunit spindle checkpoint complex subunit
MAD3 YJL013C molecular_function unknown mitotic spindle checkpoint nucleus YEL061C YGL116W YER016W YOR026W YAL040C YGR014W YGL229C YNL236W YFL037W YPR141C YDR332W YML124C YPL241C YPR135W YMR078C YCL016C YPL008W YLR200W YGR078C YNL153C YEL003W YML094W YOR349W checkpoint protein required for cell cycle arrest in response to loss of microtubule function spindle checkpoint complex subunit Null mutant is viable, benomyl/nocodazole sensitive
MAE1 YKL029C malate dehydrogenase (oxaloacetate-decarboxylating) activity pyruvate metabolism* mitochondrion YLR447C YMR090W YGL137W YPR054W YDL047W Mitochondrial malic enzyme malic enzyme null mutant exhibits no malic enzyme activity and synthetic phenotypes with pyk1 and pyk2 mutations
MAF1 YDR005C molecular_function unknown negative regulation of transcription from Pol III promoter nucleus YOR116C YER081W YGL044C YJR091C Mod5 protein sorting. Negative effector of Pol III synthesis. Mislocalizes Mod5p to the nucleus. tRNA levels are elevated in maf1 mutant cells.
MAG1 YER142C alkylbase DNA N-glycosylase activity DNA dealkylation nucleus YML056C YGR090W YBL002W YOL041C YHR216W YGL049C YGR162W YAL035W YBR010W YLR432W YOL090W YIR002C YPR190C Q0050 YPL127C 3-methyladenine DNA glycosylase 3-methyladenine DNA glycosylase Null mutant is viable, deficient in 3-methyladenine DNA glycosylase activity and shows enhanced sens
MAK11 YKL021C molecular_function unknown ribosomal large subunit biogenesis* membrane fraction YPR016C YGR103W YNL061W YMR049C YGL141W essential for cell growth and replication of M dsRNA virus; contains four beta-transducin repeats Null mutant is inviable, mak11-1 mutants result in specific loss of M1 double stranded RNA
MAK16 YAL025C molecular_function unknown ribosomal large subunit biogenesis* nucleolus YJR044C YHR066W YGR103W YOR005C putative nuclear protein nuclear protein (putative) Null mutant is inviable, conditional mutants arrest at G(sub)1, are deficient in maintenance of kill
MAK21 YDR060W molecular_function unknown ribosomal large subunit assembly and maintenance nucleus YPL211W YOL077C YHR052W YML124C YNL002C YGR103W YNL110C YOL041C YBL004W YMR290C YDL014W YPL012W YLR276C YLR398C YOR206W YBR142W YMR049C YGR195W YNL118C YJL109C YOR272W YGR281W YLR221C YDR382W YEL026W YNL061W YPL043W YHR066W YKR081C YPL024W essential for 60s ribosome biogenesis; involved in nuclear export of pre-ribosomes deficient in maintenance of killer
MAK3 YPR051W peptide alpha-N-acetyltransferase activity virus-host interaction* cytoplasm YEL053C YCR020C-A YCL032W YLR039C YLR262C YGR078C YML094W N-acetyltransferase N-acetyltransferase deficient in maintenance of killer
MAK5 YBR142W ATP dependent RNA helicase activity rRNA processing* nucleus YKL014C YMR163C YPL043W YPL093W YMR012W YNL002C YDR496C YOL041C YMR290C YGL195W YLR398C YNL061W YMR049C YJL005W YGL111W YOR272W YDR170C YHR066W YDR060W YHR052W Necessary for maintenance of dsRNA killer plasmids. Is predicted to encode an DEAD-box RNA helicase deficient in maintenance of killer
MAL11 YGR289C alpha-glucoside:hydrogen symporter activity* alpha-glucoside transport* membrane fraction YDR413C Part of MAL1 complex locus; encodes funct. maltose permease in all strains, exhibits sign. seq. vari alpha-glucoside transporter|hexose transporter|maltose permease Mutant is defective in maltose fermentation.
MAL13 YGR288W transcription factor activity regulation of transcription, DNA-dependent* nucleus Part of complex locus MAL1; nonfunctional in S288C, shows homology to both functional & nonfunctiona MAL-activator protein defective maltose fermentation
MAL31 YBR298C alpha-glucoside:hydrogen symporter activity alpha-glucoside transport membrane fraction Part of the complex locus MAL3; functional in S288C; highly homologous to MAL61 from S. cerevisiae, maltose permease Defective maltose fermentation
MAL33 YBR297W transcription factor activity regulation of transcription, DNA-dependent* nucleus Part of complex locus MAL3; nonfunctional in S288C, shows homology to both functional & nonfunctiona MAL-activator protein Defective maltose fermentation
MAM1 YER106W molecular_function unknown meiotic chromosome segregation condensed nuclear chromosome kinetochore YCR086W Monopolar microtubule Attachment during Meiosis I Monopolin Null: Null mutant is viable; sister kinetochores orient towards opposite spindle poles in meiosis I
MAM33 YIL070C molecular_function unknown aerobic respiration mitochondrial matrix YJL115W YOR326W YBR146W YLR074C YPR015C YOL054W YGR103W YKL108W YNL250W YOL108C YIL061C YJR035W 33-kDa mitochondrial acidic matrix protein
MAP1 YLR244C methionyl aminopeptidase activity proteolysis and peptidolysis cytosolic ribosome (sensu Eukarya) YBL091C methionine aminopeptidase methionine aminopeptidase Null mutant is viable
MAP2 YBL091C methionyl aminopeptidase activity proteolysis and peptidolysis cytoplasm YLR244C YNL290W methionine aminopeptidase 2 methionine aminopeptidase 2 Null mutant is viable, map1 map2 double null mutant is inviable
MAS1 YLR163C mitochondrial processing peptidase activity mitochondrial processing mitochondrial processing peptidase complex YBR245C YOL021C YHR069C YHR024C YLR086W YHR120W YIL066C mitochondrial processing protease subunit mitochondrial processing protease subunit Null mutant is inviable; Elevated mitotic recombination and chromosomal missegregation when overprod
MAS2 YHR024C mitochondrial processing peptidase activity mitochondrial processing mitochondrial processing peptidase complex YLR163C YHR120W YIL066C 53 kDa subunit of the mitochondrial processing protease mitochondrial processing protease 53 kDa subunit Null mutant is inviable
MAS6 YNR017W protein transporter activity mitochondrial translocation mitochondrion* YIL022W YJL143W YML054C 23 kDa mitochondrial inner membrane protein 23 kDa mitochondrial inner membrane protein Null mutant is inviable; conditional mutants accumulate mitochondrial precursor proteins at restrict
MATALPHA1 YCR040W transcription co-activator activity regulation of transcription from Pol II promoter* nucleus transcription factor involved in the regulation of alpha-specific genes involved in the regulation of alpha-specific genes|transcription factor
MATALPHA2 YCR039C transcription co-repressor activity regulation of transcription from Pol II promoter* nucleus YDL116W Homeobox-domain containing protein which, in haploid cells, acts with MCM1 to repress a-specific gen
MBA1 YBR185C molecular_function unknown aerobic respiration* mitochondrial inner membrane YJR063W involved in assembly of mitochondrial respiratory complexes Null mutant is viable, conditionally defective in the assembly of mitochondrial respiratory complexe
MBF1 YOR298C-A transcription co-activator activity positive regulation of transcription from Pol II promoter nucleus bridges the DNA-binding region of GCN4 and TBP; similar to multiprotein bridging factor 1 of Bombyx multiprotein bridging factor Null mutant is viable, shows reduced transcription of HIS3
suppresses frameshift mutation
MBP1 YDL056W transcription factor activity* regulation of cell cycle* nucleus YLR182W YIL131C transcription factor transcription factor
MCA1 YOR197W caspase activity apoptosis nucleus YDR311W YER022W YGR166W YJL141C YJR091C YMR257C YBL106C metacaspase putative cysteine protease
MCD1 YDL003W molecular_function unknown mitotic chromosome condensation* nuclear cohesin complex YGL250W YPL017C YNL153C YEL061C YER016W YML094W YPR141C YCL061C YGR188C YMR048W YOR026W YPR135W YDR254W YHR191C YPL018W YCL016C YDR318W YJR135C YLR381W YMR078C YNL273W YPL008W YPR046W YFL008W YIL026C YJL074C YER147C YMR001C Mitotic Chromosome Determinant; similar to S. pombe RAD21; may function in chromosome morphogenesis Null mutant is inviable; temperature sensitive mutants are defective in mitotic sister chromatid coh
MCD4 YKL165C molecular_function unknown GPI anchor biosynthesis* cell wall (sensu Fungi)* Required for GPI anchor synthesis Null mutant is inviable; viability dependent on a functionnal morphogenesis checkpoint. Mutation aff
MCH1 YDL054C transporter activity* transport membrane YER140W YGR173W Monocarboxylate Permease Homologue
MCH2 YKL221W transporter activity* transport membrane YMR047C YOR221C monocarboxylate permease homologue
MCH4 YOL119C transporter activity* transport vacuolar membrane (sensu Fungi) YPL031C monocarboxylate permease homologue
MCH5 YOR306C transporter activity* transport membrane monocarboxylate permease homologue
MCK1 YNL307C glycogen synthase kinase 3 activity* protein amino acid phosphorylation* soluble fraction YIL105C YOR266W YAL038W YDL112W YGR140W YLR175W YER016W YPL174C YPR141C YPR135W YMR078C YDL102W Disp. for mitosis, required for chr. segregation, benomyl resist., basal IME1 transcript. in mitosis 43.1 kDa serine/threonine/tyrosine protein kinase Null mutant is viable, cold sensitive, temperature sensitive, and benomyl sensitive; associated with
MCM1 YMR043W DNA binding* regulation of transcription from Pol II promoter* nucleus* YLR082C YER022W YOR088W Involved in cell-type-specific transcription and pheromone response contains the 56 amino-acid MADS (MCM1, AG, DEFAm SRF)-box motif within its DNA binding domain, plays Null mutant is inviable, Pro97Leu mutant is sterile, exhibits defects in minichromosome maintenance
MCM10 YIL150C chromatin binding DNA replication initiation* nucleus YBL023C YGL201C YBR202W YPL161C YLR288C Protein required for S-phase (DNA synthesis) initiation or completion Null mutant is inviable; conditional allele demonstrates cell-cycle arrest at the restrictive temper
MCM16 YPR046W protein binding chromosome segregation condensed nuclear chromosome kinetochore YJR135C YMR268C YER081W YFR008W YGR113W YGR119C YER016W YPL269W YEL061C YPR141C YPR135W YDL003W YPL008W YJL030W YLR200W YGR078C YNL153C YEL003W YML094W YOL006C Involved in a nonessential role that governs the kinetochore-microtubule mediated process of chromos Null mutant is viable, exhibits increased sensitivity to the anitmitotic drugs benomyl and thiabenza
MCM2 YBL023C chromatin binding* DNA replication initiation* nucleus* YPL001W YDR052C YDL171C YOR196C YDL017W YBR126C YOR080W YIL150C Member of complex that acts at ARS's to initiate replication Null mutant is inviable, at nonpermissive temperature mcm2(ts) mutants arrest with a large bud and a
MCM21 YDR318W protein binding chromosome segregation condensed nuclear chromosome kinetochore YDL026W YDL041W YDL050C YDL096C YDL110C YDL118W YDL162C YDR455C YDR542W YEL068C YER084W YFL015C YFR054C YGL239C YGR018C YGR146C YHL042W YIL141W YLL037W YHR142W YHR152W YER029C YGR036C YDL046W YDL098C YDL053C YDL061C YDL067C YDL181W YDR478W YER035W YH Involved in minichromosome maintenance Null mutant is viable but exhibits defects in the stability of minichromosomes. Mutants also exhibit
MCM22 YJR135C protein binding chromosome segregation condensed nuclear chromosome kinetochore YPR046W YBR107C YER016W YEL061C YPR141C YPR135W YDL003W YPL008W YJL030W YLR200W YGR078C YNL153C YEL003W YML094W Required for maintenance of chromosomes and minichromosomes Null mutant is viable
MCM3 YEL032W chromatin binding* DNA replication initiation* nucleus* YLR274W YOR080W YBR202W Member of complex that acts at ARS's to initiate replication Null mutant is inviable, at nonpermissive temperature mcm3(ts) mutants arrest with a large bud and a
MCM6 YGL201C chromatin binding* DNA replication initiation* nucleus* YPL093W YDR427W YDL185W YLR274W YIL150C YLR233C YCL059C YER161C YMR216C Member of the MCM/P1 family of proteins involved in DNA replication Null mutant is inviable.
MCR1 YKL150W cytochrome-b5 reductase activity response to oxidative stress* mitochondrial intermembrane space* YGL070C YFR028C NADH-cytochrome b5 reductase NADH-cytochrome b5 reductase
MCT1 YOR221C acyl-carrier protein S-malonyltransferase activity aerobic respiration* mitochondrion YKL221W malonyl-CoA:ACP transferase malonyl-CoA:ACP transferase Null mutant is viable, respiratory deficient
MCX1 YBR227C chaperone activity* biological_process unknown mitochondrial matrix YML064C YKR026C Mitochondrial ATP-binding protein, similar to ClpX ATP-binding protein|similar to ClpX
MDG1 YNL173C molecular_function unknown signal transduction during conjugation with cellular fusion plasma membrane YOR020C YDR514C YIL128W multicopy suppressor of bem1 mutation, may be involved in G-protein mediated signal transduction; bi Null mutant is viable. Deletion of MDG1 causes sterility in cells in which the wild-type G beta has
MDH1 YKL085W L-malate dehydrogenase activity tricarboxylic acid cycle* mitochondrial matrix YPL204W YPR110C YNL094W YGL163C YDR129C YGL116W YER054C YHR183W YOL128C YPL111W YKL108W YER171W YBR136W YGR173W YPL153C YCR079W YJR035W YER133W YLR074C YJR062C YDR306C YBR055C mitochondrial malate dehydrogenase malate dehydrogenase Null mutant is viable
MDH2 YOL126C malic enzyme activity gluconeogenesis* cytoplasm* YIL108W YDL100C YIL128W YDL147W YCL043C YJR068W YMR246W YLR300W cytosolic malate dehydrogenase malate dehydrogenase Null mutant is viable; fails to grow on minimal medium with acetate or ethanol as carbon source
MDH3 YDL078C malic enzyme activity fatty acid beta-oxidation* peroxisomal matrix YBR055C malate dehydrogenase malate dehydrogenase Null mutant is viable, does not grow on oleate and grows slowly on acetate
MDJ1 YFL016C co-chaperone activity protein folding* mitochondrial inner membrane YHL045W YJR045C YIL061C YKL189W YER081W YDR128W YER179W involved in protection against heat-induced protein aggregation but not necessary for protein import DnaJ homolog|involved in mitochondrial biogenesis and protein folding Null mutant is viable, displays a petite phenotype, loss of mitochondrial DNA, and inviability at 37
MDJ2 YNL328C molecular_function unknown protein folding mitochondrial inner membrane YLR295C Protein of the mitochondrial inner membrane with similarity to E. coli DnaJ and other DnaJ-like prot chaperonin Null mutant is viable, mdj1 mdj2 double mutants display severe grwoth defects at high temperature
MDL1 YLR188W ATPase activity* oligopeptide transport mitochondrial inner membrane ATP-binding cassette (ABC) transporter family member Null mutant is viable
MDL2 YPL270W ATP-binding cassette (ABC) transporter activity aerobic respiration mitochondrial inner membrane YJR091C YOL095C ATP-binding cassette (ABC) transporter family member Null mutant is viable
MDM1 YML104C structural constituent of cytoskeleton mitochondrion organization and biogenesis* cytoplasm* YPR099C YDL030W Required for nuclear and mitochondrial transmission to daughter buds. intermediate filament protein Null mutant is inviable; temperature sensitive mutants display defective transfer of nuclei and mito
MDM10 YAL010C molecular_function unknown mitochondrion organization and biogenesis* mitochondrial outer membrane YPL235W YMR203W YJL066C Mitochondrial outer membrane protein involved in mitochondrial morphology and inheritance mitochondrial outer membrane protein Null mutant has short actin cables. Point mutants exhibit giant, spherical mitochondria and are defe
MDM12 YOL009C molecular_function unknown mitochondrion organization and biogenesis* mitochondrial outer membrane YOR023C YLR330W YGR227W Required for normal mitochondrial morphology and distribution mitochondrial outer membrane protein. An Mdm12p homolog exists in S. Pombe which confers a dominant Null mutant is viable, temperature sensitive, and possesses abnormally large, round mitochondria tha
MDM20 YOL076W peptide alpha-N-acetyltransferase activity* cytoskeleton organization and biogenesis* intracellular YOR326W YNL271C Subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal Null mutant is viable; some alleles demonstrate temperature sensitive growth at 37C
MDN1 YLR106C ATPase activity rRNA processing* nucleus YER006W YLR074C YBR009C YPL043W YGR245C YCR072C YNL110C YML029W YOL133W YDR394W YJR017C a large protein with a conserved N-terminal domain, a central AAA ATPase domain (with similarity to midasin Null: non-viable
MDR1 YGR100W Rab GTPase activator activity biological_process unknown soluble fraction YLR453C Mac1-dependent regulator GTPase activating protein (GAP) for Ypt6 Null mutant is viable
MDS3 YGL197W molecular_function unknown sporulation cytoplasm YMR117C YMR308C YDL047W YBR225W YPL204W Mck1 Dosage Suppressor 3; negative regulator of early meiotic gene expression Null mutant is viable; mds3 pmd1 double deletion mutants exhibit starvation-independent expression o
MDV1 YJL112W molecular_function unknown mitochondrial genome maintenance* mitochondrial outer membrane YLL001W WD repeat protein that regulates steps in the Dnm1p-dependent process of mitochondrial fission. Null mutant is viable, mitochondrial fission blocked, mitochondrial membranes form nets
MEC1 YBR136W inositol/phosphatidylinositol kinase activity meiotic recombination* nucleus YGL245W YKL085W YGR180C YIR009W YMR012W YOR027W YLR304C YDR097C YAR007C YBR143C YDR499W Required for mitotic growth, DNA repair and mitotic recombination, regulates phosporylation of Rad53 Null mutant is inviable; overproduction of Rad53p rescues some esr1 alleles
MEC3 YLR288C DNA binding chromatin silencing at telomere* nucleus YBR124W YBR197C YCR007C YCR016W YHR180W YJR146W YJR157W YKL044W YKL107W YLL023C YLR003C YLR021W YLR050C YLR051C YLR104W YLR124W YLR125W YLR202C YLR252W YLR254C YLR290C YMR295C YNL013C YNL158W YNL190W YOL046C YOL131W YJL084C YLR200W YMR159C YIR009W YD Involved in checkpoint control and DNA repair Null mutant is viable
MED1 YPR070W RNA polymerase II transcription mediator activity transcription from Pol II promoter mediator complex YDL005C YOL135C YBL093C YBR253W YPR048W YLR418C YLR200W YGR078C YNL153C YEL003W YML094W YLR103C Subunit 1 of the Mediator complex essential for transcriptional regulation essential for transcriptional regulation|mediator complex subunit 1 Defects in both repression and induction of GAL genes; supresses loss of the Snf1 kinase
MED11 YMR112C RNA polymerase II transcription mediator activity transcription from Pol II promoter mediator complex YAL036C YBR253W YNL180C YDL005C YOL135C YBL093C YER022W YIL128W 14 Kd mediator subunit of RNA polymerase II holoenzyme RNA polymerase II holoenzyme/mediator subunit 14 kDa
MED2 YDL005C RNA polymerase II transcription mediator activity transcription from Pol II promoter mediator complex YOR174W YGL025C YPR168W YBR193C YER157W YML007W YGL151W YPR070W YPL042C YBR079C YBR169C YHR058C YHR041C YIL021W YOL135C YNL236W YBR253W YNR010W YOL051W YMR112C YLR071C YER022W YGR104C YCR081W YDR443C YDL153C RNA Polymerase II transcriptional regulation mediator RNA polymerase II holoenzyme/mediator subunit Null mutant is viable, unable to grow on galactose
MED4 YOR174W RNA polymerase II transcription mediator activity transcription from Pol II promoter mediator complex YMR102C YGL025C YBR193C YIL021W YOL135C YER022W YNR039C YBL093C YBR253W YML098W YDL076C YGL127C YNL086W YDL005C YDR408C YNR010W YDR308C Member of RNA Polymerase II transcriptional regulation mediator RNA polymerase II holoenzyme/mediator subunit Null mutant is inviable
MED6 YHR058C RNA polymerase II transcription mediator activity transcription from Pol II promoter mediator complex YDL005C YOL135C YBL093C YBR253W YBR061C YCL016C YGL127C YKL023W YPR086W YER022W RNA polymerase II transcriptional regulation mediator Null mutant is inviable
MED7 YOL135C RNA polymerase II transcription mediator activity transcription from Pol II promoter mediator complex YIL077C YOR174W YGL025C YOL086C YHR174W YBR193C YKL060C YFR019W YDR448W YGL151W YPR070W YKR059W YHR058C YHR041C YIL021W YNL236W YGL112C YCR012W YBR253W YNR010W YMR112C YLR071C YER022W YGR104C YCR081W YDR443C YDR308C YBL093C YFR008W YGL127C YDL005C YB Member of RNA Polymerase II transcriptional regulation mediator RNA polymerase II holoenzyme/mediator subunit Null mutant is inviable
MED8 YBR193C RNA polymerase II transcription mediator activity transcription from Pol II promoter mediator complex YGL025C YIL021W YER022W YBL093C YBR253W YGL127C YHR041C YLR295C YMR047C YOR264W YPR086W YDL005C YOR174W YOL135C YGR104C Member of RNA Polymerase II transcriptional regulation mediator RNA polymerase II holoenzyme/mediator subunit Null mutant is inviable
MEF1 YLR069C translation elongation factor activity translational elongation mitochondrion mitochondrial elongation factor G-like protein mitochondrial elongation factor G-like protein Null mutant is viable, respiratory defective, displays pleiotropic deficiency in cytochromes a, a3 a
MEF2 YJL102W translation elongation factor activity translational elongation mitochondrion YIR013C YOL133W mitochondrial elongation factor G-like protein mitochondrial elongation factor G-like protein
MEK1 YOR351C protein serine/threonine kinase activity protein amino acid phosphorylation* nucleus YMR323W YHR027C YHR170W YHR178W YIL072W YLR263W Disp. for chr. pairing & chr. condensation seen by in situ hybrid. Required for full double strand b meiosis-specific serine/threonine protein kinase Null mutant is viable, however diploids homozygous for a mek1 null mutation produce only low percent
MEP1 YGR121C ammonium transporter activity ammonium transport plasma membrane YIR038C YEL017W belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH(4)( ammonia permease
MEP2 YNL142W ammonium transporter activity pseudohyphal growth* plasma membrane YER036C belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH(4)( ammonia transport protein Null mutant is viable.
MEP3 YPR138C ammonium transporter activity ammonium transport plasma membrane YBR067C ammonia permease of high capacity and low affinity; shows sequence similarity to Mep1p and Mep2p NH4+ transporter Null mutant is viable. mep1 mep2 mep3 triple mutants cannot grow on media containing less than 5mM N
MER1 YNL210W pre-mRNA splicing factor activity meiosis nucleus YKL142W YER022W YNL090W YDR247W Disp. for axial elements in meiosis but required for full chr. pairing & chr. condensation seen by i RNA-binding motif protein required for MRE2-dependent mRNA splicing Null mutant is viable, associated with decreased levels of inter-and intrachromosomal meiotic recomb
MES1 YGR264C methionine-tRNA ligase activity amino acid activation cytoplasm YGL112C YDR386W YGL105W methionyl tRNA synthetase methionine-tRNA ligase no growth at 36 degrees C
MET12 YPL023C methylenetetrahydrofolate reductase (NADPH) activity methionine metabolism cell YKR086W Gene encodes mthfr which catalyzes step before methionine synthesis. methylenetetrahydrofolate reductase (mthfr) (putative) Null mutant is viable and shows no phenotypes; double disruption of MET12 and MET13 (the two putativ
MET13 YGL125W structural constituent of ribosome* protein biosynthesis* mitochondrial large ribosomal subunit* YDR034C converts 5,10-CH2-H4folate to 5-CH3-H4folate. methylenetetrahydrofolate reductase (mthfr) (putative) Null mutant is viable and shows methionine auxotrophy; double disruption of MET12 and MET13 (the two
MET14 YKL001C adenylyl-sulfate kinase activity methionine metabolism* cell YLR288C YNL311C adenylylsulfate kinase adenylylsulfate kinase Null mutant is viable, and is a methionine auxotroph
MET16 YPR167C phosphoadenylyl-sulfate reductase (thioredoxin) activity methionine metabolism* intracellular YMR106C 3'phosphoadenylylsulfate reductase 3'phosphoadenylylsulfate reductase Null mutant is viable, and is a methionine auxotroph
MET17 YLR303W O-acetylhomoserine aminocarboxypropyltransferase activity* methionine metabolism cytoplasm YNL189W O-Acetylhomoserine-O-Acetylserine Sulfhydralase O-acetylhomoserine (thiol)-lyase Null mutant is viable, methionine auxotroph, becomes darkly pigmented in the presence of Pb2+ ions;
MET18 YIL128W RNA polymerase II transcription factor activity transcription from Pol II promoter* nucleoplasm YPL191C YEL060C YIL033C YMR112C YNL173C YER068W YPL064C YDL029W YPR110C YLR291C YBR217W YDR388W YER171W YOL126C YDR267C YMR117C YLR418C YDR052C Involved in nucleotide excision repair and regulation of TFIIH TFIIH regulator Null mutant is viable but is temperature-sensitive, defective in ability to remove UV_induced dimers
MET2 YNL277W homoserine O-acetyltransferase activity methionine biosynthesis* cytoplasm YBR119W YKL028W YPL169C catalyzes the conversion of homoserine to O-acetyl homoserine which in turn combines with hydrogen s homoserine O-trans-acetylase Null mutant is viable, and is a methionine auxotroph
MET22 YOL064C 3'(2'),5'-bisphosphate nucleotidase activity sulfate assimilation* cytoplasm YBR058C YHL026C YOR299W YLR085C YLR103C involved in salt tolerance and methionine biogenesis; converts pAp (adenosine 3',5' bisphosphate), a 3'(2')5'-bisphosphate nucleotidase Methionine requiring; lacks 3'-phosphoadenylylsulfate (PAPS) reductase activity; unable to grow on s
MET28 YIR017C DNA binding* regulation of transcription from Pol II promoter* nucleus YDR306C YLR423C YNL103W YNL016W YGL127C YLR437C YJR060W Transcriptional activator of sulfur amino acid metabolism transcriptional activator in the Cbf1p-Met4p-Met28p complex Null mutant is viable but is a methionine-auxotroph and resistant to toxic analogs of sulfate.
MET30 YIL046W protein binding ubiquitin-dependent protein catabolism* nuclear ubiquitin ligase complex* YNL103W YBR138C YBR270C YDR095C YNL182C YJL058C YJL187C YDR328C YKL081W YNL007C YDR139C YDL132W YLL039C YEL015W YLR082C YOR087W YPL038W YOL133W YJR131W YNL245C YDR054C F-box protein involved in sulfur metabolism and protein ubiquitination contains five copies of WD40 motif and interacts with and regulates Met4p
MET31 YPL038W DNA binding* sulfur amino acid metabolism* nucleus* YEL009C YIL046W Involved in methionine metabolism highly homologous to Met32p|transcriptional regulator of sulfur amino acid metabolism|zinc finger pr
MET32 YDR253C DNA binding* sulfur amino acid metabolism nucleus Involved in methionine metabolism highly homologous to Met31p|transcriptional regulator of sulfur amino acid metabolism|zinc finger pr
MET4 YNL103W transcription co-activator activity positive regulation of transcription from Pol II promoter* nucleus YIL046W YJR060W YIR017C main transcriptional activator of the sulfate assimilation pathway leucine zipper family|transcriptional activator Null mutant is viable, and is a methionine auxotroph
MET7 YOR241W tetrahydrofolylpolyglutamate synthase activity one-carbon compound metabolism cytoplasm* YCR001W METhionine requiring folylpolyglutamate synthetase Null mutant is viable, requires methionine for growth, and is respiration-deficient
MEU1 YLR017W molecular_function unknown glutamate biosynthesis cytoplasm YIL061C Protein that regulates ADH2 gene expression Null mutant is viable, displays reduced ADH2 expression
MEX67 YPL169C protein binding* mRNA-nucleus export cytoplasm* YOR128C YBR072W YLR377C YER023W YKL025C YNL277W YHR015W YMR123W YJR042W Involved in nuclear mRNA export, binds both poly(A) a poly(A)+RNA binding protein Null mutant is inviable
MFA1 YDR461W pheromone activity signal transduction during conjugation with cellular fusion soluble fraction* YBR061C YLR384C a-factor mating pheromone precursor a-factor mating pheromone precursor
MFT1 YML062C nucleic acid binding mRNA-nucleus export* THO complex YNL097C YDR138W YCL011C YHR193C YOL006C Protein involved in mitochondrial import of fusion proteins mitochondrial targeting protein Null mutant is viable.
MGA2 YIR033W transcriptional activator activity positive regulation of transcription from Pol II promoter* endoplasmic reticulum membrane YKL020C YKL081W YNL298W Product of gene unknown Null mutant is viable, shows subtle effects on growth, UV sensitivity, and galactose utilization; mg
MGE1 YOR232W chaperone activity mitochondrial translocation mitochondrion* YMR147W YJR045C YCR052W YGR142W YLR423C YML064C YOR239W YPL222W YPL204W YDR266C YGL163C YMR167W YKL108W YFR003C YJR062C YCR009C involved in protein import into mitochondria GrpE homolog Null mutant is inviable
MGM1 YOR211C dynamine GTPase activity mitochondrion organization and biogenesis* mitochondrial intermembrane space involved in the propagation of functional mitochondria yeast GTP-binding domain protein related to dynamin Null mutant is viable, has a reduced number of copies of the mitochondrial chromosome per cell at ea
MGM101 YJR144W DNA binding DNA repair* mitochondrial chromosome YDR097C YDL130W YNL312W YIL131C YLR427W YDR386W YDL213C YLR074C YMR137C YIL035C YLR085C Involved in mitochondrial genome maintenance mitochondrial nucleoid protein Null mutant is viable. Meiotic segregants with a disrupted mgm101 allele cannot undergo more than 10
MGS1 YNL218W ATPase activity* DNA replication* nucleus YJL030W YNL218W YEL058W YGR010W YIL050W YMR190C YDR477W YML064C YMR102C YJR057W YDR363W Maintenance of Genome Stability 1 mgs1 is synthetic lethal with rad6 and exhibits a synergistic growth defect with rad18 and rad5. mgs
MGT1 YDL200C methylated-DNA-[protein]-cysteine S-methyltransferase activity DNA dealkylation nucleus 6-O-methylguanine-DNA methylase 6-O-methylguanine-DNA methylase Null mutant is viable, sensitive to alkylation induced killing and mutation
MHP1 YJL042W structural constituent of cytoskeleton cell wall organization and biogenesis* microtubule YLR128W YER133W YCR005C Similar to a 250 kD Drosophila microtubule-associated protein (MAP) (which can rescue MHP1 null muta microtubule-associated protein (MAP) (putative) Null mutant is inviable; overexpression of the MHP1 C-terminus results in short spindles
MHR1 YDR296W transcription regulator activity mitochondrial genome maintenance nucleus* YNL284C YNL185C YGR220C Involved in mitochondrial homologous DNA recombination. Binds to activation domains of acidic activa Temperature sensitive in the maintenance of mitochondrial DNA
MID1 YNL291C calcium channel activity calcium ion transport plasma membrane YHR132C YOR144C YLR039C YPR135W YDL102W YNL250W N-glycosylated integral plasma membrane protein N-glycosylated integral plasma membrane protein Null mutant is viable; Ca2+ influx and mating defective
MID2 YLR332W transmembrane receptor activity cell wall organization and biogenesis* integral to plasma membrane YLR111W YLR338W YDR129C YJR118C YGR229C YOR008C YML115C YLR371W YLL043W YLR110C YLR328W YLR342W Protein required for mating Null mutant is viable, dies when exposed to mating pheromone
MIF2 YKL089W centromeric DNA binding mitotic spindle assembly (sensu Saccharomyces) nucleus* YGR140W YJR060W centromere protein required for normal chromosome segregation and spindle integrity Null mutant is inviable, temperature sensitive mutants accumulate large budded cells and broken spin
MIG1 YGL035C specific RNA polymerase II transcription factor activity regulation of transcription from Pol II promoter* nucleus* YPL025C YOL041C YDR194C YKL074C YMR240C YBR126C Transcription factor involved in glucose repression C2H2 zinc finger protein that resembles the mammalian Egr and Wilms tumour proteins Null mutant is viable, exhibits partial derepression of numerous glucose regulated transcripts; MIG1
MIG2 YGL209W specific RNA polymerase II transcription factor activity regulation of transcription from Pol II promoter* nucleus Involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; contains zinc fingers very similar to zinc fingers in Mig1p Null mutant is viable; a strain that contains a double disruption of MIG1 and MIG2 is defective in g
MIG3 YER028C transcription factor activity* transcription initiation nucleus YBR061C Hypothetical ORF DNA binding transcription co-repressor Multicopy inhibitor of growth during genotoxic stress in snf1 mutants
MIP1 YOR330C gamma DNA-directed DNA polymerase activity DNA dependent DNA replication mitochondrion catalytic subunit of mitochondrial DNA polymerase mitochondrial DNA polymerase catalytic subunit Null mutant is viable, associated with total loss of mitochondrial DNA and mitochondrial DNA polymer
MIP6 YHR015W RNA binding mRNA-nucleus export nuclear pore YDR172W YPL169C RNA-binding protein, interacts with MEX67
MIR1 YJR077C inorganic phosphate transporter activity phosphate transport mitochondrion* YDR062W YBR114W YDR170C YBR069C YLR288C YER100W Product of gene unknown Null mutant is viable on glucose containing media, but is unable to grow on a non-fermentable carbon
MIS1 YBR084W formate-tetrahydrofolate ligase activity* nucleobase, nucleoside, nucleotide and nucleic acid metabolism* mitochondrion YKL135C YHR013C YHR089C YBR009C YBL024W YBL035C YFR031C-A YBR143C YAL019W YBL032W YAL035W YGR285C mitochondrial C1-tetrahydroflate synthase C1-tetrahydrofolate synthase Null mutant is viable, exhibits no apparent defects in cell growth
MKC7 YDR144C aspartic-type signal peptidase activity proteolysis and peptidolysis cell wall (sensu Fungi) YLR453C YLR200W YGR078C YML094W protease involved in protein processing that shares functions with Yap3 and Kex2 aspartyl protease|related to Yap3p Null mutant is viable, mkc7 yap3 double mutants are temperature sensitive, and mkc7 yap3 kex2 triple
MKK1 YOR231W MAP kinase kinase activity protein amino acid phosphorylation* bud tip YHR030C YLL021W YLR313C YIL014W YLR447C YJL095W Mitogen-activated kinase-kinase involved in protein kinase C pathway MAP kinase kinase (MEK) Null mutant is viable but cannot grow on glycerol, is sensitive to nitrogen starvation, and cannot g
MKK2 YPL140C MAP kinase kinase activity protein amino acid phosphorylation* intracellular YJR072C YHR030C YJL095W YHR027C YDL029W YDR190C YBR260C YEL060C YPR108W YLL021W YLR313C YCL028W YIL094C YMR275C YNL037C YJR091C YGL116W YBR088C YMR106C Member of MAP kinase pathway involving PKC1, BCK1, and SLT2. Shows functional redundancy with MKK1 protein kinase Null mutant is viable and shows no obvious phenotypes; mkk1 mkk2 double mutant is caffeine-sensitive
MKS1 YNL076W transcriptional repressor activity regulation of nitrogen utilization intracellular YBR126C Pleiotropic regulatory factor involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen reg negative transcriptional regulator Null mutant is viable, fails to grow on galactose media containing ethidium bromide at 25 degrees an
MLC1 YGL106W microfilament motor activity establishment of cell polarity (sensu Saccharomyces)* actin cap (sensu Saccharomyces) YOR326W YHR023W YAL029C YHR019C YBR109C YBR130C may stabilize Myo2p by binding to the neck region myosin Myo2p light chain Null mutant is inviable; MLC1 is halploinsufficient, the haploinsufficiency exhibited by MLC1 is sup
MLH1 YMR167W DNA binding* meiotic recombination nucleus YNL082W YOR232W YOR155C YER095W YDL017W Required for mismatch repair in mitosis and meiosis, low levels of postmeiotic segregation, and high forms a complex with Pms1p and Msh2p to repair mismatched DNA|mutL homolog Null mutant is viable; displays a dramatic increase in the instability of simple sequence repeats, d
MLH2 YLR035C molecular_function unknown DNA repair nucleus YOR261C YDR120C YGR165W YJR091C YMR206W Mutl Homolog Null mutant is viable but non-Mendelian segregation is elevated and parity is altered during meiosis
MLH3 YPL164C molecular_function unknown meiotic recombination* nucleus YPR191W YNL128W Mutl Homolog Null mutant is viable. Null mutant exhibits reduced (70%) rate of meiotic cross over.
MLP1 YKR095W molecular_function unknown protein-nucleus import nuclear membrane* YBR253W Mlp proteins restrict telomere length by influencing the Rif1-Tel1 pathway of telomerase regulation; colied-coil protein (putative), similar to myosin and TPR
MLP2 YIL149C molecular_function unknown protein-nucleus import nuclear membrane* YNL135C YNL128W Mlp proteins restrict telomere length by influencing the Rif1-Tel1 pathway of telomerase regulation; coiled-coil protein (putative), similar to myosin and TPR
MLS1 YNL117W malate synthase activity glyoxylate cycle cytoplasm* YBR218C YGL062W YNL250W carbon-catabolite sensitive malate synthase carbon-catabolite sensitive malate synthase Null mutant is viable
MMF1 YIL051C molecular_function unknown mitochondrial genome maintenance* mitochondrion* YLR295C Maintenance of Mitochondrial Function Null mutant is viable but cannot utilize glycerol as a carbon source; the mitochondrial DNA is delet
MMM1 YLL006W molecular_function unknown mitochondrion organization and biogenesis* mitochondrial outer membrane YJL054W YOR112W YGR078C YNL153C YEL003W YML094W Involved in mechanism by which mitochondrial shape is established or maintained mitochondrial outer membrane protein Null mutant is viable, fails to grow on nonfermentable carbon sources, demonstrates abnormal mitocho
MMP1 YLL061W S-methylmethionine transporter activity S-methylmethionine transport plasma membrane S-MethylMethionine Permease high affinity S-methylmethionine permease Null mutant is viable but is unable to use S-methylmethionine as a sulfur source
MMS2 YGL087C ubiquitin conjugating enzyme activity ubiquitin-dependent protein catabolism* nucleus* YOR220W YER125W YOL081W YDR092W YPR135W YLR200W YGR078C YEL003W YML094W Member of error-free postreplication DNA repair pathway Null mutant is viable and is sensitive to MMS and UV
MMS4 YBR098W transcription co-activator activity* DNA repair* nucleus YLR235C YLR373C YDR363W YDR369C YLR234W YPL024W YMR190C YKL113C YDR386W YBL007C YOR144C YOL006C YDL102W YLR103C YJR057W YJL092W endonuclease null is synthetically lethal with sgs1 null
MMT1 YMR177W molecular_function unknown iron ion homeostasis mitochondrion* YLR295C Protein involved in mitochondrial iron accumulation mitochondrial metal transporter (putative) Null mutant is viable, mmt1 mmt2 double deletion mutants exhibit a growth defect on low iron medium
MMT2 YPL224C molecular_function unknown iron ion homeostasis mitochondrion* YLR141W YEL003W Protein involved in mitochondrial iron accumulation Null mutant is viable, mmt1 mmt2 double deletion mutants exhibit a growth defect on low iron medium
MND1 YGL183C molecular_function unknown meiotic recombination condensed nuclear chromosome YPL051W needed for Meiotic Nuclear Divisions Null mutant is viable; arrests after DNA-replication but before nuclear divisions after shift to spo
MND2 YIR025W molecular_function unknown meiotic recombination* anaphase-promoting complex YJR091C YMR308C needed for Meiotic Nuclear Division arrests after DNA-replication but before nuclear divisions after shift to sporulation medium
MNL1 YHR204W carbohydrate binding ER-associated protein catabolism endoplasmic reticulum YER126C YGL030W YOR312C YJL053W YMR304W YHR019C mannosidase like
MNN1 YER001W alpha-1,3-mannosyltransferase activity O-linked glycosylation* Golgi apparatus Adds the terminal mannose to the outer chain branches of N-linked mannan, masking mannosylphosphate. alpha-1,3-mannosyltransferase Null mutant is viable
MNN10 YDR245W alpha-1,6-mannosyltransferase activity actin filament organization* mannosyltransferase complex YIL034C YPL094C YDR129C YPL031C YHR030C YLR418C YJR043C YBR023C YLR330W YHR142W YDR420W YBL061C YGR229C YCR009C YDR388W Required for mannan synthesis and for polarized growth and bud emergence galactosyltransferase Null mutant is viable, is larger than wild-type cells, is deficient in bud emergence, and depends up
MNN11 YJL183W alpha-1,6-mannosyltransferase activity protein amino acid glycosylation mannosyltransferase complex YBR234C YDL029W YKL190W YOR070C YLR200W YNL153C YEL003W YLR330W YJL099W YLR342W YLR113W YGR229C YNL322C member of a cis Golgi complex that is involved in mannan synthesis, other complex members include Mn mannosyltransferase complex component Null mutant is viable, exhibits defects in mannan synthesis
MNN2 YBR015C alpha-1,2-mannosyltransferase activity protein amino acid glycosylation Golgi apparatus YHR030C YJL095W YBR023C YCR009C YDR388W Probable type II membrane protein involved in mannan synthesis. Catalyzes addition of first mannose golgi alpha-1,2-mannosyltransferase (putative) Null mutant is viable. Mannan lacks the main alpha-1,2-linked branches
MNN5 YJL186W alpha-1,2-mannosyltransferase activity protein amino acid glycosylation Golgi apparatus YDL138W mannan synthesis golgi alpha-1,2-mannosyltransferase (putative) Null mutant is viable but defective in addition of the alpha-1,3-linked mannose branch to the mannan
MNN9 YPL050C mannosyltransferase activity N-linked glycosylation membrane* YAL028W YML115C YLR447C YEL036C YJR075W YCR009C YDR388W Protein required for complex glycosylation required for complex glycosylation mnn9 is lethal in combination with chs3.
MNR2 YKL064W magnesium ion transporter activity magnesium ion transport membrane Product of gene unknown overexpression overcomes manganese toxicity
MNS1 YJR131W mannosyl-oligosaccharide 1,2-alpha-mannosidase activity N-linked glycosylation endoplasmic reticulum YGL019W YIL046W YML064C YDR235W specific alpha-mannosidase alpha-mannosidase Null mutant is viable
MOB1 YIL106W kinase regulator activity protein amino acid phosphorylation* bud neck YBR255W YIL169C YDL028C YNR052C YMR001C YNL161W YFL028C YAL024C YAR019C YGR092W YJR122W YPR111W Mps One Binder Null mutant is inviable; conditional mutants arrest in late mitosis
MOB2 YFL034C-B protein kinase activator activity protein amino acid phosphorylation* nucleus* YOL036W YGL070C YIR016W YKL002W YNL161W YCL011C Mps One Binder Mob1p-like protein Null is viable; other mutants have synthetic interactions with MPS1
MOD5 YOR274W tRNA isopentenyltransferase activity tRNA modification nucleus* YER010C transfer RNA isopentenyl transferase transfer RNA isopentenyl transferase Null mutant is viable but temperature sensitive and cannot grow on nonfermentable carbon sources.
MOG1 YJR074W RAN protein binding protein-nucleus import nucleus YLR293C YOR185C Required for nuclear-protein import nuclear protein that interacts with GTP-Gsp1p Null mutant is viable, temperature sensitive, exhibits defects in nuclear-protein import; MOG1 overe
MON1 YGL124C molecular_function unknown protein-vacuolar targeting* cytosol* YKL025C YDR162C YHR129C YPL174C YKR054C YDR424C YMR299C YDR150W YML094W Product of gene unknown null mutant is sensitive to monensin and brefeldin A
MON2 YNL297C molecular_function unknown protein-vacuolar targeting* endosome YJL168C YPL051W YLR039C YLR262C YMR048W YBR094W YBR164C protein with similarity to N-terminal region of the human protein BIG1 Null: null mutant is sensitive to monensin and brefeldin A
deletion is synthetically lethal with
MOT1 YPL082C ATPase activity regulation of transcription from Pol II promoter nuclear chromosome YER148W YOL086C YLR249W YKR001C YGL195W YLR044C YBL002W YBR245C YBR089C-A YBR049C YLR176C YPR073C YDR392W YOR194C involved in TBP (TATA-binding protein) regulation helicase (putative) Null mutant is inviable
MOT2 YER068W 3'-5' exoribonuclease activity* regulation of transcription from Pol II promoter* cytoplasm* YCR093W YAL021C YPR072W YIL038C YIL128W Negative regulator of gene expression zinc finger protein (putative) Null mutant is viable, exhibits a modest increase in basal transcription of several pheromone-respon
MOT3 YMR070W DNA binding* transcription nucleus DNA-binding protein implicated in heme-dependent repression, repression of a subset of hypoxic genes 2 Cys2-His2 zinc fingers at c-terminus, glutamine and asparagine rich Null mutant is viable, displays modest increase in Ty mRNA levels; mot3 deletion can partially suppr
MPC54 YOR177C structural molecule activity spore wall assembly (sensu Saccharomyces) spindle pole body YJR132W YGR218W YOR265W YHR135C YNL244C YMR216C Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytopl Null: viable. Other phenotypes: sporulation deficient.
MPD2 YOL088C protein disulfide isomerase activity protein folding endoplasmic reticulum YLR312C YHR091C protein disulfide isomerase related protein protein disulfide isomerase related protein Null mutant is viable; overproduction of Mpd2p suppresses lethality and carboxypeptidase Y maturatio
MPE1 YKL059C molecular_function unknown mRNA polyadenylation* mRNA cleavage and polyadenylation specificity factor complex YER133W YGL049C YNL317W YMR061W YGR156W YLR277C YPR107C YDR228C YOR344C YDR301W YLR115W YJR093C YKR002W YAL043C YDR195W Protein required for cell viability
MPH1 YIR002C RNA helicase activity DNA repair nucleus YDR097C YAR007C YDL041W YIL158W YIL131C YER142C YJL092W RNA helicase that influences the mutation rate of nuclear and mitochondrial genomes
MPH2 YDL247W maltose porter activity* carbohydrate transport plasma membrane YDR034C Maltose Permease Homologue. Maltose transporter family member, able to transport hexoses. Capable of alpha-glucoside permease
MPH3 YJR160C maltose porter activity* carbohydrate transport plasma membrane Maltose Permease Homologue. Maltose transporter family member, able to transport hexoses. Capable of alpha-glucoside permease
MPM1 YJL066C molecular_function unknown biological_process unknown mitochondrion* YAL010C YPR086W mitochondrial membrane protein
MPP10 YJR002W molecular_function unknown rRNA modification* nucleus* YBR247C YCL059C YCR057C YGR090W YDL153C YHR148W YNL075W part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) U3 snoRNP protein Null mutant is inviable
MPS1 YDL028C protein threonine/tyrosine kinase activity mitotic spindle checkpoint* condensed nuclear chromosome kinetochore* YEL061C YIL106W Required for spindle pole body duplication and a mitotic checkpoint function. Null mutant is inviable. Eliminating the expression of MPS1 causes accumulation of non-viable cells
MPS2 YGL075C structural constituent of cytoskeleton spindle pole body duplication (sensu Saccharomyces)* spindle pole body* YDL070W Monopolar spindle two, encodes a membrane protein localized at the nuclear envelope and the spindle Null mutant is inviable, however some null spore clones can survive with abnormal ploidy; the mps2-1
MPS3 YJL019W molecular_function unknown spindle pole body duplication (sensu Saccharomyces)* integral to membrane* YMR001C YOL104C YLR233C YOL012C MonoPolar Spindle
98 kDa Nuclear Envelope Protein. essential integral membrane protein that local Spindle pole body duplication|nuclear envelope protein Null: null mutant is inviable. Other phenotypes: ts mutants fail in SPB duplication; The temperature
MRD1 YPR112C snoRNA binding* 35S primary transcript processing nucleolus Multiple RNA Binding Domain; essential for synthesis of the small ribosomal subunit Null mutant is inviable (haploid divides 2-3 times)
MRE11 YMR224C protein binding* DNA repair* nucleus YMR117C YNL250W YMR224C YDR369C YKL113C YNL023C YDL154W YOR144C YER016W YPR135W YMR078C YCL016C YOL006C YNL192W YLR330W YJL174W YHR031C YMR263W Disp. for premeiotic DNA synthesis, but required for both double strand break formation & resection, Null mutant is viable, methyl methanesulfonate-sensitive and displays hyper-recombination in mitosis
MRF1 YGL143C translation release factor activity protein biosynthesis* mitochondrion YER107C Mitochondrial polypeptide chain release factor mitochondrial polypeptide chain release factor Null mutant is viable but shows high instability of the mitochondrial genome, reduced synthesis of m
MRH1 YDR033W molecular_function unknown biological_process unknown plasma membrane Membrane protein related to Hsp30p; Localized by immunofluorescence to membranes, mainly the plasma Null mutant is viable
MRH4 YGL064C RNA helicase activity ribosome biogenesis mitochondrion YGR220C mitochondrial RNA helicase mitochondrial DEAD box RNA helicase Null: viable, slow growth, respiratory deficient
MRL1 YPR079W receptor activity vacuolar transport cytoplasm* YDL138W YLR039C YLR262C Mannose 6-phosphate Receptor Like
MRM2 YGL136C rRNA (uridine-2'-O-)-methyltransferase activity rRNA modification mitochondrion Mitochondrial rRNA Methyltransferase; methylates the 21S (mitochondrial) rRNA at position U2791 2'O-ribose methyltransferase Null: thermosensitive respiration; loses mitochondrial DNA with high frequency
MRP1 YDR347W structural constituent of ribosome protein biosynthesis mitochondrial small ribosomal subunit YHL004W YBR251W YDR036C shows allele-specific genetic interactions with pet122 and pet123 37 kDa mitochondrial ribosomal protein defective mitochondrial protein synthesis; absence of a and b type cytochromes; reduced levels of mi
MRP10 YDL045W-A structural constituent of ribosome protein biosynthesis mitochondrial small ribosomal subunit YBR251W Involved in mitochondrial translation Yml37p homolog|mitochondrial ribosome 37 S subunit component Null mutant is viable, defective in mitochondrial translation and shows a tendency to accumulate del
MRP13 YGR084C structural constituent of ribosome protein biosynthesis mitochondrial small ribosomal subunit YGR251W YHL004W YBR251W YDR036C YER081W 35 kDa mitochondrial ribosomal small subunit protein 35 kDa mitochondrial ribosomal small subunit protein Null mutant is viable, no impairment in ribosome synthesis or function
MRP17 YKL003C structural constituent of ribosome protein biosynthesis mitochondrial small ribosomal subunit YBR251W YOL006C Mitochondrial ribosomal protein MRP17 ribosomal protein MRP17 petite
MRP2 YPR166C structural constituent of ribosome protein biosynthesis mitochondrial small ribosomal subunit 14 kDa mitochondrial ribosomal protein; homologous to E. coli S14 protein 14 kDa mitochondrial ribosomal protein|similar to E. coli S14 protein defective mitochondrial protein synthesis; absence of a and b type cytochromes; reduced levels of mi
MRP20 YDR405W structural constituent of ribosome protein biosynthesis mitochondrial large ribosomal subunit YNL185C YGR220C Involved in mitochondrial translation 263 amino acid mitochondrial ribosomal large subunit|similar to L23 family of ribosomal proteins Null mutant is viable, becomes [rho-] or [rho0]
MRP21 YBL090W structural constituent of ribosome protein biosynthesis* mitochondrial small ribosomal subunit YHL004W YBR251W Mitochondrial Ribosomal Protein mitochondrial ribosome small subunit component Null mutant is viable, exhibits completely blocked mitochondrial gene expression; missense mutations
MRP4 YHL004W structural constituent of ribosome* protein biosynthesis mitochondrial small ribosomal subunit YER086W YLR423C YPL255W YOR212W YDL100C YMR186W YMR153W YDR036C YIL093C YGL129C YGR215W YDR337W YBR103W YMR158W YDR347W YGR084C YPL118W YBR146W YNL137C YDR041W YKL155C YJR113C YMR188C YNL306W YOR243C YNR037C YGR249W YBL090W YBR251W YOR158W YJR101W YB Involved in mitochondrial protein synthesis mitochondrial ribosomal protein|mitochondrial ribosome 37 S subunit component|similar to E. coli rib Null mutant is viable
MRP49 YKL167C structural constituent of ribosome protein biosynthesis mitochondrial large ribosomal subunit YGR220C 16 kDa mitochondrial ribosomal large subunit protein 16 kDa mitochondrial ribosomal large subunit protein Null mutant is viable, cold-sensitive, respiration deficient, defective in assembly of stable 54S ri
MRP51 YPL118W structural constituent of ribosome protein biosynthesis* mitochondrial small ribosomal subunit YDR333C YGR244C YHL004W YBR251W YDR036C Mitochondrial Ribosomal Protein mitochondrial ribosome small subunit component Null mutant is viable, exhibits completely blocked mitochondrial gene expression; missense mutations
MRP7 YNL005C structural constituent of ribosome* protein biosynthesis mitochondrial large ribosomal subunit YHR089C YNL284C YBL038W YNL185C YGR220C YGR091W YGR162W YBL032W YHR130C Mitochondrial ribosomal protein MRP7 (YmL2) (E. coli L27) ribosomal protein (YmL2) (E. coli L27) Null mutant is viable
MRP8 YKL142W structural constituent of ribosome protein biosynthesis mitochondrial ribosome YKL142W YMR165C YGR086C YNL210W YDR115W YMR210W YMR243C mitochondrial ribosomal protein ribosomal protein
MRPL1 YDR116C structural constituent of ribosome protein biosynthesis* mitochondrial large ribosomal subunit YNL284C YNL185C YGR220C YJL041W YDR309C YIL035C YPL174C Mitochondrial Ribosomal Protein, Large Subunit
MRPL10 YNL284C structural constituent of ribosome protein biosynthesis mitochondrial large ribosomal subunit YER006W YBL004W YDL145C YGL137W YBR122C YDR116C YFR051C YDR238C YOR201C YNL005C YCR046C YPL204W YCR071C YDR296W YBL038W YNL252C YOR150W YMR193W YBR282W YDR462W YMR024W YDR322W YML009C YLR439W YMR225C YHR147C YDR237W YBL024W Mitochondrial ribosomal protein MRPL10 (YmL10) ribosomal protein (YmL10)
MRPL11 YDL202W structural constituent of ribosome protein biosynthesis mitochondrial large ribosomal subunit YER009W YER022W Mitochondrial ribosomal protein MRPL11 (YmL11) ribosomal protein (YmL11) Null mutant is viable, respiratory deficient accompanied by a loss of mitochondrial DNA
MRPL13 YKR006C structural constituent of ribosome protein biosynthesis mitochondrial large ribosomal subunit YHL045W YGR220C mitochondrial ribosomal protein YmL13 ribosomal protein (YmL13) Null mutant is viable, grows poorly on non-fermentable carbon sources
MRPL15 YLR312W-A structural constituent of ribosome protein biosynthesis mitochondrial large ribosomal subunit YJL041W Mitochondrial ribosomal protein MRPL15 (YmL15) ribosomal protein (YmL15)
MRPL16 YBL038W structural constituent of ribosome* protein biosynthesis mitochondrial large ribosomal subunit YGR033C YER155C YBL004W YJR138W YJL176C YJL005W YOR290C YNL005C YCL014W YOR150W YDR462W YMR024W YDR322W YLR439W YDR237W YKR085C YJL063C YDR164C YLR189C YML025C YPR100W YNL284C Mitochondrial ribosomal protein MRPL16 ribosomal protein
MRPL17 YNL252C structural constituent of ribosome protein biosynthesis mitochondrial large ribosomal subunit YOR344C YIR027C YNL284C YHR178W mitochondrial ribosomal protein of the large subunit ribosomal protein large subunit
MRPL19 YNL185C structural constituent of ribosome protein biosynthesis mitochondrial large ribosomal subunit YDR116C YNL005C YDR296W YMR024W YDR322W YLR439W YDR237W YML025C YDR405W mitochondrial ribosomal protein of the large subunit ribosomal protein large subunit
MRPL20 YKR085C structural constituent of ribosome protein biosynthesis* mitochondrial large ribosomal subunit YBL038W YGR220C 22.3 kDa mitochondrial ribosomal large subunit protein YmL20; homologous to L17 of E. coli ribosomal protein large subunit (YmL20)|similar to L17 of E. coli Null mutant is viable; shows loss of mitochondrial function, instability of mitochondrial DNA
MRPL22 YNL177C structural constituent of ribosome protein biosynthesis* mitochondrial large ribosomal subunit Hypothetical ORF
MRPL23 YOR150W structural constituent of ribosome protein biosynthesis* mitochondrial large ribosomal subunit YNL284C YBL038W YDR172W YER081W mitochondrial ribosomal protein of the large subunit ribosomal protein large subunit
MRPL24 YMR193W structural constituent of ribosome protein biosynthesis mitochondrial large ribosomal subunit YNL284C YGR220C YJL041W YPR086W Mitochondrial ribosomal protein MRPL24 (YmL24) ribosomal protein (YmL24)
MRPL25 YGR076C structural constituent of ribosome protein biosynthesis mitochondrial large ribosomal subunit YGR220C Mitochondrial ribosomal protein MRPL25 (YmL25) ribosomal protein (YmL25) Null mutant is viable, cells become Pet-
MRPL27 YBR282W structural constituent of ribosome protein biosynthesis mitochondrial large ribosomal subunit YGR187C YNL284C essential for mitochondrial function ribosomal protein (YmL27) Null mutant is viable, fails to grow on nonfermentable carbon sources
MRPL28 YDR462W structural constituent of ribosome protein biosynthesis mitochondrial large ribosomal subunit YNL284C YBL038W YGR220C YGR091W Mitochondrial ribosomal protein MRPL28 (YmL28) ribosomal protein (YmL28)
MRPL3 YMR024W structural constituent of ribosome protein biosynthesis mitochondrial large ribosomal subunit YNL284C YBL038W YNL185C YJL041W YGR091W YDL047W YBL039C Mitochondrial ribosomal protein MRPL3 (YmL3) ribosomal protein (YmL3)
MRPL31 YKL138C structural constituent of ribosome protein biosynthesis mitochondrial large ribosomal subunit YJR091C 15.5 kDa mitochondrial ribosomal protein YmL31 ribosomal protein (YmL31) Null mutant is viable; unable to grow on non-fermentable carbon sources
MRPL32 YCR003W structural constituent of ribosome protein biosynthesis mitochondrial large ribosomal subunit YIR039C Mitochondrial ribosomal protein MRPL32 (YmL32) ribosomal protein (YmL32)
MRPL33 YMR286W structural constituent of ribosome protein biosynthesis mitochondrial large ribosomal subunit essential for mitochondrial function ribosomal protein (YmL33) (E. coli L30) Null mutant is viable
MRPL35 YDR322W structural constituent of ribosome protein biosynthesis mitochondrial large ribosomal subunit YNL284C YBL038W YNL185C YGR220C YJL041W YGR091W Mitochondrial ribosomal protein MRPL35 (YmL35) ribosomal protein (YmL35)
MRPL36 YBR122C structural constituent of ribosome protein biosynthesis mitochondrial large ribosomal subunit YNL284C YGR220C YJR091C YLR447C YEL061C YMR078C Mitochondrial ribosomal protein MRPL36 (YmL36) ribosomal protein (YmL36)
MRPL37 YBR268W structural constituent of ribosome protein biosynthesis mitochondrial large ribosomal subunit Probable mitochondrial protein L37 ribosomal protein L37 (putative)
MRPL38 YKL170W structural constituent of ribosome protein biosynthesis mitochondrial large ribosomal subunit YGR091W mitochondrial ribosomal protein L14 ribosomal protein L14
MRPL39 YML009C structural constituent of ribosome protein biosynthesis mitochondrial large ribosomal subunit YNL284C YGR220C Mitochondrial ribosomal protein MRPL39 (YmL39) ribosomal protein (YmL39)
MRPL4 YLR439W structural constituent of ribosome protein biosynthesis mitochondrial large ribosomal subunit YIL061C YNL284C YBL038W YNL185C YGR220C YGR091W essential for mitochondrial function and for proper cell growth under non-respiratory conditions ribosomal protein 60S L4 Null mutant is viable, fails to grow on nonfermentable carbon sources, has growth defects on ferment
MRPL40 YPL173W structural constituent of ribosome protein biosynthesis mitochondrial large ribosomal subunit Mitochondrial ribosomal protein MRPL40 (YmL40) ribosomal protein (YmL40)
MRPL44 YMR225C structural constituent of ribosome protein biosynthesis mitochondrial large ribosomal subunit YNL284C YGR220C Mitochondrial ribosomal protein MRPL44 (YmL44) ribosomal protein (YmL44)
MRPL49 YJL096W structural constituent of ribosome protein biosynthesis mitochondrial large ribosomal subunit YOL075C YKL191W YCR106W mitochondrial ribosomal protein of the large subunit ribosomal protein large subunit
MRPL50 YNR022C structural constituent of ribosome protein biosynthesis mitochondrial large ribosomal subunit YAL036C YPR119W Mitochondrial Ribosome Protein, Large Subunit
MRPL51 YPR100W structural constituent of ribosome protein biosynthesis* mitochondrial large ribosomal subunit YBL038W Mitochondrial Ribosome Protein, Large Subunit
MRPL6 YHR147C structural constituent of ribosome protein biosynthesis mitochondrial large ribosomal subunit YER066W YNL284C YBL093C Mitochondrial ribosomal protein MRPL6 (YmL6) ribosomal protein (YmL6)
MRPL7 YDR237W structural constituent of ribosome protein biosynthesis mitochondrial large ribosomal subunit YNL284C YBL038W YNL185C YGR220C Mitochondrial ribosomal protein MRPL7 (YmL7) ribosomal protein (YmL7)
MRPL8 YJL063C structural constituent of ribosome protein biosynthesis* mitochondrial large ribosomal subunit YHL024W YBL038W YGR220C YJL041W YGR091W Mitochondrial ribosomal protein MRPL8 (YmL8) (E. coli L17) ribosomal protein (YmL8) (E. coli L17) Null mutant is viable; shows loss of mitochondrial function, instability of mitochondrial DNA
MRPL9 YGR220C structural constituent of ribosome* protein biosynthesis* mitochondrial large ribosomal subunit YDR115W YBR198C YGL120C YER006W YBL004W YLR371W YBR122C YDR116C YCR030C YNL236W YNL005C YCR046C YCL014W YCR071C YDR296W YMR193W YDR462W YDR322W YML009C YLR439W YMR225C YDR237W YKR085C YJL063C YLR189C YML025C YDR405W YKL167C YKR006C YGR076C YGL064C Mitochondrial ribosomal protein MRPL9 (YmL9) (E. coli L3) (human MRL3) ribosomal protein (YmL9) (E. coli L3) (human MRL3) Null mutant is viable
MRPS16 YPL013C structural constituent of ribosome protein biosynthesis mitochondrial small ribosomal subunit YBR251W YGL181W YGR185C YMR047C YLR074C
MRPS17 YMR188C structural constituent of ribosome protein biosynthesis* mitochondrial small ribosomal subunit YHL004W YDR036C
MRPS18 YNL306W structural constituent of ribosome protein biosynthesis mitochondrial small ribosomal subunit YHL004W YBR251W YDR036C
MRPS28 YDR337W structural constituent of ribosome* protein biosynthesis* mitochondrial small ribosomal subunit YDL126C YHL004W YBR251W YDL195W YDR311W YDR036C YPR084W Mitochondrial ribosomal protein MRPS28 (E. coli S15) ribosomal protein (E. coli S15) Null mutant is viable, unable to respire, spontaneously loses portions of its mitochondrial genomes
MRPS35 YGR165W structural constituent of ribosome protein biosynthesis* mitochondrial small ribosomal subunit YBR034C YLR035C YPL265W YDL175C Mitochondrial Ribosome Protein, Small Subunit
MRPS5 YBR251W structural constituent of ribosome protein biosynthesis mitochondrial small ribosomal subunit* YGR150C YOR205C YER155C YGR090W YHR197W YDR036C YPL013C YDR175C YHR059W YIL093C YBL004W YGL129C YGR215W YGR162W YDR337W YDR347W YGR084C YPL118W YBR146W YNL137C YDR041W YKL155C YJR113C YNL306W YMR128W YOR243C YGR170W YBL090W YJR101W YDL045W-A YKL003C Probable mitochondrial ribosomal protein S5 ribosomal protein S5 (putative)
MRPS8 YMR158W structural constituent of ribosome protein biosynthesis mitochondrial small ribosomal subunit YHL004W YLR418C Mitochondrial Ribosome Protein, Small subunit
MRPS9 YBR146W structural constituent of ribosome protein biosynthesis mitochondrial small ribosomal subunit YIL070C YHL004W YBR251W YDR036C Probable mitochondrial ribosomal protein S9 ribosomal protein S9 (putative) Null mutant is viable, respiration deficient, exhibits defects in mitochondrial protein synthesis as
MRS1 YIR021W RNA binding* Group I intron splicing mitochondrion YHR114W RNA splicing protein of the mitochondrial carrier (MCF) family Null mutant is viable, Pet-, exhibits accumulation of mitochondrial RNA precursors
MRS11 YHR005C-A chaperone activity* mitochondrial translocation mitochondrial intermembrane space* YEL020W-A YDL217C YMR056C YBR091C May act cooperatively with Mrs5p in mitochondrial protein import or other related essential mitochon Null mutant is inviable; depletion of Mrs11p results in accumulation of the precursor form of mitoch
MRS2 YOR334W magnesium ion transporter activity mitochondrial magnesium ion transport* mitochondrial inner membrane YDR134C YER022W mitochondrial magnesium ion transporter similar to bacterial CorA, essential for splicing of group I magnesium ion transporter Null mutant is viable; has a pet- phenotype, associated with a block in mitochondrial RNA splicing o
MRS3 YJL133W carrier activity transport* mitochondrion mitochondrial carrier protein carrier protein Null mutant is viable; high copy MRS3 can suppress the mitochondrial RNA splicing defects of several
MRS4 YKR052C carrier activity transport* mitochondrion YLR288C mitochondrial carrier protein, highly homologous to Mrs3p carrier protein|highly homologous to Mrs3p Null mutant is viable, has no defects in mitochondrial function. Mrs4p overexpression causes a tempe
MRS5 YBR091C protein transporter activity mitochondrial translocation mitochondrial intermembrane space* YHR005C-A YDL217C YEL020W-A YKL002W YLR288C YOR297C Involved in mitochondrial biogenesis, may share a common function with Mrs11p Null mutant is inviable. Mrs5p depletion causes accumulation of unprocessed precursors of the mitoch
MRS6 YOR370C Rab escort protein activity intracellular protein transport cytoplasm* YOR089C YBR264C YLR403W YFL038C YNL093W YER114C YOR098C YER031C protein of the TCD/MRS6 family of GDP dissociation inhibitors (Rab escort protein) rab geranylgeranyltransferase regulatory subunit Null mutant is inviable; multicopy MRS6 causes a mild pet- phenotype; multicopy MRS6 suppresses the
MSB1 YOR188W molecular_function unknown establishment of cell polarity (sensu Saccharomyces) bud neck* YBR009C YBR200W YER155C YAL041W YER114C YLR229C Protein that may play a role in polarity establishment and bud formation multicopy suppressor of cdc24 and cdc42 ts mutations
MSB2 YGR014W osmosensor activity establishment of cell polarity (sensu Saccharomyces)* integral to plasma membrane YNL298W YPL211W YDL165W YJL030W YNL233W YJL013C YIL144W putative integral membrane protein integral membrane protein (putative) multicopy suppressor of cdc24 ts mutation
MSB3 YNL293W Rab GTPase activator activity actin filament organization* bud tip* YLL021W YLR229C Multicopy Suppressor of Bud Emergence GTPase activating protein (GAP) for Ypt6 Null mutant is viable. msb3/msb4 double mutant exhibits slow growth and disorganized actin cytoskele
MSB4 YOL112W Rab GTPase activator activity actin filament organization bud tip* YLL021W YDR126W Multicopy Suppressor of Bud Emergence Null mutant is viable. msb3/msb4 double mutant exhibits slow growth and disorganized actin cytoskele
MSC2 YDR205W cation:cation antiporter activity zinc ion homeostasis nucleus* YNR039C Meiotic Sister-Chromatid recombination; transmembrane protein (putative) showing some protein simila Null mutant is inviable on glycerol-ethanol at 37oC and exhibits sensitivity to H2O2
MSD1 YPL104W aspartate-tRNA ligase activity protein biosynthesis mitochondrion YOR386W Aspartyl-tRNA synthetase, mitochondrial aspartyl-tRNA synthetase Null mutant is viable but shows pleiotropic phenotypes consistent with a lesion in mitochondrial pro
MSE1 YOL033W glutamate-tRNA ligase activity protein biosynthesis* mitochondrion YGR040W Mitochondrial glutamyl-tRNA synthetase glutamine-tRNA ligase An uncharacterized allele is respiratory deficient.
MSF1 YPR047W phenylalanine-tRNA ligase activity protein biosynthesis mitochondrion YMR147W YJR091C alpha subunit of yeast mitochondrial phenylalanyl-tRNA synthetase phenylalanyl-tRNA synthetase alpha subunit Null mutant is viable but is respiratory deficient
MSH1 YHR120W ATP binding DNA repair mitochondrion YHR024C YLR163C mutS homolog involved in mitochondrial DNA repair mutS homolog Null mutant is viable, petite
MSH2 YOL090W ATPase activity* DNA recombination* nuclear chromosome YBR025C YMR186W YJL138C YPR179C YNL021W YFR037C YDR295C YOR033C YOR323C YAR007C YER142C YDR097C Functions with Pms1p and Pms2/Mlh1p in a complex that interacts with Pms3p/Msh6p to repair single-ba mutS homolog Haploid mutants display 85-fold increased rate of spontaneous mutation to canavanine resistance. Mut
MSH3 YCR092C damaged DNA binding DNA recombination* nuclear chromosome YNR058W YDR224C YDR097C acts in mismatch repair in mitosis and meiosis but to a lesser extent than MSH2, required for micros forms a complex with Msh2p to repair insertion-deletion mispairs; redundant with Pms3/Msh6p in repai Null mutant is viable. Inactivation of MSH3 results in low rates of frameshift mutations.
MSH4 YFL003C DNA binding meiotic recombination nuclear chromosome YDL154W YMR125W dispensable for DNA repair, required for full levels of reciprocal exchange and spore viability meiosis specific protein, E.coli MutS protein, localizes to discrete sites on meiotic chromosomes Null mutant is viable, has no apparent defect in mismatch repair, wild-type levels of gene conversio
MSH5 YDL154W molecular_function unknown meiotic recombination nucleus YGL025C YMR224C YIL144W YGL170C YBR133C YFL003C YJR082C dispensable for DNA repair and meiotic intrachromosomal reciprocal recombination, required for full mutS homolog Null mutant is viable. Diploids lacking the MSH5 gene display decreased levels of spore viability, i
MSH6 YDR097C DNA binding* mismatch repair nucleus YDL156W YKR001C YPL235W YJR144W YAR007C YDL225W YML032C YLR234W YMR190C YDR499W YOL090W YIR002C YFR037C YBR136W YCR092C YBR114W YNL312W YJL173C Required for mismatch repair in mitosis & meiosis, low levels of postmeiotic segregation & high spor human GTBP protein homolog Mutations in MSH6 or MSH3 cause partial defects in MMR, with inactivation of MSH6 resulting in high
MSI1 YBR195C molecular_function unknown DNA repair* chromatin assembly complex* YOR308C YPR018W YLR418C YKR029C YHR004C YOR100C YPL022W YJR043C YLR103C chromatin assembly complex, subunit 3: Encodes the smallest (p50) subunit of the yeast Chromatin Ass chromatin assembly factor-I (CAF-I) p50 subunit|negative regulator of ras-mediated cAMP induction|si Null mutant is viable, UV irradiation sensitive; associated with decreased silencing of telomere-adj
MSK1 YNL073W lysine-tRNA ligase activity lysyl-tRNA aminoacylation mitochondrion YER022W YHR107C mitochondrial lysine-tRNA synthetase lysine-tRNA ligase An uncharacterized allele is respiratory deficient.
MSL1 YIR009W RNA binding nuclear mRNA splicing, via spliceosome snRNP U2 YLR456W YHR099W YLR067C YIL143C YHR197W YKL173W YNL036W YOR017W YBR114W YDL001W YNL091W YPR182W YBR152W YER136W YLR288C YNL165W YOR264W YDR184C YOR011W YKR099W YLR433C YJL092W YAL024C YBR136W YPL213W YPL016W YCL029C involved in splicing U2 snRNP component|YU2B msl1 mutants exhibit synthetic lethality in combination with mud2 deletion mutants
MSL5 YLR116W RNA binding nuclear mRNA splicing, via spliceosome commitment complex YBR012W-B YOR142W-A YPL257W-A YKL074C YDL156W YIL130W YPL105C YPL016W YDR260C YER013W YML046W YBR172C YJR066W YJR005W YDL161W YMR065W branchpoint bridging protein -- component of the splicing commitment complex
MSM1 YGR171C methionine-tRNA ligase activity methionyl-tRNA aminoacylation mitochondrion mitochondrial methionyl-tRNA synthetase methionine-tRNA ligase respiration deficient
MSN1 YOL116W molecular_function unknown hyperosmotic response nucleus YIL117C YEL003W YML094W multicopy supressor of snf1 and sta10 mutations 43 kDa protein|transcriptional activator Null mutant is viable, exhibits a decrease in invertase expression; exhibits a reduction in wild-typ
MSN2 YMR037C transcription factor activity* response to stress* nucleus* Transcription factor. Multicopy suppressor of snf1 mutation. Key regulator of stress-responsive gene zinc finger protein Null mutant is viable; msn2 msn4 double deletion mutants exhibit higher sensitivity to different str
MSN4 YKL062W transcription factor activity* response to stress* nucleus* YDL100C Transcription factor. Multicopy suppressor of snf1 mutation. Key regulator of stress-responsive gene zinc finger protein Null mutant is viable; msn2 msn4 double deletion mutants exhibit higher sensitivity to different str
MSN5 YDR335W protein binding* protein-nucleus export nucleus YGR009C YDR174W YDR146C YKL068W YOR359W YOL051W YPR008W YLR293C YER016W YLR418C YHR191C YJL099W Multicopy suppressor of snf1 mutation Disruptants are not completely sterile
MSO1 YNR049C molecular_function unknown sporulation (sensu Saccharomyces)* microsome YDR164C YDR126W multicopy suppressor of sec1; small hydrophilic protein, enriched in microsomal membrane fraction, i Null mutant is viable, exhibits accumulation of secretory vesicles in the bud; mso1 null mutants exh
MSP1 YGR028W ATPase activity mitochondrial translocation mitochondrial outer membrane 40 kDa putative membrane-spanning ATPase 40 kDa membrane-spanning ATPase Null mutant is viable, exhibits no observable growth defects
MSR1 YHR091C arginine-tRNA ligase activity protein biosynthesis* mitochondrion YOL088C Nuclear-encoded mitochondrial protein arginyl-tRNA synthetase mutants are deficient in mitochondrial protein synthesis because they cannot acylate the mitochondri
MSS1 YMR023C GTP binding protein biosynthesis mitochondrial inner membrane YGL236C YGL023C May play a part in mitochondrial translation GTPase (putative) respiratory deficient in presence of pr454 mutation in mitochondrial 15S rRNA; block in splicing of
MSS11 YMR164C specific RNA polymerase II transcription factor activity pseudohyphal growth* nucleus Multicopy Suppressor of STA10 - 11 758 amino acid polypeptide with poly-glutamine and poly-asparagine domains Null mutant is viable, exhibits diminished transcription of STA2; multiple copies suppress repressiv
MSS116 YDR194C RNA helicase activity RNA splicing mitochondrial matrix YER081W YLR233C YNL230C YNL175C YDR365C YGL035C YHR052W YDL213C Mitochondrial RNA helicase of the DEAD box family necessary for splicing of several mt introns. RNA helicase DEAD box mss116 mutations affect the splicing of several introns of the cytochrome B and cytochrome C oxidase
MSS18 YPR134W molecular_function unknown Group I intron splicing mitochondrion YER081W Protein involved in splicing intron a15beta of COX1 blocked in splicing of cox1 pre-mRNA
MSS2 YDL107W protein stabilization activity protein complex assembly* mitochondrial inner membrane cox1 pre-mRNA splicing factor cox2 pre-mRNA splicing factor Suppression of a mitochondrial RNA splice defect; COX1 pre-mRNA processing factor
MSS4 YDR208W 1-phosphatidylinositol-4-phosphate 5-kinase activity actin cytoskeleton organization and biogenesis* plasma membrane YBR036C Involved in actin cytoskeleton organization; multicopy suppressor of stt4 mutation phosphatidylinositol 4-phosphate kinase Null mutant is inviable
MST1 YKL194C threonine-tRNA ligase activity threonyl-tRNA aminoacylation mitochondrion YDR532C YBR023C YAL058W YLR113W YHR181W mitochondrial threonine-tRNA synthetase Null mutant is viable
MST27 YGL051W protein binding vesicle organization and biogenesis endoplasmic reticulum* YAR033W Hypothetical ORF protein with COPI and COPII bindng motifs Null: viable. Other phenotypes: -
MST28 YAR033W protein binding vesicle organization and biogenesis endoplasmic reticulum* YAR033W YKL174C YGL051W Multicopy suppressor of Sec Twenty one Null: viable. Other phenotypes: -
MSU1 YMR287C exoribonuclease II activity RNA catabolism mitochondrion* YPL029W YJR091C YMR106C YKL108W Protein essential for mitochondrial biogenesis 3'-5' exonuclease complex component
MSW1 YDR268W tryptophan-tRNA ligase activity tryptophanyl-tRNA aminoacylation mitochondrion YOR308C YJR091C YLR453C mitochondrial tryptophanyl-tRNA synthetase tryptophan-tRNA ligase Null mutant is viable, respiratory deficient, defective in mitochondrial protein synthesis
MSY1 YPL097W tyrosine-tRNA ligase activity amino acid activation mitochondrion YPR086W Tyrosyl-tRNA synthetase tyrosine-tRNA ligase
MTD1 YKR080W methylenetetrahydrofolate dehydrogenase (NAD) activity one-carbon compound metabolism* cytosol YLR147C NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase Null mutant is viable, associated with loss of NAD-dependent 5,10-methylene-THF dehydrogenase activi
MTF1 YMR228W transcription cofactor activity transcription from mitochondrial promoter mitochondrial matrix YLR358C YOR348C Mitochondrial RNA polymerase specificity factor mitochondrial RNA polymerase specificity factor Null mutant is viable, defective in respiration, and lacks mtDNA.
MTF2 YDL044C RNA binding protein biosynthesis* mitochondrion YLR386W YDL030W YER086W YLL051C YDR505C YDL116W YER144C YGR056W Necessary for the stability and/or processing of some large mitochondrial transcripts petite
MTG1 YMR097C GTPase activity protein biosynthesis* mitochondrial inner membrane YPL154C Peripheral GTPase of the mitochondrial inner membrane, essential for respiratory competence, likely GTPase
MTL1 YGR023W molecular_function unknown cell wall organization and biogenesis integral to plasma membrane YLR460C Mid-Two Like 1 acts in concert with Mid2p to transduce cell wall stress signals Null mutant is viable. mtl1 mutants increase severity of mid2 phenotypes
MTM1 YGR257C transporter activity* transport* mitochondrion* YGL032C Hypothetical ORF putative mitochondrial carrier protein Null: strong loss of SOD2 activity, mitochondrial iron accumulation
MTO1 YGL236C molecular_function unknown protein biosynthesis mitochondrion YIL057C YPL179W YHR114W YMR047C YBR103W YGL178W YMR023C Mitochondrial Translation Optimization; Strong similarity to E. coli GidA
MTR10 YOR160W nuclear localization sequence binding protein-nucleus import* nucleus* YDR432W YOR098C YNR007C YOL004W YLR293C YIL115C YJR042W YNL004W Protein involved in mRNA transport from nucleus to cytoplasm
MTR2 YKL186C protein binding poly(A)+ mRNA-nucleus export nuclear pore YPL138C mRNA transport regulator mRNA transport regulator Null mutant is inviable; mtr2 mutants exhibit nuclear mRNA accumulation and nucleolar fragmentation
MTR3 YGR158C 3'-5' exoribonuclease activity 35S primary transcript processing* nuclear exosome (RNase complex)* YLR345W YDL111C YNL232W YOL021C YDR280W YGR095C YGR195W YLR288C YBL026W YJR022W Involved in mRNA transport null is inviable; mutant with mtr3-1 allele has defects in both mRNA transport and in rRNA synthesis
MTR4 YJL050W ATP dependent RNA helicase activity 35S primary transcript processing nucleolus YPL190C YGL195W YMR304W YOL115W Dead-box family helicase required for mRNA export from nucleus RNA helicase Null mutant is inviable; a temperature-sensitive mtr4 mutant accumulates poly(A)+ RNA in the nucleus
MUC1 YIR019C signal transducer activity pseudohyphal growth* plasma membrane Required for invasion and pseudohyphae formation in response to nitrogen starvation cell surface flocculin with structure similar to serine/threonine-rich GPI-anchored cell wall protei Null mutant is viable, does not exhibit pseudohyphal differentiation as a diploid or invasive growth
MUD1 YBR119W RNA binding nuclear mRNA splicing, via spliceosome snRNP U1 YNL227C YIL061C YML016C YDR240C YGR013W YMR125W YML046W YKL012W YDR235W YPL178W YHR086W YFL017W-A YLR298C YIL034C YNL277W YDR110W YLR449W YLR223C U1 snRNP A protein U1 snRNP A protein Null mutant is viable
MUD2 YKL074C pre-mRNA splicing factor activity* U2-type nuclear mRNA branch site recognition commitment complex YPL105C YDL043C YLR357W YML046W YBR172C YLR116W YGL035C YPL016W Involved in early pre-mRNA splicing Null mutant is viable
MUP1 YGR055W L-methionine porter activity sulfur amino acid transport integral to plasma membrane YAL067C high affinity methionine permease high affinity methionine permease Null mutant is viable but cannot perform high-affinity methionine update.
MUP3 YHL036W L-methionine transporter activity amino acid transport membrane YPR163C methionine uptake very low affinity methionine permease
MUS81 YDR386W endonuclease activity DNA repair* nucleus YPL108W YER078C YMR226C YLR235C YMR303C YKL022C YNL132W YLR196W YNL308C YGR264C YGR090W YGR234W YLR373C YJR144W YPL153C YPR181C YER006W YKR081C YOL041C YBR009C YOL139C YDL043C YMR001C YBR098W YLL039C YLR234W YPL024W YDR381W YMR190C YKL113C YOR144C YN Mms and UV Sensitive; Mus81p and Rad54p are found together in a complex from whole-cell extracts Null mutant is viable but is MMS and UV sensitive and meiosis defective, null is synthetically letha
MVD1 YNR043W diphosphomevalonate decarboxylase activity ergosterol biosynthesis* cytosol YCR057C involved in the polyisoprene biosynthesis pathway mevalonate pyrophosphate decarboxylase Null mutant is inviable; a single leucine to proline mutation causes temperature sensitivity.
MVP1 YMR004W molecular_function unknown protein-vacuolar targeting cytoplasm YFL011W YBR077C YLR039C YLR262C YBR164C Protein required for sorting proteins to the vacuole MVP1 was identified as a multicopy suppressor of dominant-negative vps1 mutations, as well as an ext
MYO1 YHR023W microfilament motor activity response to osmotic stress* contractile ring (sensu Saccharomyces) YOR326W YFL039C YIL061C YKL079W YAL029C YGL106W YPR188C YPR032W YHR013C YGR274C YER155C YBL106C Myo1 is a type II myosin, is localized to the actomyosin ring and is important for cytokinesis. class II myosin Null mutant is viable, exhibts abnormal chitin distribution and cell wall organization at the mother
MYO2 YOR326W microfilament motor activity establishment of cell polarity (sensu Saccharomyces)* actin cap (sensu Saccharomyces)* YBL062W YDR149C YGL211W YGR228W YKR074W YLL049W YNL119W YNL120C YNL298W YLR386W YHR030C YJL095W YOR035C YGL019W YNL233W YBR023C YBL061C YLR330W YHR142W YBR200W YER155C YDL006W YPL174C YGR229C YHR129C YDR424C YDR488C YKL048C YKR054C YOR269W YPL155C YI Myo2p plays a crucial role in polarized distribution of mitochondria. class V myosin Null mutant is inviable. myo2-66 (E511K), a temperature-sensitive allele, accumulates secretory vesi
MYO3 YKL129C microfilament motor activity cell wall organization and biogenesis* actin cortical patch (sensu Saccharomyces) YBR109C myosin I myosin I Null mutant is viable, myo3 myo5 double deletion mutants exhibit severe defects in growth and actin
MYO4 YAL029C microfilament motor activity mRNA localization, intracellular actin cap (sensu Saccharomyces) YFL039C YOL086C YLR249W YMR309C YBR130C YMR186W YKL130C YDR101C YGL195W YGL106W YER110C YHR023W YBR081C YBR109C YMR139W YOR181W Required for mother-specific HO expression, needed for the accumulation in daughter nuclei of Ash1p myosin V heavy chain Null mutant is viable, has no detectable phenotype, either alone or in conjunction with mutations in
MYO5 YMR109W microfilament motor activity cell wall organization and biogenesis* actin cortical patch (sensu Saccharomyces) YBR109C YGL190C YBR234C YLR200W YGR078C YNL153C YEL003W YML094W YCR009C YDR388W contains proline-rich tail homology 2 (TH2) and SH3 domains myosin I Null mutant is viable; myo3 myo5 double deletion mutants exhibit loss of actin polarity, growth arre
NAB2 YGL122C poly(A) binding mRNA polyadenylation* nucleus* YKR026C YGL122C YHR089C YNL016W YDR505C YIL092W YBR017C YMR255W YOL123W nuclear polyadenylated RNA binding protein polyadenylated RNA binding protein Null mutant is inviable
NAB3 YPL190C poly(A) binding regulation of transcription from Pol II promoter nucleoplasm YLL020C YPL178W YJL050W YNL016W YMR125W YDR172W May be required for packaging pre-mRNAs into ribonucleoprotein structures amenable to efficient nucl polyadenylated RNA binding protein|polyadenylated single strand DNA-binding protein null is inviable; overexpression reduces the expression of the G1 cyclin CLN3
NAF1 YNL124W RNA binding* transport* nucleoplasm YER020W YDL208W YDR030C YIL104C YLR175W Nuclear Assembly Factor Null: inviable. Other phenotypes: Depletion leads to loss of independently transcribed box H/ACA sno
NAM2 YLR382C mRNA binding* Group I intron splicing* mitochondrion mitochondrial leucyl tRNA synthetase leucine-tRNA ligase Null mutant is viable, respiration deficient
NAM7 YMR080C ATPase activity* mRNA catabolism* cytoplasm* YHR170W YJR132W YMR080C YLR363C YJL124C YNL016W YDL147W YBR143C YNL112W YNL118C YDR363W Involved in mRNA degradation helicase (putative) Null mutant is viable, exhibits impairment in respiratory growth that is exacerbated by low temperat
NAM8 YHR086W RNA binding* nuclear mRNA splicing, via spliceosome* snRNP U1* YIL061C YDR432W YLR249W YBR119W YLR275W YDR240C YGR013W YMR125W YGL049C YDL043C YER029C YLR147C YKL173W YML046W YKL012W YDR235W YLR298C YPL178W YDL087C YGL181W YMR257C May be non-essent. part of mito. splicing. Assoc. with spliceosomal snRNPs. Disp. for mitosis & prem RNA-binding protein|U1 snRNP protein|involved in meiosis-specific splicing of the REC107 transcripts Null mutant is viable; defective in meiotic recombination, formation of viable spores, and formation
NAM9 YNL137C structural constituent of ribosome protein biosynthesis mitochondrial small ribosomal subunit YHL004W YBR251W YDR036C putative mitochondrial S4 ribosomal protein mitochondrial S4 ribosomal protein (putative) Null mutant is viable but is respiration-deficient and loses mitochondrial DNA integrity
NAN1 YPL126W snoRNA binding processing of 20S pre-rRNA small nucleolar ribonucleoprotein complex YDL072C YER047C YHR183W YGR256W YCL059C YLR196W YCR057C YGR090W YJL069C YHR196W YDL043C part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); Net1-Associated Nucleolar U3 snoRNP protein Null mutant is inviable
NAP1 YKR048C protein binding nucleosome assembly* nucleus YOL070C YNL078W YOL012C YDR507C YIL094C YDR381W YGL241W YJR045C YCL024W YDR225W YBL002W YGR245C YDR034C YDR259C YLR347C YPL150W YKL095W YOR276W YOL115W YGR040W YMR139W YBR203W YPR119W YNL271C YDR002W nucleosome assembly protein I nucleosome assembly protein I Null mutant is viable but exhibits defects in Clb2 function.
NAS2 YIL007C molecular_function unknown ubiquitin-dependent protein catabolism cytoplasm YKL212W YDL020C YOR117W YLR304C YHR185C YMR200W Protein with similarity to the p27 subunit of mammalian proteasome modulator Null mutant is viable and has no detectable phenotype
NAS6 YGR232W molecular_function unknown proteolysis and peptidolysis proteasome regulatory particle (sensu Eukarya) YHR200W YDR088C YPR086W YNL244C YGL004C YDR394W Interaction with the 19S regulatory particle of the 26S proteasome detected by coimmunoprecipitation 26S proteasome interacting protein Null mutant is viable.
NAT1 YDL040C peptide alpha-N-acetyltransferase activity protein amino acid acetylation cytoplasm* YMR116C YHR013C YAL009W YML058W Required for entry into stationary phase, heat shock-resistance, a mating-type functions, and sporul N-terminal acetyltransferase Null mutant is viable, has reduced acetyltransferase activity, derepressed silent mating type locus
NAT2 YGR147C peptide alpha-N-acetyltransferase activity N-terminal peptidyl-methionine acetylation cytoplasm Transfers acetyl group from acetyl coenzyme A to the N-termini of proteins beginning with methionine N alpha-acetyltransferase Null mutant is inviable
NAT5 YOR253W peptide alpha-N-acetyltransferase activity protein amino acid acetylation cytoplasm N-acetyltransferase
NBP1 YLR457C molecular_function unknown biological_process unknown nucleus YAL028W YML006C YDL001W YNL258C YPR086W Nap1p Binding Protein Null mutant is inviable
NBP35 YGL091C ATPase activity biological_process unknown nucleus YIL129C YBR141C NBP35 encodes an essential evolutionary conserved protein with homology to bacterial partitioning AT 35 kDa nucleotide binding protein Null mutant is inviable
NCB2 YDR397C transcription co-repressor activity negative regulation of transcription from Pol II promoter nucleus YER159C Negative Cofactor B2 is the beta subunit of a negative regulator of RNA polymerase II holoenzyme. It Null mutant is inviable
NCE102 YPR149W molecular_function unknown protein secretion cytoplasm* YER081W involved in secretion of proteins that lack classical secretory signal sequences An uncharacterized allele exhibits defects in the export of the mammalian protein galectin-1.
NCE103 YNL036W molecular_function unknown biological_process unknown cytoplasm YOL061W YOR303W YIR009W endogenous substrate for nonclassical export (Cleves et al. J Cell Biol 1996 133:1017-26). carbonic anhydrase-like protein deletion causes an oxygen-sensitive growth defect.
NCL1 YBL024W tRNA (cytosine-5-)-methyltransferase activity tRNA methylation nucleus YGR237C YBR084W YDR382W YNL284C YLR200W YGR078C YNL153C YEL003W YML094W Nuclear protein 1, similar to NOP2 and human proliferation associated nucleolar protein p120 tRNA:m5C-methyltransferase Null mutant is viable, sensitive to paromomycin, lacks m5C methylation in total yeast tRNA
NCP1 YHR042W electron transporter activity ergosterol biosynthesis microsome NADP-cytochrome P450 reductase NADP-cytochrome P450 reductase
NDC1 YML031W structural constituent of cytoskeleton protein-nucleus import* nuclear pore* YOR284W YMR153W YGR010W YDL088C dispensable for mitotic spindle pole body duplication, but required for insertion of nascent spindle multiple transmembrane domains (putative)|nuclear envelope protein|nuclear pore complex subunit Null mutant is inviable. Conditional lethal mutants are available that show asymmetric chromosomal s
NDD1 YOR372C transcriptional activator activity G2/M-specific transcription in mitotic cell cycle nucleus YDL203C Nuclear Division Defective 1 Null mutant is inviable and arrests prior to nuclear division but after DNA replication; cells are l
NDE1 YMR145C NADH dehydrogenase activity ethanol fermentation* mitochondrion YBR017C YDL047W YKR026C Hypothetical ORF
NDE2 YDL085W NADH dehydrogenase activity ethanol fermentation* mitochondrion YGR139W YDR034C Hypothetical ORF Null mutant is viable
NDI1 YML120C NADH dehydrogenase (ubiquinone) activity mitochondrial electron transport, NADH to ubiquinone respiratory chain complex I (sensu Eukarya) YGR218W NADH dehydrogenase (ubiquinone) NADH dehydrogenase (ubiquinone)
NDJ1 YOL104C telomeric DNA binding synapsis* nuclear chromosome, telomeric region YDR383C YJL019W Meiosis-specific telomere protein Ndj1p is required for bouquet formation, effective homologue pairi Null allele exhibits errors in meiotic chromosome segregation about 10-fold higher than the wild-typ
NDT80 YHR124W transcription factor activity meiosis* nuclear chromosome Meiosis-specific gene; mRNA is sporulation specific; required for exit from pachytene and for full m DNA binding transcription factor that activates middle sporulation genes Null mutant is viable, arrests in pachytene stage of meiosis at the mononucleate stage with duplicat
NEJ1 YLR265C molecular_function unknown DNA repair* nucleus YCR087C-A YHR174W YNL044W YGL090W Nonhomologous End-Joining regulator 1; Repressed by MAT heterozygosity; Interacts with Lif1p in a ye Mating-type regulated component of NHEJ Null mutant is viable, defective in NHEJ; Overexpression restores NHEJ in MATa/MATalpha cells
NEM1 YHR004C molecular_function unknown sporulation (sensu Saccharomyces)* integral to membrane* YKL057C YJR042W YBR195C YDL116W YAL009W YLR039C YLR262C YMR307W Nuclear Envelope Morphology Null mutant is viable but exhibits slow growth at 37 deg. and 16 deg and has an abnormal nuclear env
NET1 YJL076W ribosomal DNA (rDNA) binding chromatin silencing at ribosomal DNA (rDNA)* nucleolus YDL042C YDL153C YIL131C YKL193C Nucleolar protein involved in exit from mitosis Null mutant is viable and grows slowly
NFS1 YCL017C cysteine desulfhydrase activity iron ion homeostasis* mitochondrion YJR104C YFL023W YPL135W YBL106C NifS-like protein Null mutant is inviable; spl1-1 mutant allele affects tRNA splicing
NFT1 YKR103W|YKR104W ATP-binding cassette (ABC) transporter activity transport membrane ORFs YKR103W and YKR104W are merged in different strain backgrounds. Putative MRP-type ABC transporter
NFU1 YKL040C molecular_function unknown iron ion homeostasis mitochondrial matrix Nifu-like protein Null mutant is viable on YPD 30 degrees C, and is synthetically lethal with SSQ1
NGG1 YDR176W transcription cofactor activity histone acetylation* SAGA complex YCR041W YJR080C YDL239C YOL148C YBR081C YHR099W YLR423C YDR448W YIL144W YCL010C YGL112C YPR086W YGR252W YPL254W YDR392W YDR457W Involved in glucose repression of GAL4p-regulated transcription genetic and mutant analyses suggest that Ngg1p (Ada3p) is part of two transcriptional adaptor/HAT (h Null mutant is viable, grows poorly on minimal media
NGL2 YMR285C endoribonuclease activity rRNA processing intracellular YJL203W YPR110C correct 3'-end formation of 5.8S rRNA at site E is strictly dependent on Ngl2p. RNase Null mutant is viable.
NGR1 YBR212W RNA binding* regulation of growth cytoplasm YDL167C negative growth regulatory protein glucose-repressible RNA binding protein Null mutant is viable and shows increased cell growth rate in early log phase
NHA1 YLR138W cation:cation antiporter activity monovalent inorganic cation homeostasis plasma membrane YHL010C Putative Na+/H+ antiporter Null mutant is viable but shows increased sensitivity to sodium and lithium; overexpression of NHA1
NHP2 YDL208W RNA binding rRNA modification* small nuclear ribonucleoprotein complex YKL014C YMR310C YCL037C YOR308C YMR290C YDL014W YNL124W YER029C YKL173W YOR206W YMR049C YJL109C YLR175W YBL074C YPR178W YLR409C YJR091C YDR386W YHR089C YHR072W-A HMG-like nuclear protein HMG-like protein Null mutant is inviable
NHP6A YPR052C chromatin binding regulation of transcription from Pol II promoter* nuclear chromatin Homologous to mammalian high mobility group proteins 1 and 2; functions redundantly with the highly 11 kDa nonhistone chromosomal protein Deleting both NHP6A and NHP6B gives temperature-sensitive yeast with morphological and cytoskeletal
NHP6B YBR089C-A chromatin binding regulation of transcription from Pol II promoter* nuclear chromatin YKR001C YPL235W YAR007C YJL026W YNR003C YMR125W YOR110W YOR304W YBR245C YGL133W YOR116C YFR037C YPL082C YIL126W YFR013W YLR033W Homologous to mammalian high mobility group proteins 1 and 2; functions redundantly with the highly 11 kDa nonhistone chromosomal protein Deleting both NHP6A and NHP6B gives temperature-sensitive yeast with morphological and cytoskeletal
NHX1 YDR456W monovalent inorganic cation transporter activity vacuolar acidification* late endosome YDR034C YOR123C YPL031C Required for intracellular sequestration of Na+ Na+/H+ exchanger Null mutant is viable
NIC96 YFR002W structural molecule activity mRNA-nucleus export* nuclear pore YGR120C YMR153W YGL172W YGR119C YML103C YMR129W YJL039C YJL041W Part of complex at nuclear pore containing in addition NSP1p, NUP49p, and p54 96 kDa nucleoporin-interacting component|nuclear pore complex subunit Null mutant is inviable
NIP1 YMR309C translation initiation factor activity translational initiation cytoplasm* YOR284W YOR361C YNL047C YNL244C YBR079C YPR041W YMR146C YLR175W YPR016C YGL130W YOR039W YPL001W YAL029C YPR086W YBR058C YAL035W YGL081W YBR234C YOL087C Protein required for nuclear import with some similarity to Nsr1p, another protein involved in nucle translation initiation factor eIF3 subunit Null mutant is inviable; nip1-1 is a temperature-sensitive mutant defective in nuclear transport
NIP100 YPL174C protein binding* mitotic anaphase B dynactin complex YGL217C YLR217W YPL205C YNL271C YLR200W YNL153C YEL003W YPL269W YEL061C YER114C YGL124C YGL216W YGR078C YLR210W YML094W YOR349W YPR141C YHR129C YAL013W YER007W YLR015W YPL241C YLR216C YMR138W YKL007W YIL034C YNL307C YMR263W YMR307W YDR116C YIL144W YJ Nuclear import protein large subunit of dynactin complex (putative) Null mutant is viable but exhibits slow growth and defects in partitioning into daughter cells.
NIP7 YPL211W molecular_function unknown rRNA processing* nucleolus* YER006W YAL007C YDR060W YKR081C YHR066W YJR083C YNL226W YGR103W YOR080W YOL108C YNL061W YGR014W Nip7p is required for 60S ribosome subunit biogenesis Null mutant is inviable; in the temperature-sensitive mutant nip7-1, glycine 71 is replaced by aspar
NIS1 YNL078W molecular_function unknown regulation of mitosis nucleus* YBR034C YKR048C YMR139W YLR423C YMR047C YNR012W YOL070C
NMA2 YGR010W nicotinate-nucleotide adenylyltransferase activity nicotinamide adenine dinucleotide metabolism nucleus YLR328W YGR010W YNL218W YML031W YNL189W YPL070W YLR438W NAD(+) salvage pathway nicotinamide/nicotinic acid mononucleotide adenylyltransferase Null: viable. Other phenotypes: 2 or more copies increase rDNA and telomeric silencing
NMD2 YHR077C protein binding mRNA catabolism* cytoplasm* YBR270C YGR072W YDR363W Protein involved in decay of mRNA containing nonsense codons Null mutant is viable, exhibits stabilization of nonsense-containing mRNAs
NMD3 YHR170W protein binding* ribosomal large subunit assembly and maintenance cytosol* YBR267W YDR101C YGR155W YLR075W YKL095W YLR074C YML064C YOR080W YOR351C YJL090C YLR340W YNL061W YGL173C YMR080C YDR132C putative Upf1p-interacting protein factor required for a late assembly step of the 60S subunit Null mutant is inviable, at nonpermissive temperature, nmd3 ts mutants exhibit decreased levels of 6
NMD5 YJR132W protein carrier activity protein-nucleus import nucleus* YOR098C YLR335W YIL115C YBR009C YOR326W YOR177C YDR523C YLR291C YDL193W YNL323W YMR080C YGL043W YAL040C YNL027W YER122C Involved in nuclear import Upf1p interacting protein|importin beta homolog Kap119p Null mutant is viable, exhibits mislocalization of TFIIS and Hog1p
NMT1 YLR195C glycylpeptide N-tetradecanoyltransferase activity N-terminal peptidyl-glycine N-myristoylation cytosol YMR246W N-myristoyl transferase N-myristoyl transferase Null mutant is inviable
NNF2 YGR089W molecular_function unknown biological_process unknown membrane fraction putative partner of Rpb8p
NOB1 YOR056C chaperone activity ubiquitin-dependent protein catabolism* nucleus* YOL086C YDL060W YBR247C YNL207W YMR116C YOL054W Nin1 (One) Binding protein Associated with the 26S proteasome Null: lethal
NOC2 YOR206W molecular_function unknown ribosome nucleus export* nucleus YMR117C YER006W YER126C YDL208W YPL043W YBL087C YHR066W YDR060W YGR090W YKR081C YLR453C YLR427W YNL175C YNL061W YHR052W YDL213C YMR049C NucleOlar Complex 2; involved in nuclear export of pre-ribosomes
NOC3 YLR002C protein binding* rRNA processing* nucleus* YGR079W YER006W YPR016C YKR081C YDR329C YMR049C YIL035C NucleOlar Complex 2; involved in the nuclear export of pre-ribosomes
NOC4 YPR144C molecular_function unknown processing of 20S pre-rRNA* nucleus YBR247C YCL059C YCR057C YGR090W YLR453C U3 protein, localized to the nucleolus U3 snoRNP protein Null: lethal. Other phenotypes: required for 18S RNA production
NOG1 YPL093W GTPase activity ribosome nucleus export nucleolus YAR018C YOR324C YCR086W YAL047C YOR039W YOR074C YDL175C YER006W YPR016C YER126C YBR142W YNL061W YPL043W YFR031C-A YGR245C YPR041W YKR081C YNL110C YHR066W YGR103W YMR049C YLR074C YPR017C YNL230C YPL259C YIL035C YDR110W YGL201C Nucleolar G-protein 1; LPG15w (working nomenclature) homologs identified in human and Trypanosoma brucei|nucleolar G-protein (putative) Null mutant is inviable.
NOG2 YNR053C GTPase activity ribosomal large subunit nucleus export nucleus* YJR065C YLR074C YPR016C YER126C YGR245C YKR081C YMR106C YJR022W YDL043C YJL203W YDL030W YER029C YLR456W Nuclear/Nucleolar GTP-binding protein 2 part of a pre-60S complex
NOP1 YDL014W methyltransferase activity rRNA modification* nucleolus* YOR310C YPL043W YLR197W YLR175W YPR016C YGL130W YBR247C YJL033W YCL059C YDL208W YGL120C YCR057C YGR274C YDR060W YGR090W YAL035W YIL131C YJL069C YGR103W YNL230C YER161C YNL061W YOL102C YKL078W YCL054W part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA. Low Temperature-responsive U3 snoRNP protein|similar to mammalian fibrillarin Null mutant is inviable. Temperature-sensitive alleles exhibit various defects in rRNA processing.|
NOP10 YHR072W-A RNA binding rRNA modification* small nuclear ribonucleoprotein complex YDL208W YHR089C Required for pre-rRNA pseudouridylation and processing at sites A1 and A2 H/ACA-box snoRNPs component
NOP12 YOL041C RNA binding rRNA metabolism nucleolus YJL033W YBR142W YPL043W YJL074C YDR060W YLR074C YNL230C YLR427W YER142C YOR080W YIL035C YER161C YDR365C YGL035C YDR386W YDL213C YDL060W Nucleolar Protein; isolated as a mutant exhibiting synthetic lethality with a nop2 ts allele. Null mutant is viable and shows slow growth and cold sensitivity
NOP13 YNL175C RNA binding biological_process unknown nucleolus* YHR180W YPL043W YNL308C YHR052W YGR103W YDR496C YHR216W YGR162W YKL172W YDR194C YOR206W YMR229C YLR432W YKR024C YLL008W YLR447C YMR001C YLR074C Nucleolar Protein 13
NOP14 YDL148C snoRNA binding processing of 20S pre-rRNA nucleus* YBR247C YCL059C YCR057C YGR090W YLR295C YER179W part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); NucleOlar Protein 14 U3 snoRNP protein Null: lethal
NOP15 YNL110C molecular_function unknown ribosomal large subunit biogenesis nucleus* YLL034C YPL043W YPL093W YOL077C YHR052W YNL182C YER126C YNL002C YGR245C YDR101C YER006W YGR103W YHR197W YLR106C YBL004W YMR290C YPL012W YDL031W YCL054W YGL111W YOR272W YLL008W YHR088W YLR074C YPR016C YDR060W YKR081C YLR288C YMR049C YOR005C Nucleolar protein 15 ribosome biogenesis
NOP16 YER002W molecular_function unknown ribosomal large subunit biogenesis nucleus* YPR016C YHR066W YGR103W YMR049C Nucleolar protein 16 ribosome biogenesis
NOP2 YNL061W RNA methyltransferase activity rRNA processing nucleolus YKL014C YOR227W YPL009C YPL211W YGL019W YPR016C YPL093W YOL077C YHR052W YER155C YGR090W YLR197W YMR319C YKL009W YER006W YGR103W YHR170W YDR496C YLR009W YMR290C YDL014W YOR206W YDL031W YHR051W YPL217C YGL111W YOR272W YFR001W YLR449W YFL002C YDR087C YM May participate in nucleolar function during the transition from stationary phase to rapid growth 90 kDa protein homologous to a human proliferation-associated nucleolar protein, p120 Null mutant is inviable; overexpression leads to changes in nucleolar morphology
NOP4 YPL043W RNA binding rRNA processing nucleolus YKL014C YNL132W YPL093W YOL077C YHR052W YLR197W YNL002C YER006W YGR103W YLR106C YDR496C YOL041C YBL004W YMR290C YPL012W YLR276C YNL061W YOR206W YMR049C YJL109C YOR272W YDR060W YLL008W YBR143C YLR175W YHR089C YBR142W YNL110C YHR066W YPR072W YBR234C YL RNA recognition motif-containing protein RNA binding protein (putative) Null mutant is inviable; conditional mutant shows diminished accumulation of 60S ribosomal subunits
NOP58 YOR310C molecular_function unknown rRNA modification* small nucleolar ribonucleoprotein complex* YDL014W YJL033W YCR057C YPR137W YHR052W YDL213C YCL054W part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); 57 kDa nucleolar protein U3 snoRNP protein Null mutant is inviable; in vivo depletion impairs synthesis of the 40S ribosomal subunit
NOP7 YGR103W molecular_function unknown processing of 20S pre-rRNA* nucleus* YPR143W YPL211W YPR016C YPL093W YOL077C YHR052W YIL070C YER126C YKL009W YNL002C YER006W YKR081C YNL110C YLR009W YMR290C YDL014W YOR039W YOR061W YKL172W YMR229C YDL031W YMR049C YCL054W YGL111W YAL025C YOR272W YFR001W YER002W YDR087C YLL008W YHR088W YP Nucleolar protein present in purified ribosome assembly intermediates. Required for rRNA processing; Null: lethal.
NOP8 YOL144W molecular_function unknown rRNA processing* nucleolus YML121W Nucleolar protein required for 60S ribosome biogenesis Null mutant is inviable
NOT3 YIL038C 3'-5' exoribonuclease activity regulation of transcription from Pol II promoter* cytoplasm* YCR093W YDR214W YPR072W YDR381W YLR044C YLR180W YPL231W YER068W General negative regulator of transcription; may inhibit RNA polymerase II transcription machinery CCR4 transcriptional complex component Null mutant is viable, overexpression of NOT3 suppresses cdc39(not1) and cdc36(not2) mutations
NOT5 YPR072W 3'-5' exoribonuclease activity regulation of transcription from Pol II promoter* cytoplasm* YPL043W YER068W YCR093W YDL165W YIL038C member of the NOT complex, a global negative regulator of transcription NOT complex member, a global negative regulator of transcription Null mutant is viable, mutations in not4(mot2) are synthetically lethal with mutations in not5, over
NPL3 YDR432W mRNA binding mRNA-nucleus export nucleus* YPL178W YHR086W YBL017C YNL016W YGR054W YKL139W YIR001C YLR427W YDL213C YDL175C YIL079C YBR034C YOR160W involved as a protein carrier in mRNA export, involved in mitochondrial protein targeting contains RNA recognition motif|nuclear shuttling protein Null mutant is inviable, npl3 mutants are temperature-sensitive for growth, but do not exhibit a def
NPL4 YBR170C protein binding* mRNA-nucleus export* endoplasmic reticulum* YGR048W YDR259C YLR044C YDL126C YER081W YDL190C Nuclear pore or nuclear pore-associated protein required for nuclear membrane integrity and nuclear Temperature-sensitive mutants accumulate nuclear-targeted proteins in the cytoplasm and poly(A)+RNA
NPR1 YNL183C kinase activity regulation of nitrogen utilization cytoplasm YGR241C Stablizes several nutrient transporters by antagonizing a ubiquitin-mediated protein degradation pat protein kinase homolog inactive ammonia-sensitive amino acid permeases
NPT1 YOR209C nicotinate phosphoribosyltransferase activity chromatin silencing at telomere* nucleus YCL076W YJR091C homology to bacterial nicotinate phosphoribosyl transferase; NAD(+) salvage pathway nicotinate phosphoribosyltransferase Mutations weaken silencing and also cause a reduction in the intracellular NAD(+) level.
NPY1 YGL067W NAD diphosphatase activity NADH metabolism cytoplasm* hydrolyzes the pyrophosphate linkage in NADH and related nucleotides NADH pyrophosphatase 1 No readily detected phenotype
NRD1 YNL251C RNA binding nucleobase, nucleoside, nucleotide and nucleic acid metabolism nucleus YPL178W YNL016W YNL330C YMR125W YDR172W RNA recognition motif-containing protein that participates in sequence-specific regulation of nuclea Null mutant is inviable
NRG1 YDR043C DNA binding* regulation of transcription from Pol II promoter* nucleus YBR112C involved in regulation of glucose repression binds to UAS-1 in the STA1 promoter and can interact with Ssn6p|transcriptional repressor Null mutant is viable, relieves glucose repression of SUC2 and STA1; suppresses snf mutations
NRG2 YBR066C transcriptional repressor activity invasive growth nucleus YJR091C homologue of NRG1 NRG1 homolog Null mutant is viable with no detected phenotypes
NSA2 YER126C molecular_function unknown ribosomal large subunit biogenesis nucleus YCR072C YPL093W YNR053C YKL009W YNL002C YGR245C YDR101C YER006W YHR197W YMR290C YOR206W YMR049C YLR074C YPR016C YKR081C YNL110C YER083C YGR103W YHR204W Killer toxin Resistant; Nop seven associated protein 2 ribosome biogenesis Heterozygous diploid mutant exhibit haploinsufficiency K1 killer toxin resistance
NSE1 YLR007W molecular_function unknown DNA repair* nucleus non-SMC element 1. essential for cell proliferation. nse1 mutants are highly sensitive to DNA-damaging treatments and exhibit abnormal cellular morpholog
NSP1 YJL041W structural molecule activity mRNA-nucleus export* nuclear pore YLR423C YDR116C YGL172W YDR395W YJL061W YIL115C YMR193W YMR024W YDR322W YJL063C YML025C YLR312W-A YFR002W YMR047C YDL116W YLR293C YGR119C Nucleoskeletal protein found in nuclear pores and spindle pole body nuclear pore complex subunit Null mutant is inviable.
NSR1 YGR159C RNA binding* rRNA processing* nucleus* YNL053W YKL193C YDR420W YDL049C nuclear localization sequence binding protein nuclear localization sequence binding protein Null mutant is viable, shows severe growth defect.
NTC20 YBR188C pre-mRNA splicing factor activity nuclear mRNA splicing, via spliceosome spliceosome complex YDR416W YGL070C YIL034C YLR117C Prp19p (NineTeen)-associated Complex protein splicing factor Null mutant is viable. ntc20 ntc30 double mutant is very sick and accumulates pre-mRNA. Null mutant
NTF2 YER009W RAN protein binding protein-nucleus import* nuclear membrane YER004W YDL202W YMR059W May coordinate the Ran-dependent (GSP1/GSP2) association and disassociation reactions of nuclear imp nuclear transport factor|similar to mammalian cytosolic nuclear import factor NTF2 Null mutant is inviable; temperature-sensitive mutants are defective in localization of nuclear prot
NTG1 YAL015C pyrimidine-specific oxidized base lesion DNA N-glycosylase activity* DNA repair* nucleus* YDL029W YMR058W YEL060C YDR214W YMR012W YEL030W YJR068W YNL037C YPR110C YMR146C YDL059C endonuclase III like glycosylase involved in DNA repair DNA glycosylase Null mutant is viable but is sensitive to H202 and menadione
NTG2 YOL043C pyrimidine-specific oxidized base lesion DNA N-glycosylase activity base-excision repair, AP site formation nucleus YOR264W YCL032W Endonuclease III-like glycosylase endonuclease III DNA base excision repair N-glycosylase
NUC1 YJL208C endodeoxyribonuclease activity* DNA recombination* mitochondrial inner membrane YKL222C YKR079C YDL130W YNL192W YLR342W mitochondrial nuclease nuclease Null mutant is viable
NUD1 YOR373W structural constituent of cytoskeleton microtubule nucleation spindle pole body Spindle pole body protein Null mutant is inviable
NUF2 YOL069W structural constituent of cytoskeleton chromosome segregation* condensed nuclear chromosome kinetochore* YNL086W YMR294W YLR229C YEL034W YIL144W YGR119C YGR238C YER099C Protein associated with spindle pole body and critical for nuclear division 53 kDa coiled-coil protein Null mutant is inviable; temperature-sensitive mutants arrest with single undivided or partially div
NUG1 YER006W molecular_function unknown rRNA processing nucleus* YCR072C YPL146C YPL211W YPL093W YHR052W YKL009W YNL002C YGR245C YDR101C YGR103W YHR197W YLR106C YMR290C YNL061W YOR206W YLR002C YDL031W YMR049C YCL054W YER126C YNL284C YGR220C YPL043W YFR031C-A YKR081C YNL110C YPL204W YLR074C YGL081W YDR386W YDL060W NUclear GTPase Nuclear GTPase involved in Ribosome biogenesis Null: dead.
NUM1 YDR150W tubulin binding nuclear migration (sensu Saccharomyces)* bud tip* YGL217C YLR217W YOR322C YPL205C YNL271C YLR319C YCR077C YLR200W YNL153C YEL003W YJL154C YPL269W YCR065W YEL061C YER016W YGL124C YGL216W YGR078C YGR229C YLR210W YML094W YOR349W YPR141C YGL086W YLR216C YKL007W YIL034C YNL079C YFR019W YMR055C YOR058C YJ May function in nuclear migration during mitosis and meiosis by affecting astral microtubule functio contains variable number of tandem repeats of a 64 amino-acid polypeptide, potential Ca2+-binding si Null mutant is viable; num1-disrupted strains contain many budded cells with two nuclei in mother ce
NUP1 YOR098C protein binding* mRNA-nucleus export* nuclear pore YDR132C YKL061W YKR064W YOL070C YPR172W YNL189W YHR129C YCR086W YMR159C YOR326W YMR032W YOR370C YGL037C YBR126C YBL058W YAL055W YOR229W YDR395W YKL020C YLL001W YPR187W YMR271C YLR359W YHR068W YMR096W YJR159W YBL079W YDL029W YMR235C YGL016W YBR017C YL nuclear pore complex protein nuclear pore complex subunit Davis and Fink (Cell 61:965-978) report that a NUP1 deletion is inviable, whereas Schlaich and Hurt
NUP100 YKL068W structural molecule activity mRNA-nucleus export* nuclear pore YBR216C YDR034C YDR335W YGR218W YNL243W YDL207W YMR047C YER107C YLR347C YNL298W Participates in nucleocytoplasmic transport; member of GLFG-containing family of nucleoporins nuclear pore complex subunit Null mutant is viable with no obvious phenotypes; synthetically lethal with nup116 and gle2 mutants
NUP116 YMR047C structural molecule activity mRNA-nucleus export* nuclear pore YAR066W YBL094C YBR027C YBR137W YBR144C YBR273C YDR271C YGR139W YGR151C YHL049C YHR209W YIL055C YJL061W YJR079W YJR136C YJR141W YKL061W YKL088W YLR077W YLR294C YLR312C YLR434C YMR157C YMR206W YNL194C YNL300W YNL319W YNR040W YNR061C YNR074C YOL111C YO Involved in nucleocytoplasmic transport; may be required for biogenesis of tRNA nuclear pore complex subunit Null mutant grows slowly, accumulates unspliced pre-tRNAs, acumulates poly(A)+ RNA in the nucleus, a
NUP120 YKL057C structural molecule activity mRNA-nucleus export* nuclear pore YGR161C-C YOR142W-A YER086W YNR012W YGL092W YGR249W YLR208W YDL116W YAL009W YHR004C YLR216C Nucleoporin 100 kDa protein (predicted molecular weight is 120 kDa) with two leucine zipper motifs, coiled-coil Null mutant is viable but grows slower, is temperature-sensitive, and shows nucleolar fragmentation
NUP133 YKR082W structural molecule activity mRNA-nucleus export* nuclear pore YDL116W YLR208W YLR330W YJL099W YHR142W YJR075W Nuclear pore complex protein involved in poly(A)+ RNA transport, nuclear pore distribution, and poss nuclear pore complex subunit Null mutant is viable but grows slowly and is temperature-sensitive; at nonpermissive temperature, p
NUP145 YGL092W structural molecule activity mRNA-nucleus export* nuclear pore YER107C YGL060W YLR208W YGR178C YHR036W YKL057C YMR153W YPR111W YGL100W YDL116W YLR347C Nuclear pore complex protein with GLFG motif nuclear pore complex subunit Null mutant is inviable, depletion of Nup145p in vivo leads rapidly to nuclear retention of polyaden
NUP157 YER105C structural molecule activity mRNA-nucleus export* nuclear pore YIL061C YJL030W YMR153W YEL015W YBL079W YJL061W YPR120C yeast nuclear pore complex component nuclear pore complex subunit Null mutant is viable; synthetically lethal with nup170 and nup188
NUP159 YIL115C structural molecule activity mRNA-nucleus export* nuclear pore YDR395W YDL207W YJL041W YJL061W YLR347C YOR160W YJR132W Located on cytoplasmic side of nuclear pore complex; may be involved in nuclear import or mRNA expor contains coiled-coil domain and repeated motifs typical of nucleoporins|nuclear pore complex subunit Null mutant is inviable; at nonpermissive temperature, a temperature-sensitive mutant shows cessatio
NUP170 YBL079W structural molecule activity mRNA-nucleus export* nuclear pore YOR098C YER105C YJL061W YLR335W Component of yeast nuclear pore complex; may play a role in localizing specific nucleoporins to nucl nuclear pore complex subunit Null mutant is viable; synthetically lethal with nup157, nup188, and pom152; changing NUP170 express
NUP188 YML103C structural molecule activity mRNA-nucleus export* nuclear pore YMR129W YAL009W YFR002W Localized at both the cytoplasmic and nucleoplasmic faces of the nuclear pore complex (NPC); may for nuclear pore complex subunit Null mutant is viable but exhibits abnormalities in nuclear envelope and nuclear pore morphology; do
NUP192 YJL039C structural constituent of nuclear pore nuclear pore organization and biogenesis nuclear pore YBR059C YMR153W YMR032W YBR270C YLR447C YFR002W large yeast nucleoporin nuclear pore complex subunit Null mutant is inviable.
NUP2 YLR335W structural molecule activity mRNA-nucleus export* nuclear pore YOR020C YGL044C YBL079W YGL016W YNL189W YLR347C YJR132W Localizes to discrete spots in the nuclear envelope; probably functions in transport through nuclear nucleoporin Null mutant is viable; some combinations of alleles of nup1, nsp1 and nup2 are synthetically lethal
NUP42 YDR192C structural molecule activity mRNA-nucleus export* nuclear pore YOR134W YDL207W YER081W YGR218W YJR069C YNL092W YMR255W YER107C YBR017C interacts specifically with the HIV-1 Rev protein effector domain;
Ulp1 Interacting Protein 1 42 kDa protein associated with nuclear pore complexes; structurally related to the FG-nucleoporin fa Null mutant is viable, NUP42 is essential for the export of heat shock mRNAs following stress
NUP49 YGL172W structural molecule activity mRNA-nucleus export* nuclear pore* YHR216W YMR294W YNL041C YNL086W YFR002W YJL041W YBR017C YAL034W-A YGR119C localizes to discrete spots in the nuclear envelope nuclear pore complex subunit Null mutant is inviable; some nsp1 nsp49 alleles exhibit synthetic lethality
NUP53 YMR153W structural molecule activity mRNA-nucleus export* nuclear pore YLR324W YMR153W YGL170C YGL092W YOL129W YER118C YDL088C YDR307W YER026C YGL044C YGL104C YGL237C YHL004W YHR190W YJL039C YJL057C YJL117W YLR295C YML125C YMR298W YNL234W YOL018C YML064C YML031W YFR002W YER105C YMR129W YOL065C Component of karyopherin docking complex of the nuclear pore complex karyopherin docking complex component of the nuclear pore complex|nuclear pore complex subunit Null mutant is viable but disrupts Kap121 localization to the nuclear envelope.
NUP57 YGR119C structural molecule activity mRNA-nucleus export* nuclear pore YEL043W YKL061W YKL103C YLR423C YMR294W YGR120C YPR046W YDL065C YDR416W YGL172W YGL170C YJL041W YBR017C YMR139W YPR083W YMR236W YGL005C YGR218W YOL069W YOR035C YFR002W YMR308C Forms complex with Nsp1p, Nup49p, and Nic96p at nuclear pore; this complex participates in nucleocyt nuclear pore protein (nucleoporin) Null mutant is inviable
NUP60 YAR002W structural constituent of nuclear pore nucleocytoplasmic transport* nuclear pore YLR347C YLR418C YPR141C YPR135W YMR078C YCL016C YCL061C YNL273W YNL250W YDR363W nuclear pore protein nuclear pore complex subunit
NUP82 YJL061W structural molecule activity mRNA-nucleus export* nuclear pore YKL061W YLR423C YER105C YJL041W YIL115C YMR047C YEL005C YFR008W YBL079W Interacts with nuclear pore complex and participates in nucleocytoplasmic transport; required for po 82 kDa protein, with putative coiled-coil domain, has carboxy-terminal domain, containing heptad rep Null mutant is inviable; cells depleted of Nup82p, or cells with temperature-sensitive Nup82p at non
NUP84 YDL116W structural molecule activity mRNA-nucleus export* nuclear pore YCL044C YCL069W YHR033W YOL014W YPL124W YJL117W YGL179C YKL057C YGL092W YDR113C YHR004C YMR047C YJL041W YOR180C YHL004W YCL051W YCR039C YDL044C YGL263W YJL090C YOR294W YPL091W YLR208W YKR082W YOL131W YJR042W YGL100W YAL009W component of nuclear pores; Part of complex with Nup120p, Nup85p, Sec13p, and a Sec13p homolog nuclear pore complex subunit|similar to mammalian Nup107p Null mutant is viable but has defects in nuclear membrane and nuclear pore complex organization and
NUP85 YJR042W structural molecule activity mRNA-nucleus export* nuclear pore YMR209C YOR176W YGL100W YPL215W YOR160W YDL116W YPL169C YLR208W YHR004C Protein in nuclear pore complex; may function in nuclear envelope integrity; may also be involved in nuclear pore complex subunit Null mutant is viable but is temperature-sensitive; at nonpermissive temperature, null mutant accumu
NUT1 YGL151W molecular_function unknown regulation of transcription from Pol II promoter nucleus YPR168W YDL005C YOL135C YBL093C YBR253W YNL025C YDL017W YML094W YLR103C Negative regulator of URS2 of the HO promoter Null mutant is viable, deletion of NUT1 causes a constitutive, Swi4p-independent phenotype in combin
NUT2 YPR168W RNA polymerase II transcription mediator activity transcription from Pol II promoter mediator complex YDL005C YBL093C YBR253W YGL127C YKL157W YPL276W YGL151W Negative regulator of URS2 of the HO promoter RNA polymerase II holoenzyme 21 kDa mediator subunit Null mutant is inviable, nut2-1 perturbs repression of URS2
NVJ1 YHR195W protein binding microautophagy nuclear membrane YEL013W YOL115W Vac8p binding protein; nucleus-vacuole junction Null mutant is viable; cells do not form nucleus-vacuole junctions
NYV1 YLR093C v-SNARE activity nonselective vesicle fusion vacuolar membrane YOR106W YBL050W Synaptobrevin (v-SNARE) homolog involved in vacuolar vesicle fusion vacuolar v-SNARE Null mutant is viable
OAC1 YKL120W oxaloacetate carrier activity* sulfate transport* mitochondrial inner membrane YER158C YBR017C YPR159W oxaloacetate carrier oxaloacetate transport protein
OAF1 YAL051W DNA binding* peroxisome organization and biogenesis* nucleus YOR363C Oleate-Activated transcription Factor; activates gene expression in response to oleate; many Oaf1 ta transcription factor
OAR1 YKL055C 3-oxoacyl-acyl-carrier protein reductase activity aerobic respiration* mitochondrion YER119C 3-oxoacyl-acyl-carrier-protein reductase 3-oxoacyl-acyl-carrier-protein reductase Null mutant is viable, respiratory deficient
OCH1 YGL038C alpha-1,6-mannosyltransferase activity* N-linked glycoprotein maturation Golgi cis cisterna YLR362W initiates the polymannose outer chain elongation of N-linked glycans alpha-1,6-mannosyltransferase Null mutant is viable, temperature sensitive, lacks mannose outer chains
OCT1 YKL134C metallopeptidase activity iron ion homeostasis* mitochondrion YPR086W mitochondrial protein import machinery component involved in the biogenesis of the oxidative phospho intermediate peptidase|possesses octapeptidyl amino-peptidase activity Null mutant is viable, unable to grow on nonfermentable substrates
ODC1 YPL134C intracellular transporter activity* mitochondrial transport mitochondrion* Oxodicarboxylate carrier mitochondrial 2-oxodicarboxylate transport protein
ODC2 YOR222W intracellular transporter activity* mitochondrial transport mitochondrial inner membrane YER081W mitochondrial 2-oxodicarboxylate transport protein
OGG1 YML060W purine-specific oxidized base lesion DNA N-glycosylase activity DNA repair* mitochondrion YOL010W Excises 7,8-dihydro-8-oxoguanine (8-OxoG) when 8-OxoG is oppposite cytosine or thymine (but not aden 43 kDa 8-oxo-guanine DNA glycosylase Inactivation of OGG1 creates a mutator phenotype specific for the generation of GC to TA transversio
OKP1 YGR179C protein binding chromosome segregation condensed nuclear chromosome kinetochore YBR211C YDR103W Outer Kinetochore Protein
OLE1 YGL055W stearoyl-CoA 9-desaturase activity mitochondrion inheritance* endoplasmic reticulum membrane YDL093W converts saturated fatty acyl-CoAs into cis-Delta-9 unsaturated fatty acids. delta-9-fatty acid desaturase The null mutant is inviable but can be rescued by addition of unsaturarted fatty acids to the growth
OLI1 Q0130 structural molecule activity* protein complex assembly* proton-transporting ATP synthase complex, coupling factor F(o) (sensu Eukarya) Subunit 9 of mitochondrial ATP synthase. Integral membrane protein homologous to bovine Subunit 9 an ATPase-associated proteolipid|F0-ATP synthase subunit 9 Loss-of-function mutants lack rutamycin-sensitive ATPase activity, are oligomycin resistant, and do
OM45 YIL136W molecular_function unknown biological_process unknown mitochondrial outer membrane YEL048C YGL137W 45-kDa mitochondrial outer membrane protein 45 kDa mitochondrial outer membrane protein Null mutant is viable and shows normal growth, viability, mitochondrial function and mitochondrial p
OPI1 YHL020C transcription co-repressor activity negative regulation of transcription from Pol II promoter* nucleus YER120W YGL245W YLR262C Negative regulator of phospholipid biosynthesis The null mutant is viable but constitutively accumulates INO1 mRNA.
OPI3 YJR073C phosphatidyl-N-methylethanolamine N-methyltransferase activity phosphatidylcholine biosynthesis endoplasmic reticulum YJL047C YKL190W YHR007C YPL031C YLR039C YLR262C YBR023C YHR142W YMR307W YBL061C YNL322C YAL013W Second and third steps of methylation pathway for phosphatidylcholine biosynthesis unsaturated phospholipid N-methyltransferase Null mutant is viable, temperature sensitive in the presence of monomethylethanolamine, exhibits an
OPY2 YPR075C molecular_function unknown cell cycle arrest in response to pheromone cytoplasm imparts Far- phenotype
ORC1 YML065W ATPase activity* DNA replication initiation* nuclear origin of replication recognition complex YDR171W YBR060C YLL004W YPR162C YNL261W YHR118C YPL022W binds to origins of replication and thereby directs DNA replication and is also involved in transcri origin recognition complex (ORC) 120 kDa (largest) subunit|similar to Cdc6p, Cdc18p, and Sir3p and t
ORC2 YBR060C DNA replication origin binding DNA replication initiation* nuclear origin of replication recognition complex YNL261W YPR019W YMR001C YDL017W YLL004W YPR162C YHR118C YLR103C YML065W origin recognition complex subunit 2 origin recognition complex subunit 2 Null mutant is inviable. orc2-1, a temperature-sensitive allele, blocks replication of nuclear DNA.
ORC3 YLL004W DNA replication origin binding DNA replication initiation* nuclear origin of replication recognition complex YGL169W YML065W YBR060C Third subunit of the origin recognition complex origin recognition complex subunit Null mutant is inviable
ORC4 YPR162C DNA replication origin binding DNA replication initiation* nuclear origin of replication recognition complex YML065W YBR060C Part of complex that binds to origins of replication and thereby directs DNA replication and is also origin recognition complex (ORC) 56 kDa subunit
ORC5 YNL261W ATPase activity* DNA replication initiation* nuclear origin of replication recognition complex YPR019W YBR060C YML065W YBL071C May be subunit of origin recognition complex (ORC) that mediates the ATP-dependent binding to origin ATP-binding site (putative)|origin recognition complex fifth largest subunit orc5-1 mutant is temperature-sensitive, has defects in transcriptional silencing, has elevated rate
ORC6 YHR118C DNA replication origin binding DNA replication initiation* nuclear origin of replication recognition complex YML065W YBR060C origin recognition complex (ORC) component that binds to origins of replication and thereby directs ORC 50 kDa subunit Null mutant is inviable.
ORM2 YLR350W molecular_function unknown biological_process unknown endoplasmic reticulum membrane YHR030C YLR418C YDL017W YDL049C Homologous to ORM1. Endoplasmic reticulum membrane-anchored protein Null: Single knockout is viable.
Double ORM1 ORM2 knockout shows impaired growth and high sensi
ORT1 YOR130C L-ornithine transporter activity nuclear migration (sensu Saccharomyces)* mitochondrial membrane Mitochondrial integral membrane protein, ornithine transporter Null mutant is viable, arginine bradytroph
OSH1 YAR044W oxysterol binding* steroid biosynthesis endoplasmic reticulum* YLR397C YGR192C YER120W May be involved in ergosterol synthesis Null mutant is viable but displays pleiotropic sterol-related phenotypes such as tryptophan-transpor
OSH2 YDL019C oxysterol binding steroid biosynthesis plasma membrane* YER120W Oxysterol Binding Protein Null mutant is viable
OSH3 YHR073W oxysterol binding steroid biosynthesis cytoplasm YPL043W YHR152W Oxysterol Binding Protein Null mutant is viable.
OSM1 YJR051W fumarate reductase (NADH) activity metabolism cytoplasm YFL018C osmotic growth protein osmotic growth protein Null mutant is viable, sensitive to hypertonic medium. Simultaneous disruption of YEL047C and OSM1 r
OST1 YJL002C dolichyl-diphosphooligosaccharide-protein glycosyltransferase activity N-linked glycosylation* endoplasmic reticulum lumen* YLR208W YGL100W YMR146C YML130C YML019W YGL022W YEL002C YDR034C Oligosaccharyltransferase catalyzes the transfer of oligosaccharide from dolichol-oligosaccharide do 64 kDa, alpha subunit of oligosaccharyltransferase complex; homologous to mammalian ribophorin I Null mutant is inviable; temperature-sensitive mutants show pleiotropic underglycosylation of solubl
OST2 YOR103C dolichyl-diphosphooligosaccharide-protein glycosyltransferase activity N-linked glycosylation oligosaccharyl transferase complex Oligosaccharyltransferase catalyzes the transfer of oligosaccharide from dolichol-oligosaccharide do 40% identical to vertebrate DAD1 protein|oligosaccharyltransferase complex 16 kDa epsilon subunit Null mutant is inviable; overexpression of OST2 suppresses temperature-sensitivity of wbp1-2 mutant;
OST3 YOR085W dolichyl-diphosphooligosaccharide-protein glycosyltransferase activity protein complex assembly* integral to membrane* YDL232W YOR002W YGR227W YOR067C YDR126W Catalyzes the transfer of oligosaccharide from dolichol-oligosaccharide donor to consensus glycosyla oligosaccharyl transferase glycoprotein complex 34 kDa gamma subunit Null mutant is viable but shows underglycosylation of soluble and membrane-bound glycoproteins and c
OST4 YDL232W dolichyl-diphosphooligosaccharide-protein glycosyltransferase activity* N-linked glycosylation endoplasmic reticulum membrane YOR085W subunit or accessory component of oligosaccharyltransferase 3.6 kDa protein Null mutant is viable but is cold- and heat-sensitive; vanadate-resistant, hygromycin B-sensitive; d
OST5 YGL226C-A dolichyl-diphosphooligosaccharide-protein glycosyltransferase activity N-linked glycosylation oligosaccharyl transferase complex YOR002W YGR227W YOR067C Oligosaccharyltransferase catalyzes the transfer of oligosaccharide from a dolichol-oligosaccharide oligosaccharyltransferase complex 9.5 kDa zeta subunit
OST6 YML019W dolichyl-diphosphooligosaccharide-protein glycosyltransferase activity protein complex assembly* oligosaccharyl transferase complex YJL002C YPR086W Putative new 37kDa subunit of N-oligosaccharyltransferase complex N-oligosaccharyltransferase complex 37kDa subunit (putative)
OXA1 YER154W protein transporter activity mitochondrial translocation mitochondrial inner membrane YOR121C YNR003C YPR086W Mediates the export of proteins from the mitchondrial matrix to the intermembrane space. Null mutant is viable but is respiratory-deficient and lacks cytochrome oxidase activity; oxa1 mutan
PAB1 YER165W poly(A) binding regulation of translational initiation nucleus* YGR162W YER165W YGR178C YBL105C YOL139C YGL049C YIL129C YER032W YGL044C YIL123W YBR055C YPL259C YIR001C YNL322C Poly(A) binding protein, cytoplasmic and nuclear poly(A) binding protein Null mutant is inviable.
PAC1 YOR269W molecular_function unknown nuclear migration (sensu Saccharomyces)* cytoplasm* YLR254C YGL217C YHR168W YOR296W YOR300W YNL271C YER155C YLR200W YNL153C YEL003W YPL269W YEL061C YER016W YGL216W YGR078C YML094W YPR141C YKL127W YKL007W YFR019W YAL040C YOR058C YOR326W Required for viability in the absence of the kinesin-related Cin8p mitotic motor. Mutants display dyn1-like (dynein) phenotypes
PAC10 YGR078C tubulin binding tubulin folding cytoplasm YBR108W YBR255W YCR082W YDR149C YDR334W YDR360W YEL041W YGL242C YGR054W YHL029C YJR129C YLL007C YLL049W YLR089C YNL140C YPL017C YPR050C YBL007C YNL298W YCR044C YJR075W YEL031W YER155C YMR109W YER149C YLR337C YLR200W YNL153C YBR171W YJR117W YOR216C YJ Polypeptide 3 of a Yeast Non-native Actin Binding Complex, homolog of a component of the bovine NABC bovine NABC complex component homolog|non-native actin binding complex polypeptide 3 Null mutant is viable, benomyl sensitive, cold sensitive, microtubules disassemble at 14 degrees cel
PAC11 YDR488C microtubule motor activity microtubule-based process cell YGL217C YOR172W YNL271C YLR200W YNL153C YEL003W YPL269W YPL174C YEL061C YER016W YER114C YGL216W YGR078C YLR210W YML094W YOR349W YDR424C YNR058W YIL135C YBL064C YOR058C YOR326W YPR141C Protein required in the absence of Cin8p Null mutant is viable.
PAF1 YBR279W Pol II transcription elongation factor activity RNA elongation from Pol II promoter transcription elongation factor complex YOL145C YGL244W YGL207W RNA polymerase II-associated, nuclear protein that may serve as both a positive and negative regulat Null mutant is viable but shows slow growth, temperature-sensitivity, abnormal cell morphology, and
PAI3 YMR174C endopeptidase inhibitor activity vacuolar protein catabolism cytoplasm Cytoplasmic inhibitor of proteinase Pep4p inhibitor of proteinase Pep4p Null mutant is viable but shows increased rate of protein degradation
PAN1 YIR006C cytoskeletal adaptor activity endocytosis* plasma membrane* YGR241C YOL101C YOR105W YNL084C YHR161C YBL007C YER125W YIL002C YDL161W YER133W YGL181W Involved in actin organization and endocytosis Null mutant is inviable; conditional mutants show arrest of translation initiation, alterations in m
PAP1 YKR002W polynucleotide adenylyltransferase activity mRNA polyadenylation nucleoplasm YDR390C YER133W YGR048W YNL317W YAL043C YMR061W YGR156W YKL059C YLR277C YPR107C YNL222W YJL029C YJL033W YDR228C YDR195W YGL044C YER127W YLR115W YJR093C YDR301W YER032W poly(A) polymerase poly(A) polymerase lethal
PAT1 YCR077C molecular_function unknown chromosome segregation* cytosolic small ribosomal subunit (sensu Eukarya)* YGL121C YJL124C YDL065C YDL160C YNL147W YNL118C YBR103W YBR270C YDL139C YDL175C YDL216C YGR218W YIL154C YOL149W YGL173C YBL026W YLR438C-A YER112W YER146W YDR378C YJR022W YGR074W YLR229C YLR418C YMR294W YDR150W YCL029C YOL006C YLR103C YLR330W Necessary for accurate chromosome transmission during cell; Involved in mRNA turnover Null mutant is viable; slow growth rate, reduced fidelity of chromosome segregation during both mito
PBI2 YNL015W endopeptidase inhibitor activity vacuole fusion (non-autophagic)* cytoplasm* YHL002W YPR086W Proteinase inhibitor that inhibits protease Prb1p (yscB or IB2) proteinase inhibitor I2B (PBI2) Null mutant is viable but shows 50% elevation of protein degradation rate when cells are subject to
PBN1 YCL052C molecular_function unknown protein processing endoplasmic reticulum YEL060C Protease B Non-derepressible protease B nonderepressible form Null mutant is inviable; overexpression of both PBN1 and LRE1 confers resistance to laminarinase, wh
PBP1 YGR178C molecular_function unknown mRNA polyadenylation nucleus* YHR121W YGL092W YJL035C YDL160C YGR218W YLR295C YER165W Poly(A)-binding protein binding protein Null mutant is viable; other mutant suppresses pab1 null mutant.
PBS2 YJL128C MAP kinase kinase activity* protein amino acid phosphorylation* cytoplasm YBR047W YDL006W YDR162C YMR319C YNR058W YLR362W YER178W YNR031C YER118C YLR113W YDL235C Involved in osmoregulation, member of the HOG1 mitogen-activated protein kinase (MAPK) cascade MAP kinase kinase (MEK)|may act as a scaffolding protein for Sho1p, Ste11p, and Hog1p Null mutant is viable, sensitive to high osmolarity, sensitive to the antibiotic polymyxin B; shows
PCA1 YBR295W ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism copper ion homeostasis membrane YBR135W thought to play a role in resistance to copper ion toxicity P-type ATPase Cu(2+)-transporting (putative) Null mutant is viable but ceases growth earlier when grown in minimal medium with high copper concen
PCD1 YLR151C pyrophosphatase activity biological_process unknown peroxisome YPR066W YER081W YGR218W peroxisomal nudix hydrolase active towards coenzyme A and its derivatives coenzyme A diphosphatase Null mutant is viable.
PCF11 YDR228C protein binding* mRNA polyadenylation* mRNA cleavage factor complex YLR424W YLR423C YPR049C YDR448W YIL035C YLR115W YKR002W YMR061W YLR277C YGL044C YOR250C YKL059C YJR022W pre-mRNA cleavage and polyadenylation factor I component, interacts with Rna14p and Rna15p cleavage and polyadenylation factor CF I component involved in pre-mRNA 3'-end processing Null mutant is inviable; pcf11 (ts) mutations are synthetically lethal with rna14 (ts) and rna15 (ts
PCH2 YBR186W molecular_function unknown regulation of meiosis nucleolus YGL127C YLR373C YLR200W Pachytene CHeckpoint ATPase (putative) Null mutant is viable and bypasses meiotic arrest of zip1 mutant, resulting in chromosome segregatio
PCI8 YIL071C molecular_function unknown protein deneddylation signalosome complex YDL216C YDR311W YOL117W subunit of COP9 signalosome (CSN); Proteasome-COP9 signalosome-eukarytotic Initiation factor 3 (PCI) COP9 signalosome (CSN) subunit|transcriptional regulator (putative)|translational regulator (putativ Null mutant is viable.
PCK1 YKR097W phosphoenolpyruvate carboxykinase (ATP) activity gluconeogenesis cytosol phosphoenolpyruvate carboxylkinase phosphoenolpyruvate carboxylkinase Null mutant is viable.
PCL1 YNL289W cyclin-dependent protein kinase, intrinsic regulator activity cell cycle cyclin-dependent protein kinase holoenzyme complex YNL271C G(sub)1 cyclin that associates with PHO85 G1 cyclin|associates with PHO85 Required for passage through G(sub)1 in diploid cells lacking CLN1
PCL10 YGL134W cyclin-dependent protein kinase, intrinsic regulator activity regulation of glycogen biosynthesis* cyclin-dependent protein kinase holoenzyme complex YPL031C YDL108W PHO85 cyclin Null mutant is viable.
PCL2 YDL127W cyclin-dependent protein kinase, intrinsic regulator activity cell cycle cyclin-dependent protein kinase holoenzyme complex YDR388W YDR146C YKL002W YLR453C YPL031C Interacts with cyclin-dependent kinase PHO85 to form kinase complex with G1-periodic activity involv G1 cyclin
PCL5 YHR071W cyclin-dependent protein kinase, intrinsic regulator activity cell cycle cyclin-dependent protein kinase holoenzyme complex YPL031C PHO85 cyclin Null mutant is viable.
PCL6 YER059W cyclin-dependent protein kinase, intrinsic regulator activity regulation of glycogen biosynthesis* cyclin-dependent protein kinase holoenzyme complex YBR141C YER156C YOR392W YJL084C YLR190W YPL031C YDL224C YBR160W PHO85 cyclin Null mutant is viable. A Ty insertion mutant exhibits slow growth.
PCL7 YIL050W cyclin-dependent protein kinase, intrinsic regulator activity regulation of glycogen biosynthesis* cyclin-dependent protein kinase holoenzyme complex YLR190W YNL218W YLR449W YPL031C YDL224C YLR295C YBR160W PHO85 cyclin cyclin
PCL8 YPL219W cyclin-dependent protein kinase, intrinsic regulator activity regulation of glycogen biosynthesis* cyclin-dependent protein kinase holoenzyme complex YPL031C YJR091C PHO85 cyclin cyclin Null mutant is viable.
PCL9 YDL179W cyclin-dependent protein kinase, intrinsic regulator activity cell cycle cyclin-dependent protein kinase holoenzyme complex YMR147W YDR388W YBL045C YPL031C PHO85 cyclin Null mutant is viable.
PCM1 YEL058W phosphoacetylglucosamine mutase activity N-acetylglucosamine biosynthesis cytoplasm YNL218W Phosphoacetylglucosamine Mutase phosphoacetylglucosamine mutase Null mutant is inviable; a Ty insertion mutant exhibits slow growth.
PCP1 YGR101W peptidase activity mitochondrion organization and biogenesis* mitochondrion YJL213W YHL021C processing of cytochrome c peroxidase rhomboid protease Null: lack of Ccp1 maturation, slow growth on non-fermentable media
PCS60 YBR222C AMP binding biological_process unknown cytoplasm* YAR020C Probable AMP-binding protein
PCT1 YGR202C choline-phosphate cytidylyltransferase activity phosphatidylcholine biosynthesis* nucleus* YGL137W phosphorylcholine transferase; or cholinephosphate cytidylyltransferase cholinephosphate cytidylyltransferase|phosphorylcholine transferase Null mutant is viable
PDA1 YER178W pyruvate dehydrogenase (lipoamide) activity pyruvate metabolism mitochondrion* YGR229C YKL124W YBR221C YMR308C YDR430C YJR091C YGL137W YJL128C YLR418C YNL192W alpha subunit of pyruvate dehydrogenase (E1 alpha) pyruvate dehydrogenase alpha subunit (E1 alpha) Null mutant is viable, exhibits reduced growth on glucose and increased formation of petites
PDB1 YBR221C pyruvate dehydrogenase (lipoamide) activity pyruvate metabolism mitochondrion* YLR345W YFL018C YPL259C YBR208C YFR004W YDR069C YER178W YPL151C YNL071W YGR193C YBR044C YGL130W YMR308C YDR430C YML059C YER081W YLR218C YLR418C YBR229C beta subunit of pyruvate dehydrogenase (E1 beta) pyruvate dehydrogenase beta subunit (E1 beta) Null mutant is viable
PDC2 YDR081C transcription regulator activity transcription from Pol II promoter* nucleus Regulates transcription of PDC1 and PDC5, which encode pyruvate decarboxylase asparagine and serine-rich protein Null mutant is viable but shows strongly reduced pyruvate decarboxylase specific activity; slow, res
PDI1 YCL043C protein disulfide isomerase activity protein folding endoplasmic reticulum lumen YER189W YLR354C YDR518W YJR076C YIR001C YLR233C YIL035C YOL126C Catalyzes the formation and isomerization of disulfide bonds during the folding of secretory protein protein disulfide isomerase Null mutant is inviable
PDR1 YGL013C DNA binding* regulation of transcription from Pol II promoter* nucleus YDR412W YGL013C general positive regulator of permeability genes zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type pleiotropic drug resistance, resistant to borrelidin, oligomycin, antimycin, cycloheximide, antibiot
PDR10 YOR328W ATP-binding cassette (ABC) transporter activity multidrug transport plasma membrane Putative ABC transporter highly similar to Pdr5p ABC transporter (putative)|highly similar to Pdr5p
PDR11 YIL013C ATP-binding cassette (ABC) transporter activity sterol transport membrane YDR174W ATP-dependent permease, member of ATP-binding cassette (ABC) transporter family ABC transporter (putative)
PDR12 YPL058C xenobiotic-transporting ATPase activity* transport* plasma membrane similar to Pdr5p multidrug resistance transporter Null mutant is viable, sensistive to weak organic acids.
PDR15 YDR406W ATP-binding cassette (ABC) transporter activity transport integral to membrane similar to Pdr5p and Pdr10p multidrug resistance transporter (putative)
PDR16 YNL231C phosphatidylinositol transporter activity response to drug* cytoplasm YGL014W YHR007C YNL192W involved in pleiotropic drug resistance by controlling lipids in various cellular compartments; posi Pdr17p homolog|Sec14p homolog Null mutant is viable, exhibits hypersensitivity to azole inhibitors of ergosterol biosynthesis, alt
PDR17 YNL264C phosphatidylinositol transporter activity response to drug* cytoplasm YNL098C YLR113W YDR126W involved in pleiotropic drug resistance by controlling lipids in various cellular compartments; puta Pdr16p homolog|Sec14p homolog Null mutant is viable, exhibits no observable phenotypes; pdr16 pdr17 double deletion mutants exhibi
PDR18 YNR070W ATP-binding cassette (ABC) transporter activity transport membrane pleiotropic drug resistance ABC transporter of the PDR family Null: viable
PDR3 YBL005W DNA binding* regulation of transcription from Pol II promoter* nucleus* YLR100W Zinc-finger transcription factor related to Pdr1p pleiotropic drug resistance
PDR5 YOR153W xenobiotic-transporting ATPase activity response to drug* plasma membrane YAL053W YNL236W multidrug resistance transporter multidrug resistance transporter pleiotropic drug resistance
PDR8 YLR266C DNA binding* response to stress* nucleus YNL113W Pleiotropic Drug Resistance zinc finger transcription factor Null